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Running Head: OXYTOCIN: THE CHEMICAL BONDS OF LOVE

Oxytocin 
The Chemical Bonds of Love 
 

Andrea E. Janda 
 
Portland State University 

 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
SCI‐365U‐001  
SCIENCE OF WOMENS BODIES  
Janice Montgomery 
Spring 2010 
 
June 3, 2010 

OXYTOCIN: THE CHEMICAL BONDS OF LOVE
 
Oxytocin Overview

Oxytocin (Oxt), also known as alpha-hypophamine (α–hypophamine), is a nonapeptide

hormone, (composed of nine amino acids) with a chemical formula represented as

C43H66N12O12S2. It is created and secreted by the hypothalamus and travels down the nerve

fibers to the posterior lobe of the pituitary gland where it is released into the circulatory system

(Uvnäs Moberg, 2003). Oxytocin acts both as a hormone through the bloodstream from nerve

endings to target organs and as a neurotransmitter, a signaling substance in the nervous system

reaching cell receptors and producing specific, localized effects (Du Vigneaud et al, 1953; Uvnäs

Moberg, 2003, Angier, 2009). Traveling along the hypothalamic-pituitary-adrenal axis (HPA or

HTPA axis), oxytocin’s effects are varied including its ability to modulate reactions to stress and

anxiety, to regulate mood, emotion, digestion, and immune function, and to facilitate sexual

response, orgasm, pair-bonding, trust, and maternal behaviors as well as social interaction and

function (Bales, Pfeifer, & Carter, 2004; Carter, Lederhendler, & Kirkpatrick, 1999; Fisher,

2004; Kuchinas, 2009; Leonie, 2008; Uvnäs Moberg, 2003; Pedersen, 2004; Young & Zuoxin,

2004).

Oxytocin was first discovered by Sir Henry Dale, an English scientist in 1909 who noted its

presence within the pituitary gland. Dale described its uterine-contracting properties and because it

sped up the birthing process, he named it oxytocin from the Greek words for “quick” and “birth”

(Uvnäs Moberg, 2003, p. 3) Oxytocin was also one of the very first hormones to have its

chemical construction mapped within the mid-twentieth century by Vincent du Vigneaud, who

subsequently received the Nobel Prize for chemistry in 1955 (Du Vigneaud et al, 1953). Since

then, oxytocin has grown up—once thought to be solely associated with the feminine

reproductive domain of childbirth (uterine contractions) and breast feeding (milk letdown),

 
 

OXYTOCIN: THE CHEMICAL BONDS OF LOVE
 
oxytocin’s functional roles are being explored and redefined in the human arenas of love, sex,

trust, and socialization.

“Fight or Flight” vs. “Calm and Connection”

Descriptively, oxytocin’s effect on the body runs the gamut between physiological states

and psychological processes. Indeed, the mind body-connection and the age-old “fight or flight”

response are related to the oxytocin response. Uvnäs Moberg proposes the “calm and

connection” system which she describes as the “other end of the seesaw” or the “opposite pole”

to the fight or flight reaction, associating it with trust and curiosity instead of fear, and with

friendliness instead of anger (Uvnäs Moberg, 2003, introduction, p. x). Juxtaposing the calm and

connection system with the stress system features oxytocin as the mirror opposite to adrenaline, a

stress hormone which acts in the short term and the antidote to cortisol, a stress hormone that has

long term effects (Grippo et al., 2007). After the rush of the stress response, oxytocin is partly

responsible for acting as a thermostat, dialing the body’s temperature, balancing the fluids in the

body, stimulating cell division and wound healing and regulating the levels of stress hormones,

namely cortisol. (Uvnäs Moberg, 2003; Kuchinas, 2009).

Oxytocin is closely related to another peptide hormone, the blood-pressure-raising

vasopressin (Kuchinas, 2009). In fact vasopressin differs only slightly from oxytocin by two

mere amino acids. Despite being so similar, in some ways, there’s still a bit of sexualized

hormonal action, reaction and association that oxytocin doesn’t escape in terms of evolutionary

adaptations. In women, Kuchinas (2009) discusses how oxytocin is “crucial for maternal

behavior” as well as forming the bonds between lovers and parent to child (p.17). Oxytocin

functions as an anxiolytic and allows for relaxation, growth and healing. In men, however,

Kuchinas (2009) flags the structurally similar vasopressin as being “central to male bonding,”

inspiring the paternal instinct, and acting as a motivator in men’s desire to defend the family (p.
 
