Professional Documents
Culture Documents
anticoagulants, 18
antihypertensive drugs, 194
Antipyrin, 94
antitoxins, 25, 7, 911, 22, 23, 25, 26, 154,
195, 198
ants, 189
Apple, Rima D., 150
Arloing, Saturnin, 37, 42, 44, 45
arsenics, 7, 9, 19
Aschenbrand, Theodor, 77
Aschkinazi, Eugne, 40
ascorbic acid, 14, 96, 1002
Aspirin, 12, 94
assay, 14, 20, 22, 50, 58, 68, 90, 94, 95,
1013, 118, 119, 163, 177, 179, 190,
197
Assistance Publique-Hpitaux de Paris, 127,
131
Associations pour le Don dOrganes et de Tissus humains (ADOT, France), 130
avitaminosis see deficiency disorders
Copyright
bacteria, 1, 5, 17, 31, 33, 41, 44
bacteriology, 7, 10, 11, 26, 45, 124
Banting, Frederick, 151, 152, 1546, 165, 168
Bard, Louis, 38, 39
Bauer, Susanne, 123
Bayer (company), 94, 143, 148, 151, 160,
163, 166, 167
Behring, Emil, 10, 36
Belladonna, 57
benefit sharing, 1849, 191, 247
Benjamin, Harry, 92
Berg, Marc, 36
beriberi, 92, 95, 141, 142
Bernard, Claude, 13, 22, 91
Best, Charles, 151, 152, 1546, 165, 168
251
252 Biologics, A History of Agents Made From Living Organisms in the Twentieth Century
beta blocker, 193
Betaxin, 96
bioassay see assay
biobank see collection
Biogen, 17
biological medicine, 124, 18, 19, 25, 34,
35, 46, 156
biologically active substances see Wirkstoffe
Biologics Control Act, 4, 5, 9, 16, 20
biomedicine/biomedical, 3, 14, 16, 19, 28,
108, 136
biopiracy, 31, 1859, 191
bioprospecting, 176, 185, 190, 195, 196
biosimilars, 1, 2, 19, 197
biotechnology, 2, 1519, 27, 31, 48, 97, 108,
122, 134, 161, 174, 196, 197
blood, 3, 4, 7, 9, 11, 13, 18, 20, 33, 35, 44,
45, 55, 110, 115, 118, 1213, 1269,
132, 133, 134, 136, 152, 155
plasma, 9, 18, 107, 126
Blum, Josef, 153
body, 2, 1214, 17, 268, 30, 65, 68, 72,
77, 79, 82, 86, 8993, 959, 10210,
11418, 12137, 141, 150, 156, 170,
198
Bhnke-Reich, Heinrich, 11
Boston Childrens Hospital, 15
botany, 31, 49, 52, 63
Bowker, Geoffrey, 111
Boyer, Herbert, 17
brands, 96, 142, 149, 165, 171
Brandt, Christina, 97
Brown-Squard, Charles-douard, 13, 91
Bureau of Biologics see Food and Drug
Administration
Brger, Max, 170
Burq, Victor B., 79, 80
Butenandt, Adolf, 96, 98, 100, 103
Copyright
C. A. F. Kahlbaum (company), 163
caffeine, 4850, 524, 98
Caillavet, H., 134
calibration, 1448, 150, 151
Calmette, Albert, 158
cancer, 17, 21, 98, 103, 116, 198
Canguilhem, Georges, 10, 98
Cannon, Walter B., 98
carbohydrate, 133, 141, 156, 170
Index
conservation, 15, 31, 52, 77, 128, 129, 137,
178, 179, 185
Constantin, Julien, 57
consumers, 2, 3, 9, 27, 30, 60, 89, 90, 92, 95,
99, 123, 143, 149, 150, 166
contamination, 2, 4, 23, 31, 39, 56, 103, 104,
110, 119
Convention on Biological Diversity (CBD),
31, 174, 1848
see also Nagoya Protocol
Convention on International Trade in
Endangered Species (CITES), 178,
187, 180, 185, 187
cortin, 6871
cortisone, 1, 15, 25, 26, 31, 196
Corynebacterium, 41
Coward, Katharine Hope, 144
Creutzfeld-Jakob disease, 127
Cristallo S.A. (company), 149
crops, genetically modified, 31
cryobiology see cryopreservation
cryopreservation, 108, 109, 111, 113,
11518
crystallization, 67, 168
Cutter Laboratories (company), 16
253
diethylstilbestrol (DES), 21
digestion, 12, 20
Digitalis, 25, 55, 58, 59
Dioscorea, 31
diphtheria, 10, 21, 23
diphtheria serum/antitoxin, 4, 7, 10, 21,
23, 25, 3346, 163, 195, 198
