ANNA Mi DRUG DOSE CALCULA TIONS PELG DOSE CALCULATION nit conversations ike = 1000g Ig= 100mg Img = 1000 micro g Imicro g= 10% g Ing= 107 Ipg= 10"? g Mole: quantity of anything that has same number of particles found in 12g of on $2 Particles is roughly 6.022 X 10 1 mole of copper has 6.022 X 10” atoms and weighs about 63.54 gms, | mole of ammonia has 6.022 X 10 atoms and weighs about 17 gms. lolecular weigh weight of T mole of compound expressed in gms (e/mole). Equivalents : ‘Amount of substance in moles required to combine with 1 mole of other substance . Ex: HCI( 1 mole of H with Imole of Cl) 1:1 CaCI2 (1/2 mole of Ca with | mole of Cl)-1/2:1 HCI: H and Cl combine with in 1:1 ratio ( both are monovalent ) Fag 2: Ca and Cl combine in 1:2 ratio Ca is divalent. Cl is monovalent ) HCI: Imole of H is | equivalent CaC2 : 4 mole of Cais 1 equivalent, Milli equivalents (mEq/meq) : mount of substance in equivalent often have a very small magnitude so it is frequently described i terins of meq. "ris sed to measure concentration of electeolyes in solution. Volume : 1 Itr=1000m1 nillimoles of solute per liter of solution , millimoles of solute per Kg of solvent. Osmole No. of motes of solute that contribute te the osmotic pressure of a sol 11ig fem comes from the phenomenon osmosis and is typically used for osmotically active solutions i to express osmolarity or osmolality glucose Imol = losmole 3 BACK teal 2a | (NC dissociate in water to Na and C1) CaCl - Imolt =3 osm/ | | osmol 1000mittiosmot, Drop: Drop factor : No. of drops per volume of uid Macrodtipset: 20 = Iml Aoncentration ; "a solution = 1e-100mI1 2)= 1000m; 451000 solution 12/1000m! = 100G £/100mI to00miPREPARATIONS, Drops : concentration is usually measured per ml Ampoule/ vial : concentration is usually measured in | or 2 ‘measured /20ml = 500mg/20ml) Syrup/suspension : concentration is usually measured per I ml in pralidoxime ampoule i, Abbrevations: Dextrose W =Water wer luctate % dextrose in water /5g of dextrose in 100m! of water dextrose in 100m! of 0.225% saline. 9 VIN = volume/volume (drug is in liquid dosage form) % WN = weight/volume(drug is in solid dosage form) 1. Calculate no. of drops to be given /min, i macrodrops=1 nil) ? 500m of NS has to be administered in Ghrs (40 500% 20 = 10,000 da, Gh = ZOmn OM (in is required administered rie OFAfug, ? (e000 + 2adovps 100m! of 5% D has to be administered in Shrs ANS: 5 hrs-> 100m1 The -> x ml 20m! should be given per hour Inti 3. Calculate the volume of fluid to be given /hr if 500mg of Dopamine D and drug has to be given at a rate of 20 mg /r? added (o 250mt of 5% ANS: 500 mig of Dopamine> 250m! of dextrose Img of dopamine -> 250/500 = 0.5m! of dextrose Img of dopamine > 0.5ml of dextrose 20mg of dopamine -> 20/0.5 = 10mi INFERENCE: 4 How many mg of Noradrenaline is present in 4m ampoule of 1:1000 solution ? ANS: 1:1000 = Igm in 1000mI 000mg in 1000m1 1000n11- !0u0n mt 4x1000/1000 = dingne is present in 10m! ampoule 1:2,00,000 sol tion ? ANS. 1gm of