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Mircera Algorithm

Algorithm for calculating mircera dosage changes.

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jozaia
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© © All Rights Reserved
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0% found this document useful (0 votes)
140 views12 pages

Mircera Algorithm

Algorithm for calculating mircera dosage changes.

Uploaded by

jozaia
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as PDF, TXT or read online on Scribd

Corporate MAB Recommended Anemia Algorithm

Mircera IVP Administration (InCenter Only) Version 4.2 (Pilot)


Patient Name: Algorithm Initiation Date:
MRN: ICD Code:

This algorithm is for patients 18 years of age or older.


Mircera is not indicated for the following patients:
• Pregnant, or
• Actively receiving treatment with chemotherapy.
Note: For patients with a history of cancer and NOT receiving chemotherapy the decision to use any ESA should be consistent with Prescribing
Information, which is identical for EPOGEN, Aranesp, and Mircera.

Background:
• Mircera is generally administered every two weeks or less frequently, and dosing is tied to the patient’s hemoglobin result. Mircera will be
administered to all patients on the same dialysis day of the week, which is based on the facility weekly lab draw schedule. (See Lab Draw/Dose
Administration Schedule.)
• Exception to this is the New Patient:
o If a first dose of Mircera is to be administered less than or equal to 3 days before the facility Lab Draw/Dose Administration Schedule,
wait to administer the dose per the Lab Draw/Dose Administration Schedule.
o If the first dose of Mircera is to be administered more than 3 days before the Lab Draw/Dose Administration Schedule, one dose of
Mircera may be given on another day of the week per algorithm, but subsequent doses of Mircera should be administered according to the
facility Lab Draw/Dose Administration Schedule.
▪ The patient’s subsequent dosing schedule will be based upon the patient’s order frequency and the Lab Draw/Dose
Administration Schedule.

o Note: At least 11 days must elapse since the patient’s last dose of Mircera.
At least 7 days must elapse since the patient’s last dose of Aranesp.

Page 1 of 12
CMAB Recommended Anemia Algorithm
Mircera® IVP Administration (InCenter Only) Version 4.2 (Pilot0
©2014 – 2023, Fresenius Medical Care, All Rights Reserved Rev: (6/23/14, 11/13/15, 2/22/16, 12/12/16, 9/07/17) 01/01/2023
Corporate MAB Recommended Anemia Algorithm
Mircera IVP Administration (InCenter Only) Version 4.2 (Pilot)

Patient Name:
MRN:

Lab Orders:
• Spectra Hemoglobin (Hgb) to be drawn weekly.
• Spectra Hgb value used in calculating new Mircera dose must not be older than 7 days.

IF: THEN:
New patient Draw Spectra Hgb first treatment and then follow weekly Hgb lab draw schedule.

Post-hospitalization patient Draw Spectra Hgb first treatment back to facility and then follow weekly Hgb lab draw schedule.

Hgb available from hospital or other Use only facility-drawn and Spectra-resulted Hgb values. Do not use local lab Hgb values (from hospital or other
source source) in calculating Mircera dose.
Latest Hgb result older than 7 days Draw Spectra Hgb and consult Physician/NP/PA.

When a Mircera dose change is indicated per algorithm, dose calculations and Mircera order will be entered into the electronic system and documented
appropriately in the patient’s medical record. The new Mircera dose will be administered when the next scheduled dose is due following the receipt of the
Spectra Hgb result per the Lab Draw/Dose Administration Schedule.
Lab Draw/Dose Administration Schedule

Facility Collects and Ships Spectra Receives, Processes and New Dose Entered in Electronic System Patient Receives New Every Two
Spectra Transmits Result to Knowledge Center No Later Than Day Indicated Below Week Dose
Labs
Monday Tuesday Thursday Friday
Tuesday Wednesday Friday Saturday
Wednesday Thursday Monday Wednesday
Thursday Friday Monday Tuesday

Page 2 of 12
CMAB Recommended Anemia Algorithm
Mircera® IVP Administration (InCenter Only) Version 4.2 (Pilot)
©2014 - 2023, Fresenius Medical Care, All Rights Reserved Rev: (6/23/14, 11/13/15, 2/22/16, 12/12/16, 9/07/17) 01/01/2023
Corporate MAB Recommended Anemia Algorithm
Mircera IVP Administration (InCenter Only) Version 4.2 (Pilot)

Patient Name:
MRN:

