Oxygen toxicity

Oxygen toxicity

Important enzymes
Reactive oxygen species
1. Superoxide dismutase
1. OH·
a. converts oxygen to hydrogen peroxide
a. Attacks a variety of amino acids
2. Myeloperoxidase
2. O2-
a. Converts hydrogen peroxide to
3. Hydrogen peroxide hypochlorite
4. R· b. Requires chloride
5. RCOO· 3. Catalase
6. HOCl a. disables hydrogen peroxide
a. Bleach!

Action of vitamin E
Fe2+ O-2
+ + No free radicals
H2O2 H2O2
H+
Free radical propagation
Fe3+ O2
+ +
OH! H 2O
+ + Vitamin E Tocopheryl quinone
OH- OH! (reduced vitamin E)
Fenton Haber-Weiss
reaction reaction

Vitamin C

Diseases associated with ROS

1. Atheroma
2. Emphysema
3. Parkinsons
4. Aging
5. Down syndrome

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