 

OXYTOCIN: THE CHEMICAL BONDS OF LOVE
 
17). Other than kidney, and cardiovascular function, vasopressin induces male aggression,

especially towards other males, and tends to increase anxiety and vigilance (Pitkow et al., 2001).

During times of stress and especially isolation, rather than showing a decrease in levels, the body

instead produces more oxytocin as a signal to seek physical and emotional connections and lower

stress (Kuchinas, 2009; Pitkow et al., 2001; Grippo et al., 2007).

Love, Attachment, & Intimacy

The research of Helen Fisher, Kerstin Uvnäs Moberg, Karen Bale, Sue Carter and Tom

Insel all provide evidence that oxytocin and vasopressin, produced in both the hypothalamus and

the gonads are responsible for producing many of the behaviors associated with love and

attachment. Young & Zuoxin (2004) corroborate this research, noting the interaction of the

oxytocin, vasopressin and dopamine systems within the brain’s reward circuitry. Again, here is

where evolutionary biology comes into play. Fisher (2004) describes how ancestral men and

women are driven to “prefer, choose, and pursue specific mating partners” while remaining

sexually faithful long enough to conceive a child, but after birth, the chemicals of attachment

dampen romantic ecstasy and replace it with a “deep sense of union with a mate” that is

“intricate, interesting and emotionally rewarding” (p. 92-93).

Oxytocin, described by Angier (2009) and others as the “cuddle hormone” invites us to

do just that. As oxytocin is involved in the contractions of the uterus, the flood of oxytocin

released during orgasm may also cause the rhythmic vaginal contractions during climax and the

similar contractions that eject sperm. Those vaginal contractions serve a fascinating, secondary

function as well—to draw sperm toward the ovary with the best egg (Kunz, Beil, Huppert &

Leyendecker, 2007). Oxytocin works in tandem with estrogen by prodding the fallopian tube on

the side where the dominant follicle is to contract more, propelling the sperm towards the egg

that’s ready to be fertilized. One could conclude that the better the intimate bond, the more
 
 

OXYTOCIN: THE CHEMICAL BONDS OF LOVE
 
intense the sex, the more oxytocin is released, and the greater chance that conception will occur

(Kunz, et al., 2007).

Sexual pleasure exists to assure the human race of procreating and oxytocin plays an

important part in sexual function by travelling to the tissues that control erectile function and

engorgement of the clitoris (Kuchinas, 2009). During orgasm, oxytocin floods the brain and

spinal cord, stimulates the hippocampus, engages short-term and social memory and deactivates

the amygdala, rendering us calm and trusting (Kuchinas, 2009). In effect, we remember the

pleasure and trust associated with the object of our affections and crave repeat performances of

the act which brings us closer to our loved one.

There are so many various types of love: lust, romantic love, attachment . . . all in varying

degrees of intensity during different life phases and with different people. Most interesting and

important is our natural response to physical intimacy. The concept of neural plasticity, the

brain’s ability to develop, adapt and respond through ever-growing pathways, even after negative

impacts or damage is one of our grandest features. Our development is known to be both nature

and nurture; we are born with the basics and genetics but it is the extent to which our external

experiences shape us in ways that “activate, deactivate or modify” our genetic activity (Kuchinas

2009, p.12).

These outside experiences are called epigenetic and the development and sensitivity of

oxytocin receptors appear to be epigenetically influenced—in essence, we must learn to love

(Kuchinas 2009; Fisher, 2004). The patterns of intimacy and reward are established early in

infancy and persist into adulthood, influencing interpersonal relationships beyond the immediate

family (Kuchinas 2009). Oxytocin and vasopressin act on the developing nervous system with

life-long behavioral consequences. Trauma, abuse and neglect alter the neural scripts we play out

in the first years of life with our mothers and caretakers. Consequently, negative experiences can
 
 

OXYTOCIN: THE CHEMICAL BONDS OF LOVE
 
affect our brain’s ability to use oxytocin, hindering our self-image, our attachment styles and

lock us down into hypervigilance—a perpetual fear state (Kuchinas 2009). But we can learn to

love and trust again with more experiences and positive social support.

