Bladder :

1-CisplatinDocetaxel Cisplatin, 75 mg/m2 i.v. Docetaxel, 75 mg/m2 i.v. Repeat cycle every 3 wk 2-Gemcitabinecisplatin Gemcitabine, 1000 mg/m2 i.v. days 1, 8, 15 Cisplatin, 70 mg/m2 over 1 h, day 2 Repeat every 28 d 3-MVAC Methotrexate, 30 mg/m2 i.v. days 1, 15, 22 Vinblastine, 3 mg/m2 i.v. days 2, 15, 22 Doxorubicin, 1530* mg/m2 i.v. day 2 Cisplatin, 70 mg/m2 i.v. day 2 Repeat cycle every 28 d *15 mg if >20 Gy pelvic irradation in 5 d before

Brain :
1-Procarbazine + XRT Procarbazine, 150 mg/m2/d (in 34 divided doses) p.o. days 128 Repeat every 8 wk 2-Temozolamide Temozolamide, 200 mg/m2/ d 5 d Repeat every 28 d (1st cycle, give only 150 mg/m2/d 5 d; if no toxicity, then increase dose as above)

Breast
1-AC Doxorubicin, 60 mg/m2 day 1 Cyclophosphamide, 600 mg/m2 i.v. day 1 Repeat cycle every 21 d. 2-ACpaclitaxel +-trastuzumab Doxorubicin, 60 mg/m2 day 1 Cyclophosphamide, 600 mg/m2 i.v. day 1 Repeat cycle every 21 d.for 4 cycles Followed by Paclitaxel 175-225 mg/m2. Repeat cycle every 21d for4 cycles. Or paclitaxel 80 mg/m2 weekly for 12 w +- trastuzumab 4mg/kg iv with first dose of paclitaxel followed by 2 mg/kg weekly. 3-ACpaclitaxel Doxorubicin, 60 mg/m2 day 1 Cyclophosphamide, 600 mg/m2 i.v. day 1 Repeat cycle every 14 d for 4 cycles. Followed by Paclitaxel 175mg/m every 14 days for 4 cycles. 4-capecitabine Cap. 1250 mg/m p.o. bid on days 1-14 Repeat the cycle every 12 days 5-docetaxel /capecitabine Doc.75 mg/m one day one

Capecitabine 1250 mg/m po bid on day1-14 repeat cycle every 21 days. 6-FAC 5fu 500 mg/kg on day 1 and 8 Doxorubicine 50 mg on day 1 Cyclophosphamide 500 mg/m on day one Repeated cycle every 21 d. 7-FEC 5fu 500 mg/m on day 1 and 8 Epirubicin 60 mg/m on day 1 and 8 Cyclophosph.75 mg/m po one day 1-14 Repeat every 28 d. 8-GT Gemcitabine 1250 mg/m on day 1 and 8 Paclitaxel 175 mg/m on day 1.

Cervix
Cisplatin based 50 mg/m2 Gemzar / Cisplatin Gemzar 1250 mg/m on day 1 and 8 Cisplatin 50 mg /m on day 1 Repeat the cycle every 21 d.

Colorectal
1-Capecitabine (zeloda) Cap 2500 mg /m/d bid po for 2 weeks Repeat every 3 wk. 2-Fluorouracil + leucovorin Leucovorin, 500 mg/m2 i.v. over 2 h Fluorouracil, 600 mg/m2 i.v. given 1 h into leucovorin infusion Weekly for 6 wk followed by 2 wk rest 3- FOLFIRI..irinotecan/5fu/lcv Irinotecan 180 mg /m on d 1 Leuk.400 mg/m over 2 h before 5fu on d 1 and 2 5fu 400 mg/m iv bolus ,then 1200 mg/m over 46 h on d 1 and 2 4-FOLFOX 4oxaliplatin /5fu/lcv. Oxal 85 mg /m on d 1 5fu 400 mg /m bolus Followed by 600 mg/m over 22 h on d 1 and 2 Lcv 200 mg/m (before 5fu) on day 1 and 2 Repeated every 14 d

Endometrial cancer :
1-Carboplatinpaclitaxel Carboplatin, AUC 57 i.v. one day 1 Paclitaxel, 175 mg/m2 i.v.one d 1 before carb. Repeat every 4 wk (total dose =GFRx(AUC+25) )

2- Doxorubicin Doxorubicin, 60 mg/m2 i.v. Repeat every 3 wk

Gastric
1-DC Docetaxel 85 mg /m on d 1 Cisplatin 75 mg /m on d 1 repeated every 21 d 2-FOLFOX 4 (same of crc) 3-IP Irinotecan 70 mg/m on d 1 and 15 Cisplatin 80 mg /m on d1 Repeated every every 4 wk.

