Penicillin Methi,Naf,Dicloxacillin Ampicillin,Amoxycillin Ticar,carbeni,piperacillin Cephalosporin

Cell wall inhibitor

Aztreonam Imipenem, merepenem Vancomycin Aminoglycoside Tetracycline Macrolides Chloramphenicol Clindamycin Sulfonamides

Bind to PBP3 Bind to D-ala D-ala Inhibit formation of initiation complex Prevent attachment of Amino acyl tRNA Bind to 23s of 50 inhibit translocation Block peptide bond formation Inhibit dihydropteroate Reductase Inhibit DHF reductase Inhibit DNA gyrase Free radicals synthesis of Mycolic acid Inhibit DNA dependent RNA Polymerase Block fatty acid synthase I Inhibit mycolic acid product Block arabinosyltransferase Carbohydrate Polymerization Bind ergosterol Inhibit P450 which convert Lanosterol to Ergosterol Inhibit DNA synthesis by Conversion to 5-FU by cytosine deaminase Inhibit cell wall synthesis

Trimethoprim Fluoroquinolones Metronidazole Isoniazid Rifampin Pyrazinamide Ethambutol Amphotericin B Nystatin Azoles Flucytosin Caspofungin

Hypersensitivity, Hemolytic anemia Hypersensitivity, Methicillininterstitial nephritis Hypersensitivity, Ampicillin rash, pseudomembranous colitis Hypersensitivity Hypersensitivity, Vit K def Cross Hypersensitivity w/ penicillin Nephrotoxicity of aminoglycoside Disulfiram reaction w/ ethanol Non toxic, occasional GI problem GI, Skin rash, CNS seizure Nephrotoxicity, Ototoxicity, Thrombophlebitis Nephrotoxicity w/cephalosporin Ototoxicity w/loop diuretics Teratogen GI, Inhibition of bone growth in child Photosensitivity, discoloration of teeth Prolonged QT, GI, Acute cholestatic hepatitis Rash, Eosinophilia Anemia, Aplastic anemia Gray baby syndrome Pseudomembrane colitis Hypersensitivity Hemolytic anemia if G6PD deficient Nephrotoxicity, Photosensitivity Kernicterus in infant Megaloblastic anemia Leukopenia, Granulocytopenia GI, Skin rash Tendonitis/tendon rupture in adult Leg cramp/myalgias in child Metallic taste, Disulfiram like reaction Nephrotoxicity, Hepatotoxicity, Lupus Hepatotoxicity Orange body fluids Hyperuricemia, Hepatotoxicity Optic neuropathy Fever/Chills, Anemia Hypotension, arrhythmia Nephrotoxicity, IV phlebitis Fever/chills Gynecomastia Liver dysfunction (Inhibit P-450) Nausea, Vomiting, Diarrhea BM suppression GI, Flushing

Terbinafine Griseofulvin Chloroquine

Inhibit epoxidase Inhibit microtubule Formation Blocks heme polymerase

Abnormal LFTs, Visual disturbance Teratogenic, carcinogenic headache P450 and warfarin metabolism Retinopathy, G6PD hemolysis