Direction des Affaires Mdicales (France),
127, 128
Directive 2001/83/EC (EU), 19, 20
Directive 65/65/EEC 1965 (EU), 18
distillation, 20
distribution, 10, 60, 72, 1224, 126,
12833, 136, 143, 158, 163
Division of Biologics Control/Standards see
National Institutes of Health; Food and
Drug Administration
DNA, 17, 106
recombinant DNA, 2, 16, 17, 31
do-it-yourself (DIY), 108, 113
dog, 68, 69
Dohrn, Max, 95, 98
Dohyfral, 144, 145, 147, 149
dosage, 4, 13, 53, 94, 103, 121, 157, 164
Druckrey, Hermann, 98
Duke University Hospital in Durham
(North Carolina), 128
dynamometer, 26, 7881, 857
Copyright
Ecgonin, 77
economy, 9, 15, 31, 102, 112, 129, 114, 123,
1279, 131, 133, 134, 136, 137, 170, 195
efficacy/efficiency, 7, 10, 13, 14, 27, 30, 33, 35,
36, 69, 81, 86, 8995, 97, 99, 100, 101,
103, 104, 121, 136, 1436, 149, 150,
160, 167, 171, 177, 181, 183, 193, 196
egg cells see cells
Ehrlich, Paul, 7, 35
Eichholtz (representative), 163
Eidgenssische Technische Universitt (ETH,
Zurich), 69, 70
Eijkman, Christiaan, 92
electroencephalogram (EEG), 125
Eli Lilly (company), 5, 1546, 167
Embryo Protection Act (Germany), 117
embryo, 107, 109, 11012, 11618
endocrine disruptor, 21
endocrinology, 100
254 Biologics, A History of Agents Made From Living Organisms in the Twentieth Century
enhancement, 12, 26, 50, 91, 92, 118, 126
environment, 26, 30, 98, 100, 109, 110, 111,
173, 184, 185
enzymes see proteins
epibatidine, 31, 1735, 17991
epidemic, 10, 30, 3741
epinephrine see adrenaline
ergograph, 82, 33, 857
ergosterol, 141
Escherichia coli, 17
estron, 14, 189
eugenics, 13, 99
European Agency for the Evaluation of
Medicinal Products (EMEA) see European Medicines Agency
European Medicines Agency (EMA), 18, 19
European Union (EU), 18, 20, 108
European Union Tissue Directive, 108
evaporation, 20
Eviunis, 149
Exner, Sigmund, 79
extraction, 22, 45, 46, 52, 53, 59, 115, 116,
119, 122, 154, 160, 165
Copyright
Faculty of Pharmacy (Paris), 52
Falta, Wilhelm, 170
fats, 104, 133, 141, 151, 170
Federal Task Force on Organ Transplantation and the American Society of
Transplant Surgeons (US), 132
fermentation, 22
fertilizer, 59, 60, 63
filtration, 20
Fischer, Emil, 97
fitness, 90
flavonoids, 3
Food and Drug Administration (FDA, US),
4, 1618, 24
Center for Drug Evaluation and Research
(CDER), 18
Division of Biologics Standards, 16
Food, Drug and Cosmetic Act (US), 4, 9, 16
Fordism, 115
Forschungsinstitut fr Fortpflanzungsbiologie,
99
Foucault, Michel, 12
fractionation, 126
France-Transplant (FT), 130
Index
Hirschmller, Albrecht, 78
Hitler, Adolf, 99
Hoechst (Farbwerke) (company), 41, 42, 44,
152, 154, 15961, 163, 164, 167
Hoffmann-La Roche, 27, 93, 99, 101
Hogle, Linda, 105, 114
holism/holistic, 12, 13, 101, 103, 156, 170
Holmes, Sherlock, 76
homeopathics, 13, 34
Hpital des enfants malades (Paris), 40
Hopkins, Frederic Gowland, 92
hormones, 1, 3, 1315, 1719, 21, 22, 23,
25, 27, 31
follicle hormone, 93
steroids, 69, 70, 96, 99, 103, 104, 141,
142, 196
see also growth factors
Horrock, Sally, 140
Hotel-Dieu (Paris), 126
Human Leukocyte Antigen (HLA), 130
Hydrastis canadensis, 58
hygiene, 11, 13, 26, 30, 39, 40, 95, 99, 102
Hygienic Institute, University of Rostock,
101
Hygienic Laboratory of the Public Health
Service see National Institutes of Health
