metabolic/storage diseases (i.e., Hurler's syndrome, adrenoleukodystrophy disorder)
cancer of the kidneys
What are the different types of bone marrow transplants?
There are different types of bone marrow transplants depending on who the donor is. Thedifferent types of bone marrow transplant may include the following:
autologous bone marrow transplant
The donor is the child him/herself. Stem cells are taken from the child either by bonemarrow harvest or apheresis (a process of collecting peripheral blood stem cells) and thengiven back to the child after intensive treatment. Often the term "rescue" is used insteadof "transplant."
allogeneic bone marrow transplant
The donor shares the same genetic type as the child. Stem cells are taken either by bonemarrow harvest or apheresis from a genetically-matched donor, usually a brother orsister. Other donors for allogeneic bone marrow transplants include:
a parent - a haploid-identical match is when the donor is a parent and the geneticmatch is at least half identical to the recipient. Unfortunately, parents may not bea good enough match to be donors in many cases.
unrelated bone marrow transplants (UBMT or MUD for matched unrelated donor)- the genetically matched marrow or stem cells are from an unrelated donor.Unrelated donors are found through the national bone marrow registries.
umbilical cord blood transplant
Stem cells are taken from an umbilical cord immediately after delivery of an infant.These stem cells reproduce into mature, functioning blood cells quicker and moreeffectively than do stem cells taken from the bone marrow of another child or adult. Thestem cells are tested, typed, counted, and frozen until they are needed for a transplant.Because the stem cells are "new," they are able to produce more blood cells from eachstem cell. Another advantage cord blood has is that the T-lymphocytes (part of theimmune system that causes graft-versus-host disease) are not completely functional thisearly in the stage of life. Recipients of cord blood transplants have a decreased risk forsevere graft-versus-host disease.
The bone marrow transplant team:
The group of specialists involved in the care of children who are undergoing a transplantprocedure is often referred to as the "transplant team." Each individual works together to providethe best chance for a successful transplant. The bone marrow transplant team consists of: