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Pathophysiology (book based) Non-modifiable factors: AGE UTI is a prevalent disease among children and elderly SEX it has a higher incidence rate with the female gender Modifiable factors: Inadequate access to toilet facilities Avoidance of the urge to void Urinary catheterization Fistula between the intestine and bladder Inadequate fluid intake Pregnancy, and DM
Bacterial invasion (i.e. E.coli) Multiplication of the bacteria causing UTI in any part of the urinary tract Interruption in the normal homeostatic environment of the urinary tract Immune response by the body (defense mechanism of the body to foreign bodies) Cytokine and prostaglandin release Body induces the action of the cytokines and prostaglandins Change in urine color
Non-modifiable factor: Age Among elderly UTI frequency is roughly equal proportions in women and men.
Bacterial invasion (i.e. E.coli) Multiplication of the bacteria causing UTI in any part of the urinary tract Interruption in the normal homeostatic environment of the urinary tract Immune response by the body (defense mechanism of the body to foreign bodies) Body induces the action of the cytokines and prostaglandins The body responds by producing physiologic changes aimed at elevating body temperature. Cytokine and prostaglandin release Increased WBC subsequent to pus formation