Soal Onkologi 1. The current system of the laryngeal staging consider, except: A.

Site and location of the primary and regional disease B. The presence of vocal cord fixation C. Extralaryngeal spread D. Distant metastases E. Histopathology 2. The indications for Supraglottic Laryngectomy are, except: A. Supraglottic Ca T3 due to preepiglottic space invasion B. Extension to vocal cord C. Good general health D. Age < 70 years old E. Minimal medial pyriform sinus involvement above the level of the true cords 3. Indications for Supracricoid Partial Laryngectomy, except A. Supraglottic tumor T3 due to vocal cord fixation B. No preepiglottic space invasion C. Fixed arytenoids cartilage D. T2 Ca with invasion of the thyroid ala E. Poor pulmonary reseve 4. Indications for total Laryngectomy, except: A. All T3 Ca not amenable for supraglottic Laryngectomy B. All T4 Ca not amenable for supracricoid or near total Laryngectomy C. Tumor with extensive involvement of the thyroid or cricoid cartilage D. Without invasion of the surrounding soft tissue of the neck E. Extension beyond the posterior third of the base of tounge 5. Factors related for adjuvant radiation (in Laryngectomy), except A. N2 neck or evidence extracapsular spread B. Multiple level of nodal involvement C. T3 lesion D. Perineural or vascular invasion E. Metastases to inferior tracheoesophageal 6. Advance glottic lesions unfavorable, except A. Extralaryngeal involvement B. Lesion confined mostly to one side of the larynx C. Extensive bilateral disease with submucosal spread D. Extensive cartilage invasion E. Sublottic extension below the level of the lower edge of the cricoid 7. Complication of surgery (Laryngectomy), except A. Hypocalcemia

B. C. D. E.

Hematoma Aspiration pneumonia Chilous fistula Hypothyroidism

8. Methotrexate and 5-FU bekerja pada fase: A. G2 B. Resting phase C. S D. G1 E. M 9. Cisplatinum bekerja pada fase: A. G2 B. G0 C. S D. M E. G1 10. Iradiasi bekerja pada semua fase, kecuali A. G1 B. G2 C. M D. Resting phase E. S 11. Tumor cell antigens that have been indentified in the surface of the cell, except A. CD 44 B. CD 8 C. Sialyl Lewis D. Intercellular adhesion molecule E. Integrins 6 and 1 12. Possible mechanisms of immunosuppresion in head and neck cancer are, except A. Supressor T cell B. Circulating immune complex C. Histamine activation of suppressor lymphocytes inhibition of cytotoxic production D. IgG against tumor cells E. Antigen modulation of the tumor cells 13. Which one below doesnt belong to effector mechanism against head and neck cancer A. Lymphoreticular systems B. Endothelial cells C. Lymphocytes D. Immunoglobulin

E. Complement 14. Initial treatment for acute suppurative sialadenitis, except A. Improved oral hygiene B. Repeated massage of the gland C. Adequate hydration D. Intravenous antibiotics E. Surgery 15. If conservative fail for chronic sialadenitis, aggressive treatment are, except A. Use of sialogogues B. Periodic ductal dilatation C. Ligation of the duct D. Total gland irradiation E. Tympanic neurectomy 16. Which one statement below doesnt fit to Sjogrens Syndrome A. Xerostomia dan keratokonjungtivitis B. Rheumatoid factor never increased C. Second most common autoimmune disease after rheumatoid arthritis D. Ninety percent of case occur in adult women E. The average age of onset is fifty 17. Which one of the symptoms doesnt belong to Sjogrens Syndrome A. Iridocyclitis B. Achlorhydria C. Neuropsychiatric dysfunction D. Interstitial pneumonia E. Myositis 18. Necrotizing Sialometaplasia, except A. Mucosal ulceration B. Requires surgery for treatment C. Male predominant D. Always self healing E. Maybe mistaken histological for SCC or mucoepidermoid Ca 19. Yang dilakukan pada modified radical neck dissection tipe III adalah A. Pembuangan en bloc jaringan level I-III B. Pembuangan en bloc jaringan level IV-V C. Pembuangan en block jaringan level I-V D. Pembuangan n. Asesorius spinal E. Pembuangan m. Sternocleidomastoideus 20. KGB yang tidak dibuang pada posterolateral neck dissection A. Level II

B. C. D. E.

Level III Level IV Level V Sekitar preaurikular

21. Faktor yang mempengaruhi kejadian occult metastase, kecuali A. Asal tumor B. Ketebalan tumor C. Invasi perineural dan vascular D. Indicator tingkah laku biologi E. Usia penderita 22. Pernyataan yang benar di bawah ini adalah A. Inspeksi dan palpasi intra operatif tidak meningkatkan kemampuan dokter bedah untuk memprediksi nodal stage B. Staging KGB leher tanpa pemeriksaan frozen section KGB yang dicurigai tidak dapat diandalkan C. Tidak dapat dipercata pengangkatan m. Sternocleidomastoideus atau KGB pada segitiga posterior kecuali jika terdapat tumor secara nyata D. Pada Ca thyroid perlu dilakukan modified neck dissection E. Keputusan untuk memperluas selective neck dissection yang meliputi vena jugularis interna, n. XI spinal, kadang n. XII dan n. X; harus didasarkan pada temuan saat operasi dan penilaian objektif perluasan KGB 23. Which of the procedures written below is specific for Whartins tumor in parotid gland detection A. Sialography B. Stensons duct salivary fluid analysis C. Tc 99m scintigraphy D. CT scan E. MRI 24. Which one of the statement below does not correlate with medullary thyroid Ca A. Derived from C cell B. Included in MEN IIA C. Included in MEN IIB D. Increased thyrocalcitonin production E. Increased thyroglobulin production 25. In previous years we cannot make diagnosis about type of the thyroid Ca prior to excision, in what tumor written below A. Follicular Thyroid Ca B. Medullary Thyroid Ca C. Anaplastic thyroid Ca D. Papillary thyroid Ca E. Hurtle cell Ca