Lipid

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1 \cf0 1.1 Pendahuluan
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\cf0 \fi720 {\b0 Kita}{\b0
butuh}{\b0
makan}{\b0
setiap}{\b0
har
i.}{\b0
Ini}{\b0
disebabkan}{\b0
karena}{\b0
tubuh}{\b0
kita
}
\par}{\phpg\posx2270\pvpg\posy3022\absw8304\absh10310 \sl-414 \b \f20 \fs21 \cf0
\fi360 {\b0 memerlukan}{\b0 asupan}{\b0 nutrisi.}{\b0 Makanan}{\b0 meru
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sumber}{\b0 asupan }
\fi360 {\b0 nutrisi}{\b0 tersebut.}{\b0 Namun}{\b0 makanan}{\b0 yang}{\b0
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\fi360 {\b0 yang}{\b0 berbeda}{\b0 beda}{\b0 dengan}{\b0 kadar}{\b0 yang}{
\b0 berbeda}{\b0 pula.}{\b0 Hal}{\b0 ini}{\b0 menyebabkan}{\b0 kita }
\fi360 {\b0 tidak}{\b0 dapat}{\b0 mengonsumsi}{\b0 makanan}{\b0 satu}{\
b0 sejis}{\b0 saja.}{\b0 Kita}{\b0 harus}{\b0 memadukan }
\fi360 {\b0 beberapa}{\b0 jenis}{\b0 makanan}{\b0 ke}{\b0 dalam}{\b0
menu}{\b0 makan}{\b0 kita.}{\b0 Dari}{\b0 prinsip}{\b0 ini}{\b0 maka
}
\fi360 {\b0 mulai}{\b0 diperkenalkan}{\b0 pola}{\b0 makan}{\b0 empat}{\b0
sehat}{\b0 lima}{\b0 sempurna}{\b0 yang}{\b0 terdiri}{\b0 dari }
\fi360 {\b0 nasi,}{\b0 lauk-pauk,}{\b0 daging,}{\b0 buah-buahan}{\b0 dan}{\
b0 susu. }

\cf0 \fi720 {\b0 Namun}{\b0 dengan}{\b0 adanya}{\b0 perubahan}{\b0 jaman
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keras.}{\b0
Waktu}{\b0
yang}{\b
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di}{\b0
miliki}{\b0
untuk}{\b0
memelihara}{\b0
kesehatan }
\fi360 {\b0 semakin}{\b0
sedikit.}{\b0
Pola}{\b0
makan}{\b0
pun}{\b
0
menjadi}{\b0
berubah}{\b0
dan}{\b0
kadang}{\b0
bahkan }
\fi360 {\b0 terabaikan.}{\b0 Penyakit}{\b0 seperti}{\b0 gastritis}{\b0
dan}{\b0 konstipasi}{\b0 semakin}{\b0 banyak}{\b0 terjadi. }
\fi360 {\b0 Hal}{\b0 ini}{\b0 diperparah}{\b0 dengan}{\b0 pola}{\b0 makan}
{\b0 yang}{\b0 cenderung}{\b0 condong}{\b0 ke}{\b0 fast}{\b0 food. }
\fi360 {\b0 Makanan}{\b0
ini}{\b0
seringkali}{\b0
tidak}{\b0
memadukan}{\b0
makanan-makanan}{\b0
yang }
\fi360 {\b0 mengandung}{\b0 nutrisi}{\b0 yang}{\b0 duperlukan}{\b0 oleh
}{\b0 tubuh}{\b0 kita.}{\b0 Terkadang}{\b0 juga}{\b0 hanya }
\fi360 {\b0 mengandung}{\b0
satu}{\b0 jenis}{\b0 makanan}{\b0 yang}{\b
0 tentu}{\b0 saja}{\b0 tidak}{\b0 mengandung}{\b0 seluruh }
\fi360 {\b0 nutrisi}{\b0 yang}{\b0 diperlukan}{\b0 oleh}{\b0 tubuh}{\b0 ki
ta.}{\b0 Begitu}{\b0 juga}{\b0 dengan}{\b0 dengan}{\b0 makanan }
\fi360 {\b0 ringan}{\b0 yang}{\b0 memiliki}{\b0 kandungan}{\b0 nutrisi}{\b0
yang}{\b0 tidak}{\b0 begitu}{\b0 banyak. }
\cf0 \fi720 {\b0 Kita}{\b0 tahu}{\b0 bahwa}{\b0 nutrisi}{\b0 yang}{\b0
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\fi360 {\b0 Misalnya}{\b0 saja}{\b0 karbohidrat,lemak,}{\b0 protein,}{\b0
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dan}{\b0 vitamin.}{\b0 Penting}{\b0 bagi }
\fi360 {\b0 setiap}{\b0 orang}{\b0 untuk}{\b0 mengetahui}{\b0 nutrisi}{\b0
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\fi360 {\b0 yaitu}{\b0 angka}{\b0 kecukupan}{\b0 gizi.}{\b0 Selain}{\b0
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\fi360 {\b0 mengenai}{\b0 fungsi}{\b0 dari}{\b0 setiap}{\b0 kandungan}{\b0
dan}{\b0 di}{\b0 makanan}{\b0 jenis}{\b0 apa}{\b0 saja}{\b0 mereka }
\fi360 {\b0 dapat}{\b0 memperoleh}{\b0 agar}{\b0 mereka}{\b0 menjadi}{\b0
sadar}{\b0 akan}{\b0 kebutuhan}{\b0 nutrisi}{\b0 mereka }\par
}
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\sect\sectd\pard\plain
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\cf0 yang sebenarnya. Khusus dalam paper ini akan dibahas lebih menda
lam
\par}{\phpg\posx2630\pvpg\posy1712\absw7788\absh611 \sl-414 \f20 \fs21 \cf0 meng
enai lemak. \par
}
\cf0 1.2 Rumusan Masalah
\fi720 {\b0 Dari}{\b0 latar}{\b0 belakang}{\b0 di}{\b0 atas}{\b0 maka}{\b0
adapun}{\b0 rumusan}{\b0 masalah}{\b0 dari}{\b0 paper}{\b0 ini }
\fi360 {\b0 adalah: }
\fi1080 {\b0 1.}{\b0
Apa}{\b0 itu}{\b0 lipid}{\b0 dan}{\b0 bagaimanakah}
{\b0 klarifikasinya}{\b0 ? }
\fi1080 {\b0 2.}{\b0
Bagaimanakah}{\b0 struktur}{\b0 kimia}{\b0 dan}{\b0
sifat}{\b0 kimia}{\b0 atau}{\b0 fisik}{\b0 lipid}{\b0 ? }
\fi1080 {\b0 3.}{\b0
Bagaimanakah}{\b0 pencernaan,}{\b0 absorpsi,}{\b0 tra
nsportasi,}{\b0 dan}{\b0 metabolisme }

\fi1440 {\b0 lipid}{\b0 ? }
\fi1080 {\b0 4.}{\b0
Bagaimanakah}{\b0 manfaat}{\b0 dan}{\b0 dampak}{\b0
konsumsi}{\b0 lipid}{\b0 terhadap }
\fi1440 {\b0 kesehatan}{\b0 ? }\par
}
\cf0 1.3 Tujuan
\fi720 {\b0 Adapun}{\b0 tujuan}{\b0 pembuatan}{\b0 paper}{\b0 ini}{\b0 adal
ah: }
\fi720 {\b0 1.}{\b0
Untuk}{\b0 mengetahui}{\b0 pengertian}{\b0 lipid}{\b0
dan}{\b0 klarifikasinya. }
\fi720 {\b0 2.}{\b0
Untuk}{\b0 mengetahui}{\b0 struktur}{\b0 kimia}{\b0 d
an}{\b0 sifat}{\b0 kimia}{\b0 atau}{\b0 fisik}{\b0 lipid. }
\fi720 {\b0 3.}{\b0
Untuk}{\b0 mengetahui}{\b0 pencernaan,}{\b0 absorpsi,}
{\b0 transportasi,}{\b0 dan}{\b0 metabolisme }
\fi1080 {\b0 lipid. }
\fi720 {\b0 4.}{\b0
Untuk}{\b0 mengetahui}{\b0 manfaat}{\b0 dan}{\b0 damp
ak}{\b0 konsumsi}{\b0 lipid}{\b0 terhadap }
\fi1080 {\b0 kesehatan. }\par
}
2 \par
}
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\b \f20 \fs21 \cf0 BAB II
EMBAHASAN \par
}
1 \cf0 2.1 Pengertian Lipid dan Klasifikasi Lipid
\fi720 {\b0 Istilah}{\b0 lipida}{\b0 meliputi}{\b0 senyawa-senyawa}{\b0
heterogen,}{\b0 termasuk}{\b0 lemak}{\b0 dan }
{\b0 minyak}{\b0 yang}{\b0 umum}{\b0 dikenal}{\b0 di}{\b0 dalam}{\b0
makanan,}{\b0 malam,}{\b0 fosfolipida,}{\b0 sterol}{\b0 dan }
{\b0 ikatan}{\b0 lain}{\b0 sejenis}{\b0 yang}{\b0 terdapat}{\b0 di}{\
b0 dalam}{\b0 makanan}{\b0 dan}{\b0 tubuh}{\b0 manusia.}{\b0 Lipida
}
{\b0 mempunyai}{\b0
sifat}{\b0
yang}{\b0
sama,}{\b0
taitu}{\b0
larut}{\b0
dalam}{\b0
pelarut}{\b0
nonpolar}{\b0
seperti }
{\b0 etanol,eter,kloroform}{\b0
dan}{\b0
benzana.}{\b0
Secara}{\b0
umum}{\b0
lipida}{\b0
dapat}{\b0
dibagi}{\b0
dalam }
{\b0 beberapa}{\b0 kelompk}{\b0 yaitu: }
\fi720 {\b0 a.}{\b0
Lipida}{\b0 sederhana }
\fi720 {\b0 b.}{\b0
Lipida}{\b0 majemuk }
\fi720 {\b0 c.}{\b0
Lipida}{\b0 turunan }
\fi720 {\b0 Untuk}{\b0 selengkapnya}{\b0 akan}{\b0 diuraikan}{\b0 di}{\b0
bawah}{\b0 ini. }
\cf0 \fi710 A.Lipid Sederhana
\cf0 \fi720 a. Trigliserida
\cf0 \fi1440 {\b0 Trigliserida}{\b0 (atau}{\b0 lebih}{\b0 tepatnya}{\b0
triasilgliserol}{\b0 atau}{\b0 triasilgliserida) }
\fi1080 {\b0 adalah}{\b0 sebuah}{\field{\*\fldinst {\b HYPERLINK}{\b "http://i

d.wikipedia.org/wiki/Gliserida"}}
{\fldrslt{{\b0 \cf5 {\ul g}{\ul l}{\ul i}{\ul s}{\ul e}{\ul r}{\ul i}{\ul d}{\u
l a},}
}}}{\b0 yaitu}{\field{\*\fldinst {\b HYPERLINK}{\b "http://id.wikipedia.org/w/i
ndex.php?title=Ester_(kimia)&action=edit&redlink=1"}}
{\fldrslt{{\b0 \cf5 {\ul e}{\ul s}{\ul t}{\ul e}{\ul r}}
}}}{\b0 dari}{\field{\*\fldinst {\b HYPERLINK}{\b "http://id.wikipedia.org/w/in
dex.php?title=Gliserol&action=edit&redlink=1"}}
{\fldrslt{{\b0 \cf5 {\ul g}{\ul l}{\ul i}{\ul s}{\ul e}{\ul r}{\ul o}{\ul l}}
}}}{\b0 dan}{\b0 tiga}{\field{\*\fldinst {\b HYPERLINK}{\b "http://id.wikipedi
a.org/wiki/Asam_lemak"}}
{\fldrslt{{\b0 \cf5 {\ul a}{\ul s}{\ul a}{\ul m}}{\b0 \cf5 {\ul }{\ul l}{\ul e
}{\ul m}{\ul a}{\ul k}. }
\par}
}}}{\phpg\posx2270\pvpg\posy3506\absw8342\absh10189 \sl-347 \par\b \f20 \fs21 \c
f0 \fi1418 {\i 1.}{\i Lilin }
\fi1986 {\b0 Lilin}{\b0 adalah}{\b0 senyawa}{\b0 yang}{\b0 terbentuk}{\
b0 dari}{\b0 ester}{\b0 asam}{\b0 lemak }
\fi1560 {\b0 dengan}{\b0 alkohol}{\b0 bukan}{\b0 gliserol.}{\b0 Pada}{\
b0 umumnya}{\b0 asam}{\b0 lemaknya }
\fi1560 {\b0 adalah}{\b0 palmitat}{\b0 dan}{\b0 alkoholnya}{\b0 mempunyai}{
\b0 atom}{\b0 C}{\b0 sebanyak}{\b0 26- }
\fi1560 {\b0 34.}{\b0 contohnya}{\b0 adalah}{\b0 mirisil}{\b0 palmitat.}{\
b0 (Suharsono}{\b0 Martoharsono, }
\fi1560 {\b0 53). }
\fi1986 {\b0 Pada}{\b0 umunya}{\b0 malam}{\b0 merupakan}{\b0 ester}{\b0
asam}{\b0 lemah}{\b0 dengan }
\fi1560 {\b0 alkohol}{\b0
allifatik}{\b0
bermolekul}{\b0
besar,}{\b0
dan}{\b0
asamnya}{\b0
mempunyai }
\cf0 \fi1560 {\b0 jumlah}{\b0 karbon}{\b0 berkisar}{\b0 antara}{\b0 C}{\
b0\dn006 \fs12 25}{\b0 sampai}{\b0 C}{\b0\dn006 \fs12 35.}{\b0 (Purwo}{\b
0 Arbianto, }
\fi1560 {\b0 54) }\par
}
3 \par
}
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}}\par}{\phpg\posx3830\pvpg\posy1712\absw6694\absh984 \f20 \fs21 \cf0 \fi426 \f2
0 \fs21 \cf0 Jika melihat definisi ini maka dapat dikatakan bahwa proses
\par}{\phpg\posx3830\pvpg\posy1712\absw6694\absh984 \sl-414 \f20 \fs21 \cf0 terj
adinya lilin adalah merupakan suatu proses esterifikasi antara
\par}{\phpg\posx3830\pvpg\posy1712\absw6694\absh984 \sl-414 \f20 \fs21 \cf0 asam
lemak dan alkohol berantai panjang. \par
}
{\phpg\posx3710\pvpg\posy3368\absw4889\absh611 \b\i \f20 \fs21 \cf0 \b\i \f20 \f
s21 \cf0 2. Lemak
\par}{\phpg\posx3710\pvpg\posy3368\absw4889\absh611 \sl-413 \b\i \f20 \fs21 \cf0
\fi546 {\b0\i0 Terbentuk}{\b0\i0 dari}{\b0\i0 asam}{\b0\i0 lemak}{\b0\i0 de
ngan}{\b0\i0 gliserol }\par
}
\cf0 B. Lipid Kompleks
\fi730 {\b0 Lipid}{\b0 kompleks}{\b0 adalah}{\b0 kombinasi}{\b0 antara}{\b0
lipid}{\b0 dengan}{\b0 molekul}{\b0 lain. }
\fi423 {\b0 Jika}{\b0 melihat}{\b0 definisi}{\b0 ini}{\b0 maka}{\b0 li
pid}{\b0 kompleks}{\b0 dapat}{\b0 dikelompokan }
\fi423 {\b0 menjadi: }
\fi141 a. Fosfolid
\fi730 {\b0 Fosfolipid}{\b0 adalah}{\b0 lipid}{\b0 yang}{\b0 mengandung}{\b0
gugus}{\b0 ester}{\b0 fosfat. }
\par}{\phpg\posx2980\pvpg\posy4610\absw7562\absh4096 \sl-346 \par\b \f20 \fs21 \
cf0 \fi708 {\i 1.}{\i Glisero}{\i fosfolipid }

cf0 \fi708 {\b0\i 1.}{\b0\i Asam}{\b0\i fosfatidat}{\b0\i dan}{\b0\i fosfati
dilgliserol }
\fi730 {\b0 Penting}{\b0
sebagai}{\b0
perantara}{\b0
dalam}{\b0
sintesis}{\b0
triasilgliserol}{\b0
dan }
\fi730 {\b0 fosfolipid,}{\b0 ditemukan}{\b0 sedikit}{\b0 dalam}{\b0 jaringan
. }\par
}
{\phpg\posx3688\pvpg\posy9724\absw6821\absh4469 \i \f20 \fs21 \cf0 \i \f20 \fs21
\cf0 2. Fosfatidilkolin (lesitin)
\par}{\phpg\posx3688\pvpg\posy9724\absw6821\absh4469 \sl-414 \i \f20 \fs21 \cf0
\fi21 {\i0 Lesitin}{\i0 mengandung}{\i0 asam}{\i0 lemak,}{\i0 gliserol,}
{\i0 asam}{\i0 fosfat}{\i0 dan}{\i0 kolin. }
\fi21 {\i0 Lesitin}{\i0 tersebar}{\i0 luas}{\i0 dalam}{\i0 sel-sel}{\i0
tubuh}{\i0 dan}{\i0 mempunyai}{\i0 tugas }
\fi21 {\i0 metabolik}{\i0 dan}{\i0 struktur}{\i0 misal}{\i0 dalam}{\i0 memb
ran. }
\par}{\phpg\posx3688\pvpg\posy9724\absw6821\absh4469 \sl-347 \par\i \f20 \fs21 \
cf0 {\i0 Dipalmitil}{\i0 lesitin}{\i0 adalah}{\i0 zat}{\i0 yang}{\i0 s
angat}{\i0 efektif}{\i0 untuk}{\i0 mencegah }
{\i0 perlengketan}{\i0
permukaan}{\i0
dalam}{\i0
paru-paru}{\i0
yang}{\i0
disebabkan }
{\i0 tegangan}{\i0 permukaan.}{\i0 Tidak}{\i0 adanya}{\i0 dipalmitil}{\i
0 lesitin}{\i0 pada}{\i0 paru- }
{\i0 paru}{\i0 bayi}{\i0 prematur}{\i0 menyebabkan}{\i0 gangguan}{\i0 perna
fasan. }
cf0 3. Fosfatidiletanolamin (sefalin)
{\i0 Sefalin}{\i0 berbeda}{\i0 dari}{\i0 lesitin}{\i0 hanya}{\i0 pada}
{\i0 penggantian}{\i0 kolin}{\i0 oleh }
{\i0 etanolamin. }\par
}
4 \par
}
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01010101010101010101010101010101010101010101010101010101010101010101010101010101
010101010101010101ffdb0043010101010101010101010101010101010101010101010101010101
0101010101010101010101010101010101010101010101010101010101010101010101010101ffc0
001108034a025303012200021101031101ffc4001f00000105010101010101000000000000000001
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5a636465666768696a737475767778797a82838485868788898a92939495969798999aa2a3a4a5a6
00ffd9
\cf0 4.{\i Fosfatidilinositol }\par
}
{\phpg\posx3688\pvpg\posy2540\absw6563\absh984 \f20 \fs21 \cf0 \f20 \fs21 \cf0 5
.{\i Fosfatidilserin }
\par}{\phpg\posx3688\pvpg\posy2540\absw6563\absh984 \sl-413 \f20 \fs21 \cf0 Fosf
atidilserin mengandung asam amino serin, sebagai pengganti
\par}{\phpg\posx3688\pvpg\posy2540\absw6563\absh984 \sl-414 \f20 \fs21 \cf0 etan
olamin. \par
}
\cf0 6. Lisofosfolipid
\par}{\phpg\posx3688\pvpg\posy4196\absw6642\absh984 \sl-414 \i \f20 \fs21 \cf0 {
\i0 Adalah}{\i0 fosfoasilgliserol}{\i0 yang}{\i0 mengandung}{\i0 hanya}{\i0
satu}{\i0 radikal}{\i0 asil, }
\par}{\phpg\posx3688\pvpg\posy4196\absw6642\absh984 \sl-413 \i \f20 \fs21 \cf0 {
\i0 misalnya}{\i0 lisolesitin. }\par
}
\cf0 7. Plasmalogen
\fi43 {\i0 Senyawa}{\i0 ini}{\i0 merupakan}{\i0
10%}{\i0 fosfolipid}{\i
0 otak}{\i0 dan}{\i0 otot.}{\i0 Secara }
\fi21 {\i0 struktural}{\i0
plasmalogen}{\i0
menyamai}{\i0
fosfatidil
etanolamin}{\i0
tetapi }
\fi21 {\i0 mempunyai}{\i0 ikatan}{\i0 eter}{\i0 pada}{\i0 posisi}{\i0
karbon}{\i0 C1}{\i0 sebagai}{\i0 pengganti }
\fi21 {\i0 ikatan}{\i0 ester.}{\i0 Radikal}{\i0 alkil}{\i0 merupakan}{\i0 a
lkohol}{\i0 tidak}{\i0 jenuh. }\par

