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Lecture 6' - Nucleic Acid Structure

Lecture 6' - Nucleic Acid Structure

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Published by: curlicue on Oct 21, 2008
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07/31/2010

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Lecture 6 – Nucleic AcidStructure
 
Introduction
 The term, ‘Nucleic Acid’:
refers to the functional forms of polynucleotides.
Nucleic acid structure:
follows many of the principles we learned forpolypeptides.
Some important differences, however:
1.
fewer building blocks:
each type constructed from only 4 types of monomers…
for a given length, fewer molecules can beconstructed.
each monomer has many more torsion angles:
polynucleotide chains much more flexible.
 These differences will affect the number of different
 
Nucleotides
 The monomer building blocks of Nucleic Acidsare Nucleotides.
All have a D-stereoisomeric configuration.
Each nucleotide consists of:
a phosphate (PO
4-
),
attached to the 5’ Carbon = 5’ nucleotide.
attached to the 3’ Carbon = 3’ nucleotide.
a 5-member, sugar ring;
a Nucleobase;
attached to the 1’ Carbon.
 There are two major classes of Nucleotides,
classed based upon the sugar:
by the group,Xattached to the 2’ Carbon.
RNA
contains a ribose sugar (X= OH).
DNA
contains a 2’-deoxyribose sugar (X= H).

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