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  • Pathophysiology of PTB (Myrc)

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    Rj Magpayo
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    The document summarizes the pathophysiology of tuberculosis infection through airborne droplets. It describes how the Mycobacterium tuberculosis bacteria are inspired into the lungs, lodge in the upper lobes and migrate to lymph nodes where they proliferate, causing inflammation of the lungs. The immune system responds by activating macrophages and neutrophils to phagocytose the bacteria, sealing them off in tubercles that develop caseous necrosis, becoming dormant within collagenous scar tissue in the bronchi.

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    PTB patho

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    Pathophysiology of Ptb (Myrc)

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    The document summarizes the pathophysiology of tuberculosis infection through airborne droplets. It describes how the Mycobacterium tuberculosis bacteria are inspired into the lungs, lodge in the upper lobes and migrate to lymph nodes where they proliferate, causing inflammation of the lungs. The immune system responds by activating macrophages and neutrophils to phagocytose the bacteria, sealing them off in tubercles that develop caseous necrosis, becoming dormant within collagenous scar tissue in the bronchi.

    Copyright:

    Attribution Non-Commercial (BY-NC)
    Download as DOCX, PDF, TXT or read online from Scribd
    Flag for inappropriate content
    623 views2 pages

    Pathophysiology of PTB (Myrc)

    Uploaded by

    Rj Magpayo
    The document summarizes the pathophysiology of tuberculosis infection through airborne droplets. It describes how the Mycobacterium tuberculosis bacteria are inspired into the lungs, lodge in the upper lobes and migrate to lymph nodes where they proliferate, causing inflammation of the lungs. The immune system responds by activating macrophages and neutrophils to phagocytose the bacteria, sealing them off in tubercles that develop caseous necrosis, becoming dormant within collagenous scar tissue in the bronchi.

    Copyright:

    Attribution Non-Commercial (BY-NC)
    Download as DOCX, PDF, TXT or read online from Scribd
    Flag for inappropriate content
    of 2

    PATHOPHYSIOLOGY (Book Based)

    Airborne/Droplets

    Inspiration of bacteria (Mycobacterium Tuberculosis) to the lungs

    Bacilli lodge to the upper lobe Migration to the lymph nodes

    Proliferation of bacilli

    Inflammation of the lungs (Pneumonitis)

    Initiation of immune response

    Activation of alveolar macrophages and neutrophils

    Phagocytosis of the bacilli

    Sealing of the colonies of bacilli

    Formation of tubercle

    Formation of caseous necrosis

    Collagenous scar tissue grows tubercle

    Complete isolation of the bacilli in the bronchi

    Bacilli becomes dormant

    Impairment of the immune system

    Bacilli escape from the bronchi

    Endogenous reactivation of dormant bacilli

    Active bacteria spread through blood and lymphatic organs

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