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Lecture Serotonin ACh and Histamine

Lecture Serotonin ACh and Histamine

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Published by: sherbaloch922317 on Jul 28, 2010
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Psych 215Lecture 5a:Serotonin
Lecture 5a: 5-HT Objectives
Explain the derivation of the name “serotonin”
Describe the chemical features of 5-HT that distinguish it from catecholamines
Describe the two general 5-HT systems in the brain in terms of their projections
Distinguish between the projections of the D and M ascending 5-HT systems based onmorphology and sensitivity to toxins
Outline the pathway through which 5-HT is made from tryptophan, indicate which enzyme is therate-limiting step in 5-HT synthesis and highlight known regulatory mechanisms
Explain why altering dietary tryptophan levels can affect 5-HT levels
Describe the mechanisms of action of PCPA, fenfluramine, methamphetamine, MDMA (ecstasy),LSD, reserpine, ondansetron, fluoxetine, paroxetineand sertralineas they relate to 5-HTtransmission
Explain how one could demonstrate that serotonin releasers such as fenfluramineact on non-vesicular stores of 5-HT
Explain the effects of agonists and antagonists at 5-HT1A and/or 5-HT1B/1D receptors uponextracellular levels of 5-HT
Describe the intracellular signaling pathway for 5-HT1 receptors and relate this signaling to theirrole in regulating 5-HT release.
Describe the intracellular signaling pathway for 5-HT2 receptors and relate this signaling to theirhallucinogenic profile.
Describe some of the oddities observed regarding the regulation of 5-HT2 receptor expression byagonists and antagonists
Distinguish 5-HT3 receptors from other 5-HT receptors in terms of structure, function, andlocalization in brain
Explain the neuronal consequences of the repeated administrationof 5-HT releasers and predictwhich brain regions/behaviors would be most likely affected
Isolated from blood and induced muscle contraction in heart=“serum”+“tone”=serotoninIsolated from intestinal mucosa and induced musclecontraction=enteramine(secreted by enterochromaffincells in GI tract)-90% in GI; 8%-10% in blood platelets & 1-2% in brain (but several 100,000 5-HT neurons in your brain)-cannot cross the BBB

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