}
{\phpg\posx2990\pvpg\posy8616\absw7538\absh5838 \b\i \f20 \fs21 \cf0 \fi698 \b\i
\f20 \fs21 \cf0 2. Sfingofosfolipid
\par}{\phpg\posx2990\pvpg\posy8616\absw7538\absh5838 \sl-346 \par\b\i \f20 \fs21
\cf0 \fi698 {\b0\i0 1.}{\b0 Sfingomielin }
\cf0 \fi840 {\b0\i0 Sfingomielin}{\b0\i0
ditemukan}{\b0\i0
dalam}{\b0\i0
jumlah}{\b0\i0
besar}{\b0\i0
dalam}{\b0\i0
otak}{\b0\i0
dan }
\par}{\phpg\posx2990\pvpg\posy8616\absw7538\absh5838 \sl-414 \b\i \f20 \fs21 \cf
0 \fi413 {\b0\i0 jaringan}{\b0\i0
syaraf.}{\b0\i0
Pada}{\b0\i0
hidrolis
is}{\b0\i0
sfingomielin}{\b0\i0
menghasilkan}{\b0\i0
asam }
0 \fi413 {\b0\i0 lemak,}{\b0\i0
asam}{\b0\i0
fosfat,}{\b0\i0
kolin}{\b0
\i0
dan}{\b0\i0
amino}{\b0\i0
alkohol}{\b0\i0
kompleks}{\b0\i0
ya
itu }
0 \fi413 {\b0\i0 sfingosin.Tidak}{\b0\i0
terdapat}{\b0\i0
gliserol.}{\b0\i
0
Kombinasi}{\b0\i0
sfingosin}{\b0\i0
dan}{\b0\i0
asam }
0 \fi413 {\b0\i0 lemak}{\b0\i0 disebut}{\b0\i0 seramida,}{\b0\i0 struktur}{\b
0\i0 yang}{\b0\i0 juga}{\b0\i0 ditemukan}{\b0\i0 pada}{\b0\i0 glikolipid. }
\cf0 {\i0 b.}{\i0 Glikolipid }
0 \fi1123 {\b0\i0 Glikolipid}{\b0\i0
ialah}{\b0\i0
molekul}{\b0\i0
mole
kul}{\b0\i0
lipid}{\b0\i0
yang}{\b0\i0
mengandung }
0 \fi698 {\b0\i0 karbohidrat,}{\b0\i0
biasanya}{\b0\i0
pula}{\b0\i0
sederhana}{\b0\i0
seperti}{\b0\i0
galaktosa}{\b0\i0
atau }
0 \fi698 {\b0\i0 glukosa.}{\b0\i0
Akan}{\b0\i0
tetapi}{\b0\i0
istilah}{
\b0\i0
istilah}{\b0\i0
glikolipid}{\b0\i0
biasanya}{\b0\i0
dipakai }
0 \fi698 {\b0\i0 untuk}{\b0\i0 lipid}{\b0\i0 yang}{\b0\i0 mengandung}{\b0\i0
satuan}{\b0\i0 gula}{\b0\i0 tetapi}{\b0\i0 tidak}{\b0\i0 mengandung }
0 \fi698 {\b0\i0 fosfor.}{\b0\i0 Glikolipid}{\b0\i0 dapat}{\b0\i0 diturunkan}
{\b0\i0 dari}{\b0\i0 gliserol}{\b0\i0 atau}{\b0\i0 pingosine}{\b0\i0 dan }
0 \fi698 {\b0\i0 sering}{\b0\i0 dimakan}{\b0\i0 gliserida}{\b0\i0 atau}{\b0\i
0 sebagai}{\b0\i0 spingolipida. }\par
}
5 \par
}
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01010101010101010101010101010101010101010101010101010101010101010101010101010101
010101010101010101ffdb0043010101010101010101010101010101010101010101010101010101
0101010101010101010101010101010101010101010101010101010101010101010101010101ffc0
001108034a025303012200021101031101ffc4001f00000105010101010101000000000000000001
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5a636465666768696a737475767778797a82838485868788898a92939495969798999aa2a3a4a5a6
00ffd9
}}\par}{\phpg\posx2990\pvpg\posy2126\absw7506\absh6945 \b \f20 \fs21 \cf0 \b \f2
0 \fs21 \cf0 c. Lipoprotein
\fi1080 {\b0 Lipoprotein}{\b0 merupakan}{\b0 gabungan}{\b0 molekul}{\b0 glis
erida}{\b0 dan}{\b0 protein }
\fi720 {\b0 yang}{\b0 disintesis}{\b0 di}{\b0 dalam}{\b0 hati.}{\b0 Seperem
pat}{\b0 sampai}{\b0 sepertiga}{\b0 bagian }
\fi720 {\b0 dari}{\b0
lipoprotein}{\b0
adalah}{\b0
protein}{\b0
dan}
{\b0
selebihnya}{\b0
adalah}{\b0
lipida. }
\fi720 {\b0 Lipoprotein}{\b0 mempunyai}{\b0 fungsi}{\b0 mengangkut}{\b0 lipi
da}{\b0 di}{\b0 dalam}{\b0 plasma }
\fi720 {\b0 ke}{\b0
jaringan-jaringan}{\b0
yang}{\b0
membutuhkannya}
{\b0
sebagai}{\b0
sumber }
\fi720 {\b0 energy,}{\b0
sebagai}{\b0
komponen}{\b0
membrane}{\b0
sel}{\b0
atau}{\b0
sebagai }
\fi720 {\b0 prekursormetabolit}{\b0 aktif.. }
\fi1080 {\b0 Ada}{\b0 beberapa}{\b0 jenis}{\b0 lipoprotein,}{\b0 antara}{\b0
lain: }
\fi720 {\b0 1.}{\b0 Kilomikron }
\fi720 {\b0 2.}{\b0 VLDL}{\b0 (Very}{\b0 Low}{\b0 Density}{\b0 Lipoprotein)
}

\fi720 {\b0 3.}{\b0 IDL}{\b0 (Intermediate}{\b0 Density}{\b0 Lipoprotein) }
\fi720 {\b0 4.}{\b0 LDL}{\b0 (Low}{\b0 Density}{\b0 Lipoprotein) }
\fi720 {\b0 5.}{\b0 HDL}{\b0 (High}{\b0 Density}{\b0 Lipoprotein) }
\fi720 {\b0 Tubuh}{\b0 mengatur}{\b0 kadar}{\b0 lipoprotein}{\b0 melalui}{\b
0 beberapa}{\b0 cara: }
\fi720 {\b0 1.}{\b0 Mengurangi}{\b0 pembentukan}{\b0 lipoprotein}{\b0 dan}{\
b0 mengurangi}{\b0 jumlah }
\fi981 {\b0 lipoprotein}{\b0 yang}{\b0 masuk}{\b0 ke}{\b0 dalam}{\b0 darah.
}
\fi720 {\b0 2.}{\b0 Meningkatkan}{\b0 atau}{\b0 menurunkan}{\b0 kecepatan}{\
b0 pembuangan }
\fi981 {\b0 lipoprotein}{\b0 dari}{\b0 dalam}{\b0 darah. }\par
}
1 \cf0 C. Turunan Lipid (Derivat Lipid)
\fi1080 {\b0 Derivat}{\b0
lipid}{\b0
adalah}{\b0
seemua}{\b0
senyaw
a}{\b0
yang}{\b0
dihasilkan}{\b0
pada }
\fi773 {\b0 hidrolisis}{\b0 lipid}{\b0 sederhana}{\b0 dan}{\b0 lipid}{\
b0 majemuk}{\b0 yang}{\b0 masih}{\b0 mempunyai }
\fi773 {\b0 sifat-sifat}{\b0 seperti}{\b0 lemak.}{\b0 Sehingga}{\b0 deriv
at}{\b0 lipid}{\b0 dapat}{\b0 diklasifikasikan }
\fi773 {\b0 sebagai}{\b0 berikut}{\b0 : }\par
}
1 \cf0 a.Asam lemak
\fi720 {\b0 Asam}{\b0 lemak}{\b0 tidak}{\b0 lain}{\b0 adalah}{\field{\*\fld
inst {\b HYPERLINK}{\b "http://id.wikipedia.org/wiki/Asam_alkanoat"}}
{\fldrslt{{\b0 \cf5 {\ul a}{\ul s}{\ul a}{\ul m}}{\b0 \cf5 {\ul }{\ul a}{\ul l
}{\ul k}{\ul a}{\ul n}{\ul o}{\ul a}{\ul t}}
}}}{\b0 atau}{\b0 asam}{\b0 karboksilat }
\fi360 {\b0 berderajat}{\b0
tinggi}{\b0
(rantai}{\b0
C}{\b0
lebih}{
\b0
dari}{\b0
6).}{\b0
Asam}{\b0
lemak}{\b0
dibedakan }
\fi360 {\b0 menuru}{\b0 jumlah}{\b0 karbon}{\b0 yang}{\b0 dikandungnya}
{\b0 yaitu}{\b0 asam}{\b0 lemak}{\b0 rantai }
\fi360 {\b0 pendek(kurang}{\b0 dari}{\b0 6),}{\b0 asam}{\b0 lemak}{\b0
rantai}{\b0 sedang}{\b0 (8-12),}{\b0 asam}{\b0 lemak }\par
}
6 \par
}
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\cf0 rantai panjang (14-18) dan rantai sangant panjang (lebih dari 20)
.
\par}{\phpg\posx3350\pvpg\posy1712\absw7121\absh611 \sl-414 \f20 \fs21 \cf0 Adap
un rumus umum dari asam lemak adalah: \par
}
{\phpg\posx3350\pvpg\posy2780\absw2797\absh279 \f20 \fs21 \cf0 \f20 \fs21 \cf0 C
H{\dn006 \fs12 3}(CH ) COOH{\b atau} C{\dn006 \fs12 n}H \par
}
n \par
}
n+1{\fs21 -COOH }\par
}
{\phpg\posx3262\pvpg\posy3434\absw7360\absh2847 \f20 \fs21 \cf0 \fi426 \f20 \fs2
1 \cf0 Asam lemak yang terdiri atas rantai karbon yang mengingat semua
\par}{\phpg\posx3262\pvpg\posy3434\absw7360\absh2847 \sl-414 \f20 \fs21 \cf0 hyd
rogen yang dapat diikatnya dinamakan{\i asam}{\i lemak}{\i jenuh}. As
am
\par}{\phpg\posx3262\pvpg\posy3434\absw7360\absh2847 \sl-413 \f20 \fs21 \cf0 lem
ak yang mengandung satu atau lebih ikatan rangkap dimana diikat
\par}{\phpg\posx3262\pvpg\posy3434\absw7360\absh2847 \sl-414 \f20 \fs21 \cf0 tam
bahkan dengan dengan atom hydrogen disebut dengan{\i asam}{\i lemak }
\par}{\phpg\posx3262\pvpg\posy3434\absw7360\absh2847 \sl-414 \f20 \fs21 \cf0 {\i
tidak}{\i
jenuh}. Asam lemak tak jenuh yang mengandung satu ikatan
\par}{\phpg\posx3262\pvpg\posy3434\absw7360\absh2847 \sl-413 \f20 \fs21 \cf0 ran
gkap disebut dengan{\i asam}{\i lemak}{\i tak}{\i jenuh}{\i tunggal}. Asam
lemak tak
\par}{\phpg\posx3262\pvpg\posy3434\absw7360\absh2847 \sl-414 \f20 \fs21 \cf0 jen
uh yang mengandung lebih dari satu ikatan rangkap disebut dengan
asam}{\i lemak}{\i tak}{\i jenuh}{\i ganda}. \par
}
\cf0 b.Terpen
\fi730 {\b0 Terpena}{\b0
merupakan}{\b0
suatu}{\b0
golongan}{\field{\*\
fldinst {\b HYPERLINK}{\b "http://id.wikipedia.org/wiki/Hidrokarbon"}}
{\fldrslt{{\b0 \cf5
{\ul h}{\ul i}{\ul d}{\ul r}{\ul o}{\ul k}{\ul a}{\ul r}{
\ul b}{\ul o}{\ul n}}
}}}{\b0
yang}{\b0
banyak }
\fi423 {\b0 dihasilkan}{\b0 oleh}{\field{\*\fldinst {\b HYPERLINK}{\b "http://
id.wikipedia.org/wiki/Tumbuhan"}}
{\fldrslt{{\b0 \cf5 {\ul t}{\ul u}{\ul m}{\ul b}{\ul u}{\ul h}{\ul a}{\ul n}}
}}}{\b0 dan}{\b0 terutama}{\b0 terkandung}{\b0 pada}{\field{\*\fldinst {
\b HYPERLINK}{\b "http://id.wikipedia.org/wiki/Getah"}}
{\fldrslt{{\b0 \cf5 {\ul g}{\ul e}{\ul t}{\ul a}{\ul h}}
}}}{\b0 dan }
\fi423 {\field{\*\fldinst {\b HYPERLINK}{\b "http://id.wikipedia.org/wiki/Vakuol
a"}}
{\fldrslt{{\b0 \cf5 {\ul v}{\ul a}{\ul k}{\ul u}{\ul o}{\ul l}{\ul a}}{\b0 \cf5
{\ul s}{\ul e}{\ul l}{\ul n}{\ul y}{\ul a}.}
}}}{\b0 Senyawa}{\b0 dasar}{\b0 terpen}{\b0 merupakan}{\b0 satuan}{\b0
C5}{\b0 disebut }
\fi423 {\b0 isoprene. }
\fi730 {\b0 Table}{\b0 1.1}{\b0 Turunan}{\b0 lipid }\par
}
Jumlah
\par}{\phpg\posx2586\pvpg\posy10314\absw787\absh4040 \sl-414 \f20 \fs21 \cf0 kar
bon
\par}{\phpg\posx2586\pvpg\posy10314\absw787\absh4040 \sl-327 \par\f20 \fs21 \cf0
2
4
\par}{\phpg\posx2586\pvpg\posy10314\absw787\absh4040 \sl-296 \f20 \fs21 \cf0 6
\par
}
{\phpg\posx3564\pvpg\posy10314\absw571\absh239 \f20 \fs21 \cf0 \f20 \fs21 \cf0 a
tom \par
}
{\phpg\posx4150\pvpg\posy11020\absw1454\absh3405 \f20 \fs21 \cf0 \fi108 \f20 \fs
21 \cf0 Trivial
\par}{\phpg\posx4150\pvpg\posy11020\absw1454\absh3405 \sl-363 \f20 \fs21 \cf0 As
am asetat
\par}{\phpg\posx4150\pvpg\posy11020\absw1454\absh3405 \sl-295 \par\f20 \fs21 \cf
0 Asam butirat
am kaproat
am kaprilat
am kaprat
am laurat
am miristat
am palmitat
am stearat
am arakidat \par
}
Nama
0 Sistematik
am binoat
0 Asam tetranoat
am hekdanoat
am oktanoat
am dekanoat
am dodekanoat
am tetradekanoat
am heksadekanoat
am oktadekanoat
am eiokosnoat \par
}
Rumus umum/molekul
0 CH{\dn006 \fs12 3}(CH{\dn006 \fs12 2})COOH
0 CH{\dn006 \fs12 3}(CH{\dn006 \fs12 2}{\dn006 \fs12
2) }C OOH
\par}{\phpg\posx8384\pvpg\posy11020\absw2310\absh3411 \sl-295 \f20 \fs21 \cf0 CH
{\dn006 \fs12 3}(CH{\dn006 \fs12 2}{\dn006 \fs12
4) }C OOH
{\dn006 \fs12 3}(CH{\dn006 \fs12 2}{\dn006 \fs12
6) }C OOH
{\dn006 \fs12 3}(CH{\dn006 \fs12 2}{\dn006 \fs12
8) }C OOH
{\dn006 \fs12 3}(CH ) COOH
{\dn006 \fs12 3}(CH ) COOH
{\dn006 \fs12 3}(CH ) COOH
{\dn006 \fs12 3}(CH ) COOH
{\dn006 \fs12 3}(CH ) COOH \par
}
10 \par
}
12 \par
}
14 \par
}
16 \par
}
18 \par
}
7 \par
}
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0 \fs21 \cf0 c.Steroid
\fi698 {\b0 Suatu}{\b0 steroid}{\b0 adalah}{\b0 senyawa}{\b0 yang}{\b0
mengandung}{\b0 system}{\b0 cincin }
\fi413 {\b0 berikut}{\b0
yaitu}{\b0 tiga}{\b0
cincin}{\b0 6}{\b0 dan
}{\b0 1}{\b0 cincin}{\b0
5.}{\b0 Steroid}{\b0 yang}{\b0 banyak }
\fi413 {\b0 terdapat}{\b0 dalam}{\b0 kehidupan}{\b0 adalah}{\b0 sterol,}{\b0
suatu}{\b0 alkohol}{\b0 yang}{\b0 berintikan }
\fi413 {\b0 perhidroksisiklopentano}{\b0 fenantren.}{\b0 Contohnya}{\b0 ad
alah}{\b0 kolesterol}{\b0 yang }
\fi413 {\b0 banyak}{\b0 terdapat}{\b0 dalam}{\b0 otak,}{\b0 system}{\b0
saraf,}{\b0 membrane}{\b0 dan}{\b0 lain-lain. }
\fi413 {\b0 Dalam}{\b0 tanaman}{\b0 terdapat}{\b0 fitosterol,}{\b0 misalnya}
{\b0 stigmasterol}{\b0 dan}{\b0 sitostrol. }
\fi413 {\b0 Mikosterol}{\b0 adalah}{\b0 sterol}{\b0 yang}{\b0 terdapat}{\b0
dalam}{\b0 jamur}{\b0 dan}{\b0 ragimisalnya }
\fi413 {\b0 elgosterol}{\b0 yang}{\b0 merupakan}{\b0 bahan}{\b0 baku}{\b0 v
itamin}{\b0 D. }\par
}
\cf0 2.2 Struktur Kimia dan Sifat Kimia atau Fisik Lipid
\fi360 {\fs19 A.}{\fs19
Sumber}{\fs19 Lemak }
cf0 \fi1133 a.Lemak simpanan dalam Sel Lemak
\fi1440 {\b0 Lemak}{\b0 hewan}{\b0 terutama}{\b0 terdiri}{\b0 atas}{\b0
triasilgliserol,}{\b0 berupa}{\b0 lemak }

\fi1133 {\b0 jenuh}{\b0
asam}{\b0
palmitat}{\b0
dan}{\b0
asam}{\b0
oleat,}{\b0
di}{\b0
samping}{\b0
kolesterol}{\b0
dan }
\fi1133 {\b0 vitamin}{\b0
larut}{\b0
lemak}{\b0
A,D,E,}{\b0
dan}{\b0
K.}{\b0
susunan}{\b0
asam}{\b0
lemak}{\b0
hewan }
\fi1133 {\b0 banyak}{\b0 bergantung}{\b0 dari}{\b0 jenis}{\b0 makanan}{\b0
yang}{\b0 diberikan. }
\fi1236 {\b0 Tabel}{\b0 1.2}{\b0 Komposisi}{\b0 asam}{\b0 lemak}{\b0 bebera
pa}{\b0 lemak}{\b0 hewan }\par
}
{\phpg\posx2762\pvpg\posy8971\absw812\absh199 \f20 \fs18 \cf0 \f20 \fs18 \cf0 Ma
kanan \par
}
:0 \par
}
:0 \par
}
:1 \par
}
:0 \par
}
:1 \par
}
{\phpg\posx5000\pvpg\posy9203\absw1959\absh199 \f20 \fs18 \cf0 \f20 \fs18 \cf0 g
/100g asam lemak total \par
}
\cf0 3
\par}{\phpg\posx5334\pvpg\posy9675\absw210\absh1653 \sl-230 \f20 \fs18 \cf0 \fi5
0 0
0 1
0 6
0 1 \par
}
1
0 6
\par}{\phpg\posx6034\pvpg\posy9675\absw210\absh1653 \sl-230 \f20 \fs18 \cf0 27 \
par
}

\cf0 4
0 4
0 3
0 9
0 3
0 3
0 9 \par
}
{\phpg\posx2266\pvpg\posy9675\absw1082\absh822 \f20 \fs18 \cf0 \f20 \fs18 \cf0 B
iri - Biri
\par}{\phpg\posx2266\pvpg\posy9675\absw1082\absh822 \sl-230 \f20 \fs18 \cf0 Kuni
ng Telur
\par}{\phpg\posx2266\pvpg\posy9675\absw1082\absh822 \sl-231 \f20 \fs18 \cf0 Lema
k Babi
\par}{\phpg\posx2266\pvpg\posy9675\absw1082\absh822 \sl-230 \f20 \fs18 \cf0 Lema
k Sapi \par
}
{\phpg\posx2266\pvpg\posy10599\absw672\absh406 \f20 \fs18 \cf0 \f20 \fs18 \cf0 M
inyak
cod }\par
}
{\phpg\posx3094\pvpg\posy10599\absw370\absh199 \f20 \fs18 \cf0 \f20 \fs18 \cf0 H
ati \par
}
{\phpg\posx3646\pvpg\posy10599\absw386\absh199 \f20 \fs18 \cf0 \f20 \fs18 \cf0 I
kan \par
}
Susu (Sapi)
\par}{\phpg\posx2266\pvpg\posy11061\absw1314\absh615 \sl-230 \f20 \fs18 \cf0 Sus
u (Kambing)
\par}{\phpg\posx2266\pvpg\posy11061\absw1314\absh615 \sl-232 \f20 \fs18 \cf0 Ung
gas \par
}
:0\par}{\phpg\posx4314\pvpg\posy8971\absw356\absh2287 \sl-232 \f20 \fs18 \cf0 12:0
\par}{\phpg\posx4314\pvpg\posy8971\absw356\absh2287
\fi128 0
28 0
28 0
28 0
28 0
8 13
\sl-235 \par\f20 \fs18 \cf0

