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TG Synthesis

The document discusses the synthesis of triacylglycerol, primarily occurring in the liver and adipose tissues. It outlines the biochemical pathway involving glycerol, dihydroxyacetone phosphate, and various enzymes, highlighting the absence of glycerol kinase in adipose tissue. The synthesis process culminates in the formation of triacylglycerol from phosphatidic acid.

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Manoj Sigdel
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50 views6 pages

TG Synthesis

The document discusses the synthesis of triacylglycerol, primarily occurring in the liver and adipose tissues. It outlines the biochemical pathway involving glycerol, dihydroxyacetone phosphate, and various enzymes, highlighting the absence of glycerol kinase in adipose tissue. The synthesis process culminates in the formation of triacylglycerol from phosphatidic acid.

Uploaded by

Manoj Sigdel
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as PPTX, PDF, TXT or read online on Scribd

TG synthesis

Manoj Sigdel
Asst Prof
Department of Biochemistry
MCOMS
Synthesis of triacylglycerol

Occurs mostly in liver and adipose tissues


Glycerol Dihydroxyacetone phosphate
ATP glycerol fatty acyl CoA
kinase
ADP
Glycerol-3-P CoA
fatty acyl CoA Acyldihydroxyacetone phosphate
NADPH
CoA
Lysophosphatidic NADP+
acid fatty acyl CoA
Pi
CoA
Phosphatidic Diacylglycerol
acid phosphatase fatty acyl CoA

CoA
Triacylglycerol

Note: glycerol Kinase is absent in adipose tissue


Fig: Formation of phosphatidic acid from glycerol-3-P or DHAP,
and its conversion to triacylglycerol (Synthesis of triacylglycerides)
Thank You

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