Professional Documents
Culture Documents
PROBENECID (GOUT)
MOA Increases renal excretion of uric acid by blocking its renal tubular
reabsorption.
Patient counselling -This medicine may be taken with food to reduce stomach upset.
–Do not take aspirin for pain relief as it will reduce the effect of probenecid.
-Make sure that you drink lots of fluids during treatment to prevent kidney
stones.
Drug-Food Interaction -
aspirin + probenecid
Drug-Drug Interaction Aspirin reduces uricosuric effect of probenecid; avoid aspirin and/or salicylates
during probenecid treatment; the use of low-dose aspirin (antiplatelet).
Dosage Forms To Be 250 mg twice daily for 1 week. Maintenance, 500 mg twice daily, increasing if
Used necessary every 4 weeks (by increments of 500 mg) up to 2 g daily in divided
doses.
When to see doctor -experienced painful/difficult urination, blood in urine or urine is cloudy/foamy.
ALLOPURINOL
Drug Class
Drug-Food Interaction
Do not take with other drugs such as; amoxicillin it may cause high risk in
rash
Drug-Drug Interaction
AZETHIOPRINE
Dosage Forms To Be
Used
When to see doctor If you have been developing severe rash, swollen lips/mouth, stop taking
allopurinol
COLCHICINE
Ulcer
GI Disease
Dosage 1mg ASAP then 500mcg 1hr later. Do not repeat the course
within 3 days wait after 12 hr. before resuming
How to take drug? When to take? Do not take more than 3 tablets (1.5 mg) in a course
to treat acute gout or repeat the course within
(Drug administration)
3 days. Take 1mg (2 Tabs) ASAP daily
Taken orally
Consulting Doctor/ Pharmacist if; Stop taking this medicine, and tell your doctor if you
develop severe diarrhea or vomiting; muscle pain,
tenderness or weakness; numbness or tingling in
your fingers or toes; unusual bleeding or bruising or
an infection.