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Scenario 3

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Mansoor Tariq
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14 views1 page

Scenario 3

Uploaded by

Mansoor Tariq
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as DOCX, PDF, TXT or read online on Scribd

A 42-year-old male presents on postoperative day 10 following a living donor liver

transplant (LDLT) for hepatitis B-related cirrhosis. He is on tacrolimus,


mycophenolate mofetil, and prednisolone. He develops low-grade fever, elevated
transaminases (AST 210, ALT 195), and has normal Doppler findings. Tacrolimus
trough level is within the therapeutic range.

Q1. What are the potential causes of elevated liver enzymes and fever in this early
postoperative period?

Q2. How would you differentiate between acute cellular rejection and infection in this
setting?

Q3. What is the rationale behind the triple immunosuppressive therapy used post-
transplant?

Q4. How would you manage suspected acute cellular rejection?

1. Discuss the rationale and long-term management strategy of immunosuppressive


therapy in recipients of living donor liver transplantation (LDLT)

2.Critically evaluate the use of biomarkers and surveillance tools for early detection
of graft dysfunction or rejection in liver transplant recipients.

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