Hydatiform mole
1-EMA-CO Etoposide, 100 mg/m2 i.v. (over 30 min) day 1, 2 Actinomycin-D, 0.5 mg IVP day 1, 2 Methotrexate, 100 mg/m2 IVP, then 200 mg/m2 i.v. over 12 h, day 1 Folinic acid, 15 mg i.m. or p.o. q12h 4 doses (starting 24 h after start of methotrexate) Vincristine, 1 mg/m2 IVP, day 8 Cyclophosphamide, 600 mg/m2 i.v. over 30 min day 8 Repeat cycle every 2 wk

2-Methotrexate Methotrexate, 3050 mg/m2 i.m. q wk.

Head and neck

1-TIP Paclitaxel, 175 mg/m2 i.v. over 3 h day 1 Ifosfamide, 1000 mg/m2 i.v. over 2 h, days 13 Mesna, 600 mg/m2/d divided as 400 mg/m2 i.v. before ifosfamide and 200 mg/m2 i.v. 4 h after ifosfamide Cisplatin, 60 mg/m2 i.v. day 1 Repeat cycle every 34 wk 2-TPF Docetaxel 75mg/m on d 1 Cisplatin 75-100 mg/m on d 1 5fu 1000mg/m on d 1-4 Repeated every 21 d

Hepatocellular
1-Doxorubicin. Doxorubicin, 6075 mg/m2 i.v. Repeat every 3 wk 2-capecitabine. Cap.1000 mg/m po on d 1-14 Repeated cycle every 21d.

ALL
Hyper -CVAD + - imatinib Course I,III,V and VII Cyclophosphamide, 300 mg/m2 i.v. over 2 h every 12 h 6 doses (days 13) Mesna 600 mg/m CIVI dialy on d 1-3 Vincristine, 2 mg i.v. (days 4 and 11) Doxorubicin, 50 mg/m2 i.v. (day 4) Dexamethasone, 40 mg p.o. qd (days 14 and 1114) Filgrastim 10 ug /kg s.c. In divided dose started on day 5 Course II,IV,VI,VIII Methotrexate, 1g/m2 over 24 h (day 1) with leucovorin rescue Cytarabine, 3 g/m2 over 2 h every 12 h 4 doses (days 2 and 3) Methylprednisolone 50 mg iv bid on d 1-3 Filgrastim 10 ug /kg s.c. In divided dose started on day 4 +- imatinib 400 mg po daily on d 1-14of all intensive chemotherapy courses.

AML
7+3 Cytarabine, 100 mg/m2/d CIVI days 17 Daunorubicin, 45 mg/m2/d i.v. days 13 Or Idarubicin 12 mg/m on d 1-3 Mitoxantrone 12 mg/m on d 1-3

CLL
1-CVP Cyclophosphamide 300 mg/m po on d 1-5 Vincristine 1.4 mg/m on d 1 (max.dose 2 mg) Prednisolone 100 mg/m po daily on d 1-5 Repeated every 21 d 2-FC Fludarabine 30 mg/m on d 1-3 Cyclo. 250-300 mg/m iv on d 1-3 Repeated every 28-42 d 3-FCR Like NH Lymphoma

CML
imatinib Imatinib 400 mg po daily(chronic phase) Imatinib 600 mg po daily (accelerated phase or blast crisis)

Hairy cell leukemia

Cladribine Cladribine, 0.1 mg/kg/d CIVI days 17 One cycle only

Myelodysplastic syndrome
1-Decitabine Decitabine 15 mg /m iv q8h for 3 d Repeated every 6 wk 2-Azacitindine Azac. 75 mg/m s.c dialy for 7 days Repeated every 28 d

Lung Nonsmall cell

1-Carbo-Tax Paclitaxel, 200 mg/m2 i.v. day 1, followed by carboplatin (AUC 6) i.v d1. Repeat every 3 wk 2-Cisplatinetoposide Cisplatin, 60 mg/m2 i.v. day 1 Etoposide, 100 mg/m2/d i.v. days 4, 6, 8 Repeat cycle every 3-4 wk 3-Cisplatinpaclitaxel Paclitaxel, 175 mg/m2 i.v. on day 1 Cisplatin, 80 mg/m2 i.v. day 1 Repeat every 3 wk 4-Cisplatinvinorelbine Cisplatin, 100 mg/m2 i.v. day 1 Vinorelbine, 25-30 mg/m2 i.v. weekly (d1,8,15,22)

repeated every 4 wk 5-Docetaxel Docetaxel, 75 mg/m2 over 1 h i.v. Repeat every 3 wk 6-Docetaxelcisplatin Docetaxel, 75 mg/m2 i.v. day 1 Cisplatin, 75 mg/m2 i.v. day 1 Repeat every 3 wk 7-Gemcitabinecisplatin Gemcitabine, 1000 mg/m2 i.v. days 1, 8, 15 Cisplatin, 100 mg/m2 i.v. day 1 Repeat every 28 d

