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Management of Adult SEAE Tumors

Adult supratentorial extraventricular anaplastic ependymomas (SEAE) are rare tumors. The literature review analyzed cases of SEAE in adults to determine treatment approaches and prognostic factors. Statistical analysis found that young age, incomplete tumor resection especially in eloquent areas, histological anaplasia, supratentorial location, and extraventricular location were associated with poorer outcomes. The conclusion is that complete surgical resection followed by adjuvant radiation therapy is the preferred approach for SEAE in adults, though the role of chemotherapy is unclear. Recurrent SEAE may be treated with reoperation if possible, radiation if not previously used, or salvage chemotherapy.

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Babu Ramakrishnan
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54 views1 page

Management of Adult SEAE Tumors

Adult supratentorial extraventricular anaplastic ependymomas (SEAE) are rare tumors. The literature review analyzed cases of SEAE in adults to determine treatment approaches and prognostic factors. Statistical analysis found that young age, incomplete tumor resection especially in eloquent areas, histological anaplasia, supratentorial location, and extraventricular location were associated with poorer outcomes. The conclusion is that complete surgical resection followed by adjuvant radiation therapy is the preferred approach for SEAE in adults, though the role of chemotherapy is unclear. Recurrent SEAE may be treated with reoperation if possible, radiation if not previously used, or salvage chemotherapy.

Uploaded by

Babu Ramakrishnan
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
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Adult Supratentorial Extraventricular Anaplastic Ependymoma :

Background : Supratentorial Extraventricular Anapalstic Ependymomas (SEAE)are rare tumors


in adult patients as evident from Pubmed Data. Maximal Safe resection and use of radiation
therapy are standard treatment approaches in patients with SEAE. However the role of
Chemotherapy is unclear.
Aim: To discuss on Management of Adult Supratentorial Extraventricular Anaplastic
Ependymoma with a Case Report of Recurrent Adult SEAE from our institute & Literature
Review.
Settings and Designs : Literature Review & Statistical Analysis of Pubmed Data was analysed for
Case Reports of adult intraaxial SEAE .
Materials and Methods : Statistical Analysis of the literature data with repect to Age, Tumor
and its Topographical distribution with presenting symptoms , Treatment , Follow up ,
Recurrence and Survival Period was done .The rare Case report of recurrent adult SEAE from
the institute also included to the data and was correlated.
Statistical Analysis :Literature Statistical Analysis considers the following as poor prognostic
factors: Young Age, Incomplete Tumor Resection-eloquent area location, Histological anaplasia,
Supratentorial, Extraventicular location. Therefore Complete Tumor Resection Should be
considered in all Cases of Adult SEAE.
Conclusion: SEAE in adults is rare. Controversy exits in its approach and management. Poor
prognostic factors have been earmarked in the literature and Clinical review of
literaturesuggests that Gross Total Resection is the preferred approach followed by adjuvant
treatment with radiotherapy. The role of Chemotherapy is unclear. Recurrent SEAE are treated
by reoperation when the tumors are surgically accessible, by radiotherapy if not previously
administered and by salvage Chemotherapy.
Surgery is the mainstay of therapy with adjuvant radiotherapy and /or Chemotherapy in adult
SEAE.

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