This audio program discusses how ketamine creates its rapid antidepressant effect, skin-picking disorder, the IQ and behavioral problems in children of mothers who took antidepressants during pregnancy comparing them with children whose mothers were depressed but untreated and with children of nondepressed mothers, psychopathology in adolescent offspring of parents with panic disorder or depression, and the continuity of psychiatric disorders between ages 3 and 6. Articles can be viewed online at www.ajp.psychiatryonline.org.