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Determination of Tobacco Specific Haemoglobin Adducts in Smoking Mothers and New Born Babies by Mass Spectrometry

Determination of Tobacco Specific Haemoglobin Adducts in Smoking Mothers and New Born Babies by Mass Spectrometry

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Published by Aditi Patil

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Published by: Aditi Patil on Nov 14, 2009
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11/14/2009

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Determination of Tobacco SpecificHaemoglobin Adducts in SmokingMothers and New Born Babies byMass Spectrometry
BYMyers S.R. And Md.YeakubAli
Published by Biomarker Insight
2007:2, 269-282
Presented by -Miss Aditi PatilM.Sc.
II
Under theguidance of -Miss SwatiAsani
 
I
ntroduction
Content of tobacco smoke
 ±
Most potent carcinogen
 NNK [4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone]
 NNN [N-nitrosonornicotine]
 Nitrosationreaction
Effect of tobacco smoke & nitrosamine
 NNNNN
Eosophagealcarcinomas & Tumourof lung, liver,Papillomas, carcinoma nasal cavity & pancreasof nasal cavity & also leads to formation of Hb-NNK adduct & DNA adduct
 
O
bjectives
To determine Tobacco Specific Haemoglobin Adductsof both African-American and Caucasian SmokingMothers and New Born Babies by MassSpectrometry.
To study the effect of nitrosamine on smokingmothers and newborn babies.
To develop new sensitive method which wouldinvolve simple extraction technique without achromatographic clean up prior to GC/MS operation.

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