III.

Pathophysiology

Predisposing Factors: Patients age is 59 y/o Past History- breast cancer Taking Tamoxifen for 1 year (Studies revealed that tamoxifen also promotes endometrial growth although an antiestrogen agent that is used to treat breast cancer)

Precipitating Factosr: High fat diet Menopause

Stimulation of increased estrogen production

Proliferation of cells in the uterus Diagnostics Transvaginal Sonography (UTZ revealed thickened endometrium) Pelvic exam

Pain Tenderness Palpable mass at hypogastric region Dysmenorrhea

Overgrowth of the endometrial lining

Develops into uterine fibroid

Compression of the bladder Urinary frequency, constipation, fatigue, feeling of heaviness

Interference in the vascular supply

Deterioration in the interior part of the fibroid