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  • Sorefinib Tosylate

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    Prathibha Siva
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    The Ras-Raf-MEK-ERK (ERK) pathway is a logical therapeutic target. It represents a common downstream pathway for several growth factor tyrosine kinase receptors which are often mutated or overexpressed in human cancers. Although considered mainly growth-promoting, in certain contexts, this pathway also seems to be apoptosis-suppressing. Several novel agents targeting this pathway have now been developed and are in clinical trials

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    The Ras-Raf-MEK-ERK (ERK) pathway is a logical therapeutic target. It represents a common downstream pathway for several growth factor tyrosine kinase receptors which are often mutated or overexpressed in human cancers. Although considered mainly growth-promoting, in certain contexts, this pathway also seems to be apoptosis-suppressing. Several novel agents targeting this pathway have now been developed and are in clinical trials

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    Attribution Non-Commercial (BY-NC)
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    4 views1 page

    Sorefinib Tosylate

    Uploaded by

    Prathibha Siva
    The Ras-Raf-MEK-ERK (ERK) pathway is a logical therapeutic target. It represents a common downstream pathway for several growth factor tyrosine kinase receptors which are often mutated or overexpressed in human cancers. Although considered mainly growth-promoting, in certain contexts, this pathway also seems to be apoptosis-suppressing. Several novel agents targeting this pathway have now been developed and are in clinical trials

    Copyright:

    Attribution Non-Commercial (BY-NC)
    Download as DOC, PDF, TXT or read online from Scribd
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    The Ras-Raf-MEK-ERK (ERK) pathway is a logical therapeutic target because it represents a common downstream pathway for several key

    growth factor tyrosine kinase receptors which are often mutated or overexpressed in human cancers. Although considered mainly growth-promoting, in certain contexts, this pathway also seems to be apoptosis-suppressing. Several novel agents targeting this pathway have now been developed and are in clinical trials. One of the most interesting new agents is BAY 43-9006.

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