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NURS 1566 Clinical Form 3: Clinical Medications WorksheetsGeneric Name
Ziprasidone
Trade Name
Geodon
Classification
Antipsychotic
Dose
80mg
Route
PO
Time/frequency
Bid
Peak
1-3 days
Onset
Withinhours
Duration
Unknown
Normal dosage range
40mg twice on first day, then 60 or 80mg twice daily onsecond day, then 40-80mg twice daily.
Why is your patient getting this medication
Psychosis
For IV meds, compatibility with IV drips and/orsolutions
N/A
Mechanism of action and indications
The mechanism of action of Ziprasidone, as withother drugs used to treat schizophrenia, is unknown.Ziprasidone exhibited high in vitro binding affinityfor the dopamine D2 and D3, the serotonin 5HT2A,5HT2C, 5HT1A, 5HT1D and alpha 1-adrenergicreceptors, and moderate affinity for the histamineH1 receptor. However, it has been proposed that thedrug's therapeutic activity in schizophrenia ismediated through a combination of dopamine Type 2(D2) and serotonin Type 2 (5HT
2
) receptor antagonism.
Nursing Implications (what to focus on)
Contraindications/warnings/interactions
Use cautiously during cases of diarrhea, hepaticimpairment, dehydration.
Common side effects
NEUROLEPTIC MALIGNANT SYNDROME, dizziness,drowsiness, restlessness, PROLONGED QT INTERVAL,constipation, diarrhea, nausea
Interactions with other patient drugs, OTC orherbal medicines
(ask patient specifically)
BuSpar: CNS and/or respiratory-depressant effectsmay be additively or synergistically increased in patients taking multiple drugs that cause theseeffects.Seroquel: There is some concern that quetiapine mayhave additive adverse cardiovascular effects incombination with other drugs that are known to prolong the QT interval of the electrocardiogram.Data are conflicting.
Lab value alterations caused by medicine
Monitor serum potassium and magnesium prior to and periodically during therapy.
Be sure to teach the patient the following about thismedication
Instruct patient to take medication as directed and not todiscontinue medication without discussing it with provider.Inform patient of risk of EPS and to report themimmediately if noticed. Advise patient to change positionslowly to minimize orthostatic hypotension. May causeseizures and drowsiness, so don’t drive or operate heavymachinery until effects are known. Avoid alcohol, other CNS depressants, OTC medications and herbal productsunless approved by provider. Notify provider if pregnancyis planned or suspected. Inform about need for follow-up psychotherapy, eye exams, and lab tests.
Nursing Process- Assessment
(Pre-administration assessment)
Monitor mental status prior to and duringtherapy. Monitor orthostatic BP prior toand frequently during initial dose titration.Assess for rash. Ensure patient is nothording medication. Assess for onset of EPS every 2 months. Monitor for constipation, seizures.
Assessment
Why would you hold or not give thismed?
Cardiac dysrythmias
Evaluation
Check after giving
Diminished psychotic behaviors.
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Geodon (ziprasidone)
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| Upload Date: | 03/31/2009 |
| Copyright: | Attribution Non-commercial |
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