Evaluating Exposure Therapy for Dissociation
Evaluating Exposure Therapy for Dissociation
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What is This?
Behavior Modification
and Derealization
Abstract
Dissociative symptoms including depersonalization and derealization are
commonly experienced by individuals suffering from panic disorder or post-
traumatic stress disorder (PTSD). Few studies have been published investi-
gating the specific treatment of these symptoms in individuals diagnosed with
panic disorder or PTSD, despite evidence that the subset of individuals with
panic disorder who experience depersonalization and derealization report
more panic attacks as well as greater panic severity and functional impair-
ment. Furthermore, it has been shown that these symptoms can impede
treatment and recovery in PTSD. Finally, recent research has shown that
interoceptive exposure generally enhances the efficacy of treatment out-
come for PTSD and PTSD with comorbid panic. This study investigated the
use of a novel interoceptive exposure technique for treatment of deperson-
alization and derealization in individuals with high anxiety sensitivity and/or
symptoms of PTSD. Results indicated significant reductions on six of seven
items as well as total score on an outcome measure of depersonalization and
derealization.Thus, this technique appears to hold promise for utilization as a
form of interoceptive exposure in the treatment of these symptoms.
Keywords
depersonalization, derealization, PTSD, panic, anxiety sensitivity
1
Fordham University, Bronx, NY, USA
Corresponding Author:
Dean McKay, Department of Psychology, Fordham University, 441 East Fordham Road,
Bronx, NY 10458, USA
Email: mckay@fordham.edu
injuries (Shalev, Peri, Canetti, & Schreiber, 1996), victims of violent assault
(Birmes et al., 2001), and survivors of natural disasters (Koopman, Classen,
& Spiegel, 1994; Weiss, Marmar, Metzer, & Ronfeldt, 1995).
A common feature of panic and PTSD is elevated anxiety sensitivity (Berenz,
Vujanovic, Coffey, & Zvolensky, 2012; Zvielli & Amit Berenz, 2012) as well as
depersonalization. Although it was noted above that panic with prominent
depersonalization have poorer treatment prognosis, this symptom in PTSD may
be considered associated with faulty processing of the traumatic event, inter-
fering with the encoding and immediate processing of traumatic memories
(Briere et al., 2005; Bryant, 2007; Marmar et al., 1994). This may account for
the relationship between peritraumatic dissociation and poorer long-term func-
tioning (Bremner & Brett, 1997; Bremner et al., 1992). Specifically, as the trau-
matic event is later not available to ordinary conscious representation, this can
distort subsequent perceptions and behaviors and lead to easy triggering of the
reexperiencing and hyperarousal symptoms of PTSD.
Accordingly, it is reasonable to expect that ongoing depersonalization
would have a larger effect on PTSD by obstructing such processing over an
extended period of time (Briere et al., 2005). Such persistent depersonaliza-
tion may have the additional effect of impeding recovery. According to infor-
mation processing models of PTSD, fear structures containing mental
representations of a traumatic experience develop following such an event;
these structures must then be activated to begin the process of modifying
them and recovering from the trauma (Foa & Kozak, 1986). Thus, persistent
depersonalization can impede activation of the fear structure and preclude the
resolution of traumatic memories necessary for recovery (Foa & Hearst-
Ikeda, 1996).
Studies that have considered persistent depersonalization have supported
the assertion that it could have a greater impact on the development and
maintenance of PTSD than peritraumatic dissociation. Persistent dissociation
was more strongly associated with PTSD than peritraumatic dissociation
among survivors of motor vehicle accidents (Murray, Ehlers, & Mayou,
2002) and community participants with a history of traumatic exposure
(Briere et al., 2005). In addition, Panasetis and Bryant (2003) found that
acute stress disorder was more strongly associated with persistent dissocia-
tion than peritraumatic dissociation.
Despite these indications that depersonalization and derealization are asso-
ciated with poorer prognosis in panic disorder, and of the importance of per-
sistent dissociative symptoms in the etiology and maintenance of PTSD,
virtually no empirical studies have been published to date investigating the
treatment of these symptoms in the context of panic disorder and PTSD. It has
generally been assumed that if the disorders are successfully treated, the
depersonalization symptoms will remit as an indirect result of therapy. Thus,
for example, it is expected that exposure therapy for PTSD will lead to the
integration of traumatic memories, allowing for the previously obstructed pro-
cessing to occur—and consequently, for the repair of any dissociative symp-
tomatology (Chu, 2007; Foa & Hearst-Ikeda, 1996; Kreidler, Zupancic, Bell,
& Longo, 2000). The same type of assumption is likely often used by clini-
cians who treat panic disorder without specifically targeting depersonalization
and derealization. No empirical findings have been published to support these
assumptions, though. However, recent investigations with samples of indi-
viduals with PTSD with or without comorbid panic have shown improved
efficacy when trauma-focused exposure therapy was preceded by interocep-
tive exposure (Wald & Taylor, 2008). Among the interoceptive exercises eval-
uated in this trial were shaking the head from side to side for 30 s, quickly
lifting the head after holding it between the knees, spinning, hyperventilation,
and staring at a visual grid. The use of strategies such as these have been found
efficacious in treating an individual with combat-related PTSD (Wald &
Taylor, 2010) and motor vehicle accident PTSD (Wald, Taylor, Chiri, & Sica,
2010). As noted above, clinical observations also indicate persistent deperson-
alization may impede recovery, as exposure therapy for PTSD would be inef-
fective for those who dissociate during imaginal reliving of traumatic
experiences (Foa & Hearst-Ikeda, 1996). For such individuals, depersonaliza-
tion symptoms certainly require direct treatment.
