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Laboratory Rodent Journal Summaries

Laboratory Rodent Journal Summaries

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Published by vetpathforum
Journal of Comparative Pathology 2008-2009 Mice Infection of Different Strains of Mice with Lawsonia intracellularis Derived from Rabbit or Porcine Proliferative Enteropathy – Lesions in mice included epithelial hyperplasia with inflammation in the ileum and cecum. Lawsonia antigen was found in early lesions more than late lesions. Mice reacted differently to Rabbit derived Lawsonia than to Porcine derived Lawsonia which suggests a difference between the two strains. Immunohistochemical Charac
Journal of Comparative Pathology 2008-2009 Mice Infection of Different Strains of Mice with Lawsonia intracellularis Derived from Rabbit or Porcine Proliferative Enteropathy – Lesions in mice included epithelial hyperplasia with inflammation in the ileum and cecum. Lawsonia antigen was found in early lesions more than late lesions. Mice reacted differently to Rabbit derived Lawsonia than to Porcine derived Lawsonia which suggests a difference between the two strains. Immunohistochemical Charac

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J Comp Path/ Vet record 2008-2009Primate
Multiple Granulomas in Three Squirrel Monkeys (Saimiri sciureus) Caused byMycobacterium microti
 
(vol 137 p 245-248)--
 
multiple granulomas in the mesentery,mesenteric lymph nodes, lung, liver, kidneys and spleen, while the other showedgranulomas only in the lung. The animal with paralysis of the legs had an abscess-likelesion in the skeletal muscle of the neck, granulomas in the mesenteric and mediastinallymph nodes, and a fracture of the thirteenth thoracic vertebra with severe lesions of thespinal cord. Histologically the granulomas showed typical features of tuberculousgranulomas, i.e., central necrosis surrounded by epithelioid cells, multinucleated giantcells, in£ammatory cells and a border of connective tissue. Ziehl-Nielsen staindemonstrated sporadic acid-fast bacilli.
Pathological Changes in Masked Palm Civets Experimentally Infected by SevereAcute Respiratory Syndrome (SARS) Coronavirus - Sy
mptoms: Infected animals become less aggressive and develop pyrexia, lethargy and diarrhoea and developmultiorgan pathology. - Histopathology: Interstitial pneumonia with edema, neuronaldegeneration and neuronophagia, lymphoid follicular depletion in lymph nodes, spleniclymphoid follicular atrophy, hepatic congestion and vacuolar degeneration, kidneys focalhemorrhage, small intestine-mild focal hemorrhages
Methicillin-resistant Staphylococcus non-aureus Infection in an Irradiated RhesusMacaque (Macaca mulatta) (Journal of the American Association for LaboratoryAnimal Science, 67 Vol 47, No 3, May 2008, P. 64-68). Gross lesions: S
kin dryness,dermatitis, hyperkeratosis, and erythema in the facial area.
Microscopic lesions:
Skin:Epidermal hyperplasia and chronic dermal inflammation. Perivascular plasma cells andlymphocytes were identified and the dermis showed a background of mucinosis.
 Peripheral Edema with Hypoalbuminemia in a Nonhuman Primate Infected with Simian–Human Immunodeficiency Virus: A Case Report:
clinically, there was slight peripheral edema, hypoalbuminemia, and proteinuria, consistent with nephroticsyndrome. Histologically, there was membranoproliferative glomerulonephritis, the resultof immune complex deposition.
Idiopathic New Bone Formation in the Femoral Shafts of a Cynomolgus Monkey (Macacafascicularis)
A 6.5-y-old cynomolgus monkey. An animal caretaker incidentally found a bone fragment protruding through the skin of the right leg. Radiographically there was one bone fragment ineach femur. The fragment consisted of a medullary cavity and bone cortex with incomplete periosteal structure. New bone formation in nonhuman primates has been reported previously, butnot with unexplained skin penetration.
 
