Professional Documents
Culture Documents
Understand how the many proteins of chr21 work together to produce cognitive deficits Learn how to manipulate the effects of trisomy 21 to lessen/prevent cognitive deficits
pharmacology
Model systems
Whole organisms
Mouse Zebrafish Fruit fly Brewers yeast
Mmu10
20 chr21 protein genes 40 chr21 protein genes
Several drug treatments correct abnormalities Weaknesses Partial trisomy mouse chr16 region only
Three copies of only 88 chr21 protein genes
How are DS cells different from control cells? How do DS cells differ from each other? How do drugs affect DS cells?
Do all drugs produce the same results? Does a drug affect all DS cells the same way? Are there correlations with cognitive strengths & weaknesses of donors?
Conclusions
Mouse is the only model system for testing of drug effects on learning & memory Human cell lines allow testing of drug effects on complete trisomy of chr21, with genetic diversity, and for correlation of cell features with human cognitive variation Human clinical trials are expensive in time, effort and $$$