Social Interaction and Trust

Supportive social interactions may be protective against stressors and certain

mental and physical illness, while social isolation may be a powerful stressor.

Prairie voles are socially monogamous rodents that model some of the behavioral

and physiological traits displayed by humans, including sensitivity to social

isolation. (Grippo et al., 2007)

Bates et al (2004) and Grippo et al (2007) studied prairie voles, considered highly social

mammals and a good translational animal model for humans. Kuchinas (2009) refers to this type

of social branch of neuroscience as social endocrinology and delineates significant differences

and changes in the brain’s chemical responses when we are with people or isolated from them

(p.53). As it turns out, Grippo et al. (2007) noted that disorders such as depression can be

induced or exacerbated by this isolation while Carter (2007) demonstrated that oxytocin acts an

anti-cortisol—a counter measure against stress.

Angier (2009) cites several recent studies that suggest oxytocin’s function as a social

lubricant, promoting trust between people. One experiment in particular found that oxytocin

inhaled through an intranasal spray allowed adults playing a ‘trust’ game “to retain their trust in a

stranger who was looking after their money, even though this trust was violated on many

occasions” (Leonie, 2008, p. 500). The subjects showed decreased activity in the amygdala and

the caudate nucleus, brain areas that are specifically involved in regulating fear, decision making,

and risk-taking (Leonie, 2008).

 
 

OXYTOCIN: THE CHEMICAL BONDS OF LOVE
 
Future implications
 
Social phobia and autism spectrum disorders exhibit over activity in the amygdala but

oxytocin inhalation shows promising results in mitigating those factors by lowering amygdala

activity, making people feel more relaxed and promoting social approach, comprehension and

interaction (Gever, 2010; BBC News, 2008; Leonie, 2008; Jacob et al., 2007). Andari (2010)

summarizes that with oxytocin, “patients respond more strongly to others and exhibit more

appropriate social behavior and affect, suggesting a therapeutic potential of oxytocin through its

action on a core dimension of autism.” In people with social behavior deficits, observing and

understanding how people naturally form trust will give us a better understanding of mental

disorders which feature these symptoms and how to treat them more effectively  (Gever, 2010;

Leonie, 2008).

There are many barriers to use of oxytocin as a medication. It is primarily used as a

solution under the name Pitocin, to stimulate contraction during child labor or as a nasal spray, to

stimulate milk expulsion in women who experience difficulty in nursing their children.

Noticeable effects are only noted though the non-friendly method of injection, as oxytocin breaks

down quickly in the bloodstream and is unable to cross the blood-brain barrier (Kuchinas, 2009;

Uvnäs Moberg, 2003). Thus, these isolated effects would be limited to analgesic, stress relief,

anti-inflammatory, wound healing, or growth enhancement as the oxytocin molecule appears to

be linked to these areas of building and repair (Kuchinas, 2009). Larry Young (2004) maintains

that reducing love to its component parts yields an understating of human sexuality, and may

lead to drugs that enhance or diminish our love for another. While the pharmacological approach

seems a futuristically feasible way to treat anxiety-related disorders in much the same way anti-

depressants have become so prevalent, there’s no love potion #9 or a simple pill enhancement to

passion (Viagra aside); and I certainly am not of the opinion that legions of lovelorn people will
 
 

OXYTOCIN: THE CHEMICAL BONDS OF LOVE
 
be eager to invest in oxytocin nasal spray whose efficacy and distribution is not currently

regulated. Uvnäs Moberg, (2003) suggests instead that we think of our health as an inner

ecology, that we must respect, nurture and replenish our resources, and to do this we must

consciously choose to relax, love and heal in order to balance our stress-oriented culture.