\sl-230 \f20 \fs18 \cf0 \fi1
\sl-231 \f20 \fs18 \cf0 \fi1
\sl-230 \f20 \fs18 \cf0 \fi1
\sl-232 \f20 \fs18 \cf0 \fi1
\sl-230 \f20 \fs18 \cf0 \fi7
\sl-232 \f20 \fs18 \cf0 \fi7
8 21
28 0 \par
}
{\phpg\posx7340\pvpg\posy9675\absw210\absh1653 \f20
0
0 9
0 8
0 3
0 7 \par
}
1
par
}
8:
8 2
\fi78 5
8 11
8 9
8 2
8 2
8 2
8 2
8 11 \par
}
0:1
\sl-230 \f20 \fs18 \cf0 \fi1

\fs18 \cf0 \f20 \fs18 \cf0 2
\sl-230 \f20 \fs18 \cf0 \fi5
\sl-231 \f20 \fs18 \cf0 15
\sl-230 \f20 \fs18 \cf0 \fi5
\sl-232 \f20 \fs18 \cf0 \fi5
\sl-230 \f20 \fs18 \cf0 11
\sl-232 \f20 \fs18 \cf0 10
\sl-230 \f20 \fs18 \cf0 \fi5
\fs18 \cf0 \f20 \fs18 \cf0 4
\sl-230
\sl-231
\sl-230
\sl-232
\sl-230
\sl-232
\sl-230
\f20
\f20
\f20
\f20
\f20
\f20
\f20
\fs18
\fs18
\fs18
\fs18
\fs18
\fs18
\fs18
\cf0
\cf0
\cf0
\cf0
\cf0
\cf0
\cf0
43
43
45
20
29
26
45 \
\fs18 \cf0 \f20 \fs18 \cf0 1

\sl-232 \f20 \fs18 \cf0 \fi7
\sl-235 \par\f20 \fs18 \cf0
\sl-230 \f20 \fs18 \cf0 \fi2
\sl-231 \f20 \fs18 \cf0 \fi7
\sl-230 \f20 \fs18 \cf0 \fi7
\sl-232 \f20 \fs18 \cf0 \fi7
\sl-230 \f20 \fs18 \cf0 \fi7
\sl-232 \f20 \fs18 \cf0 \fi7
\sl-230 \f20 \fs18 \cf0 \fi2
\fs18 \cf0 \f20 \fs18 \cf0 2
\sl-232 \f20 \fs18 \cf0 22:1

\fi127 0
27 0
27 0

27 0
7 18
27 0
27 0
27 0 \par
}
{\phpg\posx9898\pvpg\posy8971\absw630\absh2287 \f20 \fs18 \cf0 \f20 \fs18 \cf0 A
TLJG
2 RPa{\up006 \fs10 1) }
\fi256 0
56 0
56 0
56 0
06 20
56 0
56 0
56 0 \par
}
8 \cf0 Lain
\par}{\phpg\posx10776\pvpg\posy8971\absw600\absh2287 \sl-232 \f20 \fs18 \cf0 -la
inny
\par}{\phpg\posx10776\pvpg\posy8971\absw600\absh2287 \sl-230 \f20 \fs18 \cf0 \fi
240 a
234 6
234 4
234 0
234 7
234 5
234 4
234 0
234 1 \par
}
0 \fs21 \cf0 1.Lemak susu
\fi306 {\b0 Lemak}{\b0 susu}{\b0 terutama}{\b0 terdiri}{\b0 atas}{\b0 tria
silgliserol}{\b0 yang}{\b0 terdapat}{\b0 dalam }

{\b0 bentuk}{\b0 emulsi}{\b0 di}{\b0 mana}{\b0 butiran}{\b0 halus}{\b
0 lemak}{\b0 diselubungi}{\b0 memebran }
{\b0 yang}{\b0 terdiri}{\b0 atas}{\b0 protein,}{\b0 fosfolipida}{\b0
dan}{\b0 kolesterol}{\b0 yang}{\b0 mencegah }
{\b0 butiran-butiran}{\b0
lemak}{\b0
tersebut}{\b0
menyatu.}{\b0
Bu
tiran}{\b0
lemak}{\b0
ini}{\b0
juga }
{\b0 mengandung}{\b0 sedikit}{\b0 ester}{\b0 kolesterol,}{\b0 vitamin}{
\b0 larut}{\b0 lemak,}{\b0 terutama }
{\b0 vitamin}{\b0 A,}{\b0 D,dan}{\b0 Beta-karoten.}{\b0 Karakteristik}{\b0
asam}{\b0 lemak}{\b0 susu}{\b0 hewan }
{\b0 memamah}{\b0 biak}{\b0 mengandung}{\b0 relatife}{\b0 tinggi}{\b0
asam}{\b0 lemak}{\b0 jenuh}{\b0 rantai }\par
}
8 \par
}
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}}\par}{\phpg\posx2784\pvpg\posy1712\absw7872\absh10671 \f20 \fs21 \cf0 \fi620 \
f20 \fs21 \cf0 pendek dan sedang serta asam lemak rantai jenuh rantai p
anjang dan
\par}{\phpg\posx2784\pvpg\posy1712\absw7872\absh10671 \sl-414 \f20 \fs21 \cf0 \f
i620 tunggal. Kandungan asam lemak tidak jenuh ganda sangat keci
l.

i620 Lemak dalam bentuk emulsi mempunyai permukaan yang lebih luas
i620 daripada lemak dalam bentuk tidak emulsi, oleh karena itu dapat lebih
i620 cepat dicernakan. Di samping itu lemak dalam bentuk emulsi
i620 mempengaruhi secara positif rasa enak makanan.
0 \fi620 {\b 2.}{\b Telur }
i926 Lemak telur berada dalam keadaan emulsi. Satu telur rata -rata
i620 mengandung 6-7 gram triasilgliserol dan fosfolipida serta 250-300 mg
i620 kolesterol. Pentingnya telur dalam makanan sehari - hari bukan hanya
i620 terletak pada nilai gizinya, akan tetapi juga kontribusi yang diberikan
i620 oleh lipoprotein kuning telur terhadap struktur
makanan, terutama
i620 terhadap kualitas structural cake dan sejenisnya setelah dibakar.
0 \fi620 {\b 3.}{\b Minyak}{\b Ikan }
i926 Ikan secara garis besar digolongkan dalam ikan kurus yang
i620 menyimpan lemaknya sebagai triasilgliserol dalam hati (misalnya ikan
i620 {\i cod}) dan ikan{\i gemuk} (makarel dan haring). Minyak ikan mengandung
i620 banyak asam lemak rantai sangat panjang dengan lebih dari dua puluh
i620 atom karbon yang sebagian besar mempunyai 5-6 ikatan rangkap.
i620 Komposisi
asam
lemak
iakan
berbeda,
bergantung
jenis
i
kan,
i620 makanannya, dan musim
0 \fi620 {\b 4.}{\b Daging}{\b Otot }
i926 Lemak daging otot terutama terdiri atas fosfolipida dan kolesterol
i620 bebas, walau[un banyak daging otot hewan diinfiltrasi oleh simpanan
i620 triasilgliserol ({\i marbling}).
Sebanyak 85% asam lemak daging ot
ot
i620 terdiri dari atas asam palmitat, stearat, okleat, linoleat dan arakidonat.
i620 Komposisi lemak daging otot menyerupai komposisi lemak simpanan.
\par}{\phpg\posx2784\pvpg\posy1712\absw7872\absh10671 \sl-413 \f20 \fs21 \cf0 Ta
bel 1.3 komposisi asam lemak beberapa lemak daging dan daun hijau \par
}
18 \cf0 Makanan
0 Ayam (hati)
\par}{\phpg\posx2644\pvpg\posy13587\absw1314\absh1248 \sl-232 \f20 \fs18 \cf0 Ay
am (otot)
\par}{\phpg\posx2644\pvpg\posy13587\absw1314\absh1248 \sl-230 \f20 \fs18 \cf0 Ba
bi (otak)
\par}{\phpg\posx2644\pvpg\posy13587\absw1314\absh1248 \sl-232 \f20 \fs18 \cf0 Bi
ri - biri (otak) \par
}
16:
77 0
27 25
27 23
27 19
27 22 \par
}
16:
78 1
78 3
78 6
78 2
78 1 \par
}
8:0 \par
}
8:1 \par
}
8:2 \par
}
g/100g asam lemak total \par
}
7
par
}
6
par
}
5

0 1 \par
}
18:
78 3
78 1
78 1
78 0
78 0 \par
}
20:
77 4
77 6
77 6
77 8
77 4 \par
}
ATLJG
90 RPa{\up006 \fs10 1) }
256 6
256 0
256 0
206 14 \par
}
8 \cf0 Lain
innya
277 1
277 1
227 14
227 12 \par
}
9 \par
}
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\cf0 Biri - biri (otot)
\par}{\phpg\posx2644\pvpg\posy1719\absw1465\absh823 \sl-232 \f20 \fs17 \cf0 Cod
(gemuk)
\par}{\phpg\posx2644\pvpg\posy1719\absw1465\absh823 \sl-230 \f20 \fs17 \cf0 Dagi
ng sapi (otot)
\par}{\phpg\posx2644\pvpg\posy1719\absw1465\absh823 \sl-232 \f20 \fs17 \cf0 Daun
hijau \par
}
ar
}
r
}
\sl-232 \f20 \fs17 \cf0 22

\sl-230 \f20 \fs17 \cf0 16
\sl-232 \f20 \fs17 \cf0 13 \p
4
ar
}
\sl-232 \f20 \fs17 \cf0 \fi50
r
}
cf0 18
1
26
ar
}
cf0 4
p006 \fs10 2) }
1
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\sl-230 \f20 \fs17 \cf0 20
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\fs17 \cf0 \f20 \fs17 \cf0 2

\sl-232 \f20 \fs17 \cf0 2
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\sl-232 \f20 \fs17 \cf0 3 \pa
\fs17 \cf0 \f20 \fs17 \cf0 13
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\sl-232 \f20 \fs17 \cf0 ss \p
\fs17 \cf0 \f20 \fs17 \cf0 30
\fs17 \cf0 \fi32 \f20 \fs17 \

\sl-232 \f20 \fs17 \cf0 \fi82
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\sl-232 \f20 \fs17 \cf0 16 \p
\fs17 \cf0 \fi76 \f20 \fs17 \
\sl-232 \f20 \fs17 \cf0 ss{\u
\sl-230 \f20 \fs17 \cf0 \fi76

56 \par
}
{\phpg\posx8404\pvpg\posy1719\absw210\absh823 \f20 \fs17 \cf0 \fi50 \f20 \fs17 \
cf0 7
4
0 \par
}
{\phpg\posx9112\pvpg\posy1719\absw210\absh823 \f20 \fs17 \cf0 \fi50 \f20 \fs17 \
cf0 0
0
0 \par
}
\cf0 4
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0 5 \par
}
\cf0 5. Minyak Nabati
\fi1560 {\b0 Sebagian}{\b0 besar}{\b0 tumbuh}{\b0 -}{\b0 tumbuhan}{\b0
menyimpan}{\b0 lemak}{\b0 didalam }
\fi1133 {\b0 biji}{\b0 -}{\b0 bijiannya}{\b0 (kacang}{\b0 kedelai,}{\b0
biji}{\b0 bunga}{\b0 matahari,}{\b0 jagung)}{\b0 atau }
\fi1133 {\b0 dalam}{\b0 dagingnya}{\b0 (apokat).}{\b0
Jenis}{\b0 palma}{\b
0 menyimpan}{\b0 minyak}{\b0 di}{\b0 dalam }
\fi1133 {\b0 biji}{\b0 maupun}{\b0 di}{\b0 dalam}{\b0 dagingnya.}{\b0
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\fi1133 {\b0 sama}{\b0 lain}{\b0 dalam}{\b0 komposisi}{\b0 asam}{\b0 l
emak.}{\b0 Minyakl}{\b0 biji}{\b0 -}{\b0 bijian}{\b0 juga }
\fi1133 {\b0 merupakan}{\b0
sumber}{\b0
fosfolipida,}{\b0
karotenoid,}{
\b0
dan}{\b0
sterol}{\b0
tumbuh}{\b0
- }
\fi1133 {\b0 tumbuhan. }
\fi306 {\b0 Tabel}{\b0 1.4}{\b0 komposisi}{\b0 asam}{\b0 lemak}{\b0 beberap
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}
{\phpg\posx2690\pvpg\posy6665\absw1688\absh199 \f20 \fs17 \cf0 \f20 \fs17 \cf0 M
akanan
8:0 \par
}
:0 \par
}
:0 \par
}
:0 \par
}
:1 \par
}
{\phpg\posx6034\pvpg\posy6897\absw1959\absh199 \f20 \fs17 \cf0 \f20 \fs17 \cf0 g
/100g asam lemak total \par
}
\cf0 0
0 ss
0 1
0 ss
0 1
0 1
0 ss
0 ss \par
}
\cf0 20
5 6
0 9
0 9
5 4
par
}
ar
}
\sl-230
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\sl-230
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\sl-230
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\sl-230
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\sl-230
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\cf0
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\cf0
6
3
2
4
3
2
4
1
2 \p

Apokat
\par}{\phpg\posx2266\pvpg\posy7369\absw1585\absh2069 \sl-230 \f20 \fs17 \cf0 Bij
i bunga matahari
\par}{\phpg\posx2266\pvpg\posy7369\absw1585\absh2069 \sl-232 \f20 \fs17 \cf0 Bij
i kelapa sawit
\par}{\phpg\posx2266\pvpg\posy7369\absw1585\absh2069 \sl-230 \f20 \fs17 \cf0 Jag
ung
\par}{\phpg\posx2266\pvpg\posy7369\absw1585\absh2069 \sl-232 \f20 \fs17 \cf0 Kac
ang kedelai
\par}{\phpg\posx2266\pvpg\posy7369\absw1585\absh2069 \sl-230 \f20 \fs17 \cf0 Kac
ang tanah
\par}{\phpg\posx2266\pvpg\posy7369\absw1585\absh2069 \sl-231 \f20 \fs17 \cf0 Kel
apa
\par}{\phpg\posx2266\pvpg\posy7369\absw1585\absh2069 \sl-230 \f20 \fs17 \cf0 Kel
apa sawit
\par}{\phpg\posx2266\pvpg\posy7369\absw1585\absh2069 \sl-232 \f20 \fs17 \cf0 Rap
e
\par}{\phpg\posx2266\pvpg\posy7369\absw1585\absh2069 \sl-230 \f20 \fs17 \cf0 Zai
tu \par
}
ar
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0:
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2:
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\fi77 0
0 ss
7 45
7 0
0 ss
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7 48
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7 0 \par
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0
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8:
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33
15
30
25
49
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\sl-232 \f20 \fs17 \cf0 \fi7
\sl-235 \par\f20 \fs17 \cf0
\sl-230 \f20 \fs17 \cf0 \fi2
\sl-232 \f20 \fs17 \cf0 \fi7
\sl-230 \f20 \fs17 \cf0 \fi2
\sl-232 \f20 \fs17 \cf0 \fi2
\sl-230 \f20 \fs17 \cf0 \fi2
\sl-231 \f20 \fs17 \cf0 \fi7
\sl-230 \f20 \fs17 \cf0 \fi7
\sl-232 \f20 \fs17 \cf0 \fi2

8 11 \par
}
8:
8 3
\fi78 0
0 ss
8 0
8 2
8 7
8 1
8 0
0 ss
8 11
8 1 \par
}
0:1
47 +
6 22:1
53 0
53 0
53 0
53 0
53 0
53 0
53 0
53 0
03 43
53 0 \par
}
Lain
in
\fi134 1
134 3
134 0
134 1
134 2
134 6
134 1
134 2
134 1
134 2 \par
}
1 \cf0 B.{\field{\*\fldinst {\b HYPERLINK}{\b "http://tawazone.blogspot.com/2009
/03/struktur-kimia-lipid.html"}}
{\fldrslt{{\cf5 {\ul S}{\ul t}{\ul r}{\ul u}{\ul k}{\ul t}{\ul u}{\ul r}}{\cf5
{\ul }{\ul K}{\ul i}{\ul m}{\ul i}{\ul a}}{\cf5 {\ul }{\ul L}{\ul i}{\ul p}{\u
l i}{\ul d} }
\par}
}}}{\phpg\posx2270\pvpg\posy10242\absw8146\absh1605 \sl-276 \par\b \f20 \fs21 \c
f0 \fi568 a.Asam lemak
\cf0 \fi993 {\b0 Asam}{\b0 lemak}{\b0 merupakan}{\b0 asam}{\b0 monokarboksil
at}{\b0 rantai}{\b0 panjang.}{\b0 Adapun }
\fi568 {\b0 rumus}{\b0 umum}{\b0 dari}{\b0 asam}{\b0 lemak}{\b0 adalah: }\
par
}
21 \cf0 Rentang ukuran dari asam lemak adalah C12 sampai dengan C24. Ada
\par}{\phpg\posx2838\pvpg\posy12910\absw7641\absh1268 \sl-413 \f20 \fs21 \cf0 du
a macam asam lemak yaitu:
i281 1. Asam lemak jenuh (saturated fatty acid) Asam lemak ini
tidak
i565 memiliki ikatan rangkap \par
}
2. Asam lemak tak jenuh (unsaturated fatty acid)
283 memiliki satu atau lebih ikatan rangkap \par
}
Asam lemak ini \par
}
0 \par
}

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0 \fs21 \cf0 b. Gliserida netral (lemak netral) \par
}
1 \par
}
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}}\par}{\phpg\posx2838\pvpg\posy1712\absw7705\absh2474 \f20 \fs21 \cf0 \fi425 \f
20 \fs21 \cf0 Fungsi dasar dari gliserida netral adalah sebagai si
mpanan energi
\par}{\phpg\posx2838\pvpg\posy1712\absw7705\absh2474 \sl-414 \f20 \fs21 \cf0 (be
rupa lemak atau minyak). Setiap gliserol mungkin berikatan dengan 1, 2
\par}{\phpg\posx2838\pvpg\posy1712\absw7705\absh2474 \sl-414 \f20 \fs21 \cf0 ata
u 3 asam lemak yang tidak harus sama. Jika gliserol berikatan dengan 1
\par}{\phpg\posx2838\pvpg\posy1712\absw7705\absh2474 \sl-413 \f20 \fs21 \cf0 asa
m lemak disebut monogliserida, jika berikatan dengan 2 asam lemak
\par}{\phpg\posx2838\pvpg\posy1712\absw7705\absh2474 \sl-414 \f20 \fs21 \cf0 dis
ebut digliserida dan jika berikatan dengan 3 asam lemak dinamakan
\par}{\phpg\posx2838\pvpg\posy1712\absw7705\absh2474 \sl-413 \f20 \fs21 \cf0 tri
gliserida. Trigliserida merupakan cadangan energi penting dari sumber
\par}{\phpg\posx2838\pvpg\posy1712\absw7705\absh2474 \sl-414 \f20 \fs21 \cf0 lip
id. \par
}
1 \cf0 Apa yang dimaksud dengan lemak (fat) dan minyak (oil)? Lemak da
n
\par}{\phpg\posx2838\pvpg\posy8198\absw7625\absh2226 \sl-413 \f20 \fs21 \cf0 min
yak keduanya merupakan trigliserida. Adapun perbedaan sifat secara
\par}{\phpg\posx2838\pvpg\posy8198\absw7625\absh2226 \sl-413 \f20 \fs21 \cf0 umu
m dari keduanya adalah:
\fi283 {\b\i 1.}{\b\i Lemak }
708 Lemak umumnya diperoleh dari hewan ,berwujud padat pada suhu
283 ruang dan tersusun dari asam lemak jenuh. \par
}
1 \cf0 2.{\b Minyak }
\fi556 {\i0 Umumnya}{\i0
diperoleh}{\i0
dari}{\i0
tumbuhan,berwujud
}{\i0
cair}{\i0
pada}{\i0
suhu }
\fi131 {\i0 ruang,tersusun}{\i0
dari}{\i0
asam}{\i0
lemak}{\i0
tak}
{\i0
jenuhFosfogliserida}{\i0
(fosfolipid). }
\fi131 {\i0 Lipid}{\i0 dapat}{\i0 mengandung}{\i0 gugus}{\i0 fosfat.}{\i0
Lemak}{\i0 termodifikasi}{\i0 ketika}{\i0 fosfat }
\fi131 {\i0 mengganti}{\i0 salah}{\i0 satu}{\i0 rantai}{\i0 asam}{\i0 lema
k. }\par
}
\cf0 c. Lipid kompleks \par
}
2 \par
}
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20 \fs21 \cf0 Lipid kompleks adalah kombinasi antara lipid dengan molekul
lain.
\par}{\phpg\posx2838\pvpg\posy1712\absw7630\absh1481 \sl-414 \f20 \fs21 \cf0 Con
toh penting dari lipid kompleks adalah lipoprotein dan glikolipid.
\fi283 1.{\b Lipoprotein }
643 Lipoprotein merupakan gabungan antara lipid dengan protein. \par
}
1 \cf0 Ada 4 kelas mayor dari lipoprotein plasma yang masing-masing
\par}{\phpg\posx3122\pvpg\posy7324\absw7349\absh4213 \sl-276 \f20 \fs21 \cf0 ter
susun atas beberapa jenis lipid, yaitu :
{\i 1.}{\i Kilomikron }
588 Kilomikron berfungsi sebagai alat transportasi trigliserid dari usus
\par}{\phpg\posx3122\pvpg\posy7324\absw7349\absh4213 \sl-275 \f20 \fs21 \cf0 ke
jaringan lain, kecuali ginjal.
{\i 2.}{\i VLDL}{\i (very}{\i low}{\i -}{\i density}{\i lypoproteins) }

