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Critical Care Nursing
lecture notes in Critical Care class
Brand name: Co-DiovanGeneric name:
Valsartan hydrochlorothiazide
Indications:
hypertension
Drug classification:
Antihypertensive agent, Angiotensin II antagonist
Mechanism of action:
hydrochlorothiazide inhibits sodium reabsorption in the distaltubules causing increased secretion of sodium and water as well as potassiumand hydrogen ions. Valsartan acts as direct antagonist of angiotensin II receptorsand causes vasoconstriction, aldosterone release, arginine vasopressin release,water intake, and hyperthopic responses.
Dosage:
1 tab daily; 25-100mg/d
Special precaution:
risk of hypotension in Na and/or vol-depleted patients, renal arterystenosis. Hepatic and renal disease, disturbance of serum electrolyte balance.May impair ability to drive or operate machinery. Lactation.
Pregnancy risk category:
C
Adverse reaction:
headache, dizziness, fatigue. Hydrochlorothiazide: Hypokalemia,hyperuricemia, electrolyte disturbances, postural hypotension, rise in bloodlipids. Rarely, jaundice, cardiac arrhythmias, blood dyscrasias. Very rarely,
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Brand Name: Co-Diovan Generic Name: Valsartan Hydrochlorothiazide Indications: Hypertension Drug
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| Upload Date: | 10/17/2009 |
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