Patient New to Facility: Exception to the Lab Draw/Dose Administration Schedule:

Patient New to Dialysis: • If TSAT is less than 20% and Ferritin is greater than 1200 ng/mL, consult the Physician/NP/PA.
Iron Evaluation and Administration • Otherwise, if Hgb is less than 10.0 g/dL and either TSAT is less than 20% or Ferritin is less than 100 ng/mL,
▪ Do not start Mircera until the patient has received a 1 gram iron repletion sequence per signed iron
algorithm or Physician/NP/PA order.
▪ If during administration of the 1 gram iron sequence, Hgb values decrease by greater than 1.0 g/dL, consult
with Physician/NP/PA regarding earlier initiation of Mircera.
▪ Upon completion of the 1 gram iron sequence, recheck Spectra Hgb at next scheduled facility lab draw.
If Hgb is less than 10.0 g/dL, start Mircera according to Starting Dose Chart.
Note: If patient has been on Aranesp, administer Mircera no sooner than 7 days after last Aranesp
dose per the facility Lab Draw/Dose Administration schedule.

Patient New to Dialysis – Starting When either TSAT is 20% or greater and Ferritin is 100 ng/mL or greater,
Dose or
Patient has received a 1 gram iron sequence:

1. If Hgb is less than 10.0 g/dL: Administer Mircera per Starting Dose Chart.
2. If Hgb 10.0 g/dL or greater: Do not begin administration of Mircera. Start Mircera when Hgb
is less than 10.0 g/dL per Starting Dose Chart.

Page 3 of 12
CMAB Recommended Anemia Algorithm
Mircera® IVP Administration (InCenter Only) Version 4.2 (Pilot)
©2014 - 2023, Fresenius Medical Care, All Rights Reserved Rev: (6/23/14, 11/13/15, 2/22/16, 12/12/16, 9/07/17) 01/01/2023
Corporate MAB Recommended Anemia Algorithm
Mircera IVP Administration (InCenter Only) Version 4.2 (Pilot)

Patient Name:
MRN:

Exception to the Lab Draw/Dose Administration Schedule (cont.):

Patient New to Facility (Transfer from • Draw Spectra Hgb on patient’s first treatment.
another facility). • Obtain the Spectra Hgb result.
• Obtain previous ESA dose and last date of administration from transferring facility.

IF: THEN:
Patient not on any ESA at time of transfer Obtain Physician/NP/PA order for Mircera.
Previous ESA dose or last date of Obtain Physician/NP/PA order for Mircera.
administration is not available
Patient on subcutaneous Mircera Administer Mircera dose IVP according to the
Mircera Maintenance Dose Chart.
Patient on Aranesp Administer IVP Mircera dose according to the Aranesp to
Mircera Conversion Dose Chart.
Patient on EPOGEN Administer IVP Mircera dose according to the EPOGEN to
Mircera Conversion Dose Chart.
Note: At least 11 days must elapse since the patient’s last dose of Mircera 
At least 7 days must elapse since the patient’s last dose of Aranesp 

Missed Dose for less than or equal to If a dose of Mircera is not administered on the scheduled dosing day, administer the missed dose within
7 days (not due to hospitalization) 3 days.
▪ If unable to administer Mircera within the 3 days, then administer Mircera at the next dosing day per
the Lab Draw/Dose Administration schedule.
o Revise the patient’s active Mircera order per the dosing schedule based upon the patient’s:
▪ Current Spectra Hgb result within 7 days and
▪ Mircera order frequency.

Note: Mircera dose changes will be made every 28 days, using Maintenance Dose Chart unless patient meets
exception criteria (see Exceptions to Monthly Dose Changes).

Page 4 of 12
CMAB Recommended Anemia Algorithm
Mircera® IVP Administration (InCenter Only) Version 4.2 (Pilot)
©2014 - 2023, Fresenius Medical Care, All Rights Reserved Rev: (6/23/14, 11/13/15, 2/22/16, 12/12/16, 9/07/17) 01/01/2023
Corporate MAB Recommended Anemia Algorithm
Mircera IVP Administration (InCenter Only) Version 4.2 (Pilot)

Patient Name:
MRN:
General Orders:

Weight to Determine Starting Use patient’s post weight to determine starting dose. If post weight is unavailable, use patient’s estimated dry weight.
Dose Note: Round patient’s weight to nearest kg, up or down (i.e., 74.4 kg is rounded to 74 kg; 74.5 kg is rounded to 75 kg).
Prior to Calculating Mircera Review last available Spectra Hgb result prior to calculating Mircera  dose.
Dose
Route of Administration All Mircera doses will be administered IVP.
Dosing Frequency Mircera is administered every two weeks unless otherwise noted in the Maintenance Dose Chart.
Frequency of Dose Change Mircera dose changes will be made every 28 days using Maintenance Dose Chart unless patient meets exception criteria
(see Exceptions to Monthly Dose Changes).

