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Sympathomimetic Drug Overview and Safety

Fluoxetine and sertraline are the preferred first-line SSRI drugs for treating sympathomimetics due to their mild side effect profiles. Tricyclic antidepressants are an alternative if SSRIs cause adverse effects, but MAOIs are less frequently prescribed due to risks of hypertensive crisis from foods high in tyramine. While all antidepressants carry overdose risks, SSRIs and MAOIs are safer than tricyclic antidepressants and tetracyclines, which are the most lethal, though SSRIs also have relatively low cardiac side effects compared to tricyclics.

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Reno Jun Nagasan
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48 views7 pages

Sympathomimetic Drug Overview and Safety

Fluoxetine and sertraline are the preferred first-line SSRI drugs for treating sympathomimetics due to their mild side effect profiles. Tricyclic antidepressants are an alternative if SSRIs cause adverse effects, but MAOIs are less frequently prescribed due to risks of hypertensive crisis from foods high in tyramine. While all antidepressants carry overdose risks, SSRIs and MAOIs are safer than tricyclic antidepressants and tetracyclines, which are the most lethal, though SSRIs also have relatively low cardiac side effects compared to tricyclics.

Uploaded by

Reno Jun Nagasan
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as PPTX, PDF, TXT or read online on Scribd

SYMPATHOMIMETIC

S
USE
Improvement within 1 week and are
indicated in closely monitored situations
CHOICE OF DRUG
Based on
History of good response to the agent
Adverse effect of the drug
SSRI
Preferred as the 1st line drugs
SSRI
Fluoxetine Sertraline
1st clinically may cause:
available SSRI Transient
less likely to produce stomach pain
sedation Loose stools
may cause: Paroxetine
transient agitation May cause sedation
insomnia Fluvoxamine
Anorexia
May cause
transient nausea
ALTERNATIVE TX
TCA alternative if patient complains of
adverse effects

MAOIs less frequently chosen because it


may cause hypotensive crisis when
patient ingest food high in TYRAMINE
content
ADVERSE REACTIONS
based on the lethality
TCA and teracyclines are the
most lethal
SSRIs and MAOIs are safer but can be

lethal when taken in overdose in


combination with alcohol and drugs
Cardiac safety

TCA least safe


SSRI less hypotension

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