V. B.1.

Pathopysiology diagram

Risk factors: Predisposing factors:

-Family history of cervical cancer, - High fat diet
ovarian cancer, Breast, uterine, - Low fiber diet
pancreatic, colorectal cancer. - Exposure to asbestos or talc applied to
-Personal history of cervical cancer. genitalia
-Age: Menopausal. - History of smoking
-Early menarche: Before age 12
-Late menopause: after age 50
- First Pregnancy after age 30

Carcinogens damage the cells in

the ovaries

Chronic cell injury

(Failure of the DNA to
repair)

Genetic
Mutation

Replication of Mutated genes

through:
-Activation of growth promoting
oncogenes
-Inactivation of tumor suppressor
genes
-Alteration in genes that control
apoptosis
43
 Beginning of
oncogenesis

Hyperpla Dyplasi Metaplas

sia a ia

Neoplasm
formation

Malignant Neoplasm (Ovarian

Cancer)

Altered control of growth proliferation of

cancer cells in one ovary which will activate
Phagocytosis (stage 1)

Phagocyte together with cancer cell will Individual caner flow through the
flow through the blood blood

Adjacent organs will be involved in cancer

growth
(stage 2)

Phagocyte with cancer cell will continue to Uncontrolled growth of

flow systematically through the blood cancer cells

Travel through the lymph

vessels

44
 Drained by the lymph
nodes and causing
damage to the lymph

Malignant extension to urinary Large Tumor pressing on

bladder to the Kidneys drainage
system

Blockage casues urine to back up into

the kidneys

Crea=
immunosuppress WBC -21 Stasis of toxic 811 Too much excess fluid will retain in
ion wastes that are K= 3.6 the kidneys (Hydronephrosis).
needed to be Na= 245
excreted by the BUN= 29

Recurrent Urinary tract Build up of excess

infections fluid in
bloodstream
Increase levels of
uremia flow to brain to
bloodstream

Excess fluid may

causes increase
Lethargi Seizure
pressure in blood
c s

45
 Causing fluid shifting Increase blood
between blood vessel pressure of
and interstitial spaces 160/90-210/130
and lungs

Dyspne Bipedal non pitting

a edema

46