• If the correct prefilled syringes per the Prefilled Syringe Selection Chart are not available for the ordered Mircera
Missed Dose Due to Mircera 
dose, delay the administration until the next scheduled dialysis treatment when the correct prefilled Mircera
Prefilled Syringe Availability syringes are available.

• If the correct Mircera syringes are not available and dose is delayed for more than 1 week, contact
Physician/NP/PA for order.
• Continue to follow the facility Lab Draw/Dose Administration schedule.
Minimum Dose Per Treatment The minimum dose of Mircera is 30 mcg. If the calculated dose is less than 30 mcg/every 2 weeks, follow the
Maintenance Dose Chart to change frequency.
Minimum Days Between ESA • At least 11 days must elapse since the patient’s last dose of Mircera.
Doses • At least 7 days must elapse since the patient’s last dose of Aranesp.
Mircera® on Hold and No Open If Mircera® is on hold and there is no open Mircera® order in the last 3 months, when the Hgb is less than or equal to
Mircera® Order in Last 3 Months 11.1 g/dL contact the Physician/NP/PA to obtain a re-start dose.
Copies of the Algorithm in Following the physician/NP/PA ordering the algorithm, a copy of the algorithm will automatically be uploaded into
Patient’s Medical Record the electronic medical record unless a copy of the standing order is required to be placed in the chart by State Board of
Pharmacy or local regulations

Page 5 of 12
CMAB Recommended Anemia Algorithm
Mircera® IVP Administration (InCenter Only) Version 4.2 (Pilot)
©2014 - 2023, Fresenius Medical Care, All Rights Reserved Rev: (6/23/14, 11/13/15, 2/22/16, 12/12/16, 9/07/17) 01/01/2023
Corporate MAB Recommended Anemia Algorithm
Mircera IVP Administration (InCenter Only) Version 4.2 (Pilot)

Patient Name:
MRN:

General Orders (cont.):

Converting Patients to Mircera In patients previously receiving EPOGEN:


 
• Administer final EPOGEN dose on treatment prior to first Mircera dose (based upon facility Lab Draw/Dose
Administration Schedule).
▪ Discontinue EPOGEN order in clinical system using the following day’s date.
  
• Administer Mircera dose according to the EPOGEN to Mircera Conversion Dose Chart. Note: Generally,
Mircera should be administered no more than 3 days following the last dose of EPOGEN

▪ If delaying the Mircera Administration, contact the Physician/NP/PA for orders.



• Follow patient’s weekly lab draw schedule and administer Mircera per the Lab Draw/Dose Administration
Schedule.

In patients previously receiving Aranesp:


• Administer final Aranesp® dose one week prior to first Mircera® dose (based upon facility Lab Draw/Dose
Administration Schedule).
▪ Discontinue Aranesp order in clinical system using the following day’s date.
• Administer Mircera dose according to the Mircera to Aranesp Conversion Dose Chart. Note: Generally,
Mircera should be administered no more than 7 days following the last dose of Aranesp.
▪ If delaying the Mircera Administration, contact the Physician/NP/PA for orders.
• Follow patient’s weekly lab draw schedule and administer Mircera® per the Lab Draw/Dose Administration
Schedule.
Every 2 Week Dosing Frequency: • Do not make a Mircera® dose change based on a Spectra Hgb result obtained in a non-dosing week.
Spectra Hgb result between dosing
weeks for patient with every two week
dosing frequency
Extended Dosing Frequency: • Consult the Physician/NP/PA for the following during a non-dosing week if there has been a minimum of 14 days
Spectra Hgb results between dosing since the last dose change and:
weeks for patients on every 4 week ▪ Hgb is less than 8.0 g/dL, or
dosing frequency
▪ Hgb decreases by more than 1.0 g/dL over past 2 weeks and Mircera® dose is not currently on hold, or
▪ Hgb is less than 10.5 g/dL and decreasing over the past two weeks.