adrenaline > 2,00,000 mt 1000mg of adrenaline -> 2,00,000 ml Xmg of adrenaline > 10ml X mg= 10 X1000/2,00,000 = 0.05 mg INFERENCE: 6. How many mf of a 1:10,000 solution would you need to obtain Lg of adrenaline ? ANS: 1:10000 solution > Igm in 100¢0mi 100mg in 10000m1 Img = | x 10000/1000 = 10ml INFERENCE: 7. How many mg of lignocaine is present in a 10m ampoule of lignocaine 1'% solution ? ANS, 1% lignocaine= 1gm in 100ml = 100mg in 100m! X ing in 10 ml = 10 x 100/100 = 100mg INFERENCE: 8) How many mil of amoxicillin suspension is needed for a child of a) 4yrs b)weighing 10 kg ©) Gyrs. Recommended dose 25mg/kg/day in three divided doses? Given: commercial amoxcillin syrup-125mg/Sml. a) Dillings formula: paediatric = age/20 x adult dose a) Dillings formula: Adult dose: for Ikg > 25mg for 70kg-> ? for 70kg = 25 x 70 Adult dose = 1750mg Pediatric dose = 4 /20 x 1750mg = 350mg/day 125mg of amoxicillin in Sml For 350mg of amoxicillin in? =5/125_x 350= 14ml For 3 doses = 14ml For 1 dose = 14/3 = 4.66ml. 4.66 ml of amoxicillin syrup is needed for a child of ayrs per dose. b) for tke ane for 10kg “ 7 = 25 x 10= 250mg For 125mg-> Sml For 250mg 2 = S/125 x250=10ml For 3 doses = 10m! For Idose= 2 = 103=3.3ml 3.3 sil of amoxicillin syrup rediatvic dosemz > smi For S25mg > 2 = 5/125 x525=2Iml For 3 doses = 21mi For Idose= 2? = = 21/3 =7ml 7 ml of amoxicillin syrup is required for a child of Gyrs 9) How many mi of amoxycillin for Syr,20kg child with recommended dose SOmg/kg body weight? Given: Comm ial amoxycillin syrup-125iig/Sml Adult dose: for Ike 50mg for 70kg > ? for 70kg = 50x 70 Adult dose = 3500mg Pediatric dose = Age/20 x Adult dose Pediatric dose = 5/20 x 350mg = 87Smg/day For 125mg Sml For 875mg > 2 = 5/125 x 875=35ml 35ml of amoxicillin syrup is needed for a child of Syrs b) for tke > somg for20kg > 7 30x 20= 1000mg For 125mg > Smit For 100mg > 2 = 5/125 x 1000=40m! 40 mi of amoxicillin syrup is required for a 20kg child. {2 How many ml of amoxycillin suspension is needed for a child of a) Tyrs b) 18kg. Recommended dose SOmg/kg bw in 3 divided doses? Given: commercial amoxycillin syrup 250mg/Sml. Adult dose: for Ikg > 50mg for 70kg> 2 for 70kg = 50 x 70 Adult dose = 3500mg Pediatric dose = Age/20 x Adult dose Pediatric dose = 7/20 x 3500mg = 122Smy/day For 250mg > Sm! For 1225mg > = 5/230 x 1225=24.5ml 24.5ml 2 = 2458 =8.1m. S:1m! of amoxiciltin syrup is needed for a child of 7yrs b) for Ike-> Some for I8kg 2 = 50 x 18= 900mg For 250mg — Sml For 900mg =? = 5/250 x 900 = 18m For 3 doses = 18m! For tdose= 7 = 183 =6ml np is required for w Sky eb,29/11/2018 Dr Jyothsna C$ 11.How many millimoles of sodium bicarbonate is present in 100 ml of 8.4 % solution? Molecular weight of sodium bicarbonate is 84. 