588 VLDL mengikat trigliserid di dalam hati dan mengangkutnya
\par}{\phpg\posx3122\pvpg\posy7324\absw7349\absh4213 \sl-276 \f20 \fs21 \cf0 men
uju jaringan lemak
{\i 3.}{\i LDL}{\i (low}{\i -}{\i density}{\i lypoproteins) }
588 LDL berperan mengangkut kolesterol ke jaringan perifer
{\i 4.}{\i HDL}{\i (high}{\i -}{\i density}{\i lypoproteins) }
588 HDL mengikat kolesterol plasma dan mengangkut kolesterol ke
\par}{\phpg\posx3122\pvpg\posy7324\absw7349\absh4213 \sl-276 \f20 \fs21 \cf0 hat
i. \par
}
3 \par
}
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0145145007ffd9
0 \fs21 \cf0 b. Kolesterol
\fi424 {\b0 Selain}{\b0 fosfolipid,}{\b0 kolesterol}{\b0 merupakan}{\b0
jenis}{\b0 lipid}{\b0 yang}{\b0 menyusun }
{\b0 membran}{\b0 plasma.}{\b0 Kolesterol}{\b0 juga}{\b0 menjadi}{\b0 bagia
n}{\b0 dari}{\b0 beberapa}{\b0 hormon. }
{\b0 Kolesterol}{\b0 berhubungan}{\b0 dengan}{\b0 pengerasan}{\b0 arteri
.}{\b0 Dalam}{\b0 hal}{\b0 ini}{\b0 timbul }
{\b0 plaque}{\b0 pada}{\b0 dinding}{\b0 arteri,}{\b0 yang}{\b0 mengaki
batkan}{\b0 peningkatan}{\b0 tekanan }
{\b0 darah}{\b0 karena}{\b0 arteri}{\b0 menyempit,}{\b0 penurunan}{\b0 kema
mpuan}{\b0 untuk}{\b0 meregang. }
{\b0 Pembentukan}{\b0 gumpalan}{\b0 dapat}{\b0 menyebabkan}{\b0 infark}{\b0
miokard}{\b0 dan}{\b0 stroke. }\par
}
{\phpg\posx2270\pvpg\posy11422\absw8348\absh860 \i \f20 \fs21 \cf0 \fi3610 \i \f
20 \fs21 \cf0 Steroid
\fi720 {\i0 Beberapa}{\i0 hormon}{\i0 reproduktif}{\i0 merupakan}{\i0 steroi
d,}{\i0 misalnya}{\i0 testosteron}{\i0 dan }
{\i0 progesteron. }\par
}
4 \par
}
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0 \fs21 \cf0 Steroid lainnya adalah kortison. Hormon ini berhubungan deng
an proses
\par}{\phpg\posx2412\pvpg\posy5392\absw8134\absh984 \sl-414 \f20 \fs21 \cf0 meta
bolisme karbohidrat, penanganan penyakit arthritis rematoid, asthma,
\par}{\phpg\posx2412\pvpg\posy5392\absw8134\absh984 \sl-414 \f20 \fs21 \cf0 gang
guan pencernaan dan sebagainya. \par
}
{\phpg\posx2412\pvpg\posy9526\absw8101\absh1481 \i \f20 \fs21 \cf0 \fi2845 \i \f
20 \fs21 \cf0 Malam/lilin (waxes)
cf0 \fi578 {\i0 Malam}{\i0
tidak}{\i0
larut}{\i0
di}{\i0
dalam}{\i0
air}{\i0
dan}{\i0
sulit}{\i0
dihidrolisis.}{\i0
Malam}{\i0
ser
ing }
{\i0 digunakan}{\i0 sebagai}{\i0 lapisan}{\i0 pelindung}{\i0 untuk}{\i0
kulit,}{\i0 rambut}{\i0 dan}{\i0 lain-lain.}{\i0 Malam }
{\i0 merupakan}{\i0 ester}{\i0 antara}{\i0 asam}{\i0 lemak}{\i0 dengan}{\i0
alkohol}{\i0 rantai}{\i0 panjang. }\par
}
5 \par
}
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0 \fs21 \cf0 D. Akibat Kekurangan dan Kelebihan Lemak
cf0 \fi426 a. Obesitas
\fi851 {\b0 Obesitas}{\b0 yaitu}{\b0 suatu}{\b0 kondisi}{\b0 yang}{\b0 dici
rikan}{\b0 oleh}{\b0 kelebihan}{\b0 lemak}{\b0 tubuh. }
\fi426 {\b0 Kelebihan}{\b0 lemak}{\b0 pada}{\b0 laki-laki}{\b0 didefinisikan
}{\b0 sebagai}{\b0 level}{\b0 lemak}{\b0 tubuh}{\b0 lebih }
\fi426 {\b0 dari}{\b0 20%}{\b0 dari}{\b0 berat}{\b0 total}{\b0 dan}{\b
0 untuk}{\b0 wanita}{\b0 lebih}{\b0 dari}{\b0 25%}{\b0 dari}{\b0 t
otal}{\b0 berat }
\fi426 {\b0 badan.}{\b0 Penyebab}{\b0 obesitas,}{\b0 jelas}{\b0 Endang,}
{\b0 dipengaruhi}{\b0 beberapa}{\b0 faktor,}{\b0 yaitu }
\fi426 {\b0 pertama,}{\b0 suatu}{\b0 asupan}{\b0 makanan}{\b0 berlebih.}{\b0
Dua,}{\b0 rendahnya}{\b0 pengeluaran}{\b0 energi }
\fi426 {\b0 basal,}{\b0
dan}{\b0
ketiga,}{\b0
kurangnya}{\b0
aktivit
as}{\b0
fisik.}{\b0
Terjadinya}{\b0
obesitas}{\b0
karena }

\fi426 {\b0 adanya}{\b0 ketidakseimbangan}{\b0 antara}{\b0 asupan}{\b0 energ
i}{\b0 dan}{\b0 energi}{\b0 yang}{\b0 dikeluarkan }
\fi426 {\b0 atau}{\b0 digunakan}{\b0 untuk}{\b0 beraktivitas. }
cf0 \fi426 b. Hiperlipidemia
cf0 \fi851 {\b0 Yang}{\b0
dimakud}{\b0
dengan}{\b0
Hiperlipidemia}{\b0
adalah}{\b0
suatu}{\b0
keadaan}{\b0
yang }
\fi426 {\b0 ditandai}{\b0 oleh}{\b0 peningkatan}{\b0 kadar}{\b0 lipid/lemak}
{\b0 darah. }
cf0 \fi851 {\b0 Berdasarkan}{\b0 jenisnya,}{\b0 hiperlipidemia}{\b0 dibagi}{\
b0 menjadi}{\b0 2,}{\b0 yaitu: }
cf0 \fi720 1. Hiperlipidemia Primer
cf0 \fi1133 {\b0 Banyak}{\b0 disebabkan}{\b0 oleh}{\b0 karena}{\b0 kelai
nan}{\b0 genetik.}{\b0 Biasanya}{\b0 kelainan }
\fi720 {\b0 ini}{\b0 ditemukan}{\b0 pada}{\b0 waktu}{\b0 pemeriksaan}{\b
0 laboratorium}{\b0 secara}{\b0 kebetulan. }
\fi720 {\b0 Pada}{\b0 umumnya}{\b0 tidak}{\b0 ada}{\b0 keluhan,}{\b0 k
ecuali}{\b0 pada}{\b0 keadaan}{\b0 yang}{\b0 agak}{\b0 berat }
\fi720 {\b0 tampak}{\b0 adanya}{\b0 xantoma}{\b0 (penumpukan}{\b0 lemak}{\b0
di}{\b0 bawah}{\b0 jaringan}{\b0 kulit). }\par
}
6 \par
}
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00ffd9
}}\par}{\phpg\posx2554\pvpg\posy1712\absw8183\absh11555 \b \f20 \fs21 \cf0 \fi43
5 \b \f20 \fs21 \cf0 2. Hiperlipidemia Sekunder
\cf0 \fi849 {\b0 Pada}{\b0 jenis}{\b0 ini,}{\b0 peningkatan}{\b0 kadar}{
\b0 lipid}{\b0 darah}{\b0 disebabkan}{\b0 oleh}{\b0 suatu }
\fi435 {\b0 penyakit}{\b0 tertentu,}{\b0 misalnya}{\b0 :}{\b0 diabetes}
{\b0 melitus,}{\b0 gangguan}{\b0 tiroid,}{\b0 penyakit }
\fi435 {\b0 hepar}{\b0
&}{\b0
penyakit}{\b0
ginjal.}{\b0
Hiperlipid
emia}{\b0
sekunder}{\b0
bersifat}{\b0
reversibel }
\fi435 {\b0 (berulang).}{\b0
Ada}{\b0
juga}{\b0
obat-obatan}{\b0
yang}{\b0
menyebabkan}{\b0
gangguan }
\fi435 {\b0 metabolisme}{\b0
lemak,}{\b0
seperti}{\b0
:}{\b0
Beta-b
locker,}{\b0
diuretik,}{\b0
kontrasepsi}{\b0
oral }
\fi435 {\b0 (Estrogen,}{\b0 Gestagen). }
\cf0 \fi719 {\b0 Hiperlipidemia}{\b0
dapat}{\b0
meningkatkan}{\b0
resik
o}{\b0
terkena}{\b0\i
aterosklerosis, }
{\b0\i penyakit}{\b0\i
jantung}{\b0\i
koroner,}{\b0\i
pankreatitis}{\b
0
(peradangan}{\b0
pada}{\b0
organ}{\b0
pankreas), }
{\b0 diabetes}{\b0 melitus,}{\b0 gangguan}{\b0 tiroid,}{\b0 penyakit}{\
b0 hepar}{\b0 &}{\b0 penyakit}{\b0 ginjal.}{\b0 Yang }
{\b0 paling}{\b0 sering}{\b0 adalah}{\b0 resiko}{\b0 terkena}{\b0 penyakit
}{\b0 jantung. }
\cf0 \fi719 {\b0 Tidak}{\b0
semua}{\b0
kolesterol}{\b0
meningkatkan}{\b
0
resiko}{\b0
terjadinya}{\b0
penyakit }
{\b0 jantung.}{\b0 Kolesterol}{\b0 yang}{\b0 dibawa}{\b0 oleh}{\b0 LD
L}{\b0 (disebut}{\b0 juga}{\b0\i kolesterol}{\b0\i jahat}{\b0 ) }
{\b0 menyebabkan}{\b0 meningkatnya}{\b0 resiko;}{\b0 kolesterol}{\b0 yang}{
\b0 dibawa}{\b0 oleh}{\b0 HDL}{\b0 (disebut }
{\b0 juga}{\b0\i kolesterol}{\b0\i baik}{\b0 )}{\b0 menyebabkan}{\b0 me
nurunnya}{\b0 resiko}{\b0 dan}{\b0 menguntungkan. }

{\b0 Lalu,}{\b0 apakah}{\b0 kadar}{\b0 trigliserida}{\b0 yang}{\b0 ti
nggi}{\b0 meningkatkan}{\b0 resiko}{\b0 terjadinya }
{\b0 penyakit}{\b0 jantung}{\b0 atau}{\b0 stroke,}{\b0 masih}{\b0 belum}{\
b0 jelas.}{\b0 Kadar}{\b0 trigliserida}{\b0 darah}{\b0 diatas }
{\b0 250}{\b0
mg/dl}{\b0
dianggap}{\b0
abnormal,}{\b0
tetapi}{\b0
kadar}{\b0
yang}{\b0
tinggi}{\b0
ini}{\b0
tidak}{\b0
selalu }
{\b0 meningkatkan}{\b0
resiko}{\b0
terjadinya}{\b0
aterosklerosis}{\b0
maupun}{\b0
penyakit}{\b0
jantung }
{\b0 koroner.}{\b0 Kadar}{\b0 trigliserid}{\b0 yang}{\b0 sangat}{\b0 tingg
i}{\b0 (sampai}{\b0 lebih}{\b0 dari}{\b0 800}{\b0 mg/dl)}{\b0 bisa }
{\b0 menyebabkan}{\b0\i pankreatitis}{\b0 (gangguan}{\b0 pada}{\b0 organ}{\
b0 pankreas). }
\cf0 \fi719 {\b0 Tubuh}{\b0 sendiri}{\b0 memproduksi}{\b0 kolesterol}{\b0
sesuai}{\b0 kebutuhan}{\b0 melalui}{\b0 hati. }
{\b0 Bila}{\b0 terlalu}{\b0 banyak}{\b0 mengkonsumsi}{\b0 makanan}{\b0
yang}{\b0 mengandung}{\b0 kolesterol, }
{\b0 maka}{\b0 kadar}{\b0 kolesterol}{\b0 dalam}{\b0 darah}{\b0 bisa}{\b0
berlebih}{\b0 (disebut}{\b0 hiperkolesterolemia). }
{\b0 Kelebihan}{\b0
kadar}{\b0
kolesterol}{\b0
dalam}{\b0
darah}{\b
0
akan}{\b0
disimpan}{\b0
di}{\b0
dalam}{\b0
lapisan }
{\b0 dinding}{\b0 pembuluh}{\b0 darah}{\b0 arteri,}{\b0 yang}{\b0 disebut}
{\b0 sebagai}{\b0 plak}{\b0 atau}{\b0 ateroma}{\b0 (sumber }
{\b0 utama}{\b0 plak}{\b0 berasal}{\b0 dari}{\b0 LDL-Kolesterol.}{\b0
Sedangkan}{\b0 HDL}{\b0 membawa}{\b0 kembali }
{\b0 kelebihan}{\b0
kolesterol}{\b0
ke}{\b0
dalam}{\b0
hati,}{\b0
sehingga}{\b0
mengurangi}{\b0
penumpukan }
{\b0 kolesterol}{\b0 di}{\b0 dalam}{\b0 dinding}{\b0 pembuluh}{\b0 da
rah).}{\b0 Ateroma}{\b0 berisi}{\b0 bahan}{\b0 lembut }\par
}
7 \par
}
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00ffd9
f20 \fs21 \cf0 seperti keju, mengandung sejumlah bahan lemak, terutama{\i
kolesterol}, sel-sel
i284 otot polos dan sel-sel jaringan ikat.
0 \fi1003 Apabila makin lama plak yang terbentuk makin banyak, akan ter
jadi
i284 suatu penebalan pada dinding pembuluh darah arteri, sehingga
terjadi
i284 penyempitan pembuluh darah arteri. Kejadian ini disebut sebagai aterosklero
sis
i284 (terdapatnya aterom pada dinding arteri, berisi kolesterol da
n zat lemak
i284 lainnya). Hal ini menyebabkan terjadinya arteriosklerosis (penebal
an pada
i284 dinding arteri & hilangnya kelenturan dinding arteri). Bila
ateroma yang
i284 terbentuk semakin tebal, dapat merobek lapisan dinding arteri dan
terjadi
i284 bekuan darah (trombus) yang dapat menyumbat aliran darah dalam art
eri

i284 tersebut.
0 \fi1003 Hal ini yang dapat menyebabkan berkurangnya aliran darah serta suplai
i284 zat-zat penting seperti oksigen ke daerah atau organ tertentu sepe
rti jantung.
i284 Bila mengenai arteri koronaria yang berfungsi mensuplai darah ke otot jantu
ng
i284 (istilah medisnya{\i
miokardium}), maka suplai darah jadi be
rkurang dan
i284 menyebabkan kematian di daerah tersebut (disebut sebagai infark miokard).
0 \fi1003 Konsekuensinya adalah terjadinya serangan jantung dan menyebabka
n
i284 timbulnya gejala berupa nyeri dada yang hebat (dikenal seba
gai angina
i284 pectoris). Keadaan ini yang disebut sebagai Penyakit Jantung Koroner (PJK).
0 {\b E.}{\b Metabolisme}{\b Lipid }
0 \fi1003 Lipid yang kita peroleh sebagai sumber energi utamanya adalah
dari
i284 lipid netral, yaitu trigliserid (ester antara gliserol dengan 3 asam lemak)
. Secara
i284 ringkas, hasil dari pencernaan lipid adalah asam lemak dan gliserol,
selain itu
i284 ada juga yang masih berupa monogliserid. Karena larut dalam air,
gliserol
i284 masuk sirkulasi portal (vena porta) menuju hati. Asam-asam lemak r
antai
i284 pendek juga dapat melalui jalur ini. \par
}
8 \par
}
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20 \fs21 \cf0 Sebagian besar asam lemak dan monogliserida karena tidak larut dal
am
\par}{\phpg\posx2554\pvpg\posy5038\absw8075\absh2847 \sl-413 \f20 \fs21 \cf0 air
, maka diangkut oleh miselus (dalam bentuk besar disebut emulsi) dan
\par}{\phpg\posx2554\pvpg\posy5038\absw8075\absh2847 \sl-414 \f20 \fs21 \cf0 dil
epaskan ke dalam sel epitel usus (enterosit). Di dalam sel ini asam
lemak
\par}{\phpg\posx2554\pvpg\posy5038\absw8075\absh2847 \sl-414 \f20 \fs21 \cf0 dan
monogliserida segera dibentuk menjadi trigliserida (lipid) dan berkumpu
l
\par}{\phpg\posx2554\pvpg\posy5038\absw8075\absh2847 \sl-413 \f20 \fs21 \cf0 ber
bentuk
gelembung
yang
disebut kilomikron.
Selanjutnya
kilomikro
n
\par}{\phpg\posx2554\pvpg\posy5038\absw8075\absh2847 \sl-414 \f20 \fs21 \cf0 dit
ransportasikan melalui pembuluh limfe dan bermuara pada vena kav
a,
\par}{\phpg\posx2554\pvpg\posy5038\absw8075\absh2847 \sl-413 \f20 \fs21 \cf0 seh
ingga
bersatu
dengan
sirkulasi
darah.
Kilomikron
ini
kemudi
an
ransportasikan menuju hati dan jaringan adiposa. \par
}

21 \cf0 Di dalam sel-sel hati dan jaringan adiposa, kilomikron segera d
ipecah
\par}{\phpg\posx2554\pvpg\posy14444\absw7983\absh1270 \sl-414 \f20 \fs21 \cf0 me
njadi asam-asam lemak dan gliserol. Selanjutnya asam-asam lemak dan
0 \fi7414 19 \par
}
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0101010101010101010101010101010101010101010101010101010101010101010101010101ffc0
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5a636465666768696a737475767778797a82838485868788898a92939495969798999aa2a3a4a5a6
00ffd9
1 \cf0 gliserol tersebut, dibentuk kembali menjadi simpanan triglise
rida. Proses
\par}{\phpg\posx2554\pvpg\posy1712\absw8143\absh9926 \sl-414 \f20 \fs21 \cf0 pem
bentukan trigliserida ini dinamakan esterifikasi. Sewaktu-waktu jika kita
\par}{\phpg\posx2554\pvpg\posy1712\absw8143\absh9926 \sl-414 \f20 \fs21 \cf0 mem
butuhkan energi dari lipid, trigliserida dipecah menjadi asam lemak dan
\par}{\phpg\posx2554\pvpg\posy1712\absw8143\absh9926 \sl-413 \f20 \fs21 \cf0 gli

serol, untuk ditransportasikan menuju sel-sel untuk dioksidasi men
jadi
\par}{\phpg\posx2554\pvpg\posy1712\absw8143\absh9926 \sl-414 \f20 \fs21 \cf0 ene
rgi. Proses pemecahan lemak jaringan ini dinamakan lipolisis. Asam lemak
sebut ditransportasikan oleh albumin ke jaringan yang memerlukan dan
ebut sebagai asam lemak bebas (free fatty acid/FFA).
719 Secara ringkas, hasil akhir dari pemecahan lipid dari makanan adala
h
m lemak dan gliserol. Jika sumber energi dari karbohidrat telah mencukupi,
\par}{\phpg\posx2554\pvpg\posy1712\absw8143\absh9926 \sl-414 \f20 \fs21 \cf0 mak
a asam lemak mengalami esterifikasi yaitu membentuk ester dengan
\par}{\phpg\posx2554\pvpg\posy1712\absw8143\absh9926 \sl-413 \f20 \fs21 \cf0 gli
serol menjadi trigliserida sebagai cadangan energi jangka panjang. Jika
\par}{\phpg\posx2554\pvpg\posy1712\absw8143\absh9926 \sl-414 \f20 \fs21 \cf0 sew
aktu-waktu tak tersedia sumber energi dari karbohidrat barulah asam lemak
\par}{\phpg\posx2554\pvpg\posy1712\absw8143\absh9926 \sl-413 \f20 \fs21 \cf0 dio
ksidasi, baik asam lemak dari diet maupun jika harus memecah cadangan
gliserida jaringan. Proses pemecahan trigliserida ini dinamakan lipolisis.
719 Proses oksidasi asam lemak dinamakan oksidasi beta dan menghasilkan
\par}{\phpg\posx2554\pvpg\posy1712\absw8143\absh9926 \sl-413 \f20 \fs21 \cf0 ase
til KoA. Selanjutnya sebagaimana asetil KoA dari hasil metabolis
me
bohidrat dan protein, asetil KoA dari jalur inipun akan masuk ke dala
m
\par}{\phpg\posx2554\pvpg\posy1712\absw8143\absh9926 \sl-413 \f20 \fs21 \cf0 sik
lus asam sitrat sehingga dihasilkan energi. Di sisi lain, jika kebutuhan energi
\par}{\phpg\posx2554\pvpg\posy1712\absw8143\absh9926 \sl-413 \f20 \fs21 \cf0 sud
ah mencukupi, asetil KoA dapat mengalami lipogenesis menjadi asam
ak dan selanjutnya dapat disimpan sebagai trigliserida.
719 Beberapa lipid non gliserida disintesis dari asetil KoA. Asetil KoA
galami
kolesterogenesis
menjadi
kolesterol.
Selanjutnya
kolestero
l
galami steroidogenesis membentuk steroid. Asetil KoA sebagai hasil
\par}{\phpg\posx2554\pvpg\posy1712\absw8143\absh9926 \sl-413 \f20 \fs21 \cf0 oks
idasi asam lemak juga berpotensi menghasilkan badan-badan keton (aseto
tat, hidroksi butirat dan aseton). Proses ini dinamakan ketogenesis. Badan\par}{\phpg\posx2554\pvpg\posy1712\absw8143\absh9926 \sl-413 \f20 \fs21 \cf0 bad
an keton dapat menyebabkan gangguan keseimbangan asam-basa yang
\par}{\phpg\posx2554\pvpg\posy1712\absw8143\absh9926 \sl-414 \f20 \fs21 \cf0 din
amakan asidosis metabolik. Keadaan ini dapat menyebabkan kematian. \par
}
0 \par
}
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}}\par}{\phpg\posx2554\pvpg\posy7756\absw8064\absh2350 \i \f20 \fs21 \cf0 \fi265
6 \i \f20 \fs21 \cf0 Metabolisme gliserol
\fi719 {\i0 Gliserol}{\i0
sebagai}{\i0
hasil}{\i0
hidrolisis}{\i0
li
pid}{\i0
(trigliserida)}{\i0
dapat}{\i0
menjadi }
{\i0 sumber}{\i0 energi.}{\i0 Gliserol}{\i0 ini}{\i0 selanjutnya}{\i0
masuk}{\i0 ke}{\i0 dalam}{\i0 jalur}{\i0 metabolisme }

