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Stem Cells: Types and Applications

Embryonic stem cells come from embryos and are totipotent or pluripotent, making them flexible but also tumorigenic and requiring destruction of the embryo. Adult stem cells are found in adult tissue and are mostly multipotent, making them less flexible but also non-tumorigenic and raising fewer ethical issues. Stem cells can be used for regenerative medicine by replacing damaged cells and tissues, gene therapy by inserting genes to treat diseases, and therapeutic cloning to produce patient-matched cells.

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Rahul Mishra
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69 views14 pages

Stem Cells: Types and Applications

Embryonic stem cells come from embryos and are totipotent or pluripotent, making them flexible but also tumorigenic and requiring destruction of the embryo. Adult stem cells are found in adult tissue and are mostly multipotent, making them less flexible but also non-tumorigenic and raising fewer ethical issues. Stem cells can be used for regenerative medicine by replacing damaged cells and tissues, gene therapy by inserting genes to treat diseases, and therapeutic cloning to produce patient-matched cells.

Uploaded by

Rahul Mishra
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as PDF, TXT or read online on Scribd

STEM CELLS & THEIR APPLICATIONS

SOURCES OF STEM CELLS


Embryonic stem cells Adult stem cells
DIFFERENCES BETWEEN EMBRYONIC AND ADULT STEM CELLS
EMBRYONIC STEM CELLS ADULT STEM CELLS
SOURCE EMBRYO ADULT TISSUE
POTENCY TOTIPOTENT / PLURIPOTENT MOSTLY MULTIPOTENT
CELL CULTURE EASY CHALLENGING
FLEXIBLE LESS FLEXIBLE
IMMORTAL MORTAL WITH FINITE LIFE TIME
AVAILABLITY LIMITED QUANTITY
DIFFICULT TO DIFFERENTIATE INDUCEMENT IS SIMPLER
UNIFORMLY INTO TARGET TISSUE
IMMUNOGENIC NON IMMUNOGENIC
TUMORIGENIC NON TUMORIGENIC
ISOLATION LEADS TO DESTRUCTION OF RELATIVE EASE OF PROCUREMENT, LESS
EMBRYO, HIGH ETHICAL CONTROVERSY MORAL & LEGAL CONTROVERSY
APPLICATION OF STEM CELLS

Gene therapy
Therapeutic Regenerative
cloning medicine
THERAPEUTIC CLONING (Somatic Cell Nuclear Transfer)
REGENERATIVE MEDICINE
GENE THERAPY

• Gene therapy is insertion of genes into an individual’s cells and tissue to treat a
disease
• Mostly is being used to treat cancer, infectious diseases, heart diseases, arthritis,
Alzheimer's disease etc.
STRATEGIES FOR GENE THERAPY
QUESTIONS
1. What are stem cells and their properties?
2. How are stem cells classified on the basis of potency?
3. How are stem cells classified on the basis of sources ?
4. What is gene therapy? Explain the ex-vivo gene therapy.
5. How stem cells are used for therapeutic cloning?
6. What is regenerative medicine and how stem cells can be used in it?

DIAGRAMS
1. Therapeutic cloning
2. Gene Therapy

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