Human Biochemistry (HDD 10803)
Tutorial 3
Pathways revision exercise
Carbohydrate metabolisms
1. Three regulatory enzymes for glycolysis are hexokinase phosphofuctokinase and pyruvate
kinase. Complete the table below:
Enzymes Role in glycolysis Inhibitor/s
Hexokinase Catalyzes the Glucose 6 phosphate
phosphorylation of glucose
Phosphofructokinase Catalyzes the citrate
phosphorylation of fructose
6-phosphate
Pyruvate kinase Helps in the production of Phenylalanine
ATP and pyruvate from ADP
2. About 30% of glucose is metabolized thru Pentose phosphate pathway and NADPH was
produced.
a. Name three metabolic pathway in our body that needs NADPH.
- Glycolysis
- Gluconeogenesis
- Pentose phosphate pathway
b. PPP pathway important in production of triose, hexose, and pentose and some these
molecules is required in formation of DNA and RNA (true/false?)
-True
3. Explain about the diagram below.
Figure: Glycogen metabolisms
4. Cori acid cycle (Lactic acid pathway)
a. In which organs does the event below occur:
i. Lactic acid formation - Muscle
ii. Lactic acid breakdown – liver
b. Lactic acid cycle occur in anaerobic / low oxygen condition and i.e. during strenuous
exercise (true/false?)
-True
Protein metabolisms
1. Urea production occurs almost exclusively in __the liver__.
2. Nitrogen atoms of urea produced in the urea cycle are derived from:
a. _Ammonia_
b. _Aspartic acid_
3. Urea cycle converts from __Ammonia_ to __Urea___ and it is ___less__ toxic