8.4g in 100ml solution A: No. of Moles = Mass/Molecular weight 4/184 = 0.1M ).1*1000 mM 00 mM Inference: 100 mmol of NaHCO3 is present in 100 ml of 8.4 % solution 12. (a) How many tablets of 125 mg of chloroquine sulphate is required for a total dose of 300 mg of chloroquine base? (b) How many tablets of 100 mg of chloroquine phosphate is required for a total dose of 300 mg of chloroquine base? (©) How many ml of syrup of chloroquine sulphate is to be prescribed for a total dose of 300 mg of chloroquine base? Gi 200 mg of chloroquine sulphate contains 150 mg of base 250 mg of chloroquine phosphate contains 155 mg of base 5 ml of chloroquine sulphate contains 50 mg of base (@) 150 mg of chloroquine base + 200mg of chloroquine sulphate 300mg of chloroquine base > ? = (300 x 200) /150 mg = 400mg (Chloroquine sulphate) 125 mg is equivalent to 01 tablet 400 mg is equivalent to G ? tablets = (1x 400) /125 mg = 3.2 tablets Inferens .2 tablets are required for total dose of 300mg of base. (b) 155 mg of base > 2 }0 mg of base -> 7 0 x 300) 155 mg = 250 mg of chloroquine phosphate 2 483.8 mg (Chloroquine phosphate) 100 ing ts eawivaient ul “Ls CeQyesaliquatitysat Wes 483.8 mg is equivalent to O ? tablets = (1x 483.8)/ 100 = 4.838 tablets Inference: 4.838 tablets are required for total dose of 300mg of base. ©) 50mg of base 0 Sml 300mg of base 5 ? ml = (5.x 300) /50 mg = 30ml Inference: 30ml of chloroquine sulphate syrup is prescribed @ Patient is brought to casualty with complaints of chest pain which is den in onset and fatigue, On examination, SBP = 75 mm He, bilateral basal crepitations are heard, ECG showed anterior wall MI and X-ray showed pulmonary embolism, 2) How do you start dopamine drip? (b) Whatis the required drip rate? (© How many hours of infusion is required? 7-10 microgram/kg body weight/minute Dopamine in commercial vial = 200 mg of dopamine/ Sal 1 vial =5 mi Dopamine vials available = 200mg of Dopamine/Sml; Lvial=Sml A: 1kg 0 10 ng 70kg O 10x 70 pg = 700 yg = 0.7 mg/min 200mg 0 smi 0.7mgO ? = (5 x 0.7) /200 = 0.017Smlémin- Inference: Dopamine drip is started with 0.0175mI/min 16 drops ? = (16 x 0.0175) = 0.272 drops/min Inference: Required drip rate 0.272 drops/min ©) 0.7mg 0 1 min 200mg 0 ? = (1x 200) / 0.7 = 285.7 min 285.7 min/60 = 4.761hrs In ren 761hrs of infusion is(aya vial containing 50 mg of so. dextrose ia wee dium nitroprusside was dissolved in 5 ml of 5% trose in ind is injected into 500 ml of $ % dextrose infusion bottle. ae nitroprusside should be administered 1.5 microgram/kg body __ Weight/minute for its antihypertensive effect. “ ; Given: body weight is 70 kg. Cateulate the drip rate and the number of hours of infusion needed. (@) 1.5pg/min 9 Ikg 70kg 70 x .1.5 = 105 g/min 0.105mg/min 105 up nin Adult dose is 0.10Smg/min "i! 50 mg — 505 wt 50mg of sodium nitroprusside is present in 500 +5=50Sml 05 wy — 50d x105 505 50 ” ek 2 0.105 7 (505 x 0.105) / 50 = 10605 rnb .060SmV/min 4 — 20 mL714 Im > 16 drops am [.0605> Qi.2 1.0605 > 16 x 1.0605 : Wn Inference: Drip rate is 16.016 drops/min : ‘ \ wn b) 0.105mg in Imin 05 — wn eine ea ° ‘50mg in (1 x50) / 0.105 o4 ua = 0-105 > 1mm . =476min 30 4.0608 ml —> 4 wn 476min/60 = 7.9hs Sie 60S: Inference: 7.9 hrs of infusion is required. 