Laughing, spending time with friends and family, making love, taking a walk in nature, enjoying

meditation or massage, taking time for our children and connecting to our fellow human will go

a long way to enervating the calm and connection system of oxytocin already built into our

biology and bringing more love into our lives.

References

Andari, E. (2010, March 3). Promoting social behavior with oxytocin in high-functioning autism
spectrum disorders. Proceedings of the National Academy of Sciences of the United States of
America (0027-8424), 107 (9), 4389.

Angier, N. (2009, November 23). The Biology Behind the Milk of Human Kindness. The New
York Times.

Bales, K. L., Pfeifer, L. A. & Carter, C. S. (2004). Sex differences and developmental
effects of manipulations of oxytocin on alloparenting and anxiety in prairie voles.
Developmental Psychobiology, 44(2), 123-131. doi: 10.1002/dev.10165.

Du Vigneaud, V., Ressler, C., Swan, C. J.M., Roberts, C.W., Katsoyannis, P.G., &
Gordon, S. (1953, October). J. Am. Chem. Soc, 75(19), 4879–4880.
doi:10.1021/ja01115a553

Carter, C. S. (2007). Sex differences in oxytocin and vasopressin: Implications for autism
spectrum disorders? Behavioral Brain Research, 176 (1), 170-186.

Carter, C. S., Lederhendler, I. I., & Kirkpatrick, B. (1999). The integrative neurobiology of
affiliation. Cambridge, MA MIT Press.

Fisher, H. (2004). Why we love: The nature and chemistry of romantic love. New York,
NY: Henry Holt and Company.

Gever, J. (2010, Februry 15). Oxytocin shows promise in autism. MedPage Today. 
Retrieved from: http://www.medpagetoday.com/Neurology/Autism/18483

 
 

OXYTOCIN: THE CHEMICAL BONDS OF LOVE
 
Grippo, A.J., Gerena, D., Huang, J., Kumar, N., Shah, M., Raj Ughreja, R. & Carter, C.S.
(2007). Social isolation induces behavioral and neuroendocrine disturbances relevant
to depression in female and male prairie voles. Psychoneuroendocrinology, 32 (8-10),
966.

Jacob, S., Brune C.W., Carter, C.S., Leventhal, B.L., Lord, C., Cook, E.H. (2007, April).
Association of the oxytocin receptor gene (OXTR) in Caucasian children and
adolescents with autism. Neuroscience Letters 417 (1), 6–9.
doi:10.1016/j.neulet.2007.02.001.

Kuchinas, S. (2009). The chemistry of connection: How the oxytocin response can help you
find trust, intimacy, and love. Oakland: CA. New Harbinger Publications, Inc.

Kunz, G., Beil, D., Huppert, P., & Leyendecker. (2007). Oxytocin, a stimulator of directed
sperm transport in humans. Reproductive BioMedicine Online, 14(1), 32-39.

Leonie, W. (2008). Trust in oxytocin. Nature Reviews Neuroscience, 9(7), 500.


doi:10.1038/nrn2446.

Pedersen, C. (2004). Unleashing the 'love' hormone. Nature Medicine, 10(2), 122.
doi:10.1038/nm0204-122.

Pitkow, L. J., Sharer, C.A., Ren, X, Insel, T.R., Terwilliger, E.F. & Young, L.J .(2001).
Facilitation of affiliation and pair-bond formation by vasopressin receptor gene transfer into the
ventral forebrain of a monogamous vole. Neuroscience, 21 (18), 7392–7396

Trust drug may cure social phobia. (2008, May 21). BBC News. Health. Retrieved from:
http://news.bbc.co.uk/2/hi/health/7412438.stm

Uvnäs Moberg, K. (2003). The oxytocin factor: Tapping the hormone of calm, love, and healing.
Cambridge, MA: Da Capo Press.

Young, L., & Zuoxin, W. (2004). The neurobiology of pair bonding. Nature Neuroscience,
7(10), 1048-1054. doi:10.1038/nn1327.

