Effect of Hepatic Plasma Flow on MCR_T:

Model Calculations for Men and Women

MCR_T = QHep x EFHep + QNon-Hep x EFNon-Hep

transit time ∝ QHep-1
1500

Men:
1200 Total T = 500 ng/dL
Alb = 4.5 g/dL
SHBG = 30 nmol/L
900

600 Women:
Total T = 35 ng/dL
300(L/day) Alb = 4.5 g/dL
MCR_T SHBG = 60 nmol/L

0 250 500 750 1000 1250 1500 1750 2000

Hepatic Plasma Flow (L/day)