One of the challenges of developing effective treatment methods for
depersonalization and derealization is the difficulty of eliciting, maintaining,
and managing these unique perceptual experiences through interoceptive
exposure. Several procedures intended to induce these symptoms have been
studied in individuals with panic disorder, with staring at a dot on the wall,
staring at a mirror, and staring at a light immediately followed by reading all
found to induce increases above baseline (Antony, Ledley, Liss, & Swinson,
2006; Miller, Brown, DiNardo, & Barlow, 1994). In addition, a follow-up
study found that hyperventilating (whether for 1 or 5 min) standing in front
of a strobe light in a dark room and staring at a wall (i.e., with the strobe light
behind the subject), hyperventilating while standing in front of a strobe light
in a dark room and staring at a wall, and hyperventilating while staring at a
moving spiral on a computer screen elicited significantly greater depersonali-
zation and derealization than staring at a dot on the wall or staring at a mirror
(Lickel, Nelson, Hayes, & Deacon, 2008). No such studies have been pub-
lished with individuals with PTSD.
Additional Measures
Two measures were used to assess dissociation. The Dissociative Experiences
Scale–II (DES-II; Carlson & Putnam, 1993) is a brief self-report questionnaire
designed to identify patients with dissociative psychopathology and to provide
a means of quantifying dissociative experiences. The scale assesses a broad
range of dissociative experiences, including disturbances in memory, identity,
and cognition, and feelings of derealization, depersonalization, absorption, and
imaginative involvement. Items are endorsed along an 11-point Likert-type
scale, and total scores are obtained by averaging the 28-item scores. The
original DES had excellent reliability and validity. The DES-II has been shown
to have excellent convergent validity with the original DES (r = .96), and
therefore the DES-II may be considered psychometrically sound, as well
(Ellason, Ross, Mayran, & Sainton, 1994).
The Degree of Depersonalization and Derealization Scale (DDDS) is a
visual analog scale developed specifically for this study. Items were adapted
from the Peritraumatic Dissociative Experiences Questionnaire (PDEQ;
Marmar, Weiss, & Metzler, 1997), with only those items indicating deperson-
alization or derealization retained. The DDDS asks participants to rate their
experiences during specific tasks by making a slash mark on a 100-mm,
numerically anchored line, with responses ranging from 0% to 100%. Slash
marks were then converted to a numerical score by measuring the distance of
Baseline DDDS
3 minutes: Strobe light only
3 minutes: Strobe light and 3D glasses
2 minutes: rest, DDDS #2
3 minutes: Strobe light and 3D glasses
2 minutes: rest, DDDS #3
3 minutes: Strobe light and 3D glasses
2 minutes: rest, DDDS #4
2 minutes: Brief relaxation exercise
the mark in millimeters from the left end of the line. This measure was only
administered to participants who returned to the lab for the experimental
phase of the study, and was not part of the screening battery.
Procedure
Participants in the screening sample who scored in the upper quartile of the
screening sample on the ASI-3 (i.e., scores greater than 23), the PCL-C (i.e.,
scores greater than 39), or both were contacted and offered vouchers for free
movie tickets in exchange for returning to participate in a follow-up experi-
mental phase of the study that would include three 20-min sessions, once per
week for 3 weeks. The informed consent for this phase of the study was
characterized as an intervention related to the treatment of different percep-
tual disturbances associated with different anxious states. A total of 39 par-
ticipants comprised the sample that completed the experimental phase of the
study, including 10 with only elevated ASI-3 scores, 15 with only elevated
PCL-C scores, and 14 with elevated scores on both measures.
Upon return, participants were informed that they would be asked to par-
ticipate in a 20-min task, during which they would be given a questionnaire
several times regarding certain mild unusual perceptual experiences sensa-
tions that they might experience. Participants were assured that all answers
would remain confidential, and written consent was obtained from each par-
ticipant before participation in the experimental phase.
The procedure in each exposure session is outlined in Figure 1. In total, the
DDDS was completed four times in each of the three exposure sessions,
including one baseline DDDS prior to the initiation of exposure and three
Results
To evaluate the relevance of depersonalization experiences to individuals
with elevated anxiety sensitivity, evaluated with the ASI-3, or posttraumatic
experiences, evaluated with the PCL-C, correlations were examined for
these scales with the DDDS at each time point. This analysis showed that
all correlations were significant (rs ranged from .37 to .54, all ps < .05).