 
 
 
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OXYTOCIN: THE CHEMICAL BONDS OF LOVE
 
 

Oxytocin 
Survey 
 

 
 
 
 
 
 
 
 
 
 
 
 
 
 
 

 
 
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OXYTOCIN: THE CHEMICAL BONDS OF LOVE
 
62 responses: Summary
 
Sex 

Male 21 34%
Female 41 66%

Age 

14-18 1 2%
19-25 12 19%
26-32 17 27%
33-39 21 34%
40-46 8 13%
47-53 1 2%
54-60 2 3%
60-66 0 0%
67-73 0 0%
74-80 0 0%
80 or older 0 0%
Prefer not to say 0 0%

 
 
 
 

 
 
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OXYTOCIN: THE CHEMICAL BONDS OF LOVE
 
 
Relationship Status

Single 16 26%
Married 20 32%
Coupled or Partnered 18 29%
Second Marriage 3 5%
Third Marriage or beyond 0 0%
Divorced 5 8%
Widowed 0 0%
Other 0 0%

 
Do you own any pets? 
 

0 18 29%
1 or 2 33 53%
3 or 4 8 13%
5 or 6 1 2%
7 or more — my house is a zoo! 2 3%

 
 
I consider myself to be an emotional person 

strongly disagree 0 0%
disagree 4 6%
agree somewhat 18 29%
agree 26 42%
strongly agree 14 23%

 
 
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OXYTOCIN: THE CHEMICAL BONDS OF LOVE
 
I consider myself to be a touchy-feely person

strongly disagree 4 6%
disagree 10 16%
agree somewhat 25 40%
agree 15 24%
strongly agree 8 13%

How affectionate do you consider yourself with your family?

not affectionate at all 6 10%


moderately affectionate 29 47%
quite affectionate 21 34%
very affectionate 6 10%

How affectionate do you consider yourself with your friends? 
 

not affectionate at all 3 5%


moderately affectionate 33 53%
quite affectionate 22 35%
very affectionate 4 6%

How affectionate do you consider yourself with your love interest / partner / mate / spouse? 

not affectionate at all 0 0%


moderately affectionate 14 23%
quite affectionate 25 40%
very affectionate 23 37%

 
 
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OXYTOCIN: THE CHEMICAL BONDS OF LOVE
 
 
 
I tend to feel 'smothered' by overly affectionate people 
 

strongly disagree 11 18%


disagree 19 31%
agree somewhat 22 35%
agree 8 13%
strongly disagree 11 18%

 
 
 
Physical expression of love in the form of affection is important to me 
(i.e. touching, stroking, handholding, hugging, kissing) 

strongly disagree 1 2%
disagree 2 3%
agree somewhat 10 16%
agree 21 34%
strongly agree 28 45%

 
 
I enjoy meeting new people 
 

strongly disagree 0 0%
disagree 1 2%
agree somewhat 14 23%
agree 33 53%
strongly agree 14 23%

 
 
 

 
 
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OXYTOCIN: THE CHEMICAL BONDS OF LOVE
 
 
 
I enjoy new / interesting situations 
 

strongly disagree 0 0%
disagree 0 0%
agree somewhat 9 15%
agree 35 56%
strongly agree 18 29%

 
 
I take comfort in familiar routine and stability 
 

strongly disagree 0 0%
disagree 8 13%
agree somewhat 25 40%
agree 23 37%
strongly agree 6 10%

 
 
I attend social functions  
(i.e. dinner with friends, concerts, parties, meetings with groups / organizations) 
 

rarely 7 11%
often 31 50%
sometimes 23 37%
infrequently 1 2%
never 0 0%

 
 
 
 
 
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OXYTOCIN: THE CHEMICAL BONDS OF LOVE
 
 
 
I plan social functions  
 

rarely 19 31%
often 15 24%
sometimes 19 31%
infrequently 8 13%
never 1 2%

 
 
I smile or laugh with my family & friends 
 

rarely 1 2%
often 56 90%
sometimes 5 8%
infrequently 0 0%
never 0 0%

 
I smile or laugh with my love interest / partner / mate / spouse 
 

rarely 0 0%
often 55 89%
sometimes 5 8%
infrequently 2 3%
never 0 0%

 
 
 
 
 
 
