Etienne Robert 2010 Meas. Sci. Technol. 21 025102 doi:10.

1088/0957-0233/21/2/025102

Mass spectrometer calibration over wide concentration ranges in multicomponent gas mixtures
Etienne Robert1 Show affiliations

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AbstractReferencesCited By
A quadrupole mass spectrometer (QMS) is used to measure the mixture composition of gas samples gathered in a novel burner configuration used to generate unstretched diffusion flames. The large variations of species concentration in the mixtures found in the burning chamber lead to accuracy problems due to the nonlinearities inherent to the instrument mode of operation. To obtain precise and real-time measurements, the sensitivity of the instrument is mapped to account for important changes in the sample composition. The implemented calibration procedure accounts for the concentration of the various species of interest in the burner (H 2, He, H2O, CH4, O2, Ar, CO2) in mixtures containing up to five constituents, using up to one hundred reference mixtures. When necessary, calibration adjustments are performed using a small set of measurements to account for the effect of the drift of instrument sensitivity resulting from instrument wear or fouling. This procedure allows us to keep the relative error on the concentration of every species of interest below 5% for most of the mixtures while a classical calibration based on a limited number of reference mixtures often resulted in relative errors in excess of 50%.

PACS

07.75.+h Mass spectrometers 82.33.Vx Reactions in flames, combustion, and explosions 06.20.fb Standards and calibration
Subjects

Instrumentation and measurement Chemical physics and physical chemistry

Dates

Issue 2 (February 2010) Received 22 September 2009, in final form 10 November 2009 Published 22 December 2009

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Etienne Robert 2010 Meas. Sci. Technol. 21 025102

Calibration solutions for Thermo Scientific Mass Spectrometers

Ready-to-use standards enable quick instrument calibration.
John C. Rogers, Ph.D.; Michael M. Rosenblatt, Ph.D.; Eugene J. Cichon, B.S.; Rosa Viner, Ph.D. ; Monica Noonan, M.S.; June 1, 2011
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Routine calibration of mass spectrometers is required for optimal performance. Our new calibration solutions for Thermo Scientific Mass Spectrometers are ready-to-use liquid formulations for quick and easy instrument calibration. Calibration solutions for Thermo Scientific Ion Trap and Orbitrap Mass Spectrometers Calibration of Thermo Scientific Ion Trap and Orbitrap Mass Spectrometers is required for proper instrument performance. These high-quality calibration solutions are for regulated environments and busy laboratories and avoid time-consuming reagent preparation. Reagents are provided in high-purity Teflon*-coated containers tested rigorously to provide the highest batch-to-batch reproducibility (Figures 1 and 2).

Figure 1. Representative mass spectrum for the Thermo Scientific Pierce LTQ Velos ESI Positive Ion Calibration Solution.N-butylamine, caffeine, Met-Arg-Phe-Ala (MRFA) and Ultramark 1621 are used to calibrate Thermo Scientific LTQ Velos Ion Trap and Orbitrap Mass Spectrometers in the ESI positive ionization mode. The Nbutylamine is included to extend to low mass calibration range.

Figure 2. Representative mass spectrum for the negative ion calibration. Sodium dodecyl sulfate, sodium taurocholate and Ultramark 1621, comprise the calibration mixture used to calibrate Ion Trap and Orbitrap* Mass Spectrometers in the negative ionization mode. Calibration solutions for Thermo Scientific Triple Quadrupole Mass Spectrometers Thermo Scientific TSQ Mass Spectrometers are calibrated with multimers of tyrosine (Tyr1, Tyr3, Tyr6). All of the components of this mixture are prepared from the highest purity raw materials and are stored in inert Teflon-coated containers (Figure 3).

Figure 3. Representative mass spectrum for the triple-quadrupole MS calibration.Multimers of tyrosine are used to calibrate the TSQ series of Triple Quadrupole Mass Spectrometers.

To obtain accurate results, keep the cuvette clean and wipe off the sides before placing it into the machine. Read more: How to Calibrate a Spectrometer | eHow.com http://www.ehow.com/how_6368848_calibratespectrometer.html#ixzz1wOSulksf