PHARM.

D Chemical Pharmacognosy- I Lecture 27 May 9th, 2011

FLAVANOL GLYCOSIDES
M. Ahsan Khalid, B.Pharm, Pharm. D B.Pharm,
M.Phil Scholar (RIPS/RIU) HIPSHIPS-HUKIC

Flavonol Glycosides
Flavonoids - widely distributed natural product in plants occurring both in the free state and as glycosides. Yellow pigments structural categories flavone, flavanone, flavonol, anthocyanidin, isoflavone general biosyntheis involves the central intermediate p -c coumaroyl CoA and 3 malonyl CoA to elongate t he side chain of the original phenylpropanoid unit

Rue USP V (1873)

Synonym: Garden Rue, Herb of Grace, herbygrass Origin: leaves of Ruta graveolens (Rutaceae) Constituent: Rutin (Vit. P factor) - rhamnoglucoside of the flavonoid (quercetin) Rutin --H+ --- quercetin + rhamnose + glucose Use: treatment of various conditions characterized by capillary bleeding and increased capillary fragility Uterine stimulant, insect repellant (topical)

Rue
Note: bark contains berberine - anthelmintic, antispasmodic, antiepileptic, rubefacient, emmenagogue Adverse: bradycardia, severe kidney damage

hesperedin
Origin: rind of unripe citrus fruits synonym: hesperetin - 7 - rutinoside or hesperetin - 1 -rhamnoside - d -glucoside - methyl eriodictyol hesperedin --H+ --- hesperetin + rutinose Use: necessary for the retention of Vit C, catalyzes Vit C and protein to maintain normal capillary resistance (reduce capillary fragility) - for common colds