110605 145 Calculate the amount in (ml) of amikacin to be prescribed to a child whose weight is (a) 20kg (b) 8kg. Recommended dose is 1Smg/kgbw/day in 2 divided dose. Dosage form= 2ml vi A: Ike 20k for 250mg for 300mg for2doses_ = = 1.2m for Idose = 06m!Inference: The amount of amikacin to e prescribed to a child whos weight is 20 kg is 0.6 ml per dose two times a day. For Ikg 15mg 8kg 2 = 15x 8=120mg for 250mg Iml 120mg 2 = 1/250 x120 0.48ml for 2 doses for 1 dose Inference: The amount of amikacin to e prescribed to a child whose weight is 8 kg is 0.6 ml per dose two times a day. 16) Calculate the amount of amikacin to be given to a child whose weight is (a)l0kg (b)12kg. Recommended dose is 15mg/kgbw/day in 2 divided dose. Dosage available in 2ml vial. Strength of solution=250mg/ml. i 2 % A:Forlkg --- 15mg gut = (¢¢ 10kg ---- ? 15x10 real 150mg ; For 250mg Iml Th. For 150mg 9 ---- —? 150/250 /5=0.6ml for2 doses = 0. 6ml "2? : for ldose = 0.6/2 =0.3ml. fj, > Inference: The amount of amikacin to be prescribed to a child whose weight is 10 kg is 0.3 ml per dose two times a day. 17) Calculate the amount of gentamycin to be given to a child whose weight is 1dkg. Recommended dose is 4mg/kg bw/day. Dosage available in 2m vial. Strength of solution is 40mg/ml. A:forlkg = 4mg forl4kg = 14x 4=56me9 = 56/40 = 1.4ml For 2ml vial For Iml vial fersome Inference: The amount of gentamycin to be prescribed to a child whose weight is 14 kgis 0.7 ml per dose 18, Calculate the amount of gentamycin to be given to a child whose body weight is 8kg. Recommended dose is 4mg/kgbw/day. Dosage form available 2ml vial. Strength of solution is 40mg/ml. A:Forlkg --- 4mg For 8kg - 2 = 4x8= 32mg For 40mg - Iml For32mg ---- 7=32/40=0.8ml For 2ml vial = 0.8 ml For Iml vial = 0.4ml Inference: The amount of gentamycin to be prescribed to a child whose weight is 14 kg is 0.4 ml per dose 19. How many ml of chloroquine phosphate suspension do you need ¢9 prescribe toa child aged 8yrs. Recommended dose is Smg/kg body weight/week, which has been prescribed orally for 8weeks. [commercial preparation= 60ml syrup where it usually contains 100mg/ml]. A:Forikg —- Smg For 70kg -— 2 =5x70 Adult dose = 350mg, Pediatric dose = (age/ 20) x adult dose = 8/20 x 350 = 140mg. For 100mg = -- Iml For 140mg — -—- 140/100 = 1.4 mlvk For 8wks, 1.4m] x 8 = 112ml Inference: 20) How many ml of chloroquine phosphate suspension do you need tv prescribe toa child aged 5. : edy weightiwt prescribed for 8wks[60ml of commercial syrup contains 100mg/10ml). A:Forlkg -- Smg For 70kg --- ? =5x70 Adult dose = 350mg. For 100mg For 87.5 mg, For 8wks = 8.75 x8 Inference: © Dillwg '¢ forme = 4 x adult dose Qo : volun diveck : 2 ib — Guth date . Vorweg's formula = Age = x adult Aose, qs 1 mg ae won Ve pd > body wt x aH x Hb deficit © ‘To von aM oy x aes col ih Here tb aii dee met — Mt © Cvealimine clessame < (14D —— ge enadieecssatiouies Sew AL SB: x OBS ® Clean = 0°693 x avd cae half fe avd + a es Flarma Cone. adudved e abe =. Qf, nhinste Che a a ( G+ Mbinsie on) =