JAITESH SINGH (10) RUHI GUPTA(18)

INTRODUCTION
It is a process which is mainly concerned with the transfer of technology from the research areas to the Production and Quality Assurance environment .

The Process by which existing knowledge , facilities or capabilities developed under R & D funding are utilized to fulfill public and private need. Technology Transfer includes a range of formal & informal cooperation between technology developers and technology seekers.

Varied Roles
IDEA Start-up Firms R&D Firms Research Development Universities Research Institutes

Production
Manufacturing Distribution MARKET
3

Larger Companies

Ways Technology is Transferred

Consulting

Graduating students (moving heads) Faculty moving on (moving heads) Collaborative research Patenting and licensing Service and outreach (extension) Spin-off companies

Technology Transfer Agents

R&D Units Universities Public Research Centers Technology Institutes (institutions, labs etc)

Companies Supplier of technology and R&D to third parties Spin-off, start-ups Large R&D department Competitors, suppliers (technological alliances)

TYPES OF TECHNOLOGY
1) EMERGING TECHNOLOGY- is an innovative technology that currently is undergoing bench scale testing, in which a small version of the technology is tested in a laboratory.
2) INNOVATIVE TECHNOLOGY- is a technology that has been field tested and applied to a hazardous waste problem at a site, but lack a long history of full-scale use. 3) ESTABLISHED TECHNOLOGY- is cost and performance information technology has been used at many result fully documented is that established.

a technology for which is readily only after a different sites and the technology considered

APPROPRIATE TECHNOLOGY

Technology that suits one country may not be suitable to other countries. As such the countries develop appropriate technologies which suit their topographical conditions, climatic conditions ,soil conditions ,conditions of infrastructure ,etc.

FOR EXAMPLE Japanese automobile industry and Korean automobile industry design different types of cars which suit the Indian roads.

CONSTITUENTS OF TECHNOLOGY TRANSFER PROCESS

Technology Transfer Technology Promotion Technology Deployment Technology innovation Technology Development Technology Research Technology Assessment Technology Information and Communication Technology Investment Technology Collaboration Technology Commercialization

11 May 2012

COMMERCIALI ZATION

PROMOTION

COLLABORATION

INNOVATION

INVESTMENT

RESEARCH & DEVELOPMENT

INFORMATION & COMMUNICATION

ASSESSMENT

CONTENT OF TECHNOLOGY TRANSFER

Proper Research Peoples Acceptance 6P Paper work

Partnership Publicity

Pricing

Proper Research By proper research we mean firstly that in which the result are reproducible and issues such as scale up, stability etc and other practical now has been addressed, also that in which problem were taken up in first place.

Proper work- This refer to institutional and guidelines regarding IP Protection licensing modalities etc. which must be in place beforehand. In the absence of these, decision get delayed, lack of fairness in decision e.g. case of X institute, which came up with good technology but since no guidance were there, kept running around for two years and then gave up.

Pricing most difficult and critical area of Transfer of technology. - Too high price can put off buyer, leaving the technology unsold. - Too price a result in revenue loss. - There are basically two model regarding pricing 1) Price charged for a technology should depend upon market force i.e. impact of the technology irrespective of amount spent on developing it. 2) Price charged should include all expenses involved in developing it. Publicity It is important to identify and then approach buyer i.e. adopt targeted Publicity and not blanket publicity. Specific journal, website, letters to manufacturer, personal selective visit etc. are some common approach which help in locating buyer.

Partnership this means working along with industry. Industry takes it up, manufacturer and makes available to society. Partnership are important to ensure your technology is successfully adopted simply conveying the details may not be sufficient.

Peoples Acceptance It is no use trying to develop a technology which people will not accept e.g. due to religious reason/social concern etc. genetically modified food, irradiated vegetables processed beef in India, improved capsule made of non-vegetarian material.

LIST OF INSTITUTE IN INDIA ASSISSTING IN TECHNOLOGY TRANSFER

Asia pacific centre for Transfer of technology ( APCTT)

Technology Bureau for small enterprises ( TBSE) National Research & Development Corporation

Foundation for Innovation and Technology Transfer

Proposed Team Member and Their Responsibilities

focus for transfer activities collates documentation from donor site Process perform initial assessment of transferred project technologist for a) feasibility b) compatibility with site capabilities c) establishes resource requirements Representative Review documentation to determine compliance with Marketing authorization (MA) Review analytical methods with QC to determine capability, equipment training requirements. Initiate conversion of donor site documentation into local system/format Initiate or confirm regulatory requirement, e.g. change to manufacturing license , variations to MA if process changes needed, etc.
central

