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Pharmacrystal
<PD Inhibitors>nonslective
PDI PDI 1 PDI 2 PDI 3 Theophylline,papaverin, vinpocetin (in vinca) not exist, amrinone,milrinone,cilastazol
read Microbial source & Assay fm Piyush book question may be ask this time in GPAT, read NMR&IR(ranges) frm pavia book HAART tretment;
2 NUCLLEOSIDE REVERSE TRANSCRIPTASE INHIBITOR+ 1 NON NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITORS OR 1 OR 2 PROTEASE
: Adenosin used in sup. vent tackycardia n Mg chloride used in digoxin toxicity... Amiodaron, Flecainide,Moricizine are used in WPW HPTLC is useful for both Qualitative and Quantitative use. Do all stomata type with example Affinity chrmatography mainly use for biological compound. It is based on 'lock and key'
mechanism.
Capsule of 000 size has highest filling capsule. neostigmine use to treat mysthenia gravis . Endrophonium use to test m.gravis & to distinguish from cholinergic crisis.
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Prodrug = Drug latentiation Drug cycling betwen intestine & liver is called as enterohepatic cycling of drug.It prolongs half life
of steroidal drugs & Hormones.
Biochemical tests:
Holander test:Insulin Foulget's test: Ketohexoses Tauber's test:Aldoentoses Do such tests from appendix of Satyanarayan
PHENYTOIN:
hvng hydantoin ring in structure&bioeqvalance problm is due to poor water solublty&low therapeutic ratio.exhibit non linear p'cokonetinetics
stomata;
coca,senna-paracytic vasaka,peppermint-diacytic eucalyptus,digitalis,lobelia-anomocytic all tropane alkaloid drugs-anisocytic
read azbout karl fisher titration in kasture(very imp.) drivers test is used dor testing efficiency of wetting agents. ( NIPER 2011 ) ephedra stem has stomata
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plz read ester hydrolysis mechanism table frm jerry march.eight mechanisms are given as table
one of them is frequently asked in NIPER JEE
Terpens Biosynthsis
Terpens
mono & Di-\ sesque Tri Tetra poly
Products
Geranyl pyroPO4 ( GPP ) fernasyl pyroPO4 ( FPP ) squalene Geranyl geranial 3-methyl-3- butylpyroPO4
act on microtubules:Thibendazol,Mebendazol,Taxol,Griseofulvin,Vinca
,Colchicine..hepatotoxic:Na-valproate,paracetamol,halothane..
Examples
Atropine, Nicotine Conine, Lycopodine, piperidine indole Alka phenylethylamnine
Amino Acid
Ornithine lysine Tryptophan Tyrosin
all organic nitrate except IOSORBIDE MONONITRATE undrgos extensive 1st pass
metabolism.denitrated by glutathion reductase,aldhyd dehydro
read 1-8 Chapter frm Satyanarayan book of Biochemestry, Rewise the Microbiology w8ever yu study in 2nd year, Do all tables frm lechman
Contact At: pharmacrystalceutics@gmail.com
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vit.A in high dose cause tertogenicity and its deficiency cause xeropthalmia and night blindness, burning feet syndrome-in pantothenic ac All opioids causes BRADYCARDIA exept MEPERIDINE, drug of choice in colic pain MORPHIN, trtmnt of methanol poisonig FOMEPEZOLE Hypersensitivity & antibody involved:
Type 1 Type 2 Type 3 Type 4 IgE IgG, Ig E IgG & IgM sensitise T-cell lymphocyte
Morphine caus Pinpoint pupil, Narcotic analgesic used in pregnancy is PETHEDINE, Streptomycine is triacidic&Tetracycline is Amphoteric nat Repaglinide & nateglinide stimtents Insulin secretion Thiazolidinedione(glitazone)-ci,tro,rosi,pio
(PPAR gamma recp) increses Insulin sensitive
MAJOR SUBJCTS 4 GPAT-pharmacognsy, med chem, cology, ceutics, analysis. MINOR SUBJCTS-microbio, bio chem, bio tech, organic, forensic, clinical. Amifostin has role in cisplatin nephrotoxicity,cisplatin most nephrotoxic among all Anticancer
drug,
what is Steal phenomenon streaming potential:-(in electrophoresis) the potential between two ends is called stremg potntal
do physical pharmacy from ALFRED MARTIN
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Indinavir & Nelfinavir showed promising Antimalerial efficacy.Indinavir was found to synergise the
Antimalerial action of Artemisinin
osmotic Diuretic mannitol is used in CHF, Tachyphylaxis is associated with ephedrine Asthama is aggrevated by propanolol Adenosine and Histamine are the endogenous Anticonvolusants of the body,Pineapple contains
Bromelains which are Anti-inflamatory
In IR styrene&water used ae refs standerd, Fingerprint region 400-1500percm,Functional grp 1500-4000percm,VitB6 used in pink disease pH of 0.005M HCl ?
