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IV Bolus Drug Pharmacokinetics Analysis

The document describes a pharmacokinetic analysis of a drug administered as an intravenous bolus, detailing the effects of varying volume of distribution and clearance on plasma concentration-time profiles. It provides calculations for initial plasma concentration, half-life, mean residence time (MRT), and area under the curve (AUC) for different scenarios. Comparisons are made between the results of different volume and clearance settings, highlighting their impact on drug disposition parameters.

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32 views3 pages

IV Bolus Drug Pharmacokinetics Analysis

The document describes a pharmacokinetic analysis of a drug administered as an intravenous bolus, detailing the effects of varying volume of distribution and clearance on plasma concentration-time profiles. It provides calculations for initial plasma concentration, half-life, mean residence time (MRT), and area under the curve (AUC) for different scenarios. Comparisons are made between the results of different volume and clearance settings, highlighting their impact on drug disposition parameters.

Uploaded by

esculap
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as PDF, TXT or read online on Scribd

A drug (400 mg) is given as an intravenous bolus.

The clearance is 10 L/hr and the volume of distribution


is 50 L. Assume a one-compartment body model.

(1) Plot the expected normal and semilogarithmic plasma concentration-time profiles and
determine the initial plasma concentration C(0), t1/2, MRT and AUC.
(2) Keeping everything else the same (Dose = 400 mg, CL = 10 L/hr), double the volume of
distribution to 100 L. Plot the expected normal and semilogarithmic plasma concentration-time
profiles and determine the initial plasma concentration C(0), t1/2, MRT and AUC. Compare with
the results in (1).
(3) Keeping everything else the same (Dose = 400 mg, V = 50 L), double the clearance to 20 L/hr.
Plot the expected normal and semilogarithmic plasma concentration-time profiles and
determine the initial plasma concentration C(0), t1/2, MRT and AUC. Compare with the results in
(1).
A drug (400 mg) is given as an intravenous bolus. The clearance is 10 L/hr and the volume of distribution
is 50 L. Assume a one-compartment body model.

(1) Plot the expected normal and semilogarithmic plasma concentration-time profiles and determine
the initial plasma concentration C0, half-life, MRT and AUC.

1 - One Compartment Model, IV Bolus, First-Order Elimination, Single Dose


INPUT A B 9 OUTPUT A B
Dose (mg) 400 400 8 C(0) (mg/L) 8.0 4.0
CL (L/hr) 10 10 7 k (hr-1) 0.200 0.100
V (L) 50 100 6 t 1/2 (hr) 3.47 6.93
C [mg/L]

5 AUC (mg*hr/L) 40.0 40.0


4 AUClast (mg*hr/L) 39.6 36.4
3 MRT (hr) 5.0 10.0
2
1
0
t (last) (hr) 24 0 5 10 15 20 25 30
t [hr]

10

1
C [mg/L]

0.1

0.01
0 5 10 15 20 25 30
t [hr]

(2) Keeping everything else the same (Dose 400 mg, CL 10 L/hr), double the volume of distribution to
100 L. Plot the expected normal and semilogarithmic plasma concentration-time profiles and
determine the initial plasma concentration C0, half-life, MRT and AUC. Compare with the results
in (1).
(3) Keeping everything else the same (Dose 400 mg, Vd 50 L), double the clearance to 20 L/h. Plot
the expected normal and semilogarithmic plasma concentration-time profiles and determine the
initial plasma concentration C0, half-life, MRT and AUC. Compare with the results in (1).

1 - One Compartment Model, IV Bolus, First-Order Elimination, Single Dose


INPUT A B 9 OUTPUT A B
Dose (mg) 400 400 8 C(0) (mg/L) 8.0 8.0
CL (L/hr) 10 20 7 k (hr-1) 0.200 0.400
V (L) 50 50 6 t 1/2 (hr) 3.47 1.73
C [mg/L]

5 AUC (mg*hr/L) 40.0 20.0


4 AUClast (mg*hr/L) 39.6 20.0
3 MRT (hr) 5.0 2.5
2
1
0
t (last) (hr) 24 0 5 10 15 20 25 30
t [hr]

10

1
C [mg/L]

0.1

0.01

0.001

0.0001
0 5 10 15 20 25 30
t [hr]

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