Adenohypophysis
Cell Type Product Target/ Action Stimulation Inhibition % of PituitaryClinical
Somatotrophs(GH/Prolactinfamily)GH(somatotrophin)-Adipocytes-
↑
lipolysis-Hepatocytes-
↑
IGF-Somatic Cells-
↑
proteinsynthesis (via IGF-1)-Chondrocytes, Myoblasts-
↑
mitosis (via IGF-1)GH-RH, NeuronalSomatostatin(GH-inhibitinghormone or SRIF)50Hyposecretion-short statureHypersecretion-pre puberty-gigantism-post puberty-acromegalyLactotrophs(GH/Prolactinfamily)Prolactin (PRL)Mammary gland/alveolar cells-
↑
milk SucklingTRHDopamine (PIF)10-25HyperS- d/t prolactinoma(most common tumor)-gonadaldysfxn, galactorrhea in m&f Corticptrophs(POMC family)ACTHAdrenal cortex-
↑
glucocorticoidsynthCRH(-) feedback fromadrenal hormones15-20HyposS-2
°
adrenalinsufficiencyHyperS-Cushing’s DzGonadotrophs(Glycoproteinfamily)FSH,LHOvaries-follicle devo,
↑
ETestis(Sertoli)-
↑
gametogenesisOvaries-follicle maturation andovulation, forms CL (
↑
E,Progesterone)Testis(Leydig cells)-
↑
testosteroneGnRH(+) & (-) feedback from sex steroids10-15F-anorexia, obesity, stress,athletics can lead to
↓
gonadotrophin secretion andoligo/amenorrheaM-X-linked disorder causes
↓
GnRH –eunichoid appearance,tall stature (b/c
∅
T to closegrowth plates)Thryotrophs(Glycoproteinfamily)TSHThyroid Follicular Cells-
↑
Iodine uptake,
↑
T3, T4TRHSomatostatin<10Hypothyroidism-Children-Cretinism-Adults-MyxedemaGoiter (d/t
↑
TSH)Hyperthyroidism-Grave’s dz
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Adenohypophysis Cell Type Somatotrophs (GH/Prolactin Family) Product GH (Somatotrophin)
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| Category: | Uncategorized. |
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| Upload Date: | 05/20/2009 |
| Copyright: | Attribution Non-commercial |
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