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m h o s p h o l i p ia r ee s s e n t i a l o l e c u l e s ds We are in the age of a t h a t p l a yv i t a lr o l e si n h e a l t h n d and technology science r a r e f o u n di n c e l l u l a m e m b r a n e s . n c and we cannot live A c e l li n t h eh u m a b o d y a n n of tu n c t i o n e n o r m a l lw i t h o utth e p r e s e n co f t h e s e y withoutit. There is a p h o s p h o l i p i d s .t h e n a m ei m p l i e s , As e a es wealth of science in p h o s p h o l i p ird m a d o ft h ec o m b i n a t i o n ) t al s o f l i p i d ( f a t sa n d h em i n e r p h o s p h o r u s materials yet b o u n tdo a p o l ah e a d r o u pi k ec h o l i n e . not natural r g l l s al understood T h e s ei p i d a r ef u n d a m e nct o m p o n e n t s or completely t h ec e l m e m b r a nw h i c a r ee s s e n t i a l l es h of products forgrowth, Natural utilised. functioning maturing proper and s oi ct p h o s p h o l i pad ep r i m e c o - p r o d ud u r i n g o y a b e a n l r e f i n i n g , irs . can yield materialso f c e l l sT h u s s t a n d a r d i s eM . x e d di sterilised nd a b u i l d i n g o c ko f l i f e . bl s p h o s p h o l i pi in p o w d e r e d g r a n u l a t e d ds or wondedul health for and a f o r mp r o d u c e d d e - o i l i n g t u r a lo y a by l w id x providing nutrition cure P h o s p h o l i pm is t u r e(se c i t h i n )e r e p h o s p h o l i pad eu, s e d r a lnls i n c es a n y i rs m o y f , a m o n gh ef i r s th e a l t ho o d sa n dm o r e t for manyof the lifestyle sophistlcated y e a r sW i t h h eE Cr e g u l a t i oi n s u r o p e . t E preparations emerged have as C l d a en functional food N 0 NG M 0 e r t i f i ePp h o s p h o l i p irdis nutraceuticals and Today's diseases. urban versatile i nt d e m a n do mh e o o d u p p l e m en d u s t r y fr t f s p i i ta a r h o s p h o l i p nd s k e i en life styleandfood habits c o ndset ctlun eDt ise.itn ldyy et oi n c r e a sfeodo d i nt h ei n t e r e o tft h ec o n s u m e r s . s has i m, da u ny has madehuman being r e f i n i nagn dp r o c e s s iB ga d m i n i s t e r i n g iP n d p h o s p h o l i piitdi s p o s s i b lt e i m p r o v eP o w d e r eL e c i t h i ( L E C I V A - S 2 5s ) o victim various to complex m e m b r a nf e n c t i o na s s o c i a t ewdi t h u s e dm a i n l yo r t h e p r o d u c t i o n f o o d of f u s h i t pr ncy m e m b r a n eo t e i nasn dl i p i d sT. h e r e r e s u p p l e m e nnt sh ef o r mo f t a b l e t s ,a r d a due deficie diseases to n or a that show g e l a t i c a p s u l e s n u t r i t i o np rle m i x e s . a from studies of esse*tial *utrie*ts evidences sclinicalt a b o li im b a l a n c eGranular (LECIVA-S25G) has also Lecithin n u m b e rf c a e o f m e c s o s to and oroved be an effective convenient These very thatcanbecured intake special in the body. polar by of f o r mo f a d m i n i s t r a tao o u n t h ew o r l d i rn d l i p i d a n dp h o s p h o l i p i d s s essfitiial nutrients:come, i f o rm a n y e a r s i n c et c a nb ec o n s u m e d n y fromnature. f , A l t h o u gp r e s e nn m a n y o o d sn a t u r a l d i r e c t la s a s u p p l e m eo rt s p r i n k l e d h it

c . p h o s p h o l i p i d s e f o u n d i n h i g h e r o n s a l a d sA h e a l t h l a i mh a s b e e n ar m e fd c o n c e n t r a t i oin s o y ,e g g s ,m a r i n e f o r m u l a t eo r d e - o i l eld c i t h i(n i x e d ns t o s o u r c ea n dt h eb r a i ni s s u e f a n i m a l s .p h o s p h o l i p i d s ) : s nutritionally Phospholipids themost are also so m h t lecithin. D e - o i l e d yl e c i t h i n a y e l po m a i n t a i n important of soya constituents e a h e a l t h y h o l e s t e rlo lv e lf r o mf o o d s c providing 6 g/day. Naturaloya-Phospholipids S P d S o y aP h o s p h o l i p ia rs r e g a r d ea s S o y a h o s p h a t i d y l c h o l i n e de il v e r s a t i l a n d f u n c t i o n an g r e d i e n t s e produced solvent by T y o f f o o d . h e ya r e n a t u r a l lo c c u r r i n gPhosphatidylcholine phospholipids of natural soya d c o m p l e m i x t u r e f p h o s p h o l i p io fs fractionation x o f s s p i re s o y a T h em a i n h o s p h o l i p pd s s e n tu s i n g o o dg r a d e o l v e n ta n d g r e e n . te s, i n s o y al e c i t h ia r eP h o s p h a t i d y l c h o cih e m i s t r y c h n i q u eh a sb e e nu s e d n l n PE n s ( P C ) , h o s p h a t i d y l e t h a n o l(a m i ) ,e u c c e s s f u ltl o t r e a tl i v e rd i s e a s e s p y p h o s p h a t i d y l i n( P li)t o ld h o s p h a t i dsc p p o r t e d m u l t i p l e u b l e - b l t nid l s . os an P do ir a by iu d l iol so A c i d( P A ) . h e s e r e p r o d u c ea s a P h o s p h a t i d y l c h s ailn ea n a t u r ailp i d T a Pharma Bio World
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Ufiih the Ec regulations in Europe NoN GMo s c e r t i f i e d l P p h o s p h o l i p i d a r e i n d e m a n df r o m t h e food supplement !ndustry in the interest of the

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l T h e l u n g a n d i n t e s t i n a il n i n gc e l l s t to m u s e P h o s p h a t i d y l c h o l i n ea k e h e : gas to essential their coatings surfactant administration fluidexchange level plasma choline byoral And functions. PC is and o P h o s p h a t i d y l c h oi ln n e p s u l e r t h e p r e d o m i n ab u i l d i n b l o c k o r t h e i ca of f nt g i ie . t o n i cf o r m s S o y aP h o s p h a t i d y l c h o l cnr c u l a t i nig o p r o t e i n sC i s s a f ea n d P . l p l i5 a ( L E C I V A - S 3 s ) n a t u r ap r e c u r s o rwelltolerated beyond grams' several well if t h u so f t h e s y n t h e s os daily e of cholinand intake. An a er t h e n e u r o t r a n s m i t tc e t y l c h o l i n e is synthesis generallyN a t u r aP h o s p h o l i p ie n r i c h e w i t h rate increased of d ds l of memory P h o s p h a t i d y l c h o l r n e v a i l a b la s with associated animprovement e a i ea function. andmuscle f o r w a x yp r o d u c t s u i t a b l eo r liquid Li . P f o r m u l a t i o n sq u i d h o s p h a t i d y l c h o l i n e (l of I n 1 9 9 8t,h e I n s t i t u t e M e d i c i n eO M ) (LECIVA-35) in mainly sofigelatin is used of Academy Sciencesc a p s u l e s ,h e r e aw a x ym a t e r i a l sk e of theUS National i w s nutrient L E C I V A - S a n d L E C I V A - S c a n b e as choline an essential identified 70 50 p n c o m o o n e o ft l e c i t h i w h i c h e r f o r m s n a dai i a n dr e c o m m e n d e dl y n t a k e m o u n t s . s e df o r p h a r m a c e u t i co rl l i p o s o m a l a s u liver and reduction in functionscholesterol t p A n d i n 2 0 0 1 , h e U S F o o da n d D r u g d r u gd e l i v e rs y s t e m s .h e s e r o d u c t s T y a o f h e a l t hT h em o s t r e q u e n tf t h e s e r e , a (FDA) n Administration approvednutrient m a ya l s oh a v ep o t e n t i a lp p l i c a t i oin s of cirrhosis the liver' andchronic acute o e f c c o n t e n tl a i m o r c h o l i n e ,n a b l i nfg o d nasal lungdisease for sprays Interstitial (steatosis, of the fattydegeneration liver theirconsumers P u l m o n a riy r o s i s ) . to inform manufacturers F b ( from damage alcohol, and liver) liver fatty label. viathefood etc. medicines hydrocarbons, E g gP h o s p h o l i P i d s ( e ed T h er e c o m m e n dA v e r a g I n t a k e A l ) l n c a s e so f P r e v i o u lsi v e r d a m a g e f o r a d u l t ss 5 5 0m g / d a o f c h o l i n f o r e y i higher to In addition significantly content t h is e P h o s p h a t i d y l c h o la nb o u g ha b o u t menand425mglday women. Choline of Phosphatidylcholine, for eggphospholipids o i im a m a r k e d p r o v e m e n t h e s p e e d f i n t h e d i e tc o u l d e a v a i l a b la s f r e e e b are which the most provide proteins egg thecellmembrane, by recovery repairing s a s e s t e r s u c ha s balanced complete of amino o choline r bound acids set and n r e n e w a lo r r e g e n e r a t i o o f L i v e r g l y c e r o p h o s p h o c h o lh nn g o m y e lri n , o sp ii e, r m o f t e n i s s i nfg o m a i f o u n dn n a t u r e n d parenchyma Health in phosphatidylcholine.Europe Also is a LIPOVA-E100 protein sources. other for especially formulated have Claims been and of mixture eggphospholipids natural effect Thebeneficial of Phosphatidylcholineo s p h a t i d y l c h o l i n e : Ph yolk, of produced extractionegg proteins by as with is oniheliver connected itsrole a . Soya Phosphatidylcholine supports suitable free cholesterol powder membrane. l i v e r m e t a b o l i s mn d m a y h e l P isa fatand block building inthecell central a h a r ds h e l le n c a p s u l a t i o n o abundant detoxification foods providingf o r t a b l e t s r is the Phosphatidylcholinemost from aid and an idealnutritional for growing therefore 1.2glday. phospholipids membranes, ofcell with a n ds f b g t h e m o s ti m p o r t a n tu i l d i n b l o c k o r . S o y a P h o s P h a t i d Y l c h ohie le s c h i l d r e n / t e e n a g e r s p o r t s m e n l nP However, supplements. for needs protein mass' of membrane level replacement making cholesterol a healthy maintaining e t h i sp r o d u cits n o t s u i t a b l f o r p e o p l e 1.2gldaY. foods from Providing emulsifies breaks Phosphatidylcholine and , n f of Phosphatidylcholine d o w n a t d e p o s i tis t h e b o d Yw h i c h Thebioavailability n the for i t h e l p f u il n t h e p r e v e n t i oo f is excellent is suitable raising and make disease,choline in blood. administration heart Oral gallstones, aiherosclerosis, level d has problems. Research shown o f C h o l i n s a l t sh a su n d e s i r a bsl ie e e andliver t in e f f e c t s h i c hm a y e v e ni n c r e a s eh e is beneficial w ihat Phosphatidylcholine liver of loss severity existing damages. memory andneurological depression, morepotent lt disorders. is threetimes without issafe arising Phosphatidylcholine to take disorders Neurological Lecithin. than oi s an of froma deficiency the neurotransmitter yp r o b l e ma l,s oi n c o m b i n a t iw nt h good n s the by can acetylcholinebetreated increasing o t h e r u t r i e n te v e nd u et o t h e
42 lFebruory2012