Page 6 of 12
CMAB Recommended Anemia Algorithm
Mircera® IVP Administration (InCenter Only) Version 4.2 (Pilot)
©2014 - 2023, Fresenius Medical Care, All Rights Reserved Rev: (6/23/14, 11/13/15, 2/22/16, 12/12/16, 9/07/17) 01/01/2023
Corporate MAB Recommended Anemia Algorithm
Mircera IVP Administration (InCenter Only) Version 4.2 (Pilot)

Patient Name:
MRN:

General Orders (cont.):

Identification of Lowest Effective Dose: • Discuss with the Physician initiation of the CMAB Recommended Hyporesponse Evaluation Algorithm.
Patients at maximum Mircera dose of • Patients on the maximum Mircera dose for 3 consecutive months with: (1) a TSAT of equal to or greater than
225 mcg every two weeks for 3 30% and (2) a Ferritin greater than 200 ng/mL and (3) a Hgb greater than or equal to 10.0 g/dL and (4) not
consecutive months requiring a blood transfusion:
a. Continue to follow Physician ordered iron algorithm.

b. Decrease Mircera using Column 3 of Maintenance Dose Chart.
c. Every month thereafter, reduce the dose using Column 3 of Maintenance Dose Chart until the Hgb falls
below 10.0 g/dL, and then increase the dose to the previous prescribed Mircera dose.

• Patients on the maximum Mircera dose for 3 consecutive months with: (1) a TSAT of equal to or greater than
30% and (2) a Ferritin greater than 200 ng/mL and (3) a Hgb less than 10.0 g/dL and (4) not requiring a blood
transfusion:
a. Continue to follow Physician ordered iron algorithm.

b. Decrease Mircera using Column 3 of Maintenance Dose Chart.
c. Every month thereafter, reduce the dose using Column 3 of Maintenance Dose Chart until the Hgb drops by
0.5 g/dL or greater, and then increase the dose to the previous prescribed Mircera dose.
Changing From Every 2 Week to Every When dosing is changed from every two weeks to every 4 weeks, administer the next dose 3 weeks following the last
4 Week Dosing 2 week dose per the Lab Draw/Dose Administration Schedule.
Missed Hgb Draw and Missed Mircera® If latest Hgb result is older than 7 days, obtain Spectra resulted Hgb and consult physician regarding Mircera® dosing.
Dose Due to Patient Missing Treatments
Physician/NP/PA order apart from Follow the algorithm subsequent to that dose change unless otherwise directed.
algorithm
Consult with Physician/NP/PA Nurse to consult with Physician/NP/PA when nurse believes that, based on assessment of the patient’s condition, it
may not be appropriate to follow the algorithm.
Maximum Dose Rules If the ordered dose of Mircera® is greater than 225 mcg, submit a request to the Pharmacy and Therapeutics
(P and T) Committee.

Page 7 of 12
CMAB Recommended Anemia Algorithm
Mircera® IVP Administration (InCenter Only) Version 4.2 (Pilot)
©2014 - 2023, Fresenius Medical Care, All Rights Reserved Rev: (6/23/14, 11/13/15, 2/22/16, 12/12/16, 9/07/17) 01/01/2023
Corporate MAB Recommended Anemia Algorithm
Mircera IVP Administration (InCenter Only) Version 4.2 (Pilot)

Patient Name:
MRN:

Exceptions to Monthly Dose Changes:


Exception Criteria Minimum Day Action
Since Last Dose
Change
Hgb is greater than 14 ▪ Dosing week: Hold Mircera dose and re-evaluate with weekly Spectra Hgb checks.
11.2 g/dL ▪ Do not make Mircera Dose changes based on a Hgb result obtained in a non-dosing week.
▪ Restart Mircera when Spectra Hgb is less than or equal to 11.1 g/dL at a decreased dose using Column 3
in the Maintenance Dose Chart.
▪ The patient’s dosing schedule will be reset following the administered dose based upon the patient’s order
frequency and the Lab Draw/Dose Administration Schedule.
Hgb is less than 8.0 g/dL 1 ▪ Contact Physician/NP/PA for order.
Resume from Hold: Hgb 1 ▪ Restart Mircera when Spectra Hgb is less than or equal to 11.1 g/dL at a decreased dose using Column 3
less than or equal to in the Maintenance Dose Chart, based on the patient’s previous Mircera dose.
11.1 g/dL on Held Doses ▪ The patient’s dosing schedule will be reset following the administered dose based upon the patient’s order
frequency and the Lab Draw/Dose Administration schedule.
Hospitalization of any 1 If a patient is hospitalized for any period of time or has an absence of more than 7 days:
period of time or misses a ▪ Fill out the Absence and Hospitalization Assessment.
Mircera dose for more than ▪ Discontinue Mircera dose.
7 days ▪ If patient is admitted to the hospital, inform the Acute Dialysis Care Team and the Hospital Attending
Nephrologist of the current Mircera dose and date of last administration.
▪ Following return from hospitalization or absence complete the Absence and Hospitalization
Assessment.
▪ Draw and obtain Spectra Hgb result.
▪ Select the dose using the Maintenance Dose Chart and administer the dose following the Lab Draw/Dose
Administration schedule.
▪ Note: At least 11 days must elapse since your last dose of Mircera.
At least 7 day must elapse since your last dose of Aranesp.
▪ The patient’s dosing schedule will be reset based upon the patient’s order frequency and the Lab
Draw/Dose Administration Schedule.
▪ Obtain weekly labs according to the Lab Draw Schedule and continue to follow the facility Lab Draw/Dose
Administration Schedule.
Page 8 of 12
CMAB Recommended Anemia Algorithm
Mircera® IVP Administration (InCenter Only) Version 4.2 (Pilot)
©2014 - 2023, Fresenius Medical Care, All Rights Reserved Rev: (6/23/14, 11/13/15, 2/22/16, 12/12/16, 9/07/17) 01/01/2023
Corporate MAB Recommended Anemia Algorithm
Mircera IVP Administration (InCenter Only) Version 4.2 (Pilot)

Patient Name:
MRN:

Exceptions to Monthly Dose Changes: (cont.)

Exception Criteria Minimum Day Action


Since Last
Dose Change
Rapid Hgb Rise: Hgb is 14 Decrease dose by using Column 3 of Maintenance Dose Chart.
9.5 to 11.2 g/dL and
increases by more than
1.0 g/dL over past two
weeks

Rapid Hgb Fall: Hgb 14 Increase dose using Column 1 of the Maintenance Dose Chart. (Applicable only to patients receiving
decreases by more than Mircera, not patients on hold.)
1.0 g/dL over past 2 weeks
and Mircera dose is not
currently on hold

Hgb is less than 10.5 g/dL 14 Increase dose using Column 1 of Maintenance Dose Chart.
and decreasing by greater
than 0.5 g/dL over the past
two weeks

Page 9 of 12
CMAB Recommended Anemia Algorithm
Mircera® IVP Administration (InCenter Only) Version 4.2 (Pilot)
©2014 - 2023, Fresenius Medical Care, All Rights Reserved Rev: (6/23/14, 11/13/15, 2/22/16, 12/12/16, 9/07/17) 01/01/2023
Corporate MAB Recommended Anemia Algorithm
Mircera IVP Administration (InCenter Only) Version 4.2 (Pilot)

Patient Name:
MRN:
Maintenance Dose Chart

Mircera® Maintenance Dose Chart


Column 1 - Column 2 - Column 3 - Column 4 -
Increase Dose Maintain Dose Decrease Dose Hold Dose
Hgb 8.0 - 10.0 Hgb 10.6 - 11.2
or Rapid Fall or Hgb or Rapid Hgb Rise or Hgb greater than
Hgb 10.1 - 10.5
less than 10.5 and Resume from hold using last 11.2
decreasing Mircera® dose
Current Dose Current Dose Frequency Dose Frequency Dose Frequency Dose Frequency
(mcg) Frequency (mcg) (mcg) (mcg) (mcg)
30 Every 4 weeks 50 Every 4 weeks 30 Every 4 weeks Contact physician Hold
50 Every 4 weeks 30 Every 2 weeks 50 Every 4 weeks 30 Every 4 weeks Hold
30 Every 2 weeks 75 Every 4 weeks 30 Every 2 weeks 50 Every 4 weeks Hold
75 Every 4 weeks 50 Every 2 weeks 75 Every 4 weeks 30 Every 2 weeks Hold
50 Every 2 weeks 120 Every 4 weeks 50 Every 2 weeks 75 Every 4 weeks Hold
120 Every 4 weeks 75 Every 2 weeks 120 Every 4 weeks 50 Every 2 weeks Hold
75 Every 2 weeks 100 Every 2 weeks 75 Every 2 weeks 120 Every 4 weeks Hold
100 Every 2 weeks 150 Every 2 weeks 100 Every 2 weeks 75 Every 2 weeks Hold
150 Every 2 weeks 200 Every 2 weeks 150 Every 2 weeks 100 Every 2 weeks Hold
200 Every 2 weeks 225 Every 2 weeks 200 Every 2 weeks 150 Every 2 weeks Hold
225 Every 2 weeks 225 Every 2 weeks 225 Every 2 weeks 200 Every 2 weeks Hold