SDS PAGE is used for protein seperation. Circular dichromism microscopy is used for optically active compound
read clinical trail phases, antidotes.read tables in mohamad ali and piyush COGNOSY-Read Terpenoids and its isoprene units
Basic nucleus of Alkaloidal drugs Types of gums substances and its hydrolytic products
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tables ( Pharmacrystal rapid Revision Booklet contain all IMP tables for GPAT & NIPER )
draw backs of coating sieve number,mesh size types of ointments size of capsules types of Mills particle size methods
active form of cyclophosphamide is phospharamide mustard and toxic agnt formd is acrolein
causes cystic nephritis
Sennoside A=dextro
Sennoside B=Meso Lieberman Buchnard test for detection of STEROIDS Chenopodium=Ascaridole Papaverine=optically inact
CHOLERA vacine strains-inaba and ogawa, ensyme precursors-zymogens, allopurinol-acute anti gout agnt nd xanthine oxidase inhbtr,ergot od r n Disulfiram like action produced by cefoperazone, mebendazole, metronidazole, procarbazine,
chlorpropamide, nitrofurantoin....
Read Microbial source & Assay fm IP2007. question may be ask this time in GPAT,read NMR&IR(ranges) frm pavia book. stomata;
coca,senna-paracytic vasaka,peppermint-diacytic eucalyptus,digitalis,lobelia-anomocytic all tropane alkaloid drugs-anisocytic
Pharmacrystal
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Denosumab is anti RANK Ligand antibody,do all organ systems from RANG N DALE. Plicamycin(mithramycin) is the only one antibiotic which used in hypercalcemia. Trypnosoma rhodesiense and Trypnosoma gambience cause sleeing seekness. chagas' disease caused by trypnosoma cruzi.. captopril, enalppril, ciclosporin ..this 3 peptide given as oraly..... Amiodaron, Flecainide,Moricizine are used in WPW( Ward -Romano syndrom).. Adenosine used in supraventricular tackycardiya and Magnesium chloride used in digoxin toxicity MYCOPHENOLATE MOEFTIL is ionosine monophosphatedehydrogenase inhibitor.. Everolimus which is mamalion target of Rapamycin(m-TOR)INHIBITOR used in organ transplant
rejection.
HAART tretment;
2 NUCLLEOSIDE REVERSE TRANSCRIPTASE INHIBITOR+ 1 NON NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITORS OR 1 OR 2 PROTEASE INHIBITOR
Raman spectroscopy:
tunable lasers sourc:He-Ni laser DETECTOR: photomultipliers Charge-coupled device detector DETECTION ANGLE:135,90,
Act on microtubules:Thibendazol,Mebendazol,Taxol,Griseofulvin,Vinca
,Colchicine..Hepatotoxic:Na-valproate,paracetamol,halothane..
Pharmacrystal
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Resin:Sulfonamide-Formaldehyde Plasticizer:Dibutyl Pthalate;Colorants:Lake dyes;
New compound BUCHAPINE used to decrease HIV type1 virus proved by NIPER MOHALI.
Proud to be an Indian
ICH temps:
cold place cool place room temp warm excessive warm 2-8c 8-25c 25c 30-40c >40
Imipenem gets rapidly hydrolysed by d enzyme dehydropeptidase I in renal tublr cells.cilastatin is reversible inhibitr of d enzyme.so use in combination.
Montelukast is used for asthma. It will decrease the symptoms and the number of acute asthma
attacks.(new asthma patients only)
Cimetidine have anti androgenic effect(gynecomastia) n cytochrome p-450 inhibitory action also Canrenon is metabolite of Spironolacton n Eplerone is the other Aldosteron antagonist which
have less oestrogen SE
Vit D2-Ergocalciferol
Vit D3- Cholecalciferol 25-OH Vit D3- Calcidiol 1,25 di OH Vit D3- Calcitriiol
kETOCONAZOLE HAVE STREOIODOGENESIS LIKE SIDE EFFECT Pracarbazine, Metronidazole and Sulfonylurea have DISULFIRAM LIKE EFFECT... REFRACTIVE INDEX DETECTOR is also called as BULK PROPERTY DETECTOR...
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RADIO IMMUNO ASSAY is developed by Yellow and Berson in 1959 for assay of insulin...
the Lyman-alpha forest is the sum of absorption lines arising from the Lyman-alpha transition of
the neutral hydrogen in the spectra of distant gal
XAS data are obtained by tuning the photon energy using a crystalline monochromator to a range
where core electrons can be excited (0.1-100 keV pho
side effaects:
vancomycin -redman syn
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ScillarinA on enzymatic hydrolysis gives ProscillaridinA, on acid hydrolysis gives ScillaridinA Anthranol dnt giv Borntrager te Turmeric+sulphuric acid=crimson colour
Liquorice+sulphuric acid=yellow colour Reserpine+vanillin =red colour
in mass spctrum,peak with high m/z value=molecular ion peak, peak with high intensity=base peak. HLB value of SLS=40 niper 2010bit. rfr hlb scale,values,formulas,tweens nd spans names ( Pharmacrystal Postal )