Production representative

11 May (with process Review process instructions2012 technologist) to confirm capacity/ capability Considers any safety implication e.g. solvents, toxic, sanitizing materials Consider impact on local standard operating procedures (SOPs) Consider training requirement of supervisors/ operator

Engineering representative

Review (with production representative) equipment requirement Initiate required engineering modification/ change/ part purchase. Review preventative maintenance/ calibration impact, e.g. use of more aggressive ingredients: more temperature sensitive process, and modifies accordingly.
16

FUNCTION OF TECHNOLOGY TRANSFER TEAM

1) Coordinate- Coordinating between technology users and developer, between researcher and manufacturers is important element of technology transfer.
2) Nurture- A main ingredient for moving technology from a research laboratory to a new business enterprises successfully in an environment that is supportive for entrepreneurship. 3) LINK- Cataloging resources related to business enterprises & connecting would be entrepreneurship / researcher and other technology developers to outside group & organization which can help in the process of starting new product, companies etc. such linkage provide referrals for individual business counseling, sources of financing.

FACTOR AFFECTING TECHNOLOGY TRANSFER

TIPS Method ( Technology implementation Potential for Success) Communication Factor TIPS Financial Factor TIPS External Factor TIPS

Human Factor TIPS

Corporate Factor TIPS

Technology Factor TIPS

TECNOLOGY TRANSFER CHECKLIST

Production master formula
Manufacturing instruction Dispensing instruction Analytical methods

Previous process validation Stability reports Exicipient specification and source Active specification and source

Primary packaging material specification and source

Packaging instruction
Customer complaints Process deviation file Analytical deviation file Reject /Rework file Specimen manufacturing batch record

Specimen Cartons, Labels, Leaflets

EXAMPLES OF TECHNOLOGY TRANSFER

# Chinese company offer technology for the production of L- Phenyl alanine by the enzyme method.

CHINA

L Phenyl alanine By enzyme method (Ref : APC 4041 TOF)

Area of Application
# Food industry

Advantage

11 May 2012

Low input Advanced process No environmental contamination Clear production

21

Stage of development
commercialized

Economic data
Total project cost 4 million Equipment 1.38million

Transfer form
Known how, consultancy, equipment, training

Target country
world wide

Language
English

A Novel, Non-infringing Process for the manufacture of levobupivacaine

NIPER, mohali offer a non-infringing process for the manufacturer of an improved widely used local anesthetic, levobupivacaine.
The process uses a chiral catalyst for asymmetric synthesis of the product.

Area of Application
Local anesthetic product widely used in hospital in surgical procedure.

Advantage of technology
Uses easily available raw material Faster compared to existing process as no resolution involved. Cheaper as use of expensive resolving agent is altogether eliminated Non-infringing new process Stage of Development Process at laboratory scale Scale up to be done Facilities for scale up exist at institute ( pilot plant available) Economic Data Product name Chirocane, ( approved clinically) No manufacturer in India till date Transfer form Technology licensing and Known how

PROBLEM IN TECHNOLOGY TRANSFER

India pushes for tech. transfer at Durban climate talks

India has proposed that the climate talks in Durban should be refocused onto technology transfer, equity and trade barriers. According to the Delhi-based nongovernmental organization Centre for Science and Environment, proposals were made at the UN Climate Change Conference in Cancun, Mexico, last year, to set up a technology executive committee and a climate technology centre and network. But the final agreement does not mention intellectual property rights, which means patented technologies cannot be accessed.

Manufacturer of Pharmaceutical Raw Materials, Pharmacopoeial Fine Chemicals, Active Nutraceuticals, Laboratory Reagents (Bulk) (LR /AR/ ACS/FCC)

Nutraceuticals
Pharmacopoeial Fine Chemicals EDTA Fine Chemicals

Phosphates Fine Chemicals

Azithromycin APIs Sorbic Acid & Potassium Sorbate Potassium Phthalimide Citrate Fine Chemicals

Inositol & Inositol Nicotinate

TECHNOLOGIES TRANSFER :
Bimal pharma PVT. Ltd. A team of technically highly qualified technocrats in the pharmaceutical field, having experience of manufacturing of API, intermediates, pharma fine chemicals and pharma formulations, for more than 25 years, they offer complete turn-key project services including detailed engineering, complete demonstration of manufacturing processes of all apis; intermediates for apis; pharma fine chemicals and pharma formulations.

They are also experts in supplying the best quality intermediates / penultimate stages, along with technologies to make final apis to suit your US FDA / WHO-GMP approved manufacturing units for different countries.

hank you