{\i0 karbohidrat}{\i0 yaitu}{\i0 glikolisis.}{\i0 Pada}{\i0 tahap}{\i0
awal,}{\i0 gliserol}{\i0 mendapatkan}{\i0 1}{\i0 gugus }
{\i0 fosfat}{\i0 dari}{\i0 ATP}{\i0 membentuk}{\i0 gliserol}{\i0 3-fos
fat.}{\i0 Selanjutnya}{\i0 senyawa}{\i0 ini}{\i0 masuk }
{\i0 ke}{\i0 dalam}{\i0 rantai}{\i0 respirasi}{\i0 membentuk}{\i0 dihi
droksi}{\i0 aseton}{\i0 fosfat,}{\i0 suatu}{\i0 produk }
{\i0 antara}{\i0 dalam}{\i0 jalur}{\i0 glikolisis. }\par
}
\cf0 Oksidasi asam lemak (oksidasi beta) \par
}
1 \par
}
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20 \fs21 \cf0 Untuk memperoleh energi, asam lemak dapat dioksidasi dalam
proses
\par}{\phpg\posx2554\pvpg\posy1712\absw7997\absh1729 \sl-414 \f20 \fs21 \cf0 yan
g dinamakan oksidasi beta. Sebelum dikatabolisir dalam oksidasi beta,
m lemak harus diaktifkan terlebih dahulu menjadi asil-KoA. Dengan adanya
\par}{\phpg\posx2554\pvpg\posy1712\absw7997\absh1729 \sl-413 \f20 \fs21 \cf0 ATP
dan Koenzim A, asam lemak diaktifkan dengan dikatalisir oleh enzim
\par}{\phpg\posx2554\pvpg\posy1712\absw7997\absh1729 \sl-414 \f20 \fs21 \cf0 asi
l-KoA sintetase (Tiokinase). \par
}
1 \cf0 Asam lemak bebas pada umumnya berupa asam-asam lemak rantai
\par}{\phpg\posx2554\pvpg\posy7018\absw7966\absh1356 \sl-413 \f20 \fs21 \cf0 pan
jang. Asam lemak rantai panjang ini akan dapat masuk ke dala
m
\par}{\phpg\posx2554\pvpg\posy7018\absw7966\absh1356 \sl-413 \f20 \fs21 \cf0 mit
okondria dengan bantuan senyawa karnitin, dengan rumus (CH3)3N+-CH2\par}{\phpg\posx2554\pvpg\posy7018\absw7966\absh1356 \sl-413 \f20 \fs21 \cf0 CH(
OH)-CH2-COO-. \par
}
2 \par
}
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5a636465666768696a737475767778797a82838485868788898a92939495969798999aa2a3a4a5a6
00ffd9
20 \fs21 \cf0 Langkah-langkah masuknya asil KoA ke dalam mitokondria dijelaskan
\par}{\phpg\posx2554\pvpg\posy1712\absw8040\absh7070 \sl-276 \f20 \fs21 \cf0 seb
agai berikut:
719 Asam lemak bebas (FFA) diaktifkan menjadi
asil-KoA dengan
\par}{\phpg\posx2554\pvpg\posy1712\absw8040\absh7070 \sl-414 \f20 \fs21 \cf0 dik
atalisir oleh enzim tiokinase.Setelah menjadi bentuk aktif, asil-K
oA
onversikan oleh enzim karnitin palmitoil transferase I yang terdapat pa
da
bran eksterna mitokondria menjadi asil karnitin. Setelah menjadi asil
nitin,
barulah
senyawa
tersebut
bisa
menembus
membran
inter
na
\par}{\phpg\posx2554\pvpg\posy1712\absw8040\absh7070 \sl-413 \f20 \fs21 \cf0 mit
okondria.
719 Pada membran interna mitokondria terdapat enzim karnitin asil karnitin
\par}{\phpg\posx2554\pvpg\posy1712\absw8040\absh7070 \sl-413 \f20 \fs21 \cf0 tra
nslokase yang bertindak sebagai pengangkut asil karnitin ke dalam dan
nitin keluar. Asil karnitin yang masuk ke dalam mitokondria selanjutnya
eaksi
dengan
KoA
dengan
dikatalisir
oleh
enzim
karnitin
\par}{\phpg\posx2554\pvpg\posy1712\absw8040\absh7070 \sl-413 \f20 \fs21 \cf0 pal
mitoiltransferase II yang ada di membran interna mitokondria menjadi Asil
\par}{\phpg\posx2554\pvpg\posy1712\absw8040\absh7070 \sl-414 \f20 \fs21 \cf0 Koa
dan karnitin dibebaskan.Asil KoA yang sudah berada dalam mitokondria
\par}{\phpg\posx2554\pvpg\posy1712\absw8040\absh7070 \sl-413 \f20 \fs21 \cf0 ini
selanjutnya masuk dalam proses oksidasi beta.
719 Dalam oksidasi beta, asam lemak masuk ke dalam rangkaian siklus
\par}{\phpg\posx2554\pvpg\posy1712\absw8040\absh7070 \sl-413 \f20 \fs21 \cf0 den
gan 5 tahapan proses dan pada setiap proses, diangkat 2 atom C denga
n
\par}{\phpg\posx2554\pvpg\posy1712\absw8040\absh7070 \sl-413 \f20 \fs21 \cf0 has
il akhir berupa asetil KoA. Selanjutnya asetil KoA masuk ke dalam sik
lus
m sitrat. Dalam proses oksidasi ini, karbon {\field{\*\fldinst SYM
BOL 98 \\f Symbol }} asam lemak dioksidasi
jadi keton. \par
}
3 \par
}
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\cf0 24 \par
}
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20 \fs21 \cf0 Telah dijelaskan bahwa asam lemak dapat dioksidasi jika di
aktifkan
lebih dahulu menjadi asil-KoA. Proses aktivasi ini membutuhkan energi
\par}{\phpg\posx2554\pvpg\posy8960\absw8035\absh5331 \sl-414 \f20 \fs21 \cf0 seb
esar 2P. (-2P) Setelah berada di dalam mitokondria, asil-KoA a
kan
galami tahap-tahap perubahan sebagai berikut:

849 1. Asil-KoA diubah menjadi delta2-trans-enoil-KoA. Pada tahap ini
1134 terjadi rantai respirasi dengan menghasilkan energi 2P (+2P).
849 2. delta2-trans-enoil-KoA diubah menjadi L(+)-3-hidroksi-asil-KoA.
849 3. L(+)-3-hidroksi-asil-KoA diubah menjadi 3-Ketoasil-KoA. Pada
1134 tahap ini terjadi rantai respirasi dengan menghasilkan energi 3P
1134 (+3P).
849 4. Selanjutnya terbentuklah asetil KoA yang mengandung 2 atom C
1134 dan asil-KoA yang telah kehilangan 2 atom C.
\fi709 Dalam satu oksidasi beta dihasilkan energi 2P dan 3P sehingga
total
\par}{\phpg\posx2554\pvpg\posy8960\absw8035\absh5331 \sl-414 \f20 \fs21 \cf0 ene
rgi satu kali oksidasi beta adalah 5P. Karena pada umumnya asam lemak
\par
}
5 \par
}
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00ffd9
1 \cf0 memiliki banyak atom C, maka asil-KoA yang masih ada akan menga
lami
idasi beta kembali dan kehilangan lagi 2 atom C karena membentuk asetil
\par}{\phpg\posx2554\pvpg\posy1712\absw8069\absh7691 \sl-414 \f20 \fs21 \cf0 KoA
. Demikian seterusnya hingga hasil yang terakhir adalah 2 asetil-KoA.
\par}{\phpg\posx2554\pvpg\posy1712\absw8069\absh7691 \sl-413 \f20 \fs21 \cf0 Ase
til-KoA yang dihasilkan oleh oksidasi beta ini selanjutnya akan masuk
\par}{\phpg\posx2554\pvpg\posy1712\absw8069\absh7691 \sl-414 \f20 \fs21 \cf0 sik
lus asam sitrat.
\par}{\phpg\posx2554\pvpg\posy1712\absw8069\absh7691 \sl-413 \f20 \fs21 \cf0 {\b
a.}{\b Penghitungan}{\b energi}{\b hasil}{\b metabolisme}{\b lipid }
719 Dari uraian di atas kita bisa menghitung energi yang dihasilkan ol
eh
idasi beta suatu asam lemak. Misalnya tersedia sebuah asam lemak dengan
atom C, maka kita memerlukan energi 2 ATP untuk aktivasi, dan energi
\par}{\phpg\posx2554\pvpg\posy1712\absw8069\absh7691 \sl-414 \f20 \fs21 \cf0 yan
g di hasilkan oleh oksidasi beta adalah 10 dibagi 2 dikurangi 1, yaitu 4 kali
idasi beta, berarti hasilnya adalah 4 x 5 = 20 ATP. Karena asam lem
ak
iliki 10 atom C, maka asetil-KoA yang terbentuk adalah 5 bua
h.
\par}{\phpg\posx2554\pvpg\posy1712\absw8069\absh7691 \sl-413 \f20 \fs21 \cf0 Set
iap asetil-KoA akan masuk ke dalam siklus Kreb's yang masing-masing
\par}{\phpg\posx2554\pvpg\posy1712\absw8069\absh7691 \sl-413 \f20 \fs21 \cf0 aka
n menghasilkan 12 ATP, sehingga totalnya adalah 5 X 12 ATP = 60 ATP.
\par}{\phpg\posx2554\pvpg\posy1712\absw8069\absh7691 \sl-414 \f20 \fs21 \cf0 Den
gan demikian sebuah asam lemak dengan 10 atom C, akan dimetabolisir
gan hasil -2 ATP (untuk aktivasi) + 20 ATP (hasil oksidasi beta) + 60 ATP
\par}{\phpg\posx2554\pvpg\posy1712\absw8069\absh7691 \sl-413 \f20 \fs21 \cf0 (ha
sil
siklus
Kreb's)
=
78
ATP.
\par}{\phpg\posx2554\pvpg\posy1712\absw8069\absh7691 \sl-413 \f20 \fs21 \cf0 Seb
agian dari asetil-KoA akan berubah menjadi asetoasetat, selanjutny
a
toasetat berubah menjadi hidroksi butirat dan aseton. Aseto asetat, hidroksi
\par}{\phpg\posx2554\pvpg\posy1712\absw8069\absh7691 \sl-414 \f20 \fs21 \cf0 but
irat dan aseton dikenal sebagai badan-badan keton. Proses perubahan asetil\par}{\phpg\posx2554\pvpg\posy1712\absw8069\absh7691 \sl-413 \f20 \fs21 \cf0 KoA
menjadi benda-benda keton dinamakan ketogenesis. \par
}
6 \par
}
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0 \fs21 \cf0 Sebagian dari asetil KoA dapat diubah menjadi kolesterol (prosesnya
\par}{\phpg\posx2484\pvpg\posy8264\absw7782\absh984 \sl-414 \f20 \fs21 \cf0 dina
makan kolesterogenesis) yang selanjutnya dapat digunakan sebagai bahan
85 untuk disintesis menjadi steroid (prosesnya dinamakan steroidogenesis). \par
}
7 \par
}
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}}\par}{\phpg\posx2270\pvpg\posy10478\absw8313\absh3468 \b \f20 \fs21 \cf0 \b \f
20 \fs21 \cf0 b. Sintesis asam lemak
\cf0 \fi1003 {\b0 Makanan}{\b0 bukan}{\b0 satu-satunya}{\b0 sumber}{\b0
lemak}{\b0 kita.}{\b0 Semua}{\b0 organisme }
\fi284 {\b0 dapat}{\b0 men-sintesis}{\b0 asam}{\b0 lemak}{\b0 sebagai}{

\b0 cadangan}{\b0 energi}{\b0 jangka}{\b0 panjang}{\b0 dan }
\fi284 {\b0 sebagai}{\b0 penyusun}{\b0 struktur}{\b0 membran.}{\b0 Pada
}{\b0 manusia,}{\b0 kelebihan}{\b0 asetil}{\b0 KoA }
\fi284 {\b0 dikonversi}{\b0 menjadi}{\b0 ester}{\b0 asam}{\b0 lemak.}{\
b0 Sintesis}{\b0 asam}{\b0 lemak}{\b0 sesuai}{\b0 dengan }
\fi284 {\b0 degradasinya}{\b0 (oksidasi}{\b0 beta). }
\fi1003 {\b0 Sintesis}{\b0 asam}{\b0 lemak}{\b0 terjadi}{\b0 di}{\b0
dalam}{\b0 sitoplasma.}{\b0 ACP}{\b0 (acyl}{\b0 carrier }
\fi284 {\b0 protein)}{\b0 digunakan}{\b0 selama}{\b0 sintesis}{\b0 seba
gai}{\b0 titik}{\b0 pengikatan.}{\b0 Semua}{\b0 sintesis }
\fi284 {\b0 terjadi}{\b0 di}{\b0 dalam}{\b0 kompleks}{\b0 multi}{\b0 enzim
-fatty}{\b0 acid}{\b0 synthase.}{\b0 NADPH}{\b0 digunakan }\par
}
8 \par
}
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51450014514500145145007fffd9
\cf0 untuk sintesis. Tahap-tahap sintesis asam lemak ditampilkan
pada skema
\par}{\phpg\posx2554\pvpg\posy1712\absw7926\absh611 \sl-414 \f20 \fs21 \cf0 beri
kut. \par
}

1 \cf0 Penyimpanan lemak dan penggunaannya kembali. Asam-asam lemak akan
impan jika tidak diperlukan untuk memenuhi kebutuhan energi. Tempat
\par}{\phpg\posx2554\pvpg\posy8596\absw7965\absh2847 \sl-413 \f20 \fs21 \cf0 pen
yimpanan utama asam lemak adalah jaringan adiposa. Adapun tahap-tahap
\par}{\phpg\posx2554\pvpg\posy8596\absw7965\absh2847 \sl-414 \f20 \fs21 \cf0 pen
yimpanan tersebut adalah: Asam lemak ditransportasikan dari hati sebagai
\par}{\phpg\posx2554\pvpg\posy8596\absw7965\absh2847 \sl-413 \f20 \fs21 \cf0 kom
pleks VLDL. Asam lemak kemudian diubah menjadi trigliserida di sel
\par}{\phpg\posx2554\pvpg\posy8596\absw7965\absh2847 \sl-414 \f20 \fs21 \cf0 adi
posa
untuk
disimpan.
Gliserol
3-fosfat
dibutuhkan
untuk
mem
buat
gliserida. Ini harus tersedia dari glukosa. Akibatnya, kita tak
dapat
yimpan lemak jika tak ada kelebihan glukosa di dalam tubuh. \par
}
9 \par
}
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00ffd9
20 \fs21 \cf0 Jika kebutuhan energi tidak dapat tercukupi oleh kar
bohidrat, maka
\par}{\phpg\posx2554\pvpg\posy2264\absw8067\absh1729 \sl-414 \f20 \fs21 \cf0 sim
panan trigliserida ini dapat digunakan kembali. Trigliserida akan dipeca
h
jadi gliserol dan asam lemak. Gliserol dapat menjadi sumber energi (lihat
\par}{\phpg\posx2554\pvpg\posy2264\absw8067\absh1729 \sl-414 \f20 \fs21 \cf0 met
abolisme gliserol). Sedangkan asam lemak pun akan dioksidasi untu
k
enuhi kebutuhan energi pula (lihat oksidasi beta). \par
}
\cf0 2.3 Pencernaan, Absorpsi, Transportasi, dan Metabolisme Lipid
\fi720 {\b0 Sebagian}{\b0
besar}{\b0
lemak}{\b0
pada}{\b0
makanan}{\
b0
yang}{\b0
terdiri}{\b0
dari}{\b0
trigliserida/ }
{\b0 trigliserol}{\b0 harus}{\b0 dipecah}{\b0 terlebih}{\b0 dahulu}{\b0
untuk}{\b0 mempermudah}{\b0 proses}{\b0 reabsorpsi }
{\b0 dalam}{\b0 tubuh.}{\b0 Pada}{\b0 sebagian}{\b0 orang}{\b0 dewasa}
{\b0 lemak}{\b0 dapat}{\b0 dicerna}{\b0 secara}{\b0 efisien }
{\b0 hingga}{\b0 95%}{\b0 dari}{\b0 yang}{\b0 dikonsumsi. }
\fi720 {\b0 Lemak}{\b0 yang}{\b0 tidak}{\b0 bermuatan}{\b0 listrik}{\b0 seh
ingga}{\b0 bersifat}{\b0 netral}{\b0 dan}{\b0 hidrifobik. }
{\b0 Bila}{\b0 dicampur}{\b0 dengan}{\b0 air,}{\b0 lemak}{\b0 akan}{\b
0 memisah.}{\b0 Enzim,}{\b0 sebaliknya}{\b0 mempunyai }
{\b0 bagian-bagian}{\b0 yang}{\b0 bermuatan}{\b0 positif}{\b0 dan}{\b0 nega
tive.oleh}{\b0 karena}{\b0 itu}{\b0 enzim}{\b0 bersifat }
{\b0 hidrofilik,}{\b0 yaitu}{\b0 dapat}{\b0 bercampur}{\b0 baik}{\b0 dengan
}{\b0 air}{\b0 yang}{\b0 bersifat}{\b0 polar.}{\b0 Agar}{\b0 lemak }
{\b0 dapat}{\b0 bercampur}{\b0 baik}{\b0 dengan}{\b0 air,}{\b0 dan}{\b0 en
zim}{\b0 dapat}{\b0 bekerja}{\b0 untuk}{\b0 mencerna}{\b0 lemak, }
{\b0 terlebih}{\b0 dahulu}{\b0 harus}{\b0 mengalami}{\b0 proses}{\b0 emulsi
fikasi. }
\fi720 {\b0 Emulsifikasi}{\b0 adalah}{\b0 proses}{\b0 dimana}{\b0 terjad
i}{\b0 pengikatan}{\b0 lemak}{\b0 oleh}{\b0 garam }
{\b0 empedu}{\b0 sehingga}{\b0 nantinya}{\b0 dalam}{\b0 bentuk}{\b0 em
ulsi}{\b0 ini}{\b0 dapat}{\b0 mempermudah}{\b0 proses }
{\b0 penyerapan}{\b0
dan}{\b0
pencernaannnya.}{\b0
Emulsi}{\b0
lemak
}{\b0
terjadi}{\b0
di}{\b0
dalam}{\b0
usus}{\b0
halus }
{\b0 dengan}{\b0
bantuan}{\b0
garam}{\b0
empedu.}{\b0
Pada}{\b0
w
aktu}{\b0
lemak}{\b0
memasuki}{\b0
usus}{\b0
halus, }
{\b0 hormone}{\b0
kolesitokinin}{\b0
memberi}{\b0
isyarat}{\b0
k
epada}{\b0
kantong}{\b0
empedu}{\b0
untuk }
{\b0 mengeluarkan}{\b0 cairan}{\b0 empedu.}{\b0 Cairan}{\b0 empedu}{\b0 ter
dapat}{\b0 sebagai}{\b0 asam}{\b0 empedu}{\b0 dan }
{\b0 garam}{\b0 empedu.}{\b0 Asam}{\b0 empedu}{\b0 dibuat}{\b0 oleh}{\
b0 hati}{\b0 dari}{\b0 kolesterol}{\b0 untuk}{\b0 kemudian }
{\b0 disimpan}{\b0 di}{\b0 dalam}{\b0 kantung}{\b0 empedu}{\b0 hingga}{\b0
saat}{\b0 diperlukan.}{\b0 Pada}{\b0 salah}{\b0 satu}{\b0 ujung }
{\b0 molekul}{\b0 asam}{\b0 empedu}{\b0 terdapat}{\b0 rantai}{\b0 samping}{
\b0 yang}{\b0 terdiri}{\b0 atas}{\b0 asam}{\b0 amino}{\b0 yang }
{\b0 menarik}{\b0 air,}{\b0 sedangkan}{\b0 pada}{\b0 ujung}{\b0 lainny
a}{\b0 terdapat}{\b0 sterol}{\b0 yang}{\b0 menarik}{\b0 lemak. }
{\b0 Demikianlah}{\b0 asam}{\b0 empedu}{\b0 dapat}{\b0 menarik}{\b0 mo
lekul}{\b0 lemak}{\b0 yang}{\b0 sudah}{\b0 dipecah }
{\b0 menjadi}{\b0 bagian-bagian}{\b0 kecil}{\b0 ini}{\b0 ke}{\b0 dalam}{\b0
cairan}{\b0 tubuh.}{\b0 Enzim}{\b0 lipase}{\b0 yang}{\b0 bersal }
{\b0 dari}{\b0 dinding}{\b0 usus}{\b0 halus}{\b0 dan}{\b0 pancreas}{\b0 ke
mudian}{\b0 mencrnakan}{\b0 lemak}{\b0 dalam}{\b0 bentuk }
{\b0 emulsi}{\b0 ini. }\par
}
0 \par
}
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45140051451401ffd9
20 \fs21 \cf0 Pencernaan lemak (trigliserida) sebagian besar dilakukan du
dalam usus
\par}{\phpg\posx2270\pvpg\posy1712\absw8600\absh3965 \sl-414 \f20 \fs21 \cf0 hal
us. Enzim utama yang berperan dalam pencernaan lemak ini adalah enzim
\par}{\phpg\posx2270\pvpg\posy1712\absw8600\absh3965 \sl-414 \f20 \fs21 \cf0 lip
ase. Lipase sebagian besar dibentuk oleh pancreas dan selebihnya
oleh
\par}{\phpg\posx2270\pvpg\posy1712\absw8600\absh3965 \sl-413 \f20 \fs21 \cf0 did
nding usus halus. Hampir separo dari trigliserida berasal dari
makanan
\par}{\phpg\posx2270\pvpg\posy1712\absw8600\absh3965 \sl-414 \f20 \fs21 \cf0 dih

