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Anticoagulants, Direct and Indirect Thrombin Inhibitors

Anticoagulants, Direct and Indirect Thrombin Inhibitors

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Published by Rinta Moon
DIRECT THROMBIN INHIBITORS
INDIRECT THROMBIN INHIBITORS: Mechanism of action of UFH and LMWH
VITAMIN K ANTAGONISTS
DIRECT Xa INHIBITORS
ANTICOAGULANT
DIRECT THROMBIN INHIBITORS
INDIRECT THROMBIN INHIBITORS: Mechanism of action of UFH and LMWH
VITAMIN K ANTAGONISTS
DIRECT Xa INHIBITORS
ANTICOAGULANT

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Published by: Rinta Moon on Nov 30, 2013
Copyright:Attribution Non-commercial

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11/30/2013

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ANTICOAGULANT
An
anticoagulant
 is a substance that prevents or reduces coagulation (clotting) of blood. This group of
pharmaceuticals can be used in vivo as a medication for
thrombotic disorders.
Thrombosis
 is the formation of a blood clot (thrombus) inside a blood vessel, obstructing the flow
of blood through the
circulatory system. If the clot becomes mobile and is carried away by the blood circulation, it is called an
embolus
.
 
Anticoagulants is required if one has been diagnosed with or treated for one or more of the following:
Atrial fibrillation (AF)
-
lack of an organized atrial contraction can result in some
stagnant blood in the left atrium (LA)
thrombus formation
heparin, warfarin, dabigatran, rivaroxaban
Arterial embolism
-
sudden interruption of blood flow to an organ or body part due to an embolus adhering to the wall of an artery blocking the flow of blood
warfarin, heparin
 
Deep vein thrombosis (DVT)
-
formation of a blood clot (thrombus) in a deep vein, predominantly in the legs
venous stasis, hypercoagulability, and changes in endothelial blood vessel lining (such as physical damage)
LMWH, fondaparinux, unfractionated heparin, warfarin
Pulmonary embolism (PE)
-
blockage of the main artery of the lung or one of its branches due to an embolus
most commonly results from deep vein thrombosis
LMWH, fondaparinux, unfractionated heparin, warfarin
Stroke
-
rapid loss of brain function due to disturbance in the blood supply to the brain
thrombosis, arterial embolism
Warfarin

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