Brand name: CatapresGeneric name:
Clonidine
Indication:
Clonidine is indicated in the treatment of hypertension.
Drug Classification:
Therapeutic Category: Antiadrenergics
Mechanism of Action:
Reduces sympathetic outflow from CNS, producing a decrease invasomotor tone and heart rate.
Dosage:
Adults:Oral: Initial: 0.1 mg twice daily, usual maintenance dose: 0.2-1.2 mg/day in 2-4divided doses; maximum recommended dose: 2.4 mg/day. Nicotine withdrawal symptoms: .1 mg twice daily to maximum of 0.4 mg/day for 3-4 weeks.Transdermal: once every 7 days; for initial therapy start with 0.1 mg and increase by0.1 mg at 1-2 week intervals;Elderly: Oral: initial: 0.1 mg once daily at bedtime, increase gradually as needed.
Special Precaution:
Use with caution in cerebrovascular disease, coronary insufficiency,renal impairment, sinus node dysfunction. Do not abruptly discontinue ( rapidincrease in BP and symptoms of sympathetic overactivity, eg. Increased heart rate,tremor, agitation, anxiety, insomnia, sweating, palpitations) may occur. If need to
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