This suggests that symptoms of either posttraumatic experiences or anxiety
sensitivity are significantly associated with dissociative experiences pro-
voked in the lab.
To consider changes in levels of depersonalization and derealization, peak
within-session amplitude was calculated for DDDS total scores. The results
are depicted in Figure 2. Repeated measures ANOVA were then conducted to
compare within-session peak amplitude across the three sessions. There were
significant decreases in DDDS total scores across the three exposure ses-
sions, F(2, 37) = 31.41, p < .001, partial η2 = .452. In addition, pairwise
comparisons indicated that the mean decrease in DDDS total score from
Session 1 to Session 2 (M = −8.17, SE = 1.53, p < .001) and from Session 2
to Session 3 (M = −2.77, SE = 1.132, p < .05) were significant.
Peak within-session amplitude was then calculated for each DDDS item,
and repeated measures ANOVA were again conducted to compare within-
session peak amplitude across the three sessions. The results are depicted in
Figure 3 and Table 1. Significant decreases were found for each DDDS item
across the three exposure sessions, F(2, 37) = 6.19 to 37.18, ps < .005, partial
η2 = .140 to .495, with the exception of the final item, “I felt like a spectator
watching what was happening to me,” which was nonsignificant.
As the exposure sample consisted of three subgroups—individuals with
only elevated ASI-3 scores, only elevated PCL-C scores, or elevated scores on
both measures—ANOVA was conducted to compare change in DDDS scores
between the three groups. No significant differences were found between the
groups in change on DDDS total score, F(2, 37) = .732, p = .488, partial η2 =
.039, or change on any of the seven-item scores, F(2, 37) = .15 to .86, ps = .43
to .86, partial η2 = .008 to .046.
Finally, paired samples t tests were conducted to assess changes on the pre
and post ASI-3, PCL-C, and DES-II. There was a significant decrease in
ASI-3 scores, t(38) = 2.418, p < .05, but there were no significant changes in
PCL-C or DES-II scores.
Discussion
In the present study, staring at a strobe light while wearing 3D glasses over
three 20-min interoceptive exposure sessions was found to lead to significant
decreases in depersonalization and derealization. This analog investigation is
the first, as far as we are aware, of any sustained multisession standard inter-
vention for depersonalization. The results suggest, preliminarily, that deper-
sonalization-oriented interoceptive exposure procedures may alleviate these
symptoms either as a stand-alone intervention or as part of a larger program
directed at alleviating anxiety symptoms associated with this specific percep-
tual disturbance.
On one particular item—“I felt like a spectator watching what was happening
to me”—a significant difference was not found. In considering differences
between the individual items that make up the DDDS, it is noteworthy that par-
ticipants reported higher levels of the items representing derealization (i.e., “I
felt spaced out,” “Things felt in slow motion,” and “I felt I was in a dream state”)
than the remaining items. Thus, it is possible that the exposure exercise used in
(Wald & Taylor, 2010), motor vehicle accidents (Wald et al., 2010), and in a
group examination of individuals with PTSD, as well as PTSD with comor-
bid panic disorder (Wald & Taylor, 2008).
There are a few limitations worth noting. First, the fact that this study used
an undergraduate sample limits the generalizability of the findings. Second,
as self-report measures were used in the screening sample, no formal diagno-
ses could be determined. Therefore, it is not possible to draw any conclusions
regarding the impact of this interoceptive exposure technique in a clinical
sample. Last, the small size of the subgroups that comprised the exposure
sample (i.e., those with elevated scores on the ASI-3, the PCL-C, or both)
limits statistical power for the group differences considered.
With regard to future directions, it would be important to investigate
whether the effects of this exposure task carry over and impact symptomatol-
ogy outside the laboratory. In addition, the effectiveness of this task in
decreasing other dissociative symptoms was not considered. This question is
particularly important in light of the debate discussed in the introduction to
this article regarding whether dissociation is a unified or multifaceted con-
struct. Finally, it would be interesting to consider the possible impact of this
task on other symptoms of panic disorder or PTSD. Pre and post ASI-3 scores
in this study showed a significant decrease in anxiety sensitivity; in addition,
a preliminary investigation by McKay and Moretz (2008) reported that this
technique led to decreases in panic symptoms. Thus, it appears that this inter-
vention may have broader effects than its impact on depersonalization and
derealization.
Authors’ Note
Portions of these data were presented at the annual meeting of the Association for
Behavioral and Cognitive Therapies, November 2011, Toronto, Ontario, Canada.
Funding
The author(s) received no financial support for the research, authorship, and/or pub-
lication of this article.
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Bios
Elliot Weiner, PhD, completed his doctorate at Fordham University. His research
interests are in cognitive behavioral models of the conceptualization and treatment of
trauma. He is presently completing a postdoctoral fellowship at the Honolulu
Veteran’s Affairs.