Small cell

1-CAV Cyclophosphamide, 1000 mg/m2 i.v. Doxorubicin, 45 mg/m2 i.v. on d1 Vincristine, 2 mg i.v. on d1 Repeat every 21 d 2-EC Etoposide, 100 mg/m2/d i.v. days 13 Carboplatin, 300 mg/m2 i.v. day 1 Repeat every 21 d

3-EP Etoposide, 80 mg/m2/d i.v. days 1-3 Cisplatin, 80 mg/m2/d i.v. days 1 Repeat every 3wk 4-Irinotecancisplatin Irinotecan, 60 mg/m2 i.v. days 1, 8, 15 Cisplatin, 60 mg/m2 i.v. day 1 Repeated every 28 d 5-Topotecan Topotecan, 1.5 mg/m2/d i.v. over 30 min, days 15 Repeat every 21 d

Lymphoma Hodgkins L.

ABVD Doxorubicin, 25 mg/m2 i.v. days 1, 15 Bleomycin, 10 mg/m2 i.v. days 1, 15 Vinblastine, 6 mg/m2 i.v. days 1, 15 Dacarbazine, 375 mg/m2 i.v. days 1, 15 Repeat cycle every 28 d

Non hodjkins lymphoma

1-CHOP +- rituximab Rituximab, 375 mg/m2 i.v. day 0

Cyclophosphamide, 750 mg/m2 i.v. day 1 Doxorubicin, 50 mg/m2 i.v. day 1 Vincristine, 1.4 mg/m2 i.v. day 1 (max, 2 mg) Prednisone, 100 mg /d p.o. 5 days Repeat cycle every 21 d 8 2- DHAP Dexamethasone, 40 mg p.o. or i.v. days 14 Cisplatin, 100 mg/m2/d CIVI over 24 h, d 1 Cytarabine, 2000 mg/m2 i.v. q12h 2 doses day 2 Repeat cycle every 34 wk 3-ESHAP Etoposide, 40 mg/m2/d i.v. days 14 Methylprednisolone, 500 mg/d i.v. days 14 Cisplatin, 25 mg/m2/d CIVI days 14 Cytarabine, 2000 mg/m2 i.v. day 5 immediately after completion of cisplatin Repeat cycle every 21 d 4- FCR Fludrabine 25 mg/d on d 1-3 Cycloph. 250 mg/m on d 1-3 Rituximab375mg/m on d 1 Repeated every 28 d 5-hyper-CVAD Same of leukemia 6-rituximab Rit. 375 mg/m iv weekly x 4 cycles.

Melanoma
1-CVD Cisplatin, 20 mg/m2/d i.v. days 25 Vinblastine, 1.6 mg/m2/d i.v. days 15 Dacarbazine, 800 mg/m2 i.v. day 1 Repeat every 3 wk 2-Dacarbazine Dacarbazine, 250 mg/m2/d i.v. 5 d Repeat every 21 d 3- temozolomide Temo.200 mg/m po d 1-5 Repeated every 28 d

Multiple myeloma
1-MP Melphalan, 8 mg/m2 p.o. days 14 Prednisone, 60 mg/m2 p.o. days 14 Repeat cycle every 28 d 2-VAD Vincristine, 0.4 mg/d CIVI days 14 Doxorubicin, 9 mg/m2/d CIVI days 14 Dexamethasone, 40 mg p.o. q.a.m. days 14, 912, 1720 Repeat cycle every 2835 d

3-thalidomide /dexamethasone Thal. 100-200 mg po every day at bed time and increased ats tolerated . Dexa.40 mg po daily on days 1-4 , 9-12 , and 17-20 Repeated cycle every 28 d. 4-VAD (used) Vincristine, 0.4 mg/d CIVI days 14 Doxorubicin, 9 mg/m2/d CIVI days 14 Dexamethasone, 40 mg p.o. q.a.m. days 14, 912, 1720 Repeat cycle every 2835 d

Ovarian
1-CarboplatinPaclitaxel Paclitaxel, 175 mg/m2 i.v. over 3 h day 1 followed by carboplatin (AUC 5) day 1 Repeat cycle every 21 d 2- paclitaxel /cisplatin Paclitaxel 135mg/m CIVI over 24 h on d1 Cisplatin 75 mg/m iv on d2 Repeated every 21 d. 3-DC Docetaxel, 75 mg/m2 i.v. over 1 h Carboplatin, (AUC 5) i.v. Repeat every 21 d 6 4-Gemcitabine Gemcitabine, 1250 mg/m2 i.v. over 30 min days 1, 8, 15 of a 28-day cycle

5-gemcitabine/carboplatin Gem. 1000 mg/m on d 1 and 8 Carbo.AUC 4on d 1 Repeated every 21 d 6- vinorelbine Vino. 30 mg/m iv on d 1 and 8 Repeat cycle every 21 d .

