October 12, 2012

THUYT TRNH SINH HC

Copyright Hoang V. Pham

October 12, 2012

Protein
Protein l g?

Protein c cu trc nh th no?

Protein c tc dng g?
Copyright Hoang V. Pham

October 12, 2012

I. Protein l g?
Hp cht hu c. i phn t Cu trc theo nguyn tc a phn

Gm hng trm n phn

n phn l axit amin
Copyright Hoang V. Pham

October 12, 2012

Minh ha mng t bo v mt s protein quan trng

Copyright Hoang V. Pham

October 12, 2012

Axit amin
n phn ca protein C hn 20 loi axit amin Gm nhm amin NH2, nhm cacboxyl

COOH v 1 nguyn t C lin kt vi 1 H v 1 gc R Gc R quyt nh tnh cht ca axit amin

Copyright Hoang V. Pham

October 12, 2012

Cu trc ca Axit amin

Copyright Hoang V. Pham

October 12, 2012

Copyright Hoang V. Pham

October 12, 2012

II. Cu trc ca protein o

Bn dng cu trc khng gian: Cu trc (I): chui plipptt cc axit amin Cu trc (II): s co xon hoc gp np cc chui plipptt Cu trc (III): protein khng gian 3 chiu Cu trc (IV): protein c 2 hay nhiu chui polipptt phi hp vi nhau

Copyright Hoang V. Pham

October 12, 2012

Cu trc bc mt
Cc axit amin lin kt vi nhau thng qua

lin kt pptt to thnh chui plipptt L trnh t sp xp cc axit amin trong chui plipptt, to ra tnh a dng v tnh c th cho protein Mt protein c th c cu to t ch vi chc cho n hng nghn axit amin
Copyright Hoang V. Pham

10

October 12, 2012

Minh ha cu trc bc mt ca protein

Copyright Hoang V. Pham

11

October 12, 2012

Cu trc bc hai
Chui plipptt co xon li hoc gp

np to thnh cu trc bc hai 2 dng:

Xon alpha

Gp np beta

c gi vng nh cc lin kt hir

Copyright Hoang V. Pham

12

October 12, 2012

Minh ha cu trc bc hai ca protein

Copyright Hoang V. Pham

13

October 12, 2012

Cu trc bc ba
o

Hnh dng protein trong

khng gian 3 chiu

o

Do xon bc hai cun xp theo kiu c trng cho mi loi protein to thnh khi hnh cu

Copyright Hoang V. Pham

14

October 12, 2012

Cu trc bc bn
Khi mt protein c cu to t mt vi chui plipetit

th cc chui plipetit li lin

kt vi nhau to nn cu trc bc bn

Copyright Hoang V. Pham

15

October 12, 2012

III. Chc nng ca protein

Cu to t bo v c th D tr Axit Amin Vn chuyn cc cht

Bo v c th
Thu nhn thng tin Cht xc tc cho phn ng ha sinh
Copyright Hoang V. Pham

16

October 12, 2012

Cu trc Xc tc (Enzym)

Vn chuyn Bo v

iu ha (Hormone)

D tr

Copyright Hoang V. Pham