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Classification of Disintegrants
Generally, disintegrating agents are added before or after wet granulation and/or both in many
cases. When disintegrating agents come into contact with a fluid/water either they swell up or
wicking and then break down, thus facilitating dissolution.
Pr
obably, disintegrants acts by the following one or more mechanisms:
1. By Swelling
2. Due to heat of wetting
3. Capillary action (wicking)
4. Enzymatic reaction
5. Due to the release of gases
6. Combination action
7. Deformation
8. Electrostatic repulsion
9. Chemical reaction
Normally, Croscarmellose
sodium at concentrations up to
5% w/w may be used as a tablet
disintegrant. 2% w/w is used in
direct compressed tablets and
3% w/w in wet-granulation
processed tablets.
Reference
1. Rowe, R. C., Sheskey, P. J., Owen, S. C., & American Pharmacists Association. (2006).
Handbook of pharmaceutical excipients. London: Pharmaceutical Press.