Pancreas
1-Gemcitabine Gemcitabine, 1,000 mg/m2 i.v. over 30 min once weekly for 7 wk, followed by a 1-wk rest period Subsequent cycles once weekly for 3 consecutive weeks per 4-wk cycle. Or Gemc.1000mg/m on d 1,8,15 Repeated every 28 d 2- gemcitabine /cisplatin Gemc.1000 mg/m on day 1 and 15 Cisplatin 50 mg/m on d 1 and 15 Repeated every 28 d. 3-gemcitabine /oxaliplatin (gemOX) Gemc. 1000 mg/m over 100 min on d.1 Oxal. 100 mg /m on d 2 Repeated cycle every 2 wks. 4-GTX Capecitabine 750 mg/m po bid x14 d

Gemcitabine 750 mg/m iv on d 4 and 11 Docetaxel 30 mg /m iv on d 4 and 11 Repeated every 21 d.

Prostate
1-Mitoxantroneprednisone Mitoxantrone, 12 mg/m2 i.v. day 1 Prednisone, 5 mg p.o. b.i.d. Repeat cycle every 3 wk 2-PE Paclitaxel, 120 mg/m2 CIVI over 96 h Repeat paclitaxel every 21 d Estramustine, 600 mg/m2/d p.o. in 23 divided doses continuously starting 24 h before first paclitaxel Repeat cycle every 21 d 3-TEC Estramustine, 10 mg/kg/d in divided doses 5 days per week (start 48 h before chemo) Paclitaxel, 60100 mg/m2 i.v. weekly over 1 h Carboplatin, (AUC 6) i.v. every 4 wk.

Renal cell carcinoma

1-Interferon (IFN)- Interferon-a2b s.o. thrice weekly Week 1, 5 MU, 5 MU, 10 MU Weeks 211, 10 MU 3 times weekly

2- sorafenib Sor.400 mg po bid 3-sunitinib Sun. 50 mg po daily x 4 wk Repeated every 6 wks

Sarcoma Ewings sarcoma

CAV alternating with IE. Odd cycle Cyclo.1200 mg/m on d. 1 (with mesna ) Doxo.75 mg/m on d 1 Vinc. 2 mg on d 1 Dactinomycin 1.25 mg/m when cumulative dose of doxo.reaches 375 mg/m Even cycles Ifosfamide 1800 mg/m iv on d 1-5 (with mesna ) Etoposide 100 mg /m on d 1-5.

Gastrointestinal stromal tumor (GIST)

1-Imatinib Imatinib 400 mg po daily 2-Sunitinb Sun. 50 mg po daily

Osteosarcoma
1-CAV altenating with IE. Same as above. 2-doxorubicin /cisplatin Doxo. 25 mg/m iv on day 1-3 Cisp.100 mg/m on day 1 Repeated every 21 d. 3-gemcitabine/docetaxel Gemc.675 mg/m on day 1 and 8 Docetaxel 100 mg /m on d 8 Repeated every 21 d.

Soft tissue sarcoma

1-AIM Doxo.50 mg /m on d 1. Ifosf.5000 mg/m CIVI over 24h. on d 1 immediately following doxo. Mesna 600 mg/m before ifosf. Followed by 2500 mg/m CIVI over 24h on d 1. Mesna 1250 mg/m iv over 12 h starting at the end of the ifos. Infusion Repeated every 21 d. 2-MAID. Mesna 2500 mg/m/d CIVI daily on d 1-4 Doxo. 15 mg/m/d CIVI daily on d 1-4 Ifosf. 2000 mg /m/d CIVI on d 1-3 Dacarbazine 250 mg/m/d CIVI on day 1-4 Repeated every 21 d.

Testicular

1-BEP Cisplatin, 20 mg/m2 i.v. days 15 Bleomycin, 30 U i.v. days 2, 9, 16 Etoposide, 100 mg/m2 i.v. days 15 Repeat cycle every 3 weeks 4 2-EP Etoposide, 100 mg/m2/d i.v. days 15 Cisplatin, 20 mg/m2/d i.v. days 15 Repeat cycle every 21 d 2 3-TIP Paclitaxel 250 mg/m on d 1 Ifosf.1500 mg/m on d 2-5 Cisplatin.25 mg/m on d 2-5 Mesna 500 mg/m iv before and then 4h. and 8h. after each dose of ifosf.