idrolisis secara sempurna oleh enzim ini menjadi asam lemak dan gliser
ol.
\par}{\phpg\posx2270\pvpg\posy1712\absw8600\absh3965 \sl-413 \f20 \fs21 \cf0 Sel
ebihnya dipecah menjadi digliserida, monodigliserida dan asam lema
k.
\par}{\phpg\posx2270\pvpg\posy1712\absw8600\absh3965 \sl-414 \f20 \fs21 \cf0 Fos
folipid dicernakan oleh enzim fosfolipase yang dikeluarkan oleh pancreas
gan cara yang sama. Hasil pencernaan ini adalah dua asam lem
ak dan
\par}{\phpg\posx2270\pvpg\posy1712\absw8600\absh3965 \sl-413 \f20 \fs21 \cf0 lis
ofosfogliserid. Ester kolesterol dihidrolisis oleh enzim kolesterol esterase y
ang
eluarkan oleh pancreas.
1888 {\b Tebel}{\b ringkasan}{\b proses}{\b pencernaan}{\b lipid }\par
}
{\phpg\posx2266\pvpg\posy6276\absw2512\absh496 \f20 \fs21 \cf0 \f20 \fs21 \cf0 N
o
Saluran Pencernaan
Mulut \par
}
\par}{\phpg\posx2266\pvpg\posy7676\absw165\absh496 \sl-286 \f20 \fs21 \cf0 3 \pa
r
}
{\phpg\posx2776\pvpg\posy7676\absw1151\absh496 \f20 \fs21 \cf0 \f20 \fs21 \cf0 E
sophagus
\par}{\phpg\posx2776\pvpg\posy7676\absw1151\absh496 \sl-286 \f20 \fs21 \cf0 Lamb
ung \par
}
\par
}
{\phpg\posx2776\pvpg\posy9490\absw1095\absh239 \f20 \fs21 \cf0 \f20 \fs21 \cf0 U
sus halus \par
}
\par
}
Usu besar \par
}
Proses pencernaan
\par}{\phpg\posx5122\pvpg\posy6276\absw5426\absh6369 \sl-286 \f20 \fs21 \cf0 Men
gunyah,
mencampur
denganair
ludah
dan
elan. Kelenjar ludah mengeluarkan enzim lipase
\par}{\phpg\posx5122\pvpg\posy6276\absw5426\absh6369 \sl-413 \f20 \fs21 \cf0 lin
gual
\par}{\phpg\posx5122\pvpg\posy6276\absw5426\absh6369 \sl-286 \f20 \fs21 \cf0 Tid
ak ada pencernaan
\par}{\phpg\posx5122\pvpg\posy6276\absw5426\absh6369 \sl-286 \f20 \fs21 \cf0 Lip
ase
lingual
dalm
jumlah
terbatas
memulai
\par}{\phpg\posx5122\pvpg\posy6276\absw5426\absh6369 \sl-413 \f20 \fs21 \cf0 hid
rlolisis trigliserida menjadi digliserida dan asam

ak. Lemak susu lebih banyak dihidrolisis. Lipase
\par}{\phpg\posx5122\pvpg\posy6276\absw5426\absh6369 \sl-413 \f20 \fs21 \cf0 lam
bung menghidrolisis dalam jumlah terbatas.
\par}{\phpg\posx5122\pvpg\posy6276\absw5426\absh6369 \sl-286 \f20 \fs21 \cf0 Bah
an empedu mengemulsi lemak. Lipase berasal
\par}{\phpg\posx5122\pvpg\posy6276\absw5426\absh6369 \sl-413 \f20 \fs21 \cf0 dar
i pancreas dan dinding usus halus menghidrolisis
ak dalam bentuk emulsi menjadi digliserida,
\par}{\phpg\posx5122\pvpg\posy6276\absw5426\absh6369 \sl-413 \f20 \fs21 \cf0 mon
ogliserida, gliserol dan asam lemak. Fosfolipase
asal dari pancreas menghidrolisis fosfolipida
jadi asam lemak dan lisofogliserida. Kolesterol
\par}{\phpg\posx5122\pvpg\posy6276\absw5426\absh6369 \sl-413 \f20 \fs21 \cf0 ste
rase berasal dari pancreas menghidrolisis ester
\par}{\phpg\posx5122\pvpg\posy6276\absw5426\absh6369 \sl-414 \f20 \fs21 \cf0 kol
esterol.
\par}{\phpg\posx5122\pvpg\posy6276\absw5426\absh6369 \sl-285 \f20 \fs21 \cf0 Sed
ikit lemak dan kolesterol yang terkurung dalam
\par}{\phpg\posx5122\pvpg\posy6276\absw5426\absh6369 \sl-414 \f20 \fs21 \cf0 ser
at makanan, dikeluarkan melalui feses. \par
}
1 \cf0 Absorpsi dan transportasi lemak. Absorpsi lipida terutama terjadi
dalam
\par}{\phpg\posx2270\pvpg\posy13788\absw8289\absh984 \sl-413 \f20 \fs21 \cf0 jej
unum, hasil pencernaan lipida diabsorpsi dalam membrane mukosa usus halus
gan cara difusi pasif. Perbedaan konsentrasi diperoleh dengan cara : \par
}
1 \par
}
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20 \fs21 \cf0 1
Kehadiran protein pengikat asam lemak yang segera mengikat as
am lemak
720 yang memasuki sel.
\fi360 2
Esterifikasi kembali asam lemak menjadi monogliserida, yaitu
produk
720 utama penccernaan yang melintasi mukosa usus halus. Sebelum diabsorpsi
720 kolesterol mengalami esterifikasi kembali dikatalis oleh asetil-Koenzim A
720 dan
kolesterol
asetiltransferase.
Pembentukan
enzim-enzi
m
ini
720 dipengaruhi oleh konsentrasi tinggi kolesterol makanan.
\fi360 Sebagian besar hasil pencernaan lemak berupa monogliserida dan asam lema
k
\par}{\phpg\posx2270\pvpg\posy1712\absw8418\absh8423 \sl-413 \f20 \fs21 \cf0 ran
tai panjang (C12 atau lebih) didalam membrane mukosa usu diubah kembal
i
jadi trigliserida. Asam lemak rantai pendek dan sedang diabsorpsi langsun
g
dalam vena porta dan dibawa ke hati untuk segera dioksidasi.oleh kareana itu
m-asam lemak ini tidak mempengaruhi kadar lemak plasma dan tidak disimpan
\par}{\phpg\posx2270\pvpg\posy1712\absw8418\absh8423 \sl-413 \f20 \fs21 \cf0 dal
am jaringan.
360 Trigliserida dan lipida besar lainnya (kolesterol dan fosfolipid) yang terbe
ntuk
\par}{\phpg\posx2270\pvpg\posy1712\absw8418\absh8423 \sl-414 \f20 \fs21 \cf0 di
dalam usus halus dikemas untuk diabsorpsi secara aktif dan ditransportasi oleh
ah. Bahan - bahan ini bergabung dengan protein-protein khusus
dan
bentuk alat angkut lipid yang dinamakn lipoprotein. Tubuh membentuk
\par}{\phpg\posx2270\pvpg\posy1712\absw8418\absh8423 \sl-413 \f20 \fs21 \cf0 emp
at jenis lipoprotein yaitu :
720 {\f10 \fs19 1}{\b
Kilomikron.}
Kilomikoron
adalah
lipoprotein
paling
besar
dan
1080 mempunyai densitas paling rendah kilomikron mengangkut lipida
1080 berasal makanan dari saluran cerna ke seluruh tumbuh. Lipida yang
1080 diangkut terutama trigliserida. \par
}
1 \cf0 Hasil pencemaran lipid
{\b0 Griserol }
{\b0 Asam}{\b0 lemak}{\b0 rantai}{\b0 pendek }
{\b0 darah }
{\b0 Asam}{\b0 lemak}{\b0 rantai}{\b0 menengah }
\cf0 {\b0 Asam}{\b0 lemak}{\b0 rantai}{\b0 panjang }
{\b0 Monogliserida }
\cf0 {\b0 Trigliserial }
{\b0 Kolestrol }
{\b0 Fosfolipida }\par
}
0 \fs21 \cf0 Absorsi
cf0 {\b0 Diserap}{\b0 langsung}{\b0 ke}{\b0 dalam }\par

}
1 \cf0 Diubah menjadi trisgliserida
i67 di dalam sel-sel usus halus
0 \fi33 Membentuk kilomikron, masuk
i39 ke dalam limfe, kemudian ke
\par}{\phpg\posx6908\pvpg\posy13096\absw3217\absh1481 \sl-275 \f20 \fs21 \cf0 da
lam aliran darah \par
}
2 \par
}
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010101010101010101ffdb0043010101010101010101010101010101010101010101010101010101
0101010101010101010101010101010101010101010101010101010101010101010101010101ffc0
001108034a025303012200021101031101ffc4001f00000105010101010101000000000000000001
02030405060708090a0bffc400b5100002010303020403050504040000017d010203000411051221
31410613516107227114328191a1082342b1c11552d1f02433627282090a161718191a2526272829
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0101010101010101010000000000000102030405060708090a0bffc400b511000201020404030407
05040400010277000102031104052131061241510761711322328108144291a1b1c109233352f015
6272d10a162434e125f11718191a262728292a35363738393a434445464748494a53545556575859
5a636465666768696a737475767778797a82838485868788898a92939495969798999aa2a3a4a5a6
00ffd9

f20 \fs21 \cf0 Kilomikron merupakan tetesan besar lipida berupa trigliseri
da, dan
i360 fosfolipida denan sedikit protein (terutama berupa apolipoprotein A
i360 dan B) yang membentuk selaput pada permukaannya. Selaput di
i360 sekeliling
kilomikron
ini
memungkinkan
lipida
di
dalamnya
i360 mengembang secara bebas di dalam aliran darah yang sebagian besar
i360 terdiri atas. Kilomikron pada dasarnya mengemulsi lemak sebelum
i360 masuk ke dalam aliran darah. Proses ini menyerupai kegiatan lesiti
n
i360 dan asam lemak dalam usus halus dalam upaya mengemulasi lemak
i360 makanan selama pencernaan . perbedaannya adalah bahwa dalam
i360 pencernaan yang makanan selama pencernaan. Perbedaannya adalah
i360 bahwa dalam pencernaan yang mengelilingi tetesan lemak adalah air,
i360 sedangkan pada kilomikron, lemak dikelilingi oleh protein, kolesterol,
i360 dan fosfolipida. Dalam aliran darah trigliserida yang ada p
ada
i360 kilomikron dipecah menjadi gliserol dan asam lemak bebas oleh enzim
i360 lipoprotein. Sebagian besar asam lemak yang terbentuk di dalam tubuh
i360 diabsorpsi oleh sel-sel otot, lemak dan sel - sel lain. Asam lem
ak ini
i360 dapat langsung digunakan sebagai zat energy atau diubah kembali
i360 menjadi trigliserida. Sel-sel otot cenderung menggunakannya sebagai
i360 zat energy, sedangkan sel lemak menyimpannya sebagai trigliserida.
0 2{\b\i
Very}{\b\i
low}{\b\i
density}{\b\i
lipoprotein}
(VLD
L).
Di
dalam
hati
lipida
i360 dipersiapkan menjadi lipoprotein sehingga dapat diangkut melalu
i
i360 a;liran darah. Lipoprotein yang dibentuk dalam hati ini adalah VLDL,
i360 yaitu lipoprotein dengan densitas sangat rendah yang terutama terdi
ri
i360 atas trigliserida. Bila VLDL meninggalkan hati, lipoprotein l
ipase
i360 kembali bekerja dengan memecah trigliserida yang ada pada VLDL.

i360 VLDL kemudian mengankat kolesterol yang ada pada lipoprotein lain
i360 dalam sirkulasi darah. Dengan berkurangnya trigliserida, VLDL
i360 bertambah berat dan menjadi LDL ({\i Low}{\i Density}{\i Lipoprote
in}), yaitu
i360 lipoprotein dengan densitas rendah.
\par}{\phpg\posx2990\pvpg\posy2188\absw7622\absh11597 \sl-413 \f20 \fs21 \cf0 3{
\b\i
Low}{\b\i
Density}{\b\i
Lipoprotein} (LDL). LDL yang teru
tama terdiri atas
i360 kolesterol bersilkulasi dalam tubuh dan dibawa ke sel-sel otot, lemak, \par
}
3 \par
}
ffd8ffe000104a46494600010100000100010000ffdb004300010101010101010101010101010101
01010101010101010101010101010101010101010101010101010101010101010101010101010101
010101010101010101ffdb0043010101010101010101010101010101010101010101010101010101
0101010101010101010101010101010101010101010101010101010101010101010101010101ffc0
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31410613516107227114328191a1082342b1c11552d1f02433627282090a161718191a2526272829
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00ffd9
f20 \fs21 \cf0 dan sel-sel lainya. Trigliserida akan diperlakukan sama d
engan yang
i360 trjadi pada kilomikron dan VLDL. Kolesterol dan fosfolipida akan
i360 digunaka untuk membuat membrane sel, hormone-hormon atau ikatan
i360 lain, atau disimpan. Reseptor LDL yang ada di dalam hati
akan
i360 mengeluarkan
LDL dari sirkulasi. Pembentukan LDL oleh reseptor
i360 LDL ini penting dalam pengontrolan kolesterol darah. Disamping itu
i360 dalam pembuluh darah terdapat sel-sel .perusak yang dapat merusak
i360 LDL. Melalui jalur sel-sel perusak ini ({\i scavenger}{\i pathway})
molekul
i360 LDL dioksidasi, sehingga tidak dapat masuk kembali ke dalam aliran
i360 darah. Kolesterol yang banyak terdapat dalam LDL akan menumouk
i360 pada sel-sel perusak. Bila hal ini terjadi selama bertahuntahun,
i360 kolesterol
akan
menumpuk
pada
dinding
pembuluh
darah
d
an
i360 membentuk{\i plak}. Plak akan bercampur dengan protein dan ditutup
i360 oleh sel-sel otot dan kalsium. Hal inilah yang kemudian d
apat
i360 berkembang menjadi{\i aterosklerosis}. Pengatur utama kadar kolester
ol
i360 dalam darah adalah hati, karena sebagian besar (50-70 %) reseptor
i360 LDL terdapat didalam hati.
\par}{\phpg\posx2990\pvpg\posy1712\absw7735\absh11789 \sl-413 \f20 \fs21 \cf0 4{
\b\i
High}{\b\i Density}{\b\i Lipoprotein} (HDL). Bila sel-sel lemak
membebaskan
i360 gliserol dan asam lemak, kemungkinan kolesterol dan fosfolipid akan
i360 dikembalikan pula kedalam aliran darah. Hati dan usus halus akan
i360 memproduksi HDL (lipoprotein dengan densitas tinggi) yang masuk
i360 kedalam aliran darah. HDL menyerahkan kolesterol ke lipoprotein lain
i360 untuk
diangkut
kembali
kehati
guna
diedarkan
kembali
a
tau
i360 dikeluarkan dari tubuh. Nilai LDL dan HDL mempunyai implikasi
i360 terhadap kesehatan jantung dan pembuluh darah. Nilai LDL yang
i360 tinggi dikaitkan denga resiko tinggi terhadap serangan jantun
g.
i360 Sebaliknya HDL tinggi dikaitakan dengan resiko rendah. Oleh sebab
i360 itu, LDL dikatakan sebagai "kolesterol jahat" sedangkan HDL
i360 dikatakan "kolesterol baik". Bagian dalam dari lipoprotein terdiri dari
i360 trigliseridan dan kolesterol yang diselubungi fosfolipida. Prot
ein
i360 berada didekat ujung luar fosfolipida menutupu struktur lipoprotein.
i360 Penyusunan molekul yang bersifat hidrofobik dibagian dalam dan
\par
}
4 \par
}
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f11e8f2de7dbff00f0f62ff82597fd24b3f600ff00c4c8fd9d7ff9e35007c01ff0e0bffacd47fc17
fbff001637ff00e26e8ff8705ffd66a3fe0bfdff008b1bff00f1375f7fff00c3d8bfe0965ff492cf
d803ff001323f675ff00e78d47fc3d8bfe0965ff00492cfd803ff1323f675ffe78d401f007fc382f
feb351ff0005feff00c58dff00f89ba3fe1c17ff0059a8ff0082ff007fe2c6ff00fc4dd7dfff00f0
009e35007c01ff000e0bff00acd47fc17fbff1637ffe26e8ff008705ff00d66a3fe0bfdff8b1bfff
001375f7ff00fc3d8bfe0965ff00492cfd803ff1323f675ffe78d47fc3d8bfe0965ff492cfd803ff
001323f675ff00e78d401f007fc382ff00eb351ff05feffc58dfff0089bafc81ff0082bbff00c122
3fe1427fc3b07fe367dff057ff008d1ff0ba3fe0afff00b15fc02ff8bfbfb6affc2c6ff854ff00f0
b1bfe165ff00c5eaf82bff0016d347ff008413f680f027f63ffc5b8f88ff00f135ff008463fb5759
ff008935f7dbbf75fd3eff00c3d8bfe0965ff492cfd803ff001323f675ff00e78d5f883ff05b6ff8
284fec0bf15ffe1d19ff000ab7f6e1fd903e257fc2b5ff0082df7ec0ff00163e22ff00c201fb4b7c
17f18ffc203f0b3c1dff000b5ffe12ef897e35ff008477c6ba8ffc22bf0ffc2bfda3a7ff00c247e3
2d77ec1e1cd0fedf67fda7a95afdaa0de01f5fff00c382ff00eb351ff05feffc58dfff0089ba3fe1
c17ff59a8ff82ff7fe2c6fff00c4dd7dff00ff000f62ff0082597fd24b3f600ffc4c8fd9d7ff009e
351ff0f62ff82597fd24b3f600ff00c4c8fd9d7ff9e35007c01ff0e0bffacd47fc17fbff001637ff
00e26e8ff8705ffd66a3fe0bfdff008b1bff00f1375f7fff00c3d8bfe0965ff492cfd803ff001323
f675ff00e78d47fc3d8bfe0965ff00492cfd803ff1323f675ffe78d401f007fc382ffeb351ff0005
feff00c58dff00f89bafc81ff82f57fc1223fe197ffe093dfb567c74ff00879f7fc15fff00688ff8
41ff00e1467fc59dfda8ff006d5ff85b7f027c61ff000937ed27f077c1ff00f15cfc3dff008569e1
ff00f8483fe11fff008483fe129f0cff00c4ded3fb2bc63a2787b5bff48fecdfb2cdfd3eff00c3d8
bfe0965ff492cfd803ff001323f675ff00e78d5f883ff071e7fc1427f605f8e3ff000463fdb27e16
fc14fdb87f640f8c1f137c51ff000cf3ff0008cfc3af85bfb4b7c17f881e3bf117f627ed57f037c4
5acff617847c27e35d5fc41abff64787f48d575dd4ff00b3f4fb8fb068fa66a1a9dd7956565733c4
01fd5ed1451400514514005145140051451400514514005145140051451400514514005145140051
45140051451400514514005145140057c01ff0e9dff82597fd234ff600ff00c437fd9d7ff9dcd7df
f45007c01ff0e9dff82597fd234ff600ff00c437fd9d7ff9dcd1ff000e9dff0082597fd234ff0060
0ffc437fd9d7ff009dcd7dff0045007c01ff000e9dff0082597fd234ff00600ffc437fd9d7ff009d
cd1ff0e9dff82597fd234ff600ff00c437fd9d7ff9dcd7dff45007c01ff0e9dff82597fd234ff600
ff00c437fd9d7ff9dcd1ff000e9dff0082597fd234ff00600ffc437fd9d7ff009dcd7dff0045007c
01ff000e9dff0082597fd234ff00600ffc437fd9d7ff009dcd1ff0e9dff82597fd234ff600ff00c4
37fd9d7ff9dcd7dff45007c01ff0e9dff82597fd234ff600ff00c437fd9d7ff9dcd1ff000e9dff00
82597fd234ff00600ffc437fd9d7ff009dcd7dff0045007c01ff000e9dff0082597fd234ff00600f
fc437fd9d7ff009dcd1ff0e9dff82597fd234ff600ff00c437fd9d7ff9dcd7dff45007c01ff0e9df
f82597fd234ff600ff00c437fd9d7ff9dcd1ff000e9dff0082597fd234ff00600ffc437fd9d7ff00
9dcd7dff0045007c01ff000e9dff0082597fd234ff00600ffc437fd9d7ff009dcd1ff0e9dff82597
fd234ff600ff00c437fd9d7ff9dcd7dff45007c01ff0e9dff82597fd234ff600ff00c437fd9d7ff9
dcd1ff000e9dff0082597fd234ff00600ffc437fd9d7ff009dcd7dff0045007c01ff000e9dff0082
01ff000e9dff0082597fd234ff00600ffc437fd9d7ff009dcd1ff0e9dff82597fd234ff600ff00c4
37fd9d7ff9dcd7dff45007c01ff0e9dff82597fd234ff600ff00c437fd9d7ff9dcd1ff000e9dff00
82597fd234ff00600ffc437fd9d7ff009dcd7dff0045007c01ff000e9dff0082597fd234ff00600f
fc437fd9d7ff009dcd1ff0e9dff82597fd234ff600ff00c437fd9d7ff9dcd7dff45007c01ff0e9df
f82597fd234ff600ff00c437fd9d7ff9dcd1ff000e9dff0082597fd234ff00600ffc437fd9d7ff00
9dcd7dff0045007c01ff000e9dff0082597fd234ff00600ffc437fd9d7ff009dcd1ff0e9dff82597
fd234ff600ff00c437fd9d7ff9dcd7dff45007c01ff0e9dff82597fd234ff600ff00c437fd9d7ff9
dcd1ff000e9dff0082597fd234ff00600ffc437fd9d7ff009dcd7dff0045007c01ff000e9dff0082
01ff000e9dff0082597fd234ff00600ffc437fd9d7ff009dcd741e13ff008264ff00c136fc05e2af
0cf8ebc0bff04f9fd883c17e36f05f88346f16783bc63e13fd943e037873c55e13f15787351b6d63
c3de26f0cf88747f00d9eafa0f88342d5ececf54d1b59d2ef2d751d2f51b5b6beb1b982e608a55fb
7e8a0028a28a0028a28a0028a28a0028a28a0028a28a0028a28a0028a28a0028a28a0028a28a0028
a28a0028a28a0028a28a00ffd9
\cf0 molekul hodrofilik dibagian luar memungkinkan lipida diangkut
\par}{\phpg\posx3350\pvpg\posy1712\absw7104\absh984 \sl-414 \f20 \fs21 \cf0 mela
uli cairan darah.
312 Komposisi Lipoprotein \par
}
{\phpg\posx2516\pvpg\posy3170\absw1806\absh239 \f20 \fs21 \cf0 \f20 \fs21 \cf0 N
o.
Lipoprotein \par
}
.
\par}{\phpg\posx2602\pvpg\posy3664\absw228\absh1011 \sl-286 \f20 \fs21 \cf0 2.
\par}{\phpg\posx2602\pvpg\posy3664\absw228\absh1011 \sl-285 \f20 \fs21 \cf0 3.
\par}{\phpg\posx2602\pvpg\posy3664\absw228\absh1011 \sl-285 \f20 \fs21 \cf0 4. \
par
}
Kilomikron
\par}{\phpg\posx3086\pvpg\posy3664\absw1200\absh1011 \sl-286 \f20 \fs21 \cf0 VLD
L
\par}{\phpg\posx3086\pvpg\posy3664\absw1200\absh1011 \sl-285 \f20 \fs21 \cf0 LDL
\par
}
Trigliserida
460 %
280 80-90
280 55-65
440 10
500 5 \par
}
Kolesterol
400 %
340 2-7
\sl-285 \f20 \fs21 \cf0 HDL