Page 10 of 12
CMAB Recommended Anemia Algorithm
Mircera® IVP Administration (InCenter Only) Version 4.2 (Pilot)
©2014 - 2023, Fresenius Medical Care, All Rights Reserved Rev: (6/23/14, 11/13/15, 2/22/16, 12/12/16, 9/07/17) 01/01/2023
Corporate MAB Recommended Anemia Algorithm
Mircera IVP Administration (InCenter Only) Version 4.2 (Pilot)

Patient Name:
MRN:
Starting Dose Chart

Mircera® Starting Dose Chart


Rounded Dose Frequency
Weight
(kg) (mcg)
< 50 50 Every 4 weeks
50 - 62 30 Every 2 weeks
63 - 84 75 Every 4 weeks
85 - 99 50 Every 2 weeks
100 - 125 120 Every 4 weeks
> 125 75 Every 2 weeks

EPOGEN® to Mircera® Conversion Dose Chart

Mircera® Conversion Dose Chart


Epogen® Dose (U) Epogen® Dose (U) Epogen® Dose (U) Mircera® Dose
3 x Week 2 x Week 1 x Week Dose (mcg) Frequency
< 667 < 1,000 < 2,000 30 Every 4 weeks
667 - < 1,000 1,000 - < 1,500 2,000 - < 3,000 50 Every 4 weeks
1,000 - < 1,667 1,500 - < 2,500 3,000 - < 5,000 30 Every 2 weeks
1,667 - < 2,667 2,500 - < 4,000 5,000 - < 8,000 50 Every 2 weeks
2,667 - < 3,667 4,000 - < 6,500 8,000 - < 11,000 120 Every 4 weeks
3,667 - < 6,000 6,500 - < 9,000 11,000 - < 18,000 75 Every 2 weeks
6,000 - < 9,000 9,000 - < 13,500 18,000 - < 27,000 100 Every 2 weeks
9,000 - < 14,000 13,500 - < 21,000 27,000 - < 42,000 150 Every 2 weeks
14,000 - < 19,000 21,000 - < 28,500 42,000 - < 57,000 200 Every 2 weeks
>= 19,000 >= 28,500 >= 57,000 225 Every 2 weeks

Page 11 of 12
CMAB Recommended Anemia Algorithm
Mircera® IVP Administration (InCenter Only) Version 4.2 (Pilot)
©2014 - 2023, Fresenius Medical Care, All Rights Reserved Rev: (6/23/14, 11/13/15, 2/22/16, 12/12/16, 9/07/17) 01/01/2023
Corporate MAB Recommended Anemia Algorithm
Mircera IVP Administration (InCenter Only) Version 4.2 (Pilot)

Patient Name:
MRN:
Aranesp® to Mircera® Conversion Dose Chart

Mircera® Conversion Dose Chart


Aranesp® Dose Aranesp® Dose Aranesp® Dose
(mcg) (mcg) (mcg) Mircera® Dose
Dose
1 x Week Every 2 Weeks 1 x Month (mcg) Frequency
< 10 < 20 < 40 50 Every 4 weeks
10 - < 20 20 - < 40 40 - < 80 30 Every 2 weeks
20 - < 40 40 - < 80 80 - < 160 120 Every 4 weeks
40 - < 50 80 - < 100 160 - < 200 75 Every 2 weeks
50 - < 60 100 - < 120 200 - < 240 100 Every 2 weeks
60 - < 120 120 - < 240 240 - < 480 150 Every 2 weeks
>= 120 >= 240 >= 480 225 Every 2 weeks

Physician Signature ______________________________________________ Date _______________

RN Signature ___________________________________________________ Date _______________

Page 12 of 12
CMAB Recommended Anemia Algorithm
Mircera® IVP Administration (InCenter Only) Version 4.2 (Pilot)
©2014 - 2023, Fresenius Medical Care, All Rights Reserved Rev: (6/23/14, 11/13/15, 2/22/16, 12/12/16, 9/07/17) 01/01/2023

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