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OXYTOCIN: THE CHEMICAL BONDS OF LOVE
 
 
 
I do little special things for my love interest / partner / mate / spouse 
(i.e. love notes, make something, plan a surprise, take care of something they've been 
putting off) 
 

rarely 1 2%
often 36 58%
sometimes 23 37%
infrequently 2 3%
never 0 0%

 
 
My love interest / partner / mate / spouse does little special things for me  
 

rarely 4 6%
often 23 37%
sometimes 24 39%
infrequently 10 16%
never 1 2%

 
 
I enjoy cooking for others 
 

strongly disagree 6 10%


disagree 3 5%
agree somewhat 12 19%
agree 12 19%
strongly agree 26 42%

I don’t cook, but I would 3 5%

 
 
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OXYTOCIN: THE CHEMICAL BONDS OF LOVE
 
 
 
Sex is important in a healthy relationship 
 

strongly disagree 0 0%
disagree 1 2%
agree somewhat 5 8%
agree 25 40%
strongly agree 31 50%

 
 
If someone visited my home unannounced on a random day, they'd find it orderly 
and clean 
 

strongly disagree 11 18%


disagree 10 16%
agree somewhat 25 40%
agree 15 24%
strongly agree 1 2%

 
 
I believe that desire is chemically based (attraction, passion, lust) 
 

strongly disagree 3 5%
disagree 5 8%
agree somewhat 33 53%
agree 15 24%
strongly agree 6 10%

 
 
 
 
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OXYTOCIN: THE CHEMICAL BONDS OF LOVE
 
 
 
I believe that love is chemically based (pair‐bonding, intimacy, sustained relationship) 
 

strongly disagree 9 15%


disagree 14 23%
agree somewhat 28 45%
agree 7 11%
strongly agree 4 6%

 
 
In general, I would describe my life as having . . .  
 

plenty of love 20 32%


a good amount of love 23 37%
ample love 10 16%
a small sample of love 4 6%
not enough love 4 6%
a love deficit 1 2%
LOVE? bah! who needs
0 0%
it!?

 
 
Have you ever heard of or are you familiar with the word "oxytocin?" 
 

Yes 47 76%
No 15 24%

 
 
 
 
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OXYTOCIN: THE CHEMICAL BONDS OF LOVE
 
 
 
If you could take a pill to encourage love and the emotional feelings associated with 
love . . .  (emotional enhancement, not sexual dysfunction) 
 
I would definitely
7 11%
take it
I would consider
21 34%
taking it
I would not take it 21 34%
I would mistrust such
13 21%
a claim

 
 
 
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OXYTOCIN: THE CHEMICAL BONDS OF LOVE
 
Discussion:  
I created this survey as a way to assess the following:

• measures of intimate/affectionate contact


• satisfaction with intimacy/affection levels
• outward displays and measures of happiness
• outward displays of affection and care-taking
• sociability and interest in new people / new experiences
• beliefs on chemical basis for desire and love
• familiarity with term oxytocin
• interest in medication/intervention to increase emotion

I began the questions with basic metrics on sex, age, marital status to establish my

population. Total sample n=62 with 41 female and 21 male respondents for 28 questions.

Respondents were invited to participate via email (sent to our class roster) and two social

networking sites online (Facebook and Twitter).

I then ran three, brief statistical analyses to see if there were any significant trends with

the following three questions:

1) Do respondents reply consistently regarding their affections levels between family and their

partners?

2) Does sociability level affect respondent’s opinions on whether they would take a pill to

encourage love and the emotional feelings associated with love? i.e.: would socially anxious

people be interested in self-correcting or drawing more love and emotion into their lives?

3) Is there a relationship between the amount of love respondents perceive as having in their

lives and their relationship status?

 
 
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OXYTOCIN: THE CHEMICAL BONDS OF LOVE
 

Respondent's affection towards family and partner (n=62)

90.0%

80.0%
How affectionate do you consider yourself

not affectionate at all


70.0% moderately affectionate
quite affectionate
60.0%
with your partner?

very affectionate
50.0%

40.0%

30.0%

20.0%

10.0%

0.0%
not at all (6) moderately (28) quite affectionate (21) very affectionate (5)
How affectionate do you consider yourself w ith your fam ily?