\fs21 \cf0 \f20 \fs21 \cf0
\sl-414 \f20 \fs21 \cf0 \fi
\sl-285 \f20 \fs21 \cf0 \fi
\sl-286 \f20 \fs21 \cf0 \fi
\sl-285 \f20 \fs21 \cf0 \fi
\sl-285 \f20 \fs21 \cf0 \fi
\fs21 \cf0 \f20 \fs21 \cf0
\sl-414 \f20 \fs21 \cf0 \fi
\sl-285 \f20 \fs21 \cf0 \fi
\sl-286 \f20 \fs21 \cf0 \fi
220 10-15
380 45
380 20 \par
}
Fosfolipida
446 %
386 3-6
266 15-20
426 22
426 30 \par
}
{\phpg\posx9378\pvpg\posy2964\absw828\absh1641 \f20 \fs21 \cf0 \f20 \fs21 \cf0 P
rotein
46 %
86 1-2
26 5-10
26 25
6 45-50 \par
}
0 \fs21 \cf0 Metabolisme lemak{\b0 dimulai}{\b0 dengan}{\b0 proses}{\b0 hidr
olisis}{\b0 lemak}{\b0 (trigliserida) }
{\b0 dari}{\b0 pangan}{\b0 yang}{\b0 dikonsumsi}{\b0 oleh}{\b0 enzim}{
\b0 lipase}{\b0 (dari}{\b0 pancreas),}{\b0 menghasilkan }
{\b0 monogliserida,}{\b0 asam-asam}{\b0 lemak}{\b0 bebas}{\b0 dan}{\b0
gliserol.}{\b0 Gliserol}{\b0 diserap}{\b0 usus}{\b0 dan }
{\b0 ditransportasikan}{\b0
melalui}{\b0
saluran}{\b0
darah}{\b0 ke}{
\b0 hati.}{\b0
Selanjutnya}{\b0
gliserol}{\b0 tersebut }
{\b0 dimetabolisasi}{\b0 seperti}{\b0 karbohidrat}{\b0 untuk}{\b0 memben
tuk}{\b0 asam}{\b0 piruvat.}{\b0 Tergantung }
{\b0 dari}{\b0 kebutuhan}{\b0 tubuh,}{\b0 piruvat}{\b0 tersebut}{\b0 selanj
utnya}{\b0 dioksidasi}{\b0 mengasilkan}{\b0 energy, }
{\b0 atau}{\b0 disintesis}{\b0 menjadi}{\b0 glukosa.}{\b0 Untuk}{\b0 as
am-asam}{\b0 lemak}{\b0 (berantai}{\b0 panjang)}{\b0 dan }
{\b0 monogliserida}{\b0 (}{\b0 dari}{\b0 asam}{\b0 lemak}{\b0 rantai}{
\b0 panjang),}{\b0 senyawa}{\b0 tersebut}{\b0 diserap}{\b0 dari }
{\b0 lumen}{\b0
usus}{\b0
halus}{\b0
dire-sintesis}{\b0
lagi}{\b0
menjadi}{\b0
terigliserida,}{\b0
yang}{\b0
kemudian }
{\b0 digabungkan}{\b0 dengan}{\b0 protein}{\b0 membentuk}{\b0 khilomokron.}{

\b0 Asam}{\b0 lemak}{\b0 rantai}{\b0 pendek }
{\b0 dan}{\b0
medium}{\b0
akan}{\b0
diserap}{\b0
oleh}{\b0
usus}{
\b0
dan}{\b0 langsung}{\b0
ditransportasikan}{\b0
melalui }
{\b0 saluran}{\b0 darah}{\b0 ke}{\b0 hati}{\b0 tanpa}{\b0 melalui}{\b0
pembentukan}{\b0 khilomikron.}{\b0 Fosfolipida}{\b0 dan }
{\b0 kolesterol}{\b0 yang}{\b0 berasal}{\b0 dari}{\b0 pangan}{\b0 yang
}{\b0 dikonsumsi}{\b0 juga}{\b0 akan}{\b0 digabungkan }
{\b0 dalam}{\b0 kilomikron}{\b0 dan}{\b0 ditransportasikan}{\b0 sama}{\b0 h
alnya}{\b0 seperti}{\b0 trigliserida.}{\b0 Sebelum }
{\b0 sampai}{\b0 ke}{\b0 hati}{\b0 trigliserida}{\b0 dari}{\b0 kilomikron}{
\b0 dapat}{\b0 juga}{\b0 digunakan}{\b0 oleh}{\b0 jaringan}{\b0 otot }
{\b0 atau}{\b0 jaringan}{\b0 lain}{\b0 atau}{\b0 disimpan}{\b0 dalam}{\b0
jaringan}{\b0 adipose.}{\b0 Lemak}{\b0 (trigliserida)}{\b0 yang }
{\b0 berasal}{\b0 dari}{\b0 kilomikron}{\b0 yang}{\b0 ditransportasikan}
{\b0 oleh}{\b0 hati}{\b0 (dalam}{\b0 bentuk}{\b0 VLDL) }
{\b0 digunakan}{\b0 oleh}{\b0 sel-sel}{\b0 jaringan}{\b0 tubuh}{\b0 untuk}{
\b0 berbagai}{\b0 macam}{\b0 keperluan,}{\b0 yaitu}{\b0 : }
\fi1080 {\b0 a.}{\b0
Sebagai}{\b0 sumber}{\b0 energy }
cf0 \fi1080 {\b0 b.}{\b0
Sebagai}{\b0
cadangan}{\b0
energy}{\b0
(dis
impan}{\b0
sebagai}{\b0
trigliserida}{\b0
dalam }
\fi1440 {\b0 jaringan}{\b0 adipose) }
cf0 \fi1080 {\b0 c.}{\b0
Digabungkan}{\b0 ke}{\b0 dalam}{\b0 struktur}{\b
0 sel}{\b0 (misalnya}{\b0 membrane}{\b0 sel) }\par
}
5 \par
}
ffd8ffe000104a46494600010100000100010000ffdb004300010101010101010101010101010101
01010101010101010101010101010101010101010101010101010101010101010101010101010101
010101010101010101ffdb0043010101010101010101010101010101010101010101010101010101
0101010101010101010101010101010101010101010101010101010101010101010101010101ffc0
001108034a025303012200021101031101ffc4001f00000105010101010101000000000000000001
02030405060708090a0bffc400b5100002010303020403050504040000017d010203000411051221
31410613516107227114328191a1082342b1c11552d1f02433627282090a161718191a2526272829
2a3435363738393a434445464748494a535455565758595a636465666768696a737475767778797a
0101010101010101010000000000000102030405060708090a0bffc400b511000201020404030407
05040400010277000102031104052131061241510761711322328108144291a1b1c109233352f015
6272d10a162434e125f11718191a262728292a35363738393a434445464748494a53545556575859
5a636465666768696a737475767778797a82838485868788898a92939495969798999aa2a3a4a5a6
00ffd9
}}\par}{\phpg\posx2270\pvpg\posy1712\absw8462\absh11931 \f20 \fs21 \cf0 \fi1080
\f20 \fs21 \cf0 d. Digunakan untuk sintesis senyawa tubuh yang esensial
(vitamin,
i1440 enzim, hormone, dll)
0 Asam lemak dalam hati dapat dimetabolisme sebagai berikut :
i360 a.
Disimpan sebagai lemak (trigliserida) di dalam hati.
0 \fi360 b. Dioksidasi melalui jalur beta-oksidasi menghasilkan asetil koA, ke
mudian
i720 dioksidasi sempurna menghasilkan karbondioksida (CO2) dan air (H2O)
i720 serta energy (ATP)
0 \fi360 c.
Apabila oksidasi tidak berjalan sempurna akan dihasilkan "ketone
bodies"
i720 dan akan terdapat dalam darah
0 \fi360 d. Asetil KoA dapat disintesis menjadi kolesterol di da
lam hati, yang
i720 selanjutnya dapat diubah menjadi asam empedu atau hormone steroid
0 \fi360 e.
Diubah menjadi lipoprotein (VLDL), kemudian berada da
lam plasma
i720 darah untuk ditransportasikan dan
0 \fi360 f.
Dikeluarkan dari hati sebagai asam lemak bebas dan masuk
ke dalam
i720 darah.

0 \fi720 Bila jumlah karbohidrat (pati,gula) yang dikonsumsi banyak, maka
tubuh
\par}{\phpg\posx2270\pvpg\posy1712\absw8462\absh11931 \sl-413 \f20 \fs21 \cf0 ak
an menggunaka glukosa sebagai energy dan untuk esterifikasi asam lemak
\par}{\phpg\posx2270\pvpg\posy1712\absw8462\absh11931 \sl-414 \f20 \fs21 \cf0 be
bas. Akan tetapi jika jumlah konsumsi sedikit maka karbohidarat
hanya
gunakan untuk esterifikasi asam lemak bebas dan untuk produksi
energy
gunakan asam lemak bebas. Sebagian besar asam lemak disimpan s
ebagi
\par}{\phpg\posx2270\pvpg\posy1712\absw8462\absh11931 \sl-413 \f20 \fs21 \cf0 tr
igliserida (trigliserol) dalam sel-sel jaringan adipose (sekitar 16% dar
i berat
\par}{\phpg\posx2270\pvpg\posy1712\absw8462\absh11931 \sl-414 \f20 \fs21 \cf0 ba
dan merupakan trigliserida). Beberapa macam hormone (termasuk epinefrin,
\par}{\phpg\posx2270\pvpg\posy1712\absw8462\absh11931 \sl-414 \f20 \fs21 \cf0 no
reepinefrin, glucagon dan adenokortikotrofik) terikat pada reseptor membr
ane
\par}{\phpg\posx2270\pvpg\posy1712\absw8462\absh11931 \sl-413 \f20 \fs21 \cf0 se
l-sel lemak. Hormone menginisiasi (memulai) stimulasi kinase sfesifik ya
ng
mediasi oleh cAMP dan mengaktifkan enzim lipase untuk menghidrol
isis
\par}{\phpg\posx2270\pvpg\posy1712\absw8462\absh11931 \sl-413 \f20 \fs21 \cf0 tr
igliserida menjadi asam-asam lemak bebas dan gliserol.
i720 Gliserol yang dihasilkan terutama yang dimetabolisme oleh hati, pertama\par}{\phpg\posx2270\pvpg\posy1712\absw8462\absh11931 \sl-414 \f20 \fs21 \cf0 ta
ma diubah menjadi gliserol 1-fosfat, kemudian menjadi dihidroksi aseton-fosfat
\par}{\phpg\posx2270\pvpg\posy1712\absw8462\absh11931 \sl-413 \f20 \fs21 \cf0 ya
ng akan masuk ke dalam jalur glikolisis. Sedangkan asam-asam lemak beb
as \par
}
6 \par
}
ffd8ffe000104a46494600010100000100010000ffdb004300010101010101010101010101010101
01010101010101010101010101010101010101010101010101010101010101010101010101010101
010101010101010101ffdb0043010101010101010101010101010101010101010101010101010101
0101010101010101010101010101010101010101010101010101010101010101010101010101ffc0
001108034a025303012200021101031101ffc4001f00000105010101010101000000000000000001
02030405060708090a0bffc400b5100002010303020403050504040000017d010203000411051221
31410613516107227114328191a1082342b1c11552d1f02433627282090a161718191a2526272829
2a3435363738393a434445464748494a535455565758595a636465666768696a737475767778797a
0101010101010101010000000000000102030405060708090a0bffc400b511000201020404030407
05040400010277000102031104052131061241510761711322328108144291a1b1c109233352f015
6272d10a162434e125f11718191a262728292a35363738393a434445464748494a53545556575859
5a636465666768696a737475767778797a82838485868788898a92939495969798999aa2a3a4a5a6
00ffd9
}}\par}{\phpg\posx2270\pvpg\posy1712\absw8435\absh11789 \f20 \fs21 \cf0 \f20 \fs
21 \cf0 akan dibawa oleh darah ke jantung, jaringan otot dan hati dima
na asam lemak
bas ini akan dimetabolisasi dan dioksidasi melalui jalur beta oksidasi.
i720 Dalam jalur beta-oksidasi pertama-tama asam lemak bebas akan diaktivasi
lam sitosol (sitoplasma sel) dengan cara menambahkan ATP dan C
oA.
\par}{\phpg\posx2270\pvpg\posy1712\absw8435\absh11789 \sl-414 \f20 \fs21 \cf0 Re
aksinya dikatalis oleh enzim asil CoA sintetase (asam lemak ti
okinase).
\par}{\phpg\posx2270\pvpg\posy1712\absw8435\absh11789 \sl-413 \f20 \fs21 \cf0 Se
lanjutnya molekul asil-CoA aktif tersebut ditransfer ke molekul karnitin ( suatu
nyawa zwitterions yang dibentuk dari asam amino lisin) dengan bantuan enzim
\par}{\phpg\posx2270\pvpg\posy1712\absw8435\absh11789 \sl-414 \f20 \fs21 \cf0 ka
rnitin asli transferase membentuk asil-karnitin. Kemudian asam lemak asi
l
bawa melewati membrane daam mitokondria dengan bantuan enzim translokase
n di dalam matriks mitokondria dibentuk lagi menjadi asil-CoA, kemudian
\par}{\phpg\posx2270\pvpg\posy1712\absw8435\absh11789 \sl-413 \f20 \fs21 \cf0 ma
suk ke jalur beta-oksidasi, sedangkan karnitin menjadi bebas kembali dan siap
lakukan proses yang sama. Karnitin hanya bekerja untuk asam lemak rant
ai
\par}{\phpg\posx2270\pvpg\posy1712\absw8435\absh11789 \sl-413 \f20 \fs21 \cf0 pa
njang, asam lemak rantai pendek dan sedang dapat masuk ke ma
triks
\par}{\phpg\posx2270\pvpg\posy1712\absw8435\absh11789 \sl-413 \f20 \fs21 \cf0 mi
tokondria tanpa bantuan karnitin. Karnitin sendiri dapat disintesis dalam tubuh,
\par}{\phpg\posx2270\pvpg\posy1712\absw8435\absh11789 \sl-414 \f20 \fs21 \cf0 ja
di tidak perlu mengkonsumsi suplemen secara berlebih.
i720 Dalam jalur beta-oksidasi , asam lemak didegradasi secara b
ertahap
njadi asetil-CoA yang akan masuk ke jalur respirasi untuk dioksidasi l
ebih
\par}{\phpg\posx2270\pvpg\posy1712\absw8435\absh11789 \sl-413 \f20 \fs21 \cf0 la
njut menjadi CO2, H2O, dan energy (ATP). Namun untuk asam lemak yang
rantai ganjil hasil degradasinya adalah propinil-CoA, propinil-CoA akan diubah
njadi metil-malonil-CoA, kemudian diubah lagi menjadi suksinil-CoA yang
na akan masuk ke ddalam siklus krebs (siklus asam sitrat).
i720 Untuk asam lemak tidak jenuh diperlukan enzim-enzim isomerase dan
\par}{\phpg\posx2270\pvpg\posy1712\absw8435\absh11789 \sl-414 \f20 \fs21 \cf0 ep
imerase agar ikatan rangkapnya berubah dari bentuk cis- menjadi bentuk trans\par}{\phpg\posx2270\pvpg\posy1712\absw8435\absh11789 \sl-413 \f20 \fs21 \cf0 da
n berada dalam posisi sterokimia yang sesuai seperti halnya yang terja
di pada
\par}{\phpg\posx2270\pvpg\posy1712\absw8435\absh11789 \sl-414 \f20 \fs21 \cf0 as
am lemak jenuh dalam jalur beta-oksidasi.
i720 Apabila tubuh kekurangan asam oksaloasetat (misalnya sedang berpuasa
,
nderita diabetes atau akibat kelaparan), asetil-CoA dari jalur beta-oksi
dasi
\par}{\phpg\posx2270\pvpg\posy1712\absw8435\absh11789 \sl-414 \f20 \fs21 \cf0 ti
dak dapat masuk ke dalam siklus krebs. Oksaloasetat akan diubah menjad
i
\par}{\phpg\posx2270\pvpg\posy1712\absw8435\absh11789 \sl-413 \f20 \fs21 \cf0 gl
ukosa melalui proses glukoneogenesis, sedangkan asetil-CoA akan di
ubah
njadi asetoasetat, D-3-hidroksibutirat (dikenal juga sebagai beta-hidroksibutira
t
\par}{\phpg\posx2270\pvpg\posy1712\absw8435\absh11789 \sl-413 \f20 \fs21 \cf0 at
au aseton). Ketiga senyawa tersebut dikenal denganbama "badan keton" (ketone
\par}{\phpg\posx2270\pvpg\posy1712\absw8435\absh11789 \sl-414 \f20 \fs21 \cf0 bo
dies) dan hati merupakan organ penghasil keton bodies yang utama. \par
}
7 \par
}
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0101010101010101010101010101010101010101010101010101010101010101010101010101ffc0
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6272d10a162434e125f11718191a262728292a35363738393a434445464748494a53545556575859
5a636465666768696a737475767778797a82838485868788898a92939495969798999aa2a3a4a5a6
00ffd9
f20 \fs21 \cf0 Asetiasetat dan D-3-hidroksibuturat dapat digunakan seb
agai substrat
\par}{\phpg\posx2270\pvpg\posy1712\absw8459\absh11211 \sl-414 \f20 \fs21 \cf0 re
aksi respirasi dalam beberapa macam jaringan. Sebagai contoh jaringan o
tot
ntung dan ginjal dapat menggunakan asetoasetat sebagai substrat reaksi respirasi
\par}{\phpg\posx2270\pvpg\posy1712\absw8459\absh11211 \sl-413 \f20 \fs21 \cf0 bi
la tidak terdapat glukosa. Demikian juga kelaparan dalm jangka panjang.
Otak
pt beradpatasi untuk menngunakan aseto-asetat sebagai substrat untuk rea
ksi
\par}{\phpg\posx2270\pvpg\posy1712\absw8459\absh11211 \sl-413 \f20 \fs21 \cf0 re
spirasi.
i720 Sintesis asam lemak terjadi di dalam sitosol (sitoplasma). Sebagai sumber
\par}{\phpg\posx2270\pvpg\posy1712\absw8459\absh11211 \sl-414 \f20 \fs21 \cf0 ka
rbon yaitu Asetil Ko-A dan untuk reaksi redukasi digunakan NADPH2. Enzim
ng
beranggung
jawab
atas
sintesis
asam
lemak
adalah
asam
lemak
\par}{\phpg\posx2270\pvpg\posy1712\absw8459\absh11211 \sl-414 \f20 \fs21 \cf0 si
ntetase( fatty acid synthetase) yang merupakan enzim kompleks (terdiri