hypertension, 128, 181, 198
hypoglycaemia, 155, 162
255
Copyright
IG Farben (company), 96
immunology, 122
immunosuppressiva, 122, 124, 129, 132
impotence, 92, 93
in vitro fertilization (IVF), 107, 10912,
11517
incubator, 107, 110, 111, 117
industry, 11, 12, 14, 15, 17, 18, 21, 23, 27,
29, 47, 54, 57, 58, 60, 63, 66, 75, 89, 90,
96, 99, 101, 102, 104, 139, 140, 142,
143, 147, 148, 153, 155, 157, 159, 161,
163, 16572, 183, 195
infectious diseases, 17, 23, 30, 194
infertility, 1058, 111, 116
insemination, 108, 113
Instituto Ecuatoriano Forestal y de reas
Naturales y Vida Silvestre (INEFAN,
Ecuador), 186
Insulin Committee (Germany), 29, 15771
256 Biologics, A History of Agents Made From Living Organisms in the Twentieth Century
League of Nations see World Health Organization
Lederberg, Joshua, 17
Leiden University Hospital, 145
Leo XIII, 75
levigation, 20
Liebig, Justus, 12
Liek, Erwin, 12
Lindberg, Jesper, 113, 114
Linder (representative), 163
Loewe, Walter S., 95
Lombroso, Cesare, 76, 85
Lscher, Gottfried, 68
maceration, 20
McAfee, Kathleen, 185
McCollum, Elmer, 92, 141
MacLeod, John, 151, 154, 158
macromolecules, 20, 103
Madaus, Gerhard, 13, 49
Madsen, Thorvald, 24
Maier, Karl, 102
Mantegazza, Paolo, 75
Marey, Etienne-Jules, 85
Mariani, Angelo, 75
market/marketing, 4, 5, 9, 10, 12, 15, 19,
214, 27, 29, 47, 48, 52, 54, 568,
603, 702, 93, 95, 99, 100, 106, 107,
110, 11315, 117, 123, 124, 1279,
1357, 140, 1424, 14750, 153,
15760, 162, 1647, 171, 172, 180,
181, 189, 195
Marseille Chamber of Commerce, 49
Martin, Louis, 36
Massengill & Company (company), 9
materia medica, 11, 12, 479, 52, 53, 55, 62
measles, 7, 15
Medical Research Council (MRC, London),
146, 163
Meister, Lucius and Brning (company), 41
Meng, Heinrich, 13
menstrual disorders, 93, 99
Merck (company), 77, 78, 93, 96, 100, 102,
142, 143, 148, 159, 160, 163, 181, 187
Mestern, Armand, 162
Metabolin, 153
Meyer, J. de, 165
mice, 95, 107, 177
Copyright
Index
Nietzsche, Friedrich, 85
non-governmental organization (NGO) see
reform movements
Noorden, Carl von, 158, 169
Novocain, 94
nuclear magnetic resonance spectrometers
see spectrometer
nutrition, 13, 50, 90, 92, 95, 98102, 104, 141
ODwyer tube, 40
oocytes see cells
opium, 40, 55
opotherapy, 45
Oppenheimer, Carl, 94, 97
Organ Procurement and Transplantation
Network (OPTN, US), 134
Organ Procurement Organizations (OPO,
US), 130
Organon (company), 6872, 14150
organotherapeutics/organotherapy, 13, 19,
26, 30, 91, 92, 94, 107
organs, 3, 11, 14, 18, 23, 27, 28, 46, 52, 92,
94, 98, 12137, 195
endocrine organs, 13
glands, 13, 14, 62, 67, 91, 92, 93, 142,
165, 196
heart, 122, 1259
kidney, 122, 125, 126, 131
liver, 11, 122, 125, 126, 135
lung, 122, 128
pancreas, 122, 142, 1514, 158, 160,
164, 165, 172
Oudshoorn, Nelly, 147
257
Copyright
258 Biologics, A History of Agents Made From Living Organisms in the Twentieth Century
Public Health and Marine Hospital Service
see Public Health Service
Public Health Law (France), 10
Public Health Service (US PHS), 5, 7, 9, 16
Public Health Service Act, 4, 5, 9, 10, 16
public health, 14, 21, 30, 39, 44, 96, 99, 102,
133, 143, 193
health administration, 30, 132
purification, 17, 18, 28, 29, 33, 48, 50, 68,
75, 76, 77, 86, 93, 94, 99, 110, 117,
139, 179, 180
Pyramidon, 94
Quakers Oats Company, 149
