Science Project Summary (1)

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Our project addressed how to combat the
increasingly higher incidence rate of sitotoxism in Taiwan.
As an island, Taiwan has abundant seafood available for
consumption. Of particular concern is Vibrio paraemolyticus, an epidemic
pathogen commonly found in seafood. This pathogen can cause sitotoxism, a
disease with an incidence rate in Taiwan that is the highest worldwide. Often a
result of insufficiently cooked seafood, sitotoxism is especially prevalent from
May to August, when a large amount of seafood is consumed islandwide.
As the conventional means of identifying Vibrio paraemolyticus,
serotyping is expensive, tedious, and time consuming. Various molecular
subtyping methods are also applied to identify an appropriate means of
differentiating Vibrio paraemolyticus isolates from other serotypes. However,
whether molecular subtyping methods provide a more rapid and sensitive
alternative for differentiating among Vibrio paraemolyticus strains is unknown.
For instance, serotyping requires seven days before supplying reliable results
and, in doing so, is relatively inefficient, thus necessitating the need for a viable
alternative. The inability to develop a more reliable and efficient means of
identifying Vibrio paraemolyticus will lead to an increasingly higher incidence
rate of sitotoxism in Taiwan.
(cont)
Therefore, we developed a rapid molecular identification
method using the high specific gene of tdh gene in bacteria chromosome to
detect a major target. tdh gene was detected by
polymerase chain reaction (PCR). Exactly how V. paraemolyticus and
antibiotics are related was then determined using a drug sensitivity test. Next,
using this same test, whether bacteria are drug resistant or drug sensitive was
determined as well. Additionally, the Vibrio paraemolyticus epidemic
phenomenon in the surrounding environment was more thoroughly understood
using pulsed field gel electrophoresis. As anticipated, the
proposed molecular identification method can detect the presence of Vibrio
paraemolyticus in the environment in only a few hours. Additionally, the pulsed
field gel electrophoresis results can provide further insight into the molecular
epidemic phenomenon in the surrounding environment.
Importantly, the proposed method provides rapid and accurate
molecular biology results to detect Vibrio paraemolyticus in the environment.
(NOTE : Add 2-4 more sentences that describe more thoroughly how the
proposed method contributes to a particular field or sector)

Our recent scientific effort
addressed how to raise product output in the microelectronics industry.
As is well known, ionizing
irradiation causes material damage. The range/number of radiation
effects in solids depends on both the crystal structure and the type of
ionizing irradiation. Additionally, the energy and dosage of irradiation
essentially affect radiation processes. Ionizing irradiation excites both
electronic and ionic subsystems of crystals. Relaxation processes
occur after excitation, forming defects. Defects impair the solids,
extensively stimulating material damage. However, the
radiation-stimulated ordering effect (RSOE) is found in various
materials. At least two competitive processes are observed in crystals
and semiconductors under ionizing irradiation 1) generation of
radiation defects and 2) radiation-stimulated annihilation of defects.
For instance, on a specific stage, the annihilation of irradiation defects
can dominate the generation of defects, enhancing the structure. This
stage is referred to as RSOE.
(cont)
Therefore, low-dose irradiation could serve as an effective method for
increasing the reliability of semiconductors and the stability of parameters
in the final stage of manufacturing. This fact substantially increases
economical efficiency. Nevertheless, the RSOE mechanisms in II-VI
semiconductors remain unknown, making it impossible to implement
process applications capable of increasing the efficiency of barrier
structures. Although the application of RSOE could markedly increase
product output in microelectronics, the generalization and analysis of
RSOE remains an obstacle to further development.
Therefore, we investigated the RSOE in II-VI
semiconductors and construct a related model.
Voltage-current characteristics (VIC), voltage-capacity characteristics
(VCC) and capacity-modulated spectra for barrier structures were
measured at various irradiation doses, providing the preliminary
experimental data. Based on that data, the control parameters can then
be derived. Following Hall experiments to consider bulk effects, the
parametric changes were analyzed and synthesized.
(cont)
According to our results, low-dose radiation
processes can be clarified in solids, improving the parameters of
structures based on II-VI semiconductors. The proposed work can also
elucidate low-dose radiation processes in II-VI semiconductors. Thus,
applying this model to barrier structure manufacturing can allow us to
accurately predict the irradiation conditions to enhance the parameters of
structures based on II-VI semiconductors. The range of objects in which
the RSOE is observed can be expanded. II-VI and other (Si, III-V)
semiconductors can also be compared in terms of the RSOE
mechanisms. Analysis of RSOE in II-VI reveals the peculiarities of related
objects. In contrast with III-V
semiconductors, for which the properties of pure crystals can be
determined by impurities in II-VI semiconductors, the lattice
stoichiometric defects prevail. Naturally, RSOE can be explained by the
reconstruction of defect centers. Importantly, the proposed model can
consider the effect of the radiation-stimulated diffusion (RSD) of point
defects. (NOTE : Add 2-3 more sentences that describe more
thoroughly how the results of this study contributes to a particular field or
sector)
Further details can be found at
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