Professional Documents
Culture Documents
Neurotransmitt Er Storage Synthesis Glutamate (Amino Acid) Synaptic Vesicles
Neurotransmitt Er Storage Synthesis Glutamate (Amino Acid) Synaptic Vesicles
Storage Synaptic Vesicles Synaptic Vesicles Dense Core Vesicles No storage, synthesized
(grannules) on demand
Synthesis Minor: alpha-ketoglutarate(from Regulation via Tyrosine 170 AA w 1 copy Synthesized on demand
Krebs cycle)+ Hydroxylase(TH rate neurotensin/ 1 copy
NADPH/glutamate limiting) cofactor neuromedin Two enzyme cascade:
dehydrogenase tetrahydrobiopterine BH4 Precursor lipid: NAPE
(transcyclase) high
Major: Glutamine/ glutaminase Short Term: TH intracellular Ca required;
phosphorylation, end Phospholipase D + NAPE
product NE inhibition of anandamide and
BH4 binding phosphatic acid
Release anywhere;
not just in the
active zone
Many possibly
physiological roles:
obesity,
anxiety/depression; drug
abuse
Other Primary excitatory NT in CNS distribution, Peptides are co Ananadamide is N-
mamilian brain; found all over Physiological Roles localized w/ other NT arachadonylethanlamine
CNS; synapses "asymmetrical"; and affect and are
principle outflow neurons from affected by other NT
brain region are predominatley
glutamatergic Neurotensin
inactivation/ sucretion
is more haphazard
than other NT glu/NE