 HYPERPLASTIC DERMATITIS ASSOCIATED WITH ACARIASIS IN A SIAMANG (SYMPHALANGUS SYNDACTYLUS 
 ), Journal of Zoo and Wildlife Medicine 39(4):638–641.
- Alopecia, flaky skin, and pruritus, with trombidiiform mites identified asPsorobia (formerly Psorergates) sp. near cercopitheci. Superficial dermal edema andinfiltration, with a low to moderate number of lymphocytes and plasma cells aroundsuperficial capillaries (Fig. 2). These changes were associated with epidermal pitscontaining ovoid, organisms with chitinous exoskeletons (Fig. 3). A diagnosis of chronichyperplastic dermatitis (mange) with intracorneal embedded mites was made.
Capillaria hepatica (syncalodium hepaticum) in primates in a zoological collectionin the UK:
this is a zoonotic liver nematode of mammals with a worldwide distribution.It had as a direct life cycle. Its primary hosts are rodents. Caused granulomatous hepatitisin this monkey. Ingestion of eggs
larvae hatch in cecum
migrate to liver and matureto eggs
released after death.
Acute Megakaryocytic Leukaemia (AMKL)-like Disease in a Cynomolgus Monkey(Macaca fascicularis).
J
. Comp. Path. 2009, Vol. 140, 212e216.
Gross lesions: Theliver, kidney and spleen were markedly enlarged and the kidneys had capsular petechiae.Histo: numerous atypical cells resembling myeloid cells in the bone marrow, and
myelofibrosis
was present. Atypical cells were also present
in the blood vessels
of theliver, kidney, spleen, lymph nodes, lung, heart, bladder, adrenal gland and brain. Someneoplastic cells had oval or pleomorphic macronuclei and others were multinucleated..IHC—Positive for megakaryocyte- associated antigens
Von Willebrand Factor andCD61-IIIa
, but were negative for myeloperoxidase. This monkey was infected with
simian retrovirus type D
and it is possible that this viral infection was associated withthe development of neoplasia.
Differential diagnoses
for AMKL with myelofibrosis,include Acute Panmyelosis with Myelofibrosis (APMF- multi-lineage myeloid proliferation, no megakaryocyte-related antigens), blastic transformation of ChronicMyeloid Leukaemia (CML- clonal proliferation of mature granulocytes) or IdiopathicMyelofibrosis (IMF- abnormal depostis of collagen in BM).
 
Naturally Occurring Tyzzer’s Disease in Cotton-top Tamarins(
Saguinus oedipus
).
Vol 57, No 1February 2007. transmural, necrotizing typhlocolitis accompanied bymyocarditis and hepatitis..
Animal Models for HIV AIDS: A Comparative Review.
Vol 57, No1 February 2007. Viruses discussed are grouped as causing (1)nonlentiviral immunodeficiency-inducing diseases, (2) naturallyoccurring pathogenic infections, (3) experimentally induced lentiviralinfections, and (4) nonpathogenic lentiviral infections.
Changes in the Titer of Anti–B Virus Antibody in CaptiveMacaques (Macaca fuscata, M. mulatta, M. fascicularis). Vol57, No 1 February 2007
. B virus (Cercopithecine herpesvirus 1; BV).
-herpesvirus subfamily and usually causes mild or asymptomaticinfection in its natural macaque host. However, BV infection in humansusually develops as a fatal centralnervous system infection and for this reason BV is classifiedas a biosafety level–4 pathogen.
Dermal Melanocytosis in Japanese Monkeys (
Macaca fuscata
).
Vol 57, No 3 June 2007. the epidermis lacked melanocytes, but thedermis had numerous melanocytes with abundant melanin. Activatedmelanocytes with well-developed dendrites were distributedthroughout the upper part of the dermal layer. Melanocytes were notarranged in clusters, and elastic and collagen fibers in the dermisshowed no histological abnormalities.
Increased Production of 11
β
-hydroxysteroid DehydrogenaseType 2 in the Kidney Microsomes of Squirrel Monkeys (
Saimiri 
spp.).
Vol 58, No 2April 2008. In squirrel monkeys (Saimiri spp.), cortisol circulates atlevels much higher than those seen in man and other Old Worldprimates, but squirrel monkeys exhibit no physiologic signs of themineralocorticoid effects of cortisol. 11
β
-hydroxysteroiddehydrogenase type 2 (11
β
-HSD2), which converts cortisol to theinactive metabolite, cortisone. Pharmacologic inhibition of 11
β
-HSD2,inactivating mutations in 11
β
-HSD2, or saturation of the enzyme byhigh cortisol concentrationsresults in inappropriate activation of MR by cortisol and leads todevelopment of hypertension and electrolyte imbalance.
Pathology of Captive Moustached Tamarins (Saguinus mystax).Vol 58, No 2 April 2008
. Colitis cystica profunda (CCP), a diseasethat affects humans and is characterized by the presence of mucin-filled epithelial downgrowths and cysts in the colonic submucosa, was

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