 
I wanted to see if affection levels were similarly reported for family and partners. This chart demonstrates a correlational 
effect between respondents who answered about their levels of affection towards family and their partner. It would have 
been interesting to ask a more temporal question to track affection over time; i.e., asking respondents to consider how 
affectionate they recall their family being while growing up and follow with asking how affectionate they are with their 
partner in order to examine if family upbringing affects the way later adults relate to their mates. 

    

 
 
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OXYTOCIN: THE CHEMICAL BONDS OF LOVE
 

Happy pill preference by sociability

50.0%
not take
45.0%
mistrust
40.0%
consider
Happy pill preference

35.0% take
30.0%

25.0%
20.0%

15.0%

10.0%
5.0%

0.0%
low sociability (7-10) n=8 medium sociability (11-14) n=21 high sociability(15-19) n=32
Sociability
 

For this test, I combined 5 questions related to social behavioral tendencies and willingness to engage in new experiences: 1)  I 
attend social functions, 2) I plan social functions,  3) I enjoy cooking for others, 4) I enjoy new / interesting situations,  5) I enjoy 
meeting new people. Then I assigned a numbered rating scale from the qualitative data, combined them, and created a “Sociability 
Index” from the sample minimum of 7 to the maximum of 19 with a range of 4, then ranking them by three categories of LOW, 
MEDIUM, and HIGH sociability. From there I compared the respondent’s answer to “If you could take a pill to encourage love 
and the emotional feelings associated with love . . .” with four possible answers. The results were quite the opposite of what I 
expected. Those with a LOW Sociability Index, NONE reported a desire to take a “happy pill” and a reticence to take a pill were 
reported amongst both HIGH and LOW Sociability Indexes. 

 
 
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OXYTOCIN: THE CHEMICAL BONDS OF LOVE
 

Happy pill preference by sociability

70.0%
62.5%
59.4%
60.0% anti pill
pro pill 52.4%
47.6%
Happy pill preference

50.0%
43.8%

40.0% 37.5%

30.0%

20.0%

10.0%

0.0%
low sociability (7-10) n=8 medium sociability (11-14) n=21 high sociability(15-19) n=32
Sociability

This chart represents the same results, merely condensed down into two groups for further clarity to reduce noise. Here—
respondents who reported “not take” and “mistrust such a claim” were grouped into the anti pill category and those reporting 
“would consider” and “would take” into the pro pill category. 

 
 
25 
OXYTOCIN: THE CHEMICAL BONDS OF LOVE
 

Respondent's self described love in life by relationship status (n=62)

70.0%
love deficit
60.0% not enough
Self described love in life

small sample
50.0% ample
good amount
40.0%
plenty
30.0%

20.0%

10.0%

0.0%
single (16) coupled (18) married (20) second marriage (3) divorced (5)
Relationship status
 

I wanted to see if the levels of love reported differed with respect to relationship status. Some of the results here were predictable: 
there is some dissatisfaction or report of less love in single respondents, some in coupled/partnered relationships, and some in 
divorced while the married and those on a second marriage generally report adequate levels.

 
 
26 
OXYTOCIN: THE CHEMICAL BONDS OF LOVE
 
 

Respondent's self described love in life by relationship status (n=62)

120.0%
deficit, not enough, small
100.0% ample, good, plenty
Self described love in life

80.0%

60.0%

40.0%

20.0%

0.0%
single (16) coupled (18) married (20) second marriage (3) divorced (5)
Relationship Status

This chart represents the same results, merely condensed down into two groups for further clarity to reduce noise. Here—
respondents who reported on the negative end of the spectrum “deficit, not enough, small” were slated against respondents who 
reported on the positive end of the spectrum “ample, good, plenty.” Here, there’s an interesting effect in that the single and the 
coupled respondents show a very similar pattern in the levels of deficit and plenty, while both married categories (weighted) show 
no deficits and equal amounts of plenty, with divorced respondents rounding out the split at approximately 60 (plenty) – 40 (deficit) 
spilt.  

 
 

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