Queen Victoria, 75
Qutelet, Adolphe, 79
Quirke, Viviane, 73
rabbits, 155, 156, 160, 163, 168
Rabinbach, Anson, 78, 82
Rabot, Franois, 38, 40, 41, 42, 44
Rajan, Kaushik Sunder, 106
rat, 68, 95, 1436
recombinant proteins see proteins
recruitment, 77, 112, 113, 116, 129
reform movements, 11, 12, 14, 21, 30, 31,
72, 90, 93, 99, 1857, 191
regulation, 212, 15, 16, 1823, 257, 28,
30, 31, 37, 73, 90, 96, 97100, 105,
108, 119, 127, 133, 135, 153, 156, 158,
163, 170, 178, 185, 187, 188, 195
Reichs-Impfgesetz, 10
Reichsgesundheitsamt (German Imperial
Health Office), 10, 158, 1613
Reichspatentamt (German Imperial Patent
Office), 158, 162, 165
Reichstein, Tadeus, 6772
rejuvenation, 13, 14, 902, 99
reproduction, 13, 28, 79, 99, 105, 112, 113,
116, 117, 119, 135
reproductive cell see cells
resources, 6, 20, 23, 28, 31, 52, 57, 59, 96,
101, 105, 115, 12337, 139, 1848, 190
Rheinberger, Hans-Jrg, 29, 96
rickets, 95, 1414, 149, 150
Rietschel, Hans, 101
Rost, Eugen, 162
Roux, mile, 35, 40
Roux, Gabriel, 44
Roux, Wilhelm, 91
rubella, 15
Ruzicka, Leopold, 69
saffron, 58, 59
salvarsan, 7, 94, 162
Santillan, Jesica, 128, 129
Schaefer, Edward, 96
Schering (company), 27, 70, 96, 103, 167,
171, 172
Scheunert, Carl-Arthur, 102, 104
Schroeder, Hermann, 101, 102
Schweigart, Hans-Adalbert, 104
Schweitzer, Albert, 104
screening, 47, 112, 118, 174, 175, 182, 183,
191, 196
scurvy, 92, 95, 141, 142
Secord, James, 66
Sengoopta, Chandak, 92
sensibility, 13
serendipity, 175, 177, 180, 184, 1868
serotherapy see vaccination
serum see vaccination
sexuality/sex, 13, 25, 52, 69, 82, 90, 91, 92,
96, 99, 107, 109, 110, 112, 117, 142, 147
sheep, 13, 92
Simon, Paul, 182
slaughterhouse, 23, 90, 152
smallpox, 5, 10, 15, 30, 198
Soer, J. J., 143
Southeast Organ Procurement Foundation
(SEOPF, US), 130
Spallanzani, Lazzaro, 107
spectrography, 1446
spectrometer, 177, 179
nuclear magnetic resonance spectrometer
(NMR), 177, 179
sperm see cells
stabilization, 25, 29, 67, 133, 152, 168
standardization, 2, 3, 9, 11, 17, 226, 28, 29,
337, 39, 437, 52, 613, 657, 72,
73, 75, 76, 90, 94, 105, 106, 117, 118,
1215, 128, 131, 133, 136, 137, 140,
14462, 16772, 193, 195, 1968
Star, Susan Leigh, 111
Starling, Ernest, 13, 657, 73, 93
State Serum Institute (Copenhagen), 24
Copyright
Index
statistics, 30, 43
Steenbock, Harry, 149
Steiger, Marguerite, 71
Steinach, Eugen, 92
Stepp, Wilhelm, 92, 102, 170
sterility, 93, 99, 116
sterilization, 20, 54, 55, 57, 61, 99
steroids see hormones
Stiasny, Hans, 111
storage, 28, 105, 113, 11517, 119, 1268,
167, 180, 188
Storm van Leeuwen, Willem, 144
Straub, Walther, 93, 95
Strauss, Hermann, 158, 169
streptomycin, 194
Strophantus, 31, 59
strychnea, 22
surgery, 40, 76, 110, 1224, 127, 1324,
136, 137
synthesis, 12, 14, 22, 23, 27, 67, 69, 702,
96, 1013, 171, 183, 190, 196, 197
syphilis, 7, 20, 30
259
Copyright
260 Biologics, A History of Agents Made From Living Organisms in the Twentieth Century
Wirkstoffe, 1, 9, 12, 13, 14, 19, 27, 29,
89104
Wisconsin Alumni Research Foundation, 142
Witkop, Bernhard, 174
Whler, Friedrich, 12, 75
Wolff, Lodewijk Karel, 142, 143, 146,
14850
Woodyatt, Rollin, 156
Worboys, Michael, 249
World Health Organization (WHO), 15,
17, 11113
Committee/Commission on Biological
Standardization, 25, 146, 148, 197
Copyright