dari
berapa enzim). Jalur reaksi sintesis asam lemak terdiri dari dua tahap,yaitu:
i720 a.
aktifitas asetil Ko-A(asetil Ko-A karboksilasi)
0 \fi720 b. pemanjangan rantai karbon (elongasi) yang merupakan jalur m
alonil
i1080 Ko-A
0 \fi720 Proses pemanjangan
rantai
karbon malonil
dilakukan denga
n cara
nambahkan dua karbon(Asetil Ko-A) secara bertahap dan dibantu oleh enzi
m
ng disebut sebagai acyl carrier protein(ACP). Pada umumnya pemanjangan
\par}{\phpg\posx2270\pvpg\posy1712\absw8459\absh11211 \sl-413 \f20 \fs21 \cf0 ra
ntai karbon akan berhenti pada C16. Apabila diperlukan asam lemak den
gan
njang rantai karbon lebih dari 16 , maka enzim lain (masih merupakan anggota
\par}{\phpg\posx2270\pvpg\posy1712\absw8459\absh11211 \sl-414 \f20 \fs21 \cf0 en
zim asam lemak sintetase) akan bekerja yaitu enzim asltioesterasde rant
ai
njang9long chain acyl-thio-esterase). Asam lemak yang disimpan unt
uk
gunakan dalam bentuk trigliserida dalam semua sel, terutama adiposit da
lam
ringan adipose. Trigliserida (triasil-gliserol) teerdiri atas molekul gliserol
pada
na tiga asam lemak diesterifikasikan. Pada umumnya asam-asam lemak yang
\par}{\phpg\posx2270\pvpg\posy1712\absw8459\absh11211 \sl-414 \f20 \fs21 \cf0 te
rdapat dalam trigliserida merupakan asam lemak jnuh. Sebagai "building block"
\par}{\phpg\posx2270\pvpg\posy1712\absw8459\absh11211 \sl-413 \f20 \fs21 \cf0 ut
ama untuk sintesis trigliserida pada jaringan selain adipose adalah gli
serol,
dangkan pada jaringan digunakan dihidroksiaseton-fosfat (DHAP), yang
produksi selama proses glikolisis.
0 {\b 2.4}{\b Manfaat}{\b dan}{\b Dampak}{\b Terhadap}{\b Kesehatan }\par
}
8 \par
}
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010101010101010101ffdb0043010101010101010101010101010101010101010101010101010101
0101010101010101010101010101010101010101010101010101010101010101010101010101ffc0
001108034a025303012200021101031101ffc4001f00000105010101010101000000000000000001
02030405060708090a0bffc400b5100002010303020403050504040000017d010203000411051221
31410613516107227114328191a1082342b1c11552d1f02433627282090a161718191a2526272829
2a3435363738393a434445464748494a535455565758595a636465666768696a737475767778797a
0101010101010101010000000000000102030405060708090a0bffc400b511000201020404030407
05040400010277000102031104052131061241510761711322328108144291a1b1c109233352f015
6272d10a162434e125f11718191a262728292a35363738393a434445464748494a53545556575859
5a636465666768696a737475767778797a82838485868788898a92939495969798999aa2a3a4a5a6
00ffd9
f20 \fs21 \cf0 Faktor makanan yang paling berpengaruh terhadap kadar kolesterol
darah
\par}{\phpg\posx2270\pvpg\posy1712\absw8324\absh11417 \sl-414 \f20 \fs21 \cf0 (L
ow Density Lipoprotein/LDL) adalah lemak total, lemak jenuh dan energy total.
\par}{\phpg\posx2270\pvpg\posy1712\absw8324\absh11417 \sl-414 \f20 \fs21 \cf0 De
ngan mengurangi lemak total dalam makanan, jumlah energy total akan ik
ut
rkurang. Jenis lemak yang dikurangi sebaiknya lemak jenuh. Koles
terol
kanan sebetulnya hanya sedikit meningkatkan kolesterol makanan, tergantun
g
\par}{\phpg\posx2270\pvpg\posy1712\absw8324\absh11417 \sl-413 \f20 \fs21 \cf0 ju
mlah kolesterol yang dimakan dan kemampuan tubuh untuk mengimbanginya
\par}{\phpg\posx2270\pvpg\posy1712\absw8324\absh11417 \sl-414 \f20 \fs21 \cf0 de
ngan mensintesis lebih sedikit. Urut - urutan perubahan makanan
untuk
nurunkan kolesterol darah menurut prioritas adalah lemak, lemak jenuh d
an
\par}{\phpg\posx2270\pvpg\posy1712\absw8324\absh11417 \sl-413 \f20 \fs21 \cf0 ko
lesterol.
i720 Kenaikan trigliserida dalam plasma (Hipertrigliseridemia) juga dikait
kan
\par}{\phpg\posx2270\pvpg\posy1712\absw8324\absh11417 \sl-413 \f20 \fs21 \cf0 de
ngan terjadinya penyakit jantung koroner. Kadar trigliserida plasma bany
ak
pengaruhi oleh kandungan karbohidrat makanan dan kegemukan.
i720 Konsumsi lemak akhir - akhir ini juga dikaitkan dengan penyakit kanker.
\par}{\phpg\posx2270\pvpg\posy1712\absw8324\absh11417 \sl-413 \f20 \fs21 \cf0 Ha
l yang berpengaruh adalah jumlah lemak dan mungkin asam lemak/tidak jenuh
\par}{\phpg\posx2270\pvpg\posy1712\absw8324\absh11417 \sl-414 \f20 \fs21 \cf0 ga
nda tertentu yang terdapat dalam minyak sayuran.
i720 Asam lemak omega-3 ternyata berpengaruh baik terhadap kesehatan. Ha
l
\par}{\phpg\posx2270\pvpg\posy1712\absw8324\absh11417 \sl-413 \f20 \fs21 \cf0 in
i pertama kali ditemukan pada penduduk asli Alaska yang, walau
pun
kanannya mengandung banyak energy, banyak lemak dan banyak kolesterol,
\par}{\phpg\posx2270\pvpg\posy1712\absw8324\absh11417 \sl-413 \f20 \fs21 \cf0 te
rnyata bebas dari penyakit jantung koroner atau Arterosklerosis.
Makanan
reka terutama adalah ikan laut dalam yang kaya akan lemak omega-3 terutama
\par}{\phpg\posx2270\pvpg\posy1712\absw8324\absh11417 \sl-413 \f20 \fs21 \cf0 EP
A dan DHA.
i720 Asam lemak omega-3 diduga dapat pula mencegah penyakit kank
er,
nghambat
kecepatan
perkembangannya
serta
menurunkan
kecepata
n
\par}{\phpg\posx2270\pvpg\posy1712\absw8324\absh11417 \sl-413 \f20 \fs21 \cf0 pe
rtumbuhan,
ukuran
dan
jumlah
sel
kanker.
Asosiasi
Jantung
Amerika
nganjurkan makan ikan 2-3 kali seminggu. Suplemen berupa minyak ikan tidak
anjurkan.
Kebanyakan
mengonsumsi
minyak
ikan
dapat
menyebabkan
ndarahan atau menghambat penyembuhan luka. Suplemen minyak ikan dibuat
ri hati ikan yang mungkin tercemar dengan bahan - bahan toxid berasal
dari
stisida, logam berat dan bahan pencemar lain. Minyak ikan juga menganduing
\par}{\phpg\posx2270\pvpg\posy1712\absw8324\absh11417 \sl-414 \f20 \fs21 \cf0 vi
tamin
A
dan
D
dalam
jumlah
berlebih
sehingga
dapat
me
nimbulkan
racunan/toxid dan ekstra energy yang dapat menyebabkan kegemukan. \par
}
9 \par
}
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0101010101010101010101010101010101010101010101010101010101010101010101010101ffc0
001108034a025303012200021101031101ffc4001f00000105010101010101000000000000000001
02030405060708090a0bffc400b5100002010303020403050504040000017d010203000411051221
31410613516107227114328191a1082342b1c11552d1f02433627282090a161718191a2526272829
2a3435363738393a434445464748494a535455565758595a636465666768696a737475767778797a
0101010101010101010000000000000102030405060708090a0bffc400b511000201020404030407
05040400010277000102031104052131061241510761711322328108144291a1b1c109233352f015
6272d10a162434e125f11718191a262728292a35363738393a434445464748494a53545556575859
5a636465666768696a737475767778797a82838485868788898a92939495969798999aa2a3a4a5a6
00ffd9
20 \fs21 \cf0 Sebaliknya, penelitian pada hewan menunjukkan bahwa asam le
mak tak
\par}{\phpg\posx2270\pvpg\posy1712\absw8207\absh1356 \sl-414 \f20 \fs21 \cf0 jen
uh ganda berasal dari minyak sayuran, terutama asam lemak omeg
a-6,
punyai kemampuan lebih besar untuk menimbulkan penyakit kanker
ipada asam lemak jenuh. \par
}
\fs21 \cf0 BAB III
ENUTUP \par
}
\cf0 3.1 Kesimpulan
\fi720 {\b0 Dari}{\b0 pembahasan}{\b0 di}{\b0 atas}{\b0 maka}{\b0 dapa
t}{\b0 disimpulkan}{\b0 bahwa}{\b0 definisi}{\b0 lipid }
{\b0 adalah}{\b0 Istilah}{\b0 lipida}{\b0 meliputi}{\b0 senyawa-senyawa}
{\b0 heterogen,}{\b0 termasuk}{\b0 lemak}{\b0 dan }
{\b0 minyak}{\b0 yang}{\b0 umum}{\b0 dikenal}{\b0 di}{\b0 dalam}{\b0
makanan,}{\b0 malam,}{\b0 fosfolipida,}{\b0 sterol}{\b0 dan }
{\b0 ikatan}{\b0 lain}{\b0 sejenis}{\b0 yang}{\b0 terdapat}{\b0 di}{\b
0 dalam}{\b0 makanan}{\b0 dan}{\b0 tubuh}{\b0 manusia.}{\b0 Lipida }
{\b0 mempunyai}{\b0
sifat}{\b0
yang}{\b0
sama,}{\b0
taitu}{\b0
larut}{\b0
dalam}{\b0
pelarut}{\b0
nonpolar}{\b0
seperti }
{\b0 etanol,eter,kloroform}{\b0
dan}{\b0
benzana.}{\b0
Secara}{\b0
u
mum}{\b0
lipida}{\b0
dapat}{\b0
dibagi}{\b0
dalam }
{\b0 beberapa}{\b0 kelompk}{\b0 yaitu:}{\b0 lipida}{\b0 sederhana,}{\b0
lipida}{\b0 majemuk}{\b0 dan}{\b0 lipida}{\b0 turunan. }
{\b0 Secara}{\b0 ringkas,}{\b0 hasil}{\b0 dari}{\b0 pencernaan}{\b0 lipid}{
\b0 adalah}{\b0 asam}{\b0 lemak}{\b0 dan}{\b0 gliserol.}{\b0 Lipid }
{\b0 di}{\b0 cerna}{\b0 di}{\b0 mulut,}{\b0 lambung,}{\b0 usus}{\b0 halus}
{\b0 dan}{\b0 usus}{\b0 besar.}{\b0 Sementara}{\b0 konsumsi}{\b0 lemak }
{\b0 memiliki}{\b0 beragam}{\b0 pengaruh}{\b0 terhadap}{\b0 kesehatan,}{\b0
lemak}{\b0 jenuh}{\b0 lebih}{\b0 banyak}{\b0 dapat }
{\b0 menyebabkan}{\b0 banyak}{\b0 penyakit}{\b0 jika}{\b0 dibandingkan}{\b0
dengan}{\b0 lemak}{\b0 tak}{\b0 jenuh. }\par
}
1 \cf0 3.2 Saran
\fi720 {\b0 Dengan}{\b0
mengetahui}{\b0
jenis-jenis}{\b0
serta}{\b0
sifat-sifat}{\b0
dari}{\b0
pada}{\b0
lipida}{\b0
maka }
{\b0 hendaknya}{\b0 kita}{\b0 mulai}{\b0 mengatur}{\b0 pola}{\b0 maka
nan.}{\b0 Sebab}{\b0 banyak}{\b0 jenis}{\b0 dari}{\b0 lipida- }
{\b0 lipida}{\b0 yang}{\b0 bersifat}{\b0 tidak}{\b0 baik}{\b0 bagi}{\
b0 kesehatan}{\b0 berada}{\b0 pada}{\b0 makanan}{\b0 kita}{\b0 sehar
i- }
{\b0 hari.}{\b0 Oleh}{\b0 sebab}{\b0 itu}{\b0 maka}{\b0 pengaturan}{\
b0 pola}{\b0 makan}{\b0 yang}{\b0 menyangkut}{\b0 banyaknya }
{\b0 konsumsi}{\b0 makanan-makanan}{\b0 berlemak}{\b0 harus}{\b0 mulai}{\b0
kita}{\b0 perhatikan. }\par
}
0 \par
}
ffd8ffe000104a46494600010100000100010000ffdb004300010101010101010101010101010101
01010101010101010101010101010101010101010101010101010101010101010101010101010101
010101010101010101ffdb0043010101010101010101010101010101010101010101010101010101
0101010101010101010101010101010101010101010101010101010101010101010101010101ffc0
001108034a025303012200021101031101ffc4001f00000105010101010101000000000000000001
02030405060708090a0bffc400b5100002010303020403050504040000017d010203000411051221
31410613516107227114328191a1082342b1c11552d1f02433627282090a161718191a2526272829
2a3435363738393a434445464748494a535455565758595a636465666768696a737475767778797a
0101010101010101010000000000000102030405060708090a0bffc400b511000201020404030407
05040400010277000102031104052131061241510761711322328108144291a1b1c109233352f015
6272d10a162434e125f11718191a262728292a35363738393a434445464748494a53545556575859
5a636465666768696a737475767778797a82838485868788898a92939495969798999aa2a3a4a5a6
00ffd9
\fs21 \cf0 DAFTAR PUSTAKA \par
}
{\phpg\posx2270\pvpg\posy6819\absw8491\absh5663 \f40 \fs21 \cf0 {\f0\fs28 \bulle
t }\f40 \fs21 \cf0 {\f20
Almatsier,}{\f20 sunita.}{\f20 2003.}{\i \f20
Prinsip}{\i \f20 Dasar}{\i \f20 ILMU}{\i \f20 GIZI}{\f20 .}{\f20 Jakar
ta:}{\f20 PT.gramedia }
360 {\f20 Pustaka}{\f20 Umum }
{\f0\fs28 \bullet }{\f20
Bulletin}{\f20 CP.}{\f20 2007.}{\i \f20
Lipida}{\i \f20 dan}{\i \f20 turunannya}{\f20 .}{\f20 www}{\f20 .buleti
ncp.com.}{\f20 tanggal }
360 {\f20 akses:}{\f20 6}{\f20 Desember}{\f20 2009. }

Irawan,}{\f20
M.}{\f20
Anwar.}{\f20
2007.}{\i \f20
Cairan}{\i \f20
Tubuh,}{\i \f20
Elek
tolit}{\i \f20
dan }
360 {\i \f20 Mineral}{\f20 .www.psslab.com.}{\f20 tanggal}{\f20 akses:}{\f20
6}{\f20 Desember}{\f20 2009 }
Koswara,}{\f20
Sutrisno.}{\f20
(t.t)}{\i \f
20
Lipid}{\f20 .}{\f20
www.}{\f20
Ebokpangan}{\f20
.com.}{\f20
ta
nggal}{\f20
akses:6 }
360 {\f20 Desember}{\f20 2009 }
Lestiani,Lanny.}{\f20 (t.t).}{\i \f20 Pengaruh}
{\i \f20 Lemak}{\i \f20 Terhadap}{\i \f20 Kesehatan}{\f20 .}{\f20 www.}{\f2
0 Ilmugiziui }
360 {\f20 .com.}{\f20 tanggal}{\f20 akses:}{\f20 6}{\f20 Desember}{\f20 200
9 }
Medical,}{\f20 2008.}{\f20 Lipid.www.medical.co
m}{\f20 .}{\f20 tanggal}{\f20 akses}{\f20 :}{\f20 6}{\f20 Desember}{\f20
2009 }
Rajiman,}{\f20 2009.}{\f20 Lipid}{\f20 .www.be
lajar-online}{\f20 .com}{\f20 .}{\f20 tanggal}{\f20 akses}{\f20 :}{\f20 6}
{\f20 Desember }
360 {\f20 2009 }
Tensiska.}{\f20
2008.}{\i \f20
Serat}{\i \f
20
Makanan}{\f20 .}{\f20
www}{\f20
.unipadj.com.}{\f20
tanggal}{\f20
akses:}{\f20
6 }
360 {\f20 Desember}{\f20 2009 }\par
}
1 \par
}
ffd8ffe000104a46494600010100000100010000ffdb004300010101010101010101010101010101
01010101010101010101010101010101010101010101010101010101010101010101010101010101
010101010101010101ffdb0043010101010101010101010101010101010101010101010101010101
0101010101010101010101010101010101010101010101010101010101010101010101010101ffc0
001108034a025303012200021101031101ffc4001f00000105010101010101000000000000000001
02030405060708090a0bffc400b5100002010303020403050504040000017d010203000411051221
31410613516107227114328191a1082342b1c11552d1f02433627282090a161718191a2526272829
2a3435363738393a434445464748494a535455565758595a636465666768696a737475767778797a
0101010101010101010000000000000102030405060708090a0bffc400b511000201020404030407
05040400010277000102031104052131061241510761711322328108144291a1b1c109233352f015
6272d10a162434e125f11718191a262728292a35363738393a434445464748494a53545556575859
5a636465666768696a737475767778797a82838485868788898a92939495969798999aa2a3a4a5a6
00ffd9
\cf0 42 \par
}
}

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{\i 2.}{\i VLDL}{\i (very}{\i low}{\i -}{\i density}{\i lypoproteins) }

\par}{\phpg\posx2270\pvpg\posy6084\absw8277\absh7833 \sl-413 \b \f20 \fs21 \cf0

nurunnya}{\b0 resiko}{\b0 dan}{\b0 menguntungkan. }

\par}{\phpg\posx2270\pvpg\posy1712\absw8394\absh10689 \sl-413 \f20 \fs21 \cf0 \f

{\phpg\posx2554\pvpg\posy14444\absw7983\absh1270 \f20 \fs21 \cf0 \fi719 \f20 \fs

\par}{\phpg\posx2554\pvpg\posy1712\absw8143\absh9926 \sl-413 \f20 \fs21 \cf0 gli

\par}{\phpg\posx2554\pvpg\posy7756\absw8064\absh2350 \sl-413 \i \f20 \fs21 \cf0

galami tahap-tahap perubahan sebagai berikut:

\fi284 {\b0 dapat}{\b0 men-sintesis}{\b0 asam}{\b0 lemak}{\b0 sebagai}{

{\phpg\posx2554\pvpg\posy8596\absw7965\absh2847 \f20 \fs21 \cf0 \fi435 \f20 \fs2

\par}{\phpg\posx2270\pvpg\posy1712\absw8600\absh3965 \sl-414 \f20 \fs21 \cf0 dih

\par}{\phpg\posx5122\pvpg\posy6276\absw5426\absh6369 \sl-413 \f20 \fs21 \cf0 lem

cf0 {\b0 Diserap}{\b0 langsung}{\b0 ke}{\b0 dalam }\par

}}\par}{\phpg\posx2990\pvpg\posy2188\absw7622\absh11597 \f20 \fs21 \cf0 \fi360 \

\par}{\phpg\posx2990\pvpg\posy2188\absw7622\absh11597 \sl-414 \f20 \fs21 \cf0 \f

\sl-285 \f20 \fs21 \cf0 HDL

{\b0 digabungkan}{\b0 dengan}{\b0 protein}{\b0 membentuk}{\b0 khilomokron.}{

\par}{\phpg\posx2270\pvpg\posy1712\absw8462\absh11931 \sl-306 \par\f20 \fs21 \cf

ntetase( fatty acid synthetase) yang merupakan enzim kompleks (terdiri

{\f0\fs28 \bullet }{\f20

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