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Nutraceutical GPC Future Phospholipids of scales. on ir o a l l e r g itc e g g s( a n a p h y l a xos )s t r i c t based fourmeasurement and well is extremely absorbed appears vegetariansivegans. from outcomes clinical fo oositive c t o b e m a j o rm e t a b o l ip r e c u r s o r r Consistent by hundreds , the s t u d i e a n dt r i a l sb a c k e d s phospholipids crosses and membrane Glycerophosphorylcholine s a l brain o f c l i n i c as t u d i e s n d t h o u s a n do f it where supports barrier brain blood h a se s t a b l i s h e d st l processesdirectly e x p e r i m e n t a u d i e s by (Alpha and Glycerylphosphorylchbline function learning L-Alpha nu al of and the from increasing synthesis secretion p h o s p h o l i p i d s 't r a c e u t i cb e n e f i t s derived alfoscerate) choline GPC, The andcirculation. liver, for the brain, purified lecithin a process acetylcholine. by soya highly phospholipids extremely are nutraceutical an o f d e a c y l a t i o n dc h r o m a t o g r a p h i c and and neurons improveswelltolerated poseno toxicthreat, alsoprotects purification, natural GPC compound choline is a status. their orthomolecular with a by s i g n a t r a n s m i s s i o n s e r v i n g s a consistent l and in found thebrain in milk. to of phospholipids tendency phospholipids. Thenatural precursormembrane to inwater dispersions molecular ultrafine form o s I t i s u s e da s d i e t a r Y u P P l e m etn t the to explored improve be inmother's should further high attains concentrations n. m e m o ra n dc o g n i t i o I n a n GPC y enhance nutrients, non-phospholipids of for bioavailability of source choline being major a trial clinical onpatientsmilk, Italian multicentre and those are child. especially that costly relatively of organs the newborn theywere developing stroke, fromrecent suffering J absorbed. sharpnesspoorly mental remarkably benefits The GPC GPC supplemented for fivemonths. aged as as healthy well in middle role the trial confirmed therapeutic ofalpha- in young marketi Contact: humans patients andelderly of recovery GPC thecognitive on

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2012 > 43 Februory

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