HORMONAL
REGULATION
TUBULAR
REABSORPTION
AND TUBULAR
SECRETION
Meril Kate Mariano, MSc.
DIABETES INSIPIDUS
What is it?
Kidneys Pancreas
5 Hormones affecting Na+, Cl-,
Ca2+, and H20 reabsorption, K+
secretion by renal tubules
1. Angiotensin II
2. Aldosterone
3. Antidiuretic Hormone
4. Atrial Natriuretic peptide
5. Parathyroid Hormone
Renin-Angiotensin-Aldosterone System
Body Condition: Low blood volume and low blood pressure
Result:
The afferent arterioles’ walls are stretched less
Juxtaglomerular cells secrete RENIN into the blood.
Renin-Angiotensin-Aldosterone System
Body Condition: Low blood volume and low blood pressure
Result:
The afferent arterioles’ walls are stretched less
Juxtaglomerular cells secrete RENIN into the blood.
Renin-Angiotensin-Aldosterone System
Body Condition: Low blood volume and low blood pressure
Result:
The afferent arterioles’ walls are stretched less
Juxtaglomerular cells secrete RENIN into the blood.
Renin-Angiotensin-Aldosterone System
Body Condition: Low blood volume and low blood pressure
Result:
The afferent arterioles’ walls are stretched less
Juxtaglomerular cells secrete RENIN into the blood.
Renin-Angiotensin-Aldosterone System
Angiotensin Converting Enzyme (ACE) -
converts angiotensin I to angiotensin II
Active form of
angiotensinogen
Renin-Angiotensin-Aldosterone System
Angiotensin Converting Enzyme (ACE) -
converts angiotensin I to angiotensin II
Active form of
Angiotensin angiotensinogen
II
1. It slows down the rate of glomerular
filtration through vasoconstriction of
the afferent arterioles.
2. It improves the reabsorption of Na+,
Cl-, and H2O in the proximal
convoluted tubule through the
stimulation of Na+/H+ antiporters.
3. It stimulates the adrenal cortex to
secrete aldosterone.
Renin-Angiotensin-Aldosterone System
Angiotensin Converting Enzyme (ACE) -
converts angiotensin I to angiotensin II
Active form of
Angiotensin angiotensinogen
II
1. It slows down the rate of glomerular
filtration through vasoconstriction of
the afferent arterioles.
2. It improves the reabsorption of Na+,
Cl-, and H2O in the proximal
convoluted tubule through the
stimulation of Na+/H+ antiporters.
3. It stimulates the adrenal cortex to
secrete aldosterone.
Renin-Angiotensin-Aldosterone System
ALDOSTERONE
Principal Cells
(Collecting duct)
Renin-Angiotensin-Aldosterone System
ALDOSTERONE
Principal Cells
(Collecting duct)
Osmotic Consequence:
reabsorption of more Na+ and
Cl- resulting to less water
excreted, increasing blood
volume
Renin-Angiotensin-Aldosterone System
ALDOSTERONE
Principal Cells
(Collecting duct)
Osmotic Consequence:
reabsorption of more Na+ and
Cl- resulting to less water
excreted, increasing blood
volume
Antidiuretic Hormone (ADH or Vasopressin)
Released by: Posterior Pituitary
Function:
Increases the water permeability of the
principal cells in the last part of the
distal convoluted tubule and the
collecting duct
Antidiuretic Hormone (ADH or Vasopressin)
Released by: Posterior Pituitary
Function:
Increases the water permeability of the
principal cells in the last part of the
distal convoluted tubule and the
collecting duct
If there is no ADH, the
principal cells will have a
very low permeability to
water
Antidiuretic Hormone (ADH or Vasopressin)
Released by: Posterior Pituitary
Function:
Increases the water permeability of the
principal cells in the last part of the
distal convoluted tubule and the
collecting duct
If there is no ADH, the
principal cells will have a
very low permeability to
water
When ADH level goes down, the aquaporin
2 channels are removed (via endocytosis) -
The kidney produces more urine.
Antidiuretic Hormone (ADH or Vasopressin)
Released by: Posterior Pituitary
Function:
Increases the water permeability of the
principal cells in the last part of the
distal convoluted tubule and the
collecting duct
If there is no ADH, the
principal cells will have a
very low permeability to
water
When ADH level goes down, the aquaporin
2 channels are removed (via endocytosis) -
The kidney produces more urine.
Atrial Natriuretic Peptide
Body Condition: Large increase in blood volume
Result:
Heart will release atrial natriuretic peptide (ANP)
Atrial Natriuretic Peptide
Body Condition: Large increase in blood volume
Result:
Heart will release atrial natriuretic peptide (ANP)
Atrial Natriuretic Peptide
Body Condition: Large increase in blood volume
Result:
Heart will release atrial natriuretic peptide (ANP)
inhibits reabsorption of Na+ and water in the
distal convoluted tubule and collecting duct.
Atrial Natriuretic Peptide
Body Condition: Large increase in blood volume
Result:
Heart will release atrial natriuretic peptide (ANP)
inhibits reabsorption of Na+ and water in the
distal convoluted tubule and collecting duct.
suppresses the secretion of aldosterone and
ADH
Atrial Natriuretic Peptide
Body Condition: Large increase in blood volume
Result:
Heart will release atrial natriuretic peptide (ANP)
inhibits reabsorption of Na+ and water in the
distal convoluted tubule and collecting duct.
suppresses the secretion of aldosterone and
ADH
increases the excretion of Na+ in urine
(natriuresis) to increase urine output (diuresis)
--- decreasing blood volume and blood
pressure.
Atrial Natriuretic Peptide
Body Condition: Large increase in blood volume
Result:
Heart will release atrial natriuretic peptide (ANP)
inhibits reabsorption of Na+ and water in the
distal convoluted tubule and collecting duct.
suppresses the secretion of aldosterone and
ADH
increases the excretion of Na+ in urine
(natriuresis) to increase urine output (diuresis)
--- decreasing blood volume and blood
pressure.
Parathyroid Hormone
Body Condition: low level of Ca2+
Result:
Parathyroid glands will release
parathyroid hormone (PTH).
Parathyroid Hormone
Body Condition: low level of Ca2+
Result:
Parathyroid glands will release
parathyroid hormone (PTH).
Parathyroid Hormone
Body Condition: low level of Ca2+
Result:
Parathyroid glands will release
parathyroid hormone (PTH).
Parathyroid Hormone
Body Condition: low level of Ca2+
Result:
Parathyroid glands will release
parathyroid hormone (PTH).
Quiz
1. This increases the secretion of K+ and reabsorption of
Na+, Cl- and increases reabsorption of water.
2. This increases the reabsorption of Ca2+.
3-5. Explain
The mechanics of the Renin-Angiotensin-Aldosterone
System.
Thank You!
