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Enzyme Regulation

The document discusses the function and regulation of enzymes, focusing on allosteric enzymes and their kinetics, as well as the effects of positive and negative regulators on KM and Vmax. It also covers covalent modification in enzyme regulation, specifically glycogen synthase, and introduces chymotrypsin as a model enzyme. Additionally, it outlines key concepts and problems to understand before class, including enzyme kinetics and types of inhibitors.

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Sam Rajput
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5 views10 pages

Enzyme Regulation

The document discusses the function and regulation of enzymes, focusing on allosteric enzymes and their kinetics, as well as the effects of positive and negative regulators on KM and Vmax. It also covers covalent modification in enzyme regulation, specifically glycogen synthase, and introduces chymotrypsin as a model enzyme. Additionally, it outlines key concepts and problems to understand before class, including enzyme kinetics and types of inhibitors.

Uploaded by

Sam Rajput
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as PPT, PDF, TXT or read online on Scribd

Protein Function: Enzymes

Allosteric Enzymes Often Have Sigmoid Kinetics


Allosteric Positive and Negative Regulators:
Affecting KM
Allosteric Positive and Negative Regulators:
Affecting the Vmax
Enzyme Regulation by Covalent Modification
Glycogen Synthase Regulation: Both
Allosteric and Covalent
From Ch 15

PP1: Protein
Phosphatase-1
Zymogen Regulation
Chymotrypsin – Our Model Enzyme
Things to Know and Do Before Class

1. Know the chymotrypsin reaction and the concept of


how enzymes participate in the reaction.

2. Kinetics of multisubstrate reactions.

3. Types and kinetics of reversible enzyme inhibitors.


And, the importance of Ki.

4. Types enzyme regulation and their Michaelis Menten


kinetics.

5. Be able to do EOC Problems 12, 18, 19.

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