Scribd
Upload
72 views13 pages

Understanding Aldosterone Functions

Aldosterone is a key mineralocorticoid hormone produced by the adrenal cortex, essential for regulating blood pressure and electrolyte levels. It acts by diffusing into cells, binding to receptors, and influencing gene expression to produce proteins that manage sodium and potassium transport. Clinical conditions related to aldosterone include hypoaldosteronism, characterized by low levels, and hyperaldosteronism, marked by excessive production.

Uploaded by

Ayushman Dhar
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as PPTX, PDF, TXT or read online on Scribd
72 views13 pages

Understanding Aldosterone Functions

Aldosterone is a key mineralocorticoid hormone produced by the adrenal cortex, essential for regulating blood pressure and electrolyte levels. It acts by diffusing into cells, binding to receptors, and influencing gene expression to produce proteins that manage sodium and potassium transport. Clinical conditions related to aldosterone include hypoaldosteronism, characterized by low levels, and hyperaldosteronism, marked by excessive production.

Uploaded by

Ayushman Dhar
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as PPTX, PDF, TXT or read online on Scribd

ALDOSTERONE

By- Ayushman Dhar


B.P.T. (1ST YR)
BENGAL INSTITUTE OF PHARMACEUTICAL SCIENC
WHAT IS ALDOSTERONE?
Aldosterone is the main mineralocorticoid hormone produced by
the zona glomerulosa of the adrenal cortex in the adrenal gland. It
plays a central role in the homeostatic regulation of blood
pressure, plasma sodium (Na+), and potassium (K+) levels.
CHEMICAL NATURE
Mineralocorticoids are C21 steroids
having 21 carbon
atoms. Half-life of mineralocorticoids
is 20 minutes. Daily output and
plasma level of mineralocorticoids
are 0.15μg and 0.006μg/dL.
BIOSYNTHESIS
MECHANISM OF ACTION
FUNCTIONS
Life-saving Hormone
• 1. On Sodium Ions
• 2. On Extracellular Fluid Volume
• 3. On Blood Pressure
• 4. On Potassium Ions
• 5. On Hydrogen Ion Concentration
• 6. On Sweat Glands and Salivary Glands
• 7. On Intestine
MODE OF ACTION
Sequence of Events
1. Since aldosterone is lipid soluble, it diffuses readily into the cytoplasm of the
tubular epithelial cells through the lipid layer of the cell membrane
2. In the cytoplasm, aldosterone binds with the specific receptor protein
3. Aldosterone-receptor complex diffuses into the nucleus where it binds to
deoxyribonucleic acid (DNA) and causes formation of mRNA
4. The mRNA diffuses back into the cytoplasm and causes protein synthesis along
with ribosomes. Most of the synthesized proteins are in the form of enzymes. One of
such enzymes is sodiumpotassium ATPase, which helps in the transport of sodium
and potassium.
REGULATION OF SECRETION
RENIN-ANGIOTENSIN AXIS
CLINICAL SIGNIFICANCE
• Hypoaldosteronism is a condition characterized by abnormally low levels or
impaired function of aldosterone
CLINICAL SIGNIFICANCE
Hyperaldosteronism is a condition in which one or both of your adrenal glands
produce too much aldosterone.
REFERENCES
• Essentials of Medical Physiology, Ksembulingam.
• Hyperaldosteronism: What It Is, Causes, Symptoms & Treatment
• Hypoaldosteronism: Causes, Symptoms, Diagnosis, and Treatment - DoveMed
THANK
YOU

You might also like