In the family of this pedigree, as the females approach the age of
years they expect to become affected with cataract. Really only onefemale has had the good luck to constitute an exception to this rule;she has reached
years with good sight. Fourteen males have arrivedat or surpassed
years, but not one of them has become affected.The pedigree begins with a couple of which little information aboutthe female is available, except that she died at an age
at which theaffection is not noted at all in the other females of this family. Thesister of her husband was affected.We cannot determine from this pedigree, or from the others of hologynicheredity, whether the males can be conductors;
is not known whetherthe cataract is brought into the family by the male of the first generationas a conductor, or by the female.Notwithstanding the fact that this pedigree is not
extensive as tosolve all the questions which suggest themselves, it is clear that we havebefore us here a new form of heredity.The direct transmission from female to female and the affection of
the females exclude it as a case of dia-andric heredity; the number of theaffected females and of the unaffected males exclude also the hypothesisthat the affection might be dominant and independent of sex.Thisaffection is usually diagynic and females are usually unaffected, foraffected females could be born only if the father is affected and themother is a conductress. But
1911)has published a pedi-gree of hemophilia with some affected females. He noted this abnor-mality, but did not point out that the method of transmission is in thiscase very different from the usual diagynic; the hemophilia is here domi-nant and independent of sex. There are two other unusual pedigrees ofhemohhilia, one
nd the one referred to in this paper(figure
n which only the .females are affected.Daltonism is usually inherited as a diagynic trait; but an unusual pedi-gree is known with affected females, and in this case all the females
are affected, with direct transmission, and not one male.
is not admis-sible to assume that in all these cases the affection is a dominant one,independent of sex, and that by chance only females (all the females) areaffected. Such
possibility exists, to be sure; if we find a short pedigreeof this kind among ten thousand ordinary pedigrees of brachydactyly, forinstance, this may be by chance. But we know only three extraordi-nary pedigrees
hemophilia, with many affected females, and in two ofthese all the females are affected; of two cases
daltonism one is also ofThe same conclusion is justified in the case of hemophilia.