What is irritable bowelsyndrome (IBS)?

Irritable bowel syndrome is a disordercharacterized most commonly by cramping,abdominal pain, bloating, constipation,and diarrhea. IBS causes a great deal of discomfort and distress, but it does not per-manently harm the intestines and does notlead to a serious disease, such as cancer.Most people can control their symptoms with diet, stress management, and pre-scribed medications. For some people,however, IBS can be disabling. They maybe unable to work, attend social events,or even travel short distances. As many as 20 percent of the adult pop-ulation, or one in five Americans, havesymptoms of IBS, making it one of themost common disorders diagnosed bydoctors. It occurs more often in womenthan in men, and it begins before the ageof 35 in about 50 percent of people.

What are the symptomsof IBS?

Abdominal pain, bloating, and discomfortare the main symptoms of IBS. However,symptoms can vary from person to person.Some people have constipation, whichmeans hard, difficult-to-pass, or infrequentbowel movements. Often these peoplereport straining and cramping when tryingto have a bowel movement but cannoteliminate any stool, or they are able toeliminate only a small amount. If they areable to have a bowel movement, there maybe mucus in it, which is a fluid that moist-ens and protect passages in the digestivesystem. Some people with IBS experiencediarrhea, which is frequent, loose, watery,stools. People with diarrhea frequently feelan urgent and uncontrollable need to havea bowel movement. Other people withIBS alternate between constipation anddiarrhea. Sometimes people find that theirsymptoms subside for a few months andthen return, while others report a constant worsening of symptoms over time.

What causes IBS?

Researchers have yet to discover any spe-cific cause for IBS. One theory is thatpeople who suffer from IBS have a colon,or large intestine, that is particularly sensi-tive and reactive to certain foods and stress.The immune system, which fights infection,may also be involved.

National Digestive Diseases Information Clearinghouse

NationalInstitute ofDiabetes andDigestiveand KidneyDiseasesNATIONALINSTITUTESOF HEALTH

Irritable BowelSyndrome

U.S. Departmentof Health andHuman Services

• Normal motility, or movement, maynot be present in the colon of a person who has IBS. It can be spasmodic orcan even stop working temporarily.Spasms are sudden strong musclecontractions that come and go.• The lining of the colon called theepithelium, which is affected by theimmune and nervous systems, regu-lates the flow of fluids in and out of the colon. In IBS, the epitheliumappears to work properly. However, when the contents inside the colonmove too quickly, the colon loses itsability to absorb fluids. The result istoo much fluid in the stool. In otherpeople, the movement inside thecolon is too slow, which causes extrafluid to be absorbed. As a result, aperson develops constipation.• A person’s colon may respondstrongly to stimuli such as certainfoods or stress that would not bothermost people.• Recent research has reported thatserotonin is linked with normal gastro-intestinal (GI) functioning. Serotoninis a neurotransmitter, or chemical,that delivers messages from one partof your body to another. Ninety-fivepercent of the serotonin in your bodyis located in the GI tract, and theother 5 percent is found in the brain.Cells that line the inside of the bowel work as transporters and carry theserotonin out of the GI tract. People with IBS, however, have diminishedreceptor activity, causing abnormallevels of serotonin to exist in the GItract. As a result, they experienceproblems with bowel movement,motility, and sensation—having moresensitive pain receptors in their GItract.• Researchers have reported that IBSmay be caused by a bacterial infectionin the gastrointestinal tract. Studiesshow that people who have had gas-troenteritis sometimes develop IBS,otherwise called post-infectious IBS.• Researchers have also found very mildceliac disease in some people withsymptoms similar to IBS. People withceliac disease cannot digest gluten,a substance found in wheat, rye, andbarley. People with celiac disease can-not eat these foods without becoming very sick because their immune sys-tem responds by damaging the smallintestine. A blood test can determine whether celiac disease may be present.(For information about celiac dis-ease, see the NIDDK’s

Celiac Disease

fact sheet.)2 Irritable Bowel Syndrome

How is IBS diagnosed?

If you think you have IBS, seeing yourdoctor is the first step. IBS is gener-ally diagnosed on the basis of a completemedical history that includes a carefuldescription of symptoms and a physicalexamination.There is no specific test for IBS, althoughdiagnostic tests may be performed to ruleout other problems. These tests mayinclude stool sample testing, blood tests,and x rays. Typically, a doctor will performa sigmoidoscopy, or colonoscopy, whichallows the doctor to look inside the colon.This is done by inserting a small, flexibletube with a camera on the end of it throughthe anus. The camera then transfers theimages of your colon onto a large screen forthe doctor to see better.If your test results are negative, the doctormay diagnose IBS based on your symp-toms, including how often you have hadabdominal pain or discomfort during thepast year, when the pain starts and stops inrelation to bowel function, and how yourbowel frequency and stool consistency havechanged. Many doctors refer to a list of specific symptoms that must be presentto make a diagnosis of IBS.

Symptoms include

• Abdominal pain or discomfort forat least 12 weeks out of the previous12 months. These 12 weeks do nothave to be consecutive.• The abdominal pain or discomfort hastwo of the following three features:– It is relieved by having a bowelmovement.– When it starts, there is a changein how often you have a bowelmovement.– When it starts, there is a changein the form of the stool or the wayit looks.• Certain symptoms must also bepresent, such as– a change in frequency of bowelmovements– a change in appearance of bowelmovements– feelings of uncontrollable urgencyto have a bowel movement– difficulty or inability to pass stool– mucus in the stool– bloating• Bleeding, fever, weight loss, and per-sistent severe pain are not symptomsof IBS and may indicate other prob-lems such as inflammation, or rarely,cancer.The following have been associated with a worsening of IBS symptoms• large meals• bloating from gas in the colon• medicines• wheat, rye, barley, chocolate, milkproducts, or alcohol• drinks with caffeine, such as coffee,tea, or colas• stress, conflict, or emotional upsetsResearchers have found that women withIBS may have more symptoms duringtheir menstrual periods, suggesting thatreproductive hormones can worsen IBSproblems.In addition, people with IBS frequently suf-fer from depression and anxiety, which can worsen symptoms. Similarly, the symptomsassociated with IBS can cause a person tofeel